TN2009000138A1 - Biaryl-ether-urees - Google Patents
Biaryl-ether-ureesInfo
- Publication number
- TN2009000138A1 TN2009000138A1 TNP2009000138A TN2009000138A TN2009000138A1 TN 2009000138 A1 TN2009000138 A1 TN 2009000138A1 TN P2009000138 A TNP2009000138 A TN P2009000138A TN 2009000138 A TN2009000138 A TN 2009000138A TN 2009000138 A1 TN2009000138 A1 TN 2009000138A1
- Authority
- TN
- Tunisia
- Prior art keywords
- compounds
- biaryl
- urea
- ether
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
La présente invention concerne les composés de formule (I) ou un de leurs sels pharmaceutiquement acceptables, des procédés pour la préparation des composés, les intermédiaires utilisés dans la préparation des composés ; des compositions contenant les composés et des utilisations des composés dans le traitement de maladies ou d'affections associées à une activité d' hydrolase d'amide d'acide gras (FAAH).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US82996606P | 2006-10-18 | 2006-10-18 | |
US96521007P | 2007-08-17 | 2007-08-17 | |
PCT/IB2007/003202 WO2008047229A2 (fr) | 2006-10-18 | 2007-10-05 | Composés d'urée de bisaryle éther |
Publications (1)
Publication Number | Publication Date |
---|---|
TN2009000138A1 true TN2009000138A1 (fr) | 2010-10-18 |
Family
ID=39314409
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TNP2009000138A TN2009000138A1 (fr) | 2006-10-18 | 2009-04-14 | Biaryl-ether-urees |
Country Status (39)
Country | Link |
---|---|
US (1) | US8044052B2 (fr) |
EP (1) | EP2076508B1 (fr) |
JP (1) | JP4434313B2 (fr) |
KR (1) | KR101181194B1 (fr) |
CN (1) | CN101595102B (fr) |
AP (1) | AP2780A (fr) |
AR (1) | AR063331A1 (fr) |
AT (1) | ATE493984T1 (fr) |
AU (1) | AU2007311591B2 (fr) |
BR (1) | BRPI0717596B8 (fr) |
CA (1) | CA2663984C (fr) |
CL (1) | CL2007003000A1 (fr) |
CR (2) | CR10701A (fr) |
CY (1) | CY1111170T1 (fr) |
DE (1) | DE602007011793D1 (fr) |
DK (1) | DK2076508T3 (fr) |
EA (1) | EA015488B1 (fr) |
ES (1) | ES2357340T3 (fr) |
GE (1) | GEP20125425B (fr) |
HK (1) | HK1139652A1 (fr) |
HN (1) | HN2007000407A (fr) |
HR (1) | HRP20110158T1 (fr) |
IL (1) | IL197664A (fr) |
MA (1) | MA30801B1 (fr) |
ME (1) | ME01308B (fr) |
MX (1) | MX2009004233A (fr) |
MY (1) | MY145460A (fr) |
NO (1) | NO342266B1 (fr) |
NZ (1) | NZ575624A (fr) |
PE (1) | PE20081265A1 (fr) |
PL (1) | PL2076508T3 (fr) |
PT (1) | PT2076508E (fr) |
RS (2) | RS20090154A (fr) |
SI (1) | SI2076508T1 (fr) |
TN (1) | TN2009000138A1 (fr) |
TW (1) | TWI404715B (fr) |
UY (1) | UY30649A1 (fr) |
WO (1) | WO2008047229A2 (fr) |
ZA (1) | ZA200902548B (fr) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ME02222B (me) | 2004-12-30 | 2016-02-20 | Janssen Pharmaceutica Nv | Amid derivati piperidin-i piperazin-1-karboksilne kiseline te povezani spojevi kao modulatori amid hidrolaze masnih kiselina (faah) za liječenje tjeskobe, boli i drugih stanja |
JO3598B1 (ar) | 2006-10-10 | 2020-07-05 | Infinity Discovery Inc | الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني |
MX2009004233A (es) | 2006-10-18 | 2009-08-12 | Pfizer Prod Inc | Compuestos de biaril eter urea. |
TW201000107A (en) | 2008-04-09 | 2010-01-01 | Infinity Pharmaceuticals Inc | Inhibitors of fatty acid amide hydrolase |
US20110060012A1 (en) * | 2008-04-17 | 2011-03-10 | Pfizer Inc. | 4-[3-(aryloxy)benzylidene]-3-methyl piperidine 5-membered aryl carboxamide compounds useful as faah inhibitors |
EP2276738A1 (fr) * | 2008-04-17 | 2011-01-26 | Pfizer Inc. | Composés d'éther-benzylidène-pipéridine-aryl à 5 chaînons-carboxamide utiles comme inhibiteurs de faah |
JP2011518146A (ja) * | 2008-04-17 | 2011-06-23 | ファイザー・インク | Faah阻害剤として有用な4−[3−(アリールオキシ)ベンジリデン]−3−メチルピペリジンアリールカルボキサミド化合物 |
WO2009127944A1 (fr) * | 2008-04-17 | 2009-10-22 | Pfizer Inc. | Composés d'éther-benzylidène-pipéridine-aryl-carboxamide utiles comme inhibiteurs de faah |
WO2009127946A1 (fr) * | 2008-04-17 | 2009-10-22 | Pfizer Inc. | Composés de 4-benzylidène-3-méthylpipéridine-aryl-carboxamide utiles comme inhibiteurs de faah |
US8461159B2 (en) | 2008-11-25 | 2013-06-11 | Jannsen Pharmaceutica BV | Heteroaryl-substituted urea modulators of fatty acid amide hydrolase |
US8598356B2 (en) | 2008-11-25 | 2013-12-03 | Janssen Pharmaceutica Nv | Heteroaryl-substituted urea modulators of fatty acid amide hydrolase |
WO2010064597A1 (fr) * | 2008-12-01 | 2010-06-10 | 武田薬品工業株式会社 | Dérivé de pipéridine |
DK2385938T3 (en) | 2009-01-12 | 2015-04-27 | Pfizer Ltd | Sulfonamidderivater |
WO2010118159A1 (fr) | 2009-04-07 | 2010-10-14 | Infinity Pharmaceuticals, Inc. | Inhibiteurs d'hydrolase d'amide d'acide gras |
WO2010118155A1 (fr) | 2009-04-07 | 2010-10-14 | Infinity Pharmaceuticals, Inc. | Inhibiteurs d'amide d'hydrolase d'acide gras |
WO2010124113A1 (fr) | 2009-04-23 | 2010-10-28 | Infinity Pharmaceuticals, Inc. | Anticorps anti-acide gras amide hydrolase 2 et leurs utilisations |
US9149465B2 (en) | 2009-05-18 | 2015-10-06 | Infinity Pharmaceuticals, Inc. | Isoxazolines as inhibitors of fatty acid amide hydrolase |
US8927551B2 (en) | 2009-05-18 | 2015-01-06 | Infinity Pharmaceuticals, Inc. | Isoxazolines as inhibitors of fatty acid amide hydrolase |
US8765735B2 (en) | 2009-05-18 | 2014-07-01 | Infinity Pharmaceuticals, Inc. | Isoxazolines as inhibitors of fatty acid amide hydrolase |
WO2010141817A1 (fr) | 2009-06-05 | 2010-12-09 | Janssen Pharmaceutica Nv | Modulateurs d'amide d'acide gras hydrolase de type diamine urée spirocyclique substituée par un groupe hétéroaryle |
US8901111B2 (en) | 2009-06-05 | 2014-12-02 | Janssen Pharmaceutica Nv | Aryl-substituted heterocyclic urea modulators of fatty acid amide hydrolase |
WO2011030798A1 (fr) | 2009-09-09 | 2011-03-17 | 大日本住友製薬株式会社 | Dérivés de 8-oxodihydropurine |
WO2011077313A1 (fr) | 2009-12-22 | 2011-06-30 | Pfizer Inc. | Pipéridinecarboxamides en tant qu'inhibiteurs de mpges - 1 |
WO2011085216A2 (fr) | 2010-01-08 | 2011-07-14 | Ironwood Pharmaceuticals, Inc. | Utilisation d'inhibiteurs de faah pour traiter la maladie de parkinson et le syndrome des jambes sans repos |
CN102834401B (zh) | 2010-02-03 | 2016-08-24 | 无限药品股份有限公司 | 脂肪酸酰胺水解酶抑制剂 |
EP2539358A1 (fr) | 2010-02-25 | 2013-01-02 | Pfizer Limited | Analogues peptidiques |
US20130224151A1 (en) | 2010-03-31 | 2013-08-29 | United States Of America | Use of FAAH Inhibitors for Treating Abdominal, Visceral and Pelvic Pain |
UA108233C2 (uk) | 2010-05-03 | 2015-04-10 | Модулятори активності гідролази амідів жирних кислот | |
WO2012004714A2 (fr) | 2010-07-09 | 2012-01-12 | Pfizer Limited | Composés chimiques |
ES2533065T3 (es) | 2010-07-09 | 2015-04-07 | Pfizer Limited | Bencenosulfonamidas útiles como inhibidores de los canales de sodio |
JP2013532186A (ja) | 2010-07-12 | 2013-08-15 | ファイザー・リミテッド | 化合物 |
US9102621B2 (en) | 2010-07-12 | 2015-08-11 | Pfizer Limited | Acyl sulfonamide compounds |
CA2801032A1 (fr) | 2010-07-12 | 2012-01-19 | Pfizer Limited | Derives de n-sulfonylbenzamide utiles comme inhibiteurs du canal sodique voltage-dependant |
JP2013532185A (ja) | 2010-07-12 | 2013-08-15 | ファイザー・リミテッド | 化合物 |
CA2804877A1 (fr) | 2010-07-12 | 2012-01-19 | Pfizer Limited | Composes chimiques |
WO2012095781A1 (fr) | 2011-01-13 | 2012-07-19 | Pfizer Limited | Dérivés d'indazole comme inhibiteurs des canaux sodiques |
UA108926C2 (ru) | 2011-04-05 | 2015-06-25 | Пфайзер Лімітед | LibreOffice? [2,3-D] +" +" !+ |
ES2564366T3 (es) | 2011-07-13 | 2016-03-22 | Pfizer Limited | Análogos de encefalina |
US9682953B2 (en) * | 2011-09-23 | 2017-06-20 | Advinus Therapeutics Limited | Amide compounds, compositions and applications thereof |
WO2013054185A1 (fr) | 2011-10-13 | 2013-04-18 | Pfizer, Inc. | Dérivés de pyrimidine et de pyridine utiles en thérapie |
MX337469B (es) | 2011-10-26 | 2016-03-02 | Pfizer Ltd | Derivados de (4-fenilimidazol-2-il)etilamina utiles como moduladores de canal de sodio. |
ES2748656T3 (es) | 2011-10-28 | 2020-03-17 | Inhibitaxin Ltd | Derivados de piridazina útiles en terapia |
ES2593533T3 (es) | 2011-12-15 | 2016-12-09 | Pfizer Limited | Derivados de sulfonamida |
WO2013093688A1 (fr) | 2011-12-19 | 2013-06-27 | Pfizer Limited | Dérivés sulfonamides et leur utilisation en tant qu'inhibiteurs de vgsc |
CA2860553C (fr) | 2012-01-04 | 2016-08-23 | Pfizer Limited | N-aminosulfonylbenzamides |
WO2013114250A1 (fr) | 2012-02-03 | 2013-08-08 | Pfizer Inc. | Dérivés d'imidazopyridine et de benziimidazole en tant que modulateurs du canal sodium |
EP2903986A1 (fr) | 2012-10-04 | 2015-08-12 | Pfizer Limited | Inhibiteurs de kinases apparentés à la tropomyosine |
EP2903989A1 (fr) | 2012-10-04 | 2015-08-12 | Pfizer Limited | Inhibiteurs de kinase associée à la tropomyosine pyrrolo[2,3-d]pyrimidine |
JP2015531395A (ja) | 2012-10-04 | 2015-11-02 | ファイザー・リミテッドPfizer Limited | ピロロ[3,2−c]ピリジントロポミオシン関連キナーゼ阻害剤 |
US9630896B2 (en) | 2013-11-22 | 2017-04-25 | Tansna Therapeutics, Inc. | 2,5-dialkyl-4-H/halo/ether-phenol compounds |
EP3319968A1 (fr) | 2015-07-06 | 2018-05-16 | Rodin Therapeutics, Inc. | N-aminophényl-amides hétérocycliques en tant qu'inhibiteurs de l'histone désacétylase |
PL3319959T3 (pl) | 2015-07-06 | 2022-02-14 | Alkermes, Inc. | Hetero-haloinhibitory deacetylazy histonowej |
WO2018132533A1 (fr) | 2017-01-11 | 2018-07-19 | Rodin Therapeutics, Inc. | Inhibiteurs bicycliques d'histone désacétylase |
PL3645518T3 (pl) * | 2017-06-30 | 2021-12-06 | Amgen Inc. | Synteza omekamtywu mekarbilu |
SI3664802T1 (sl) | 2017-08-07 | 2022-10-28 | Alkermes, Inc. | Biciklični zaviralci histon deacetilaze |
EA039850B1 (ru) * | 2018-04-30 | 2022-03-21 | Эмджен Инк. | Синтез омекамтива мекарбила |
CA3107145A1 (fr) | 2018-08-24 | 2020-02-27 | Sunshine Lake Pharma Co., Ltd. | Derives de pyridinylmethylenepiperidine et leurs utilisations |
CA3227681A1 (fr) * | 2021-08-04 | 2023-02-09 | Kimberly BABSON | Methode de traitement d'un trouble de stress post-traumatique |
Family Cites Families (100)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB138405A (en) | 1919-01-16 | 1920-02-12 | Thomas Thompson | Improvements in or relating to suction or delivery valves for pumps |
GB1138405A (en) | 1966-12-28 | 1969-01-01 | Ici Ltd | Morpholine derivatives |
US3576810A (en) | 1968-06-20 | 1971-04-27 | Robins Co Inc A H | 1-substituted-3-(-4)-aroylpiperidines |
GB1260886A (en) | 1969-06-20 | 1972-01-19 | Ici Ltd | Process for aryloxymethylmorpholine derivatives |
BE758766A (fr) | 1969-11-17 | 1971-05-10 | Ici Ltd | Nouveaux derives de la morpholine et de la |
BE759013R (fr) | 1969-11-17 | 1971-05-17 | Ici Ltd | Derives de la |
US4116665A (en) | 1976-04-02 | 1978-09-26 | Eli Lilly And Company | Method of regulating the growth of aquatic weeds with pyridine derivatives |
IL56369A (en) | 1978-01-20 | 1984-05-31 | Erba Farmitalia | Alpha-phenoxybenzyl propanolamine derivatives,their preparation and pharmaceutical compositions comprising them |
GB8424979D0 (en) | 1984-10-03 | 1984-11-07 | Wyeth John & Brother Ltd | Benzenesulphonamide derivatives |
GB2167407B (en) | 1984-11-22 | 1988-05-11 | Erba Farmitalia | Enantiomers of phenoxy derivatives of benzyl morpholine and salts thereof |
KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
AU665604B2 (en) | 1991-12-18 | 1996-01-11 | Schering Corporation | Imidazoylalkyl substituted with a six membered nitrogen containing heterocyclic ring |
DE4326344A1 (de) | 1993-08-05 | 1995-02-09 | Thomae Gmbh Dr K | Carbonamide, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
AU7823894A (en) | 1993-08-27 | 1995-03-21 | Vrije Universiteit | New imidazole derivatives having agonistic or antagonistic activity on the histamine h3 receptor |
PL183865B1 (pl) | 1995-01-11 | 2002-07-31 | Samjin Pharmaceutical Co | Nowe pochodne piperazyny i środek farmaceutyczny |
US6271015B1 (en) | 1995-06-12 | 2001-08-07 | The Scripps Research Institute | Fatty-acid amide hydrolase |
GB9526560D0 (en) | 1995-12-27 | 1996-02-28 | Bayer Ag | Use of 2-Amino-Heterocycles |
FR2744449B1 (fr) | 1996-02-02 | 1998-04-24 | Pf Medicament | Nouvelles piperazines aromatiques derivees de cycloazanes substitues, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments |
GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
US6207665B1 (en) | 1997-06-12 | 2001-03-27 | Schering Aktiengesellschaft | Piperazine derivatives and their use as anti-inflammatory agents |
US6184242B1 (en) | 1997-09-04 | 2001-02-06 | Syntex Usa (Llc) | 2-(substituted-phenyl)amino-imidazoline derivatives |
DE69912590T2 (de) | 1998-04-01 | 2004-09-16 | Janssen Pharmaceutica N.V. | Pde-iv-hemmende pyridin-derivate |
JP2002533430A (ja) | 1998-12-29 | 2002-10-08 | ファルマシア・アンド・アップジョン・カンパニー | アリールエーテルの調製方法 |
PE20001566A1 (es) | 1999-03-26 | 2001-02-05 | Ucb Sa | Piperazinas 1,4-sustituidas, piperidinas 1,4-sustituidas y 4-alquilidenilpiperidinas 1-sustituidas |
CA2371940C (fr) | 1999-03-31 | 2008-07-15 | Janssen Pharmaceutica N.V. | Amidon pregelatinise dans une formulation a liberation regulee |
US6632815B2 (en) | 1999-09-17 | 2003-10-14 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
AU7556800A (en) | 1999-10-07 | 2001-05-10 | Tadeka Chemical Industries, Ltd. | Amine derivatives |
US6476041B1 (en) | 1999-10-29 | 2002-11-05 | Merck & Co., Inc. | 1,4 substituted piperidinyl NMDA/NR2B antagonists |
HUP0204272A3 (en) | 2000-01-18 | 2005-03-29 | Pfizer Prod Inc | Corticotropin releasing factor antagonists, pharmaceutical compositions containing them and their use |
KR20020073586A (ko) | 2000-02-11 | 2002-09-27 | 버텍스 파마슈티칼스 인코포레이티드 | 피페라진 및 피페리딘 유도체 |
GB0004297D0 (en) | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
JP2003525938A (ja) | 2000-03-03 | 2003-09-02 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | 3−(ジアリールメチレン)−8−アザビシクロ[3.2.1]オクタン誘導体 |
JP2001303987A (ja) | 2000-04-21 | 2001-10-31 | Toyota Motor Corp | 筒内噴射式内燃機関のスロットル制御装置 |
WO2001095856A2 (fr) | 2000-06-15 | 2001-12-20 | Chaconne Nsi Co., Ltd. | Derive d'uree en tant qu'agent anticancereux et son procede de preparation |
US20020183316A1 (en) | 2000-10-27 | 2002-12-05 | Kevin Pan | Amidoalkyl-piperidine and amidoalkyl-piperazine derivatives useful for the treatment of nervous system disorders |
AU2002243920A1 (en) | 2001-02-08 | 2002-08-19 | Nps Pharmaceuticals, Inc. | Methods and compounds for treating neurologic or neuropsychiatric disorders and identifying compounds to treat the same |
WO2003006447A2 (fr) | 2001-07-09 | 2003-01-23 | Pharmacia Italia Spa | Inhibiteurs d'interaction de tcf-4 avec de la beta-catenine |
AU2002363236A1 (en) | 2001-10-30 | 2003-05-12 | Millennium Pharmaceuticals, Inc. | Compounds, pharmaceutical compositions and methods of use therefor |
US20040034101A1 (en) | 2001-11-05 | 2004-02-19 | Cypress Bioscience, Inc. | Treatment and prevention of depression secondary to pain (DSP) |
JP3865626B2 (ja) | 2001-11-08 | 2007-01-10 | 株式会社ベステックスキョーエイ | パイプ部材 |
FR2833261B1 (fr) | 2001-12-06 | 2004-07-02 | Yang Ji Chemical Company Ltd | Nouveaux composes inhibiteurs specifiques de la phospholipase a2 secretee non pancreatique humaine du groupe ii |
US20040063726A1 (en) | 2002-02-08 | 2004-04-01 | Artman Linda D | Methods and compounds for treating neurologic or neuropsychiatric disorders and identifying compounds to treat the same |
OA12790A (en) | 2002-03-13 | 2006-07-10 | Janssen Pharmaceutica Nv | New inhibitors of histone deacetylase. |
US6995144B2 (en) | 2002-03-14 | 2006-02-07 | Eisai Co., Ltd. | Nitrogen containing heterocyclic compounds and medicines containing the same |
AU2003220184A1 (en) | 2002-03-20 | 2003-10-08 | Schering Aktiengesellschaft | Substituted piperazine antithrombotic pai-1 inhibitors |
TWI283241B (en) | 2002-05-29 | 2007-07-01 | Tanabe Seiyaku Co | Novel piperidine compound |
US20070134753A1 (en) | 2002-10-21 | 2007-06-14 | Barbier Ann J | Assay for determining the activity of fatty acid amide hydrolase |
AR043633A1 (es) | 2003-03-20 | 2005-08-03 | Schering Corp | Ligandos de receptores de canabinoides |
AU2004226278B2 (en) | 2003-04-03 | 2010-07-29 | Merck Patent Gmbh | Pyrrolidino-1,2-dicarboxy-1-(phenylamide)-2-(4-(3-oxo-morpholino-4-yl)-phenylamide) derivatives and related compounds for use as inhibitors of coagulation factor Xa in the treatment of thrombo-embolic diseases |
SE0301442D0 (sv) | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations therof and uses thereof |
SE0301443D0 (sv) | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
AR045047A1 (es) | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
GB0325287D0 (en) | 2003-10-29 | 2003-12-03 | Merck Sharp & Dohme | Therapeutic agents |
GB0325956D0 (en) | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
CA2545425C (fr) * | 2003-12-03 | 2013-09-24 | Cytopia Research Pty Ltd | Inhibiteurs de kinases a base d'azole |
US7435822B2 (en) | 2004-02-03 | 2008-10-14 | Janssen Pharmaceutica N.V. | 3-(diheteroarylmethylene)-8-azabicyclo[3.2.1]octane and 3-((aryl)(heteroaryl)methylene)-8-azabicyclo[3.2.1]octane derivatives |
EP1737861A4 (fr) * | 2004-04-09 | 2010-04-28 | Merck Sharp & Dohme | Inhibiteurs de l'activite d'akt |
US20080103209A1 (en) | 2004-04-23 | 2008-05-01 | The Regents Of The University Of California | Compounds And Methods For Treating Non-Inflammatory Pain Using Ppar Alpha Agonists |
SE0401343D0 (sv) | 2004-05-25 | 2004-05-25 | Astrazeneca Ab | Therapeutic compounds: Pyridine N oxide as scaffold |
DK1756084T3 (da) | 2004-06-04 | 2009-03-23 | Arena Pharm Inc | Substituerede aryl- og heteroarylderivater som modulatorer af metabolisme og forebyggelse og behandling af forstyrrelser beslægtet dermed |
DE102004039789A1 (de) | 2004-08-16 | 2006-03-02 | Sanofi-Aventis Deutschland Gmbh | Arylsubstituierte polycyclische Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
EP2316458A1 (fr) | 2004-09-20 | 2011-05-04 | Xenon Pharmaceuticals Inc. | Derives de pyridazine destines a l'inhibition du desaturase-coa-stearoyl de l'humain |
DE102004045796A1 (de) | 2004-09-22 | 2006-03-23 | Merck Patent Gmbh | Arzneimittel enthaltend Carbonylverbindungen sowie deren Verwendung |
US20090105221A1 (en) | 2004-09-29 | 2009-04-23 | Ranbaxy Laboratories Limited | Muscarinic receptor antagonists |
US7491720B2 (en) | 2004-10-29 | 2009-02-17 | Banyu Pharmaceutical Co., Ltd. | Aminopyridine derivatives having Aurora A selective inhibitory action |
EP1657241A1 (fr) | 2004-11-03 | 2006-05-17 | Schering Aktiengesellschaft | Nouveaux urées d' anthranylamide pyridine ayant une activité inhibitrice de kinase du récepteur de VEGF |
EP1655297A1 (fr) | 2004-11-03 | 2006-05-10 | Schering Aktiengesellschaft | Pyridineurées de nicotinamide commes inhibiteurs du recepteur kinase du facteur de croissance endothéliale vasculaire (VEGF) |
TW200633990A (en) | 2004-11-18 | 2006-10-01 | Takeda Pharmaceuticals Co | Amide compound |
GT200500375A (es) | 2004-12-20 | 2006-11-28 | Derivados de piperidina y su uso como agentes antiinflamatorios | |
US20080312281A1 (en) | 2004-12-24 | 2008-12-18 | Matthew Colin Thor Fyfe | G-Protein Coupled Receptor (Gpr116) Agonists and Use Thereof for Treating Obesity and Diabetes |
NZ555770A (en) | 2004-12-24 | 2010-12-24 | Astrazeneca Ab | Heterocyclic piperazine-carboxamide compounds as CCR2B antagonists |
ME02222B (me) | 2004-12-30 | 2016-02-20 | Janssen Pharmaceutica Nv | Amid derivati piperidin-i piperazin-1-karboksilne kiseline te povezani spojevi kao modulatori amid hidrolaze masnih kiselina (faah) za liječenje tjeskobe, boli i drugih stanja |
WO2006085196A1 (fr) | 2005-02-10 | 2006-08-17 | Warner-Lambert Company Llc | Analyse d'hydrolase d'amide d'acide gras |
ATE481407T1 (de) * | 2005-02-16 | 2010-10-15 | Neurosearch As | Neue diazabicyclische arylderivate und medizinische verwendung dafür |
KR101063663B1 (ko) | 2005-02-17 | 2011-09-07 | 아스텔라스세이야쿠 가부시키가이샤 | 피리딜 비방향족 질소 함유 헤테로환-1-카르복실산에스테르유도체 |
US20090082435A1 (en) | 2005-04-28 | 2009-03-26 | The Regents Of The University Of California | Methods, Compositions, And Compounds For Modulation Of Monoacylglycerol Lipase, Pain, And Stress-Related Disorders |
GB0510139D0 (en) | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B1 |
WO2006129842A1 (fr) | 2005-06-01 | 2006-12-07 | Banyu Pharmaceutical Co., Ltd. | Nouveau derive aminopyridine ayant une activite d’inhibition selective de l’aurora-a |
WO2006137465A1 (fr) | 2005-06-24 | 2006-12-28 | Shionogi & Co., Ltd. | Dérivé hétérocyclique azoté |
NZ564759A (en) | 2005-06-30 | 2011-08-26 | Prosidion Ltd | GPCR agonists |
WO2007005510A1 (fr) | 2005-06-30 | 2007-01-11 | Janssen Pharmaceutica N.V. | Urees n-heteroarylpiperazinyle en tant que modulateurs de l'hydrolase de l'amide d'acide gras |
EP1939189A4 (fr) | 2005-08-26 | 2013-03-13 | Shionogi & Co | Dérivé ayant une activité agoniste vis-à-vis du ppar |
US7131609B1 (en) | 2005-08-31 | 2006-11-07 | Kimberly-Clark Worldwide, Inc. | Dispenser for sheet material |
