SV2002000295A - Sintesis asimetrica de pregabalin ref.pca76-01-ca/ 20133/bb - Google Patents

Sintesis asimetrica de pregabalin ref.pca76-01-ca/ 20133/bb

Info

Publication number
SV2002000295A
SV2002000295A SV2001000295A SV2001000295A SV2002000295A SV 2002000295 A SV2002000295 A SV 2002000295A SV 2001000295 A SV2001000295 A SV 2001000295A SV 2001000295 A SV2001000295 A SV 2001000295A SV 2002000295 A SV2002000295 A SV 2002000295A
Authority
SV
El Salvador
Prior art keywords
pregabalin
pca76
ref
asymmetric synthesis
provides
Prior art date
Application number
SV2001000295A
Other languages
English (en)
Inventor
Om Prakash Goel
Marvin Simon Hoekstra
Mark Joseph Burk
Thomas Arthur Mulhern
Thomas Frederick Mich
James Andrew Ramsden
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26874236&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SV2002000295(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of SV2002000295A publication Critical patent/SV2002000295A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/23—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same unsaturated acyclic carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)

Abstract

ESTE INVENTO PROPORCIONA UN METODO PARA PREPARAR (S)-(+)-ACIDO 3-(AMINOMETIL)-5-METIL-HEXANOICO(PREGABALIN) O UNA DE SUS SALES POR MEDIO DE UNA SINTESIS DE HIDROGENACION ASIMETRICA. EL PREGABALIN ES UTIL PARA EL TRATAMIENTO Y LA PREVENCION DE TRASTORNOS CAUSADOS POR ATAQUES (ACCESOS) DE DOLOR Y DE TRASTORNOS PSICOTICOS. EL INVENTO PROPORCIONA TAMBIEN COMPUESTOