MA33365B1 - Dérivés de spiro[2.4]heptane pontés utiles en tant qu'agonistes du récepteur de alx et/ou du récepteur fprl2 - Google Patents

Dérivés de spiro[2.4]heptane pontés utiles en tant qu'agonistes du récepteur de alx et/ou du récepteur fprl2

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Publication number
MA33365B1
MA33365B1 MA34457A MA34457A MA33365B1 MA 33365 B1 MA33365 B1 MA 33365B1 MA 34457 A MA34457 A MA 34457A MA 34457 A MA34457 A MA 34457A MA 33365 B1 MA33365 B1 MA 33365B1
Authority
MA
Morocco
Prior art keywords
receptor
derivatives
agonists
fprl2
spiro
Prior art date
Application number
MA34457A
Other languages
English (en)
Inventor
Daniel Bur
Olivier Corminboeuf
Sylvaine Cren
Corinna Grisostomi
Xavier Leroy
Sylvia Richard-Bildstein
Original Assignee
Actelion Pharmaceuticals Ltd
Saba & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd, Saba & Co filed Critical Actelion Pharmaceuticals Ltd
Publication of MA33365B1 publication Critical patent/MA33365B1/fr

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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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Abstract

LA PRÉSENTE INVENTION CONCERNE DES DÉRIVÉS DE SPIRO[2.4]HEPTANE PONTÉS DE FORMULE (I), DANS LAQUELLE W, Y, Z, R1 ET R2 SONT TELS QUE DÉFINIS DANS LA DESCRIPTION, LEUR PRÉPARATION ET LEUR UTILISATION EN TANT QUE COMPOSÉS PHARMACEUTIQUEMENT ACTIFS COMME AGONISTES DU RÉCEPTEUR DE ALX ET/OU DU RÉCEPTEUR FPRL2 POUR LE TRAITEMENT DES MALADIES INFLAMMATOIRES ET OBSTRUCTIVES DES VOIES RESPIRATOIRES.
MA34457A 2009-05-18 2010-05-17 Dérivés de spiro[2.4]heptane pontés utiles en tant qu'agonistes du récepteur de alx et/ou du récepteur fprl2 MA33365B1 (fr)

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IB2009052056 2009-05-18
PCT/IB2010/052170 WO2010134014A1 (fr) 2009-05-18 2010-05-17 Dérivés de spiro[2.4]heptane pontés utiles en tant qu'agonistes du récepteur de alx et/ou du récepteur fprl2

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PL2225231T3 (pl) 2007-12-18 2012-01-31 Actelion Pharmaceuticals Ltd Pochodne aminotriazolu jako agoniści ALX
EP2440555B1 (fr) 2009-06-09 2016-05-18 Actelion Pharmaceuticals Ltd Dérivés fluorés de l'aminotriazole
CA2760887A1 (fr) 2009-06-12 2010-12-16 Actelion Pharmaceuticals Ltd Derives de l'oxazole et du thiazole en tant qu'agonistes du recepteur alx
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EP2648724B1 (fr) 2010-12-07 2016-09-21 Actelion Pharmaceuticals Ltd. Dérivés d'aminotriazole hydroxylés convenant comme agonistes du récepteur alx
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MA37618B1 (fr) * 2012-05-16 2017-08-31 Actelion Pharmaceuticals Ltd Dérivés pontés fluorés de spiro[2.4]heptane en tant qu'agonistes de récepteur alx
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TWI585082B (zh) 2012-11-29 2017-06-01 廣東東陽光藥業有限公司 作爲丙型肝炎抑制劑的螺環化合物、藥物組合物及它們的用途
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AR097279A1 (es) 2013-08-09 2016-03-02 Actelion Pharmaceuticals Ltd Derivados de benzimidazolil-metil urea como agonistas del receptor de alx
KR102310615B1 (ko) * 2013-11-21 2021-10-08 알러간, 인코포레이티드 페닐카바메이트 유도체로서의 포밀 펩타이드 수용체 조절제
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AR069650A1 (es) 2007-12-14 2010-02-10 Actelion Pharmaceuticals Ltd Derivados de aminopirazol como agonistas no peptidicos del receptor alx humano
PL2225231T3 (pl) 2007-12-18 2012-01-31 Actelion Pharmaceuticals Ltd Pochodne aminotriazolu jako agoniści ALX
EP2440555B1 (fr) 2009-06-09 2016-05-18 Actelion Pharmaceuticals Ltd Dérivés fluorés de l'aminotriazole
CA2760887A1 (fr) 2009-06-12 2010-12-16 Actelion Pharmaceuticals Ltd Derives de l'oxazole et du thiazole en tant qu'agonistes du recepteur alx
WO2011163502A1 (fr) * 2010-06-24 2011-12-29 Allergan, Inc. Dérivés d'acides cycloalkyl- et cycloalcényl-1,2-dicarboxyliques présentant une activité agoniste ou antagoniste du récepteur fprl-1

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CN102414168B (zh) 2014-05-21
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US8563714B2 (en) 2013-10-22
TW201100080A (en) 2011-01-01
AU2010250789B2 (en) 2015-05-14
JP2012527445A (ja) 2012-11-08
TWI490190B (zh) 2015-07-01
KR20120041695A (ko) 2012-05-02
BRPI1013083A2 (pt) 2016-04-05
NZ597122A (en) 2013-06-28
SG176137A1 (en) 2011-12-29
RU2540274C2 (ru) 2015-02-10
HRP20130972T1 (hr) 2013-11-22
RU2011151277A (ru) 2013-06-27
PT2432760E (pt) 2013-10-21
EP2432760A1 (fr) 2012-03-28
ES2431298T3 (es) 2013-11-25
AU2010250789A1 (en) 2012-01-19
MX2011012264A (es) 2011-12-12
WO2010134014A1 (fr) 2010-11-25
AR078508A1 (es) 2011-11-16
HK1167133A1 (en) 2012-11-23
CA2760885C (fr) 2017-03-28
PL2432760T3 (pl) 2013-12-31
US20120115841A1 (en) 2012-05-10
CN102414168A (zh) 2012-04-11
CY1114500T1 (el) 2016-10-05
KR101724765B1 (ko) 2017-04-07
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