US20070155707A1 (en) | 2005-12-29 | 2007-07-05 | Kadmus Pharmaceuticals, Inc. | Ionizable inhibitors of fatty acid amide hydrolase |
KR20080091132A (ko) | 2005-12-29 | 2008-10-09 | 엔.브이.오가논 | 지방산 아미드 가수분해 효소의 억제제 |
WO2007103456A2 (fr) | 2006-03-06 | 2007-09-13 | Trimeris, Inc. | Derives de piperazine et piperidine biaryle |
TW200811157A (en) * | 2006-05-05 | 2008-03-01 | Astrazeneca Ab | mGluR5 modulators I |
US20080076924A1 (en) | 2006-06-30 | 2008-03-27 | Patrick Betschmann | Piperazines as P2X7 antagonists |
WO2008021625A2 (fr) | 2006-08-18 | 2008-02-21 | N.V. Organon | Inhibiteur de faah et agent analgésique, anti-inflammatoire ou anti-pyrétique combinés |
WO2008024139A2 (fr) | 2006-08-18 | 2008-02-28 | N.V. Organon | Inhibiteurs d'hydrolase des amides d'acides gras |
US7888394B2 (en) | 2006-08-21 | 2011-02-15 | N.V. Organon | Synthesis, polymorphs, and pharmaceutical formulation of FAAH inhibitors |
CA2665804A1 (fr) | 2006-08-23 | 2008-02-28 | Astellas Pharma Inc. | Compose d'uree ou sel dudit compose |
US20080089845A1 (en) | 2006-09-07 | 2008-04-17 | N.V. Organon | Methods for determining effective doses of fatty acid amide hydrolase inhibitors in vivo |
US20090099240A1 (en) | 2006-10-02 | 2009-04-16 | N.V. Organon | Methods for treating energy metabolism disorders by inhibiting fatty acid amide hydrolase activity |
JO3598B1 (ar) | 2006-10-10 | 2020-07-05 | Infinity Discovery Inc | الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني |
MX2009004233A (es) | 2006-10-18 | 2009-08-12 | Pfizer Prod Inc | Compuestos de biaril eter urea. |
WO2008063714A1 (fr) | 2006-11-20 | 2008-05-29 | N.V. Organon | Inhibiteurs stabilisés métaboliquement d'hydrolase d'amides d'acide gras |
NZ552238A (en) | 2006-12-20 | 2009-07-31 | Seperex Nutritionals Ltd | An extract |
MX2009012765A (es) | 2007-05-25 | 2009-12-16 | Janssen Pharmaceutica Nv | Moduladores de urea con heteroarilo sustituido de acido graso amida hidrolasa. |
-
2007
- 2007-10-05 MX MX2009004233A patent/MX2009004233A/es active IP Right Grant
- 2007-10-05 AU AU2007311591A patent/AU2007311591B2/en active Active
- 2007-10-05 PL PL07848827T patent/PL2076508T3/pl unknown
- 2007-10-05 CA CA2663984A patent/CA2663984C/fr active Active
- 2007-10-05 BR BRPI0717596A patent/BRPI0717596B8/pt active IP Right Grant
- 2007-10-05 RS RSP-2009/0154A patent/RS20090154A/sr unknown
- 2007-10-05 DK DK07848827.7T patent/DK2076508T3/da active
- 2007-10-05 AT AT07848827T patent/ATE493984T1/de active
- 2007-10-05 EP EP07848827A patent/EP2076508B1/fr active Active
- 2007-10-05 WO PCT/IB2007/003202 patent/WO2008047229A2/fr active Application Filing
- 2007-10-05 ES ES07848827T patent/ES2357340T3/es active Active
- 2007-10-05 PT PT07848827T patent/PT2076508E/pt unknown
- 2007-10-05 JP JP2009532909A patent/JP4434313B2/ja active Active
- 2007-10-05 NZ NZ575624A patent/NZ575624A/en unknown
- 2007-10-05 EA EA200970296A patent/EA015488B1/ru not_active IP Right Cessation
- 2007-10-05 SI SI200730534T patent/SI2076508T1/sl unknown
- 2007-10-05 ME MEP-2011-49A patent/ME01308B/me unknown
- 2007-10-05 RS RS20110107A patent/RS51647B/en unknown
- 2007-10-05 AP AP2009004821A patent/AP2780A/xx active
- 2007-10-05 DE DE602007011793T patent/DE602007011793D1/de active Active
- 2007-10-05 CN CN2007800389592A patent/CN101595102B/zh active Active
- 2007-10-05 GE GEAP200711226A patent/GEP20125425B/en unknown
- 2007-10-05 KR KR1020097007835A patent/KR101181194B1/ko active IP Right Grant
