TJ313B - Erythromycin's dervatives and pharmaceutical composition on their basis - Google Patents

Erythromycin's dervatives and pharmaceutical composition on their basis

Info

Publication number
TJ313B
TJ313B TJ96000417A TJ96000417A TJ313B TJ 313 B TJ313 B TJ 313B TJ 96000417 A TJ96000417 A TJ 96000417A TJ 96000417 A TJ96000417 A TJ 96000417A TJ 313 B TJ313 B TJ 313B
Authority
TJ
Tajikistan
Prior art keywords
dervatives
erythromycin
basis
pharmaceutical composition
pharmaceutical
Prior art date
Application number
TJ96000417A
Other languages
English (en)
Inventor
Constantin Agouridas
Jean-Fransua Shanto
Deni Alexsis
D Ambrier Solange Gouin
Martret Odile Le
Original Assignee
Hoechest Marion Roussel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechest Marion Roussel filed Critical Hoechest Marion Roussel
Publication of TJ313B publication Critical patent/TJ313B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08Hetero rings containing eight or more ring members, e.g. erythromycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
TJ96000417A 1994-05-03 1996-11-01 Erythromycin's dervatives and pharmaceutical composition on their basis TJ313B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9405368A FR2719587B1 (fr) 1994-05-03 1994-05-03 Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Publications (1)

Publication Number Publication Date
TJ313B true TJ313B (en) 2001-08-06

Family

ID=9462785

Family Applications (1)

Application Number Title Priority Date Filing Date
TJ96000417A TJ313B (en) 1994-05-03 1996-11-01 Erythromycin's dervatives and pharmaceutical composition on their basis

Country Status (43)

Country Link
US (2) US5635485A (es)
EP (1) EP0680967B1 (es)
JP (4) JP2992540B2 (es)
KR (1) KR100312267B1 (es)
CN (2) CN1052984C (es)
AP (1) AP558A (es)
AT (1) ATE172203T1 (es)
AU (1) AU684027B2 (es)
BG (1) BG63087B1 (es)
BR (1) BR9507700A (es)
CA (1) CA2189271C (es)
CZ (1) CZ293455B6 (es)
DE (2) DE10299001I1 (es)
DK (1) DK0680967T3 (es)
DZ (1) DZ1878A1 (es)
EE (1) EE03263B1 (es)
ES (1) ES2122472T3 (es)
FI (1) FI111263B (es)
FR (1) FR2719587B1 (es)
GE (1) GEP19991538B (es)
HK (1) HK1010732A1 (es)
HU (2) HU219599B (es)
IL (1) IL113245A (es)
LU (1) LU90872I2 (es)
LV (1) LV11739B (es)
MA (1) MA23534A1 (es)
MD (1) MD1233C2 (es)
NL (1) NL300077I1 (es)
NO (2) NO308853B1 (es)
NZ (1) NZ285416A (es)
OA (1) OA10319A (es)
PL (1) PL182034B1 (es)
RO (1) RO113350B1 (es)
RU (1) RU2144036C1 (es)
SI (1) SI0680967T1 (es)
SK (1) SK281707B6 (es)
TJ (1) TJ313B (es)
TN (1) TNSN95049A1 (es)
TW (1) TW341573B (es)
UA (1) UA51618C2 (es)
WO (1) WO1995029929A1 (es)
YU (1) YU49235B (es)
ZA (1) ZA953501B (es)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69633289T2 (de) * 1995-06-27 2006-01-12 Takeda Pharmaceutical Co. Ltd. 4-acylamino(halogen)alkyl-chinolin derivate, deren herstellung und deren verwendung als melatonin-agonisten
FR2742757B1 (fr) 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
CN1680419A (zh) * 1996-09-04 2005-10-12 艾博特公司 酮基内酯类化合物,其用途和制备方法以及药用组合物
FR2757168B1 (fr) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
US5780605A (en) * 1997-09-08 1998-07-14 Abbott Laboratories 6,9-bridged erythromycin derivatives
FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
JP4573925B2 (ja) * 1998-07-09 2010-11-04 アベンティス・ファーマ・ソシエテ・アノニム 新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用
FR2781484B1 (fr) * 1998-07-21 2001-08-10 Hoechst Marion Roussel Inc Nouveaux derives de la 6-deoxy erythromycine, leur procede de preparation et leur application comme medicaments
DE69926005T2 (de) * 1998-09-22 2006-05-18 Pfizer Products Inc., Groton Carbamat- und carbazatketolidantibiotika
FR2785612A1 (fr) * 1998-11-10 2000-05-12 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
TW526202B (en) 1998-11-27 2003-04-01 Shionogi & Amp Co Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity
TR200102129T2 (tr) 1998-12-10 2002-01-21 Pfizer Products Inc. Karbamat ve karbazat ketolid antibiyotikleri.
PT1147121E (pt) * 1999-01-27 2004-04-30 Pfizer Prod Inc Antibioticos cetolidos
FR2789392B1 (fr) * 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
WO2000062783A2 (en) * 1999-04-16 2000-10-26 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6939861B2 (en) * 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
KR20020007374A (ko) 1999-04-16 2002-01-26 추후제출 매크롤라이드 항감염제
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
EP1180110A1 (en) * 1999-05-24 2002-02-20 Pfizer Products Inc. 13-methyl-erythromycin derivatives
FR2797875B1 (fr) * 1999-08-26 2001-10-19 Hoechst Marion Roussel Inc Agglomerats spheriques de telithromycine, leur procede de preparation et leur application dans la preparation de formes pharmaceutiques
US6946446B2 (en) 2000-02-24 2005-09-20 Abbott Laboratories Anti-infective agents useful against multidrug-resistant strains of bacteria
EP1313751B1 (en) 2000-08-22 2008-09-17 Basilea Pharmaceutica AG New macrolides with antibacterial activity
FR2821747B1 (fr) * 2001-03-09 2004-07-02 Ethypharm Lab Prod Ethiques Suspension de telithromycine a gout masque
AU2002316550A1 (en) * 2001-07-03 2003-01-21 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
US8063021B2 (en) * 2002-01-17 2011-11-22 Kosan Biosciences Incorporated Ketolide anti-infective compounds
US6995143B2 (en) 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