- 2007-10-17 TW TW096138933A patent/TWI404715B/zh active
- 2007-10-17 PE PE2007001407A patent/PE20081265A1/es active IP Right Grant
- 2007-10-17 UY UY30649A patent/UY30649A1/es not_active Application Discontinuation
- 2007-10-17 AR ARP070104596A patent/AR063331A1/es active IP Right Grant
- 2007-10-18 US US11/874,577 patent/US8044052B2/en active Active
- 2007-10-18 CL CL200703000A patent/CL2007003000A1/es unknown
- 2007-10-19 HN HN2007000407A patent/HN2007000407A/es unknown
-
2009
- 2009-03-18 IL IL197664A patent/IL197664A/en active IP Right Grant
- 2009-03-27 MY MYPI20091261A patent/MY145460A/en unknown
- 2009-03-31 CR CR10701A patent/CR10701A/es unknown
- 2009-04-14 TN TNP2009000138A patent/TN2009000138A1/fr unknown
- 2009-04-14 ZA ZA200902548A patent/ZA200902548B/xx unknown
- 2009-04-17 MA MA31798A patent/MA30801B1/fr unknown
- 2009-04-20 NO NO20091560A patent/NO342266B1/no unknown
-
2010
- 2010-05-31 HK HK10105310.0A patent/HK1139652A1/xx unknown
-
2011
- 2011-02-08 CY CY20111100140T patent/CY1111170T1/el unknown
- 2011-03-04 HR HR20110158T patent/HRP20110158T1/hr unknown
-
2014
- 2014-06-27 CR CR20140313A patent/CR20140313A/es unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TN2009000138A1 (fr) | Biaryl-ether-urees | |
MA30333B1 (fr) | Aminotetrahydropyranes utiles en tant qu'inhibiteurs de la dipeptidyle peptidase-iv pour le traitement ou la prevention du diabete. | |
TNSN07022A1 (fr) | Derives de pyridine | |
MA29926B1 (fr) | Derives de pyrazine | |
TN2010000175A1 (fr) | Piperidino-dihydrothienopyrimidines substituees | |
TNSN08445A1 (fr) | Derives de triazolopyrazine utiles comme agent anticancereux | |
MA30289B1 (fr) | Dérivés d'amines | |
MA27774A1 (fr) | Inhibiteurs de phosphatidylinositol 3-kinase | |
TNSN04151A1 (fr) | Derives de nicotinamide utiles comme inhibiteurs de pde4 | |
MA31894B1 (fr) | Composes organiques | |
MA26697A1 (fr) | Composes nouveaux inhibiteurs de gsk-3 et compositions pharmaceutiques les contenant | |
TN2009000450A1 (fr) | Derives de pyridine | |
MA30403B1 (fr) | Derives d'acides cycloalkylamines et leurs compositions pharmaceutiques | |
TNSN99095A1 (fr) | 4 - phenylpiperidines nouvelles, procede pour leur preparation et compositions pharmaceutiques les contenant | |
TNSN05073A1 (fr) | Quinazolinones spirocondensees nouvelles et leur utilisation comme inhibiteurs de phosphodiesterase | |
MA28680B1 (fr) | 3-aminocyclopentanecarboxamides utiles comme modulateurs de récepteurs de chimiokines | |
MA30696B1 (fr) | Derives de l'acide (3-amino-1,2,3,4-tetrahydro-9h-carbazol-9-yl)-acetique | |
MA31373B1 (fr) | Composes amino-heterocycliques | |
TNSN04156A1 (fr) | Pyridinones substituees servant de modulateurs de la map-kinase p38 | |
TNSN08270A1 (fr) | Dérivés pyrimidiques destinés à traiter une croissance cellulaire anormale | |
MA33178B1 (fr) | Pipéridines substituées comme antagonistes de ccr3 | |
MA32009B1 (fr) | Nouveaux derives de pyrazolo [3,4-d]pyrimidine en tant qu'agents anticancereux | |
TNSN99031A1 (fr) | Composes heterocycliques nouveaux inhibiteurs de romatases, procede pour leur preparation et compositions pharmaceutiques les contenant | |
MA29411B1 (fr) | 1h-quinazoline -2,4-diones et leur utilisation en tant que ligands du recepteur ampa | |
MA31919B1 (fr) | Composés inhibiteurs de la dipeptidyl peptidase-iv, leurs procédés de préparation, et compositions pharmaceutiques contenant ces composés comme agent actif |