RS20050008A (en) 2002-07-08 2007-06-04 Pliva-Istraživački Institut D.O.O., New compounds,compositions and methods for treatment of inflammatory diseases and conditions
WO2004005313A2 (en) 2002-07-08 2004-01-15 Pliva - Istrazivacki Institut D.O.O. Hybrid molecules of macrolides with steroid/non-steroid anti-inflammatory, antineoplastic and antiviral active molecules
US20040013737A1 (en) * 2002-07-19 2004-01-22 Philippe Becourt Taste masked oral composition of telithromycin
WO2004009059A1 (en) * 2002-07-19 2004-01-29 Aventis Pharma S.A. Taste masked oral composition of telithromycin
AR043050A1 (es) 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
US6916934B2 (en) * 2003-02-11 2005-07-12 Aventis Pharma Deutschland Gmbh Process for preparing pyridine-substituted amino ketal derivatives
EP2664331B1 (en) 2003-03-10 2015-09-16 Merck Sharp & Dohme Corp. Novel Antibacterial Agents
WO2004096823A2 (en) * 2003-04-25 2004-11-11 Chiron Corporation Novel ketolide derivatives
WO2005028493A1 (en) * 2003-09-12 2005-03-31 Chiron Corporation Antimicrobial derivatives
GB0402578D0 (en) * 2004-02-05 2004-03-10 Cambridge Theranostics Ltd Methods of treatment of atherosclerosis
CN102816194A (zh) 2004-02-27 2012-12-12 瑞伯-X医药品有限公司 大环化合物以及其制作和使用方法
EP1742957B1 (en) * 2004-04-28 2007-09-12 Alembic Limited Process for the preparation of telithromycin
JP2008508322A (ja) * 2004-07-28 2008-03-21 ランバクシー ラボラトリーズ リミテッド 抗菌剤としてのケトライド誘導体
EP1807439A2 (en) * 2004-10-25 2007-07-18 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
GEP20094834B (en) 2004-12-21 2009-11-25 Pfizer Prod Inc Macrolides, pharmaceutical compositions containing them and their use for treatment of bacterial infections
CN102290174A (zh) * 2005-02-08 2011-12-21 株式会社村田制作所 表面安装型负特性热敏电阻
FR2882522B1 (fr) 2005-02-25 2007-04-13 Aventis Pharma Sa Composition pharmaceutique solide comprenant de la telithromycine
WO2006129257A2 (en) * 2005-05-30 2006-12-07 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
WO2007039914A2 (en) * 2005-10-06 2007-04-12 Alembic Limited Novel polymorphs of telithromycin
WO2007049296A2 (en) * 2005-10-28 2007-05-03 Alembic Limited Amorphous form of telithromycin
WO2007059307A2 (en) * 2005-11-15 2007-05-24 Teva Pharmaceutical Industries Ltd. Crystalline and amorphous forms of telithromycin
WO2007060518A2 (en) * 2005-11-23 2007-05-31 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
EP1960413A2 (en) * 2005-11-23 2008-08-27 Ranbaxy Laboratories Limited Macrolides derivatives as antibacterial agents
WO2007060627A2 (en) * 2005-11-23 2007-05-31 Ranbaxy Laboratories Limited Use of macrolide derivatives for treating acne
US7595300B2 (en) 2005-12-13 2009-09-29 Kosan Biosciences Incorporated 7-quinolyl ketolide antibacterial agents
GB0600238D0 (en) * 2006-01-06 2006-02-15 Sandoz Ag Organic compounds
US8097708B2 (en) * 2006-02-07 2012-01-17 Taisho Pharmaceutical Co., Ltd. 10a-Azalide compound
KR20090042971A (ko) 2006-08-24 2009-05-04 욱크하르트 리서치 센터 항미생물 활성을 갖는 신규한 마크로라이드 및 케토라이드
WO2008023383A1 (en) * 2006-08-25 2008-02-28 Alembic Limited Novel process for the preparation of telithromycin
ES2306590B1 (es) * 2006-12-15 2009-08-07 Ercros Industrial,S .A. Formas cristalinas i y ii de telitromicina.
WO2009019868A1 (ja) 2007-08-06 2009-02-12 Taisho Pharmaceutical Co., Ltd. 10a、12位架橋型10a-アザライド化合物
US20090075917A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched telithromycin
MX2010003141A (es) 2007-09-20 2010-06-01 Miller Herman Inc Estructura de soporte de carga.
EP2214484A4 (en) 2007-10-25 2013-01-02 Cempra Pharmaceuticals Inc PROCESS FOR PREPARING ANTIBACTERIAL MAKROLIDE AGENTS
WO2009053259A1 (en) * 2007-10-25 2009-04-30 Sandoz Ag Process for the production of telithromycin
WO2009139181A1 (ja) 2008-05-15 2009-11-19 大正製薬株式会社 4員環構造を有する10a-アザライド化合物
JP5602748B2 (ja) * 2008-10-24 2014-10-08 センプラ ファーマシューティカルズ,インコーポレイテッド トリアゾール含有マクロライドを用いた生体防御
EP2435460B1 (en) 2009-05-27 2015-01-07 Wockhardt Limited Ketolide compounds having antimicrobial activity
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
AU2010292010B2 (en) 2009-09-10 2016-01-07 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
BR112012023950A2 (pt) 2010-03-22 2016-07-05 Cempra Pharmaceuticals Inc formas cristalinas de um macrolídeo, e usos dos mesmos
WO2011146829A1 (en) 2010-05-20 2011-11-24 Cempra Pharmaceuticals, Inc. Processes for preparing macrolides and ketolides and intermediates therefor
KR20130120458A (ko) * 2010-09-10 2013-11-04 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
PT2673285T (pt) 2010-12-09 2017-10-19 Wockhardt Ltd Resumo
AR085286A1 (es) 2011-02-21 2013-09-18 Taisho Pharmaceutical Co Ltd Derivado de macrolido sustituido en la posicion c-4
CN103619849B (zh) 2011-03-01 2016-05-25 沃克哈特有限公司 酮内酯中间体的制备方法
ES2603227T3 (es) 2011-03-22 2017-02-24 Wockhardt Limited Proceso para la preparación de compuestos cetólidos
KR20140139083A (ko) 2012-03-27 2014-12-04 셈프라 파마슈티컬스, 인크. 마크롤라이드계 항생제를 투여하기 위한 비경구 제제
JP6426696B2 (ja) 2013-03-14 2018-11-21 センプラ ファーマシューティカルズ,インコーポレイテッド 呼吸器疾患の治療のための方法および製剤
RU2015138797A (ru) 2013-03-15 2017-04-24 Семпра Фармасьютикалс, Инк. Конвергентные способы получения макролидных антибактериальных агентов
CN105524132B (zh) * 2014-09-30 2019-07-02 中国医学科学院药物研究所 含有喹啉取代基的红霉素a酮内酯类抗生素衍生物、其制备方法及应用
DE102015201783A1 (de) 2015-02-02 2016-08-04 Friedrich Baur Verfahren zur Herstellung eines Füllstoffs aus Textilfasern sowie Textil mit einem solchen Füllstoff
CN107129514B (zh) * 2016-03-02 2019-12-13 中国医学科学院药物研究所 红霉素a酮内酯类抗生素衍生物、其制备方法及应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2833140A1 (de) * 1978-07-28 1980-02-07 Boehringer Sohn Ingelheim Neue n-substituierte heterocyclen
IE810250L (en) * 1980-02-11 1981-08-11 Berlex Lab N-(3-phenoxy-2-hydroxypropyl) benzimidazole -1-¹alkanamines.
US4434174A (en) * 1980-02-11 1984-02-28 Berlex Laboratories, Inc. Treating cardiovascular diseases with N-(3-phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines
US4568687A (en) * 1983-02-28 1986-02-04 American Cyanamid Company N-[2-4-(1H-Imidazol-1-yl)alkyl]-arylamides and pharmaceutical compositions
ZA84949B (en) * 1983-04-06 1984-09-26 American Cyanamid Co Substituted-n-(2-4-(1h-imidazol-1-yl)alkyl)substituted amides
US4489089A (en) * 1983-04-06 1984-12-18 American Cyanamid Company Substituted N-[ω-(1H-imidazol-1-yl)alkyl]-amides
AU573828B2 (en) * 1984-05-17 1988-06-23 E.R. Squibb & Sons, Inc. Tetrahydronaphthalenols
GB8425104D0 (en) * 1984-10-04 1984-11-07 Ici America Inc Amide derivatives
DE3540376A1 (de) * 1985-11-14 1987-05-21 Bayer Ag Verfahren zur inhibierung der wasserstoffinduzierten korrosion von metallischen werkstoffen
ATE106884T1 (de) * 1986-10-29 1994-06-15 Pfizer Verfahren zur herstellung von 2-(1-pentyl-3- guanidino)-4-(2-methyl-4-imidazolyl)thiazol und dessen kristallinisches dihydrochlorid-trihydrat.
DE3930669A1 (de) * 1989-09-14 1991-03-28 Basf Ag Verfahren zur herstellung von uretdiongruppen aufweisenden polyisocyanaten
JP2899028B2 (ja) * 1989-12-01 1999-06-02 協和醗酵工業株式会社 ジベンゾオキセピン誘導体
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
US5403923A (en) * 1990-11-28 1995-04-04 Taisho Pharmaceutical Co., Ltd. 6-0-methylerythromycin A derivatives
FR2692579B1 (fr) * 1992-06-19 1995-06-02 Roussel Uclaf Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
TW444018B (en) * 1992-12-17 2001-07-01 Pfizer Pyrazolopyrimidines
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates

Also Published As

Publication number Publication date
BR9507700A (pt) 1997-08-19
JP2007045847A (ja) 2007-02-22
MX9605208A (es) 1997-09-30
CZ321496A3 (en) 1997-08-13
AU684027B2 (en) 1997-11-27
DE10299001I2 (de) 2012-07-05
CA2189271A1 (fr) 1995-11-09
DE10299001I1 (de) 2012-07-05
US6100404A (en) 2000-08-08
NO308853B1 (no) 2000-11-06
PL182034B1 (pl) 2001-10-31
JP4750755B2 (ja) 2011-08-17
JPH0853489A (ja) 1996-02-27
JP2992540B2 (ja) 1999-12-20
FR2719587B1 (fr) 1996-07-12
BG63087B1 (bg) 2001-03-30
RU2144036C1 (ru) 2000-01-10
SK281707B6 (sk) 2001-07-10
TW341573B (en) 1998-10-01
NO964654L (no) 1996-11-04
DE69505296D1 (de) 1998-11-19
MD1233C2 (ro) 2000-10-31
CZ293455B6 (cs) 2004-05-12
NZ285416A (en) 1997-07-27
SI0680967T1 (en) 1999-02-28
JP3998828B2 (ja) 2007-10-31
AU2449995A (en) 1995-11-29
FI964395A (fi) 1996-10-31
DK0680967T3 (da) 1999-06-23
EP0680967A1 (fr) 1995-11-08
YU49235B (sh) 2004-12-31
WO1995029929A1 (fr) 1995-11-09
JP4658902B2 (ja) 2011-03-23
OA10319A (fr) 1997-10-07
RO113350B1 (ro) 1998-06-30
AP558A (en) 1996-11-07
FI964395A0 (fi) 1996-10-31
MA23534A1 (fr) 1995-12-31
BG100951A (en) 1997-08-29
PL317071A1 (en) 1997-03-03
EE03263B1 (et) 2000-04-17
CN1052984C (zh) 2000-05-31
CN1151746A (zh) 1997-06-11
HU219599B (hu) 2001-05-28
HK1010732A1 (en) 1999-06-25
JP2007269810A (ja) 2007-10-18
FR2719587A1 (fr) 1995-11-10
FI111263B (fi) 2003-06-30
HUT75698A (en) 1997-05-28
EP0680967B1 (fr) 1998-10-14
LV11739B (en) 1997-08-20
MD1233B1 (en) 1999-05-31
GEP19991538B (en) 1999-03-05
LU90872I2 (fr) 2002-03-12
TNSN95049A1 (fr) 1996-02-06
IL113245A0 (en) 1995-07-31
AP9500744A0 (en) 1995-07-31
ATE172203T1 (de) 1998-10-15
DE69505296T2 (de) 1999-04-22
JPH11152296A (ja) 1999-06-08
NL300077I1 (nl) 2002-03-01
CN1229082A (zh) 1999-09-22
HU227493B1 (en) 2011-07-28
HU9603038D0 (en) 1997-01-28
YU27095A (sh) 1998-05-15
IL113245A (en) 1999-11-30
DZ1878A1 (fr) 2002-02-17
SK140296A3 (en) 1998-04-08
HU9904687D0 (en) 2000-03-28
CN1088709C (zh) 2002-08-07
KR100312267B1 (ko) 2002-06-22
NO2001027I1 (no) 2002-01-28
CA2189271C (fr) 2005-12-27
ZA953501B (en) 1996-05-02
LV11739A (lv) 1997-04-20
US5635485A (en) 1997-06-03
UA51618C2 (uk) 2002-12-16
NO964654D0 (no) 1996-11-04
ES2122472T3 (es) 1998-12-16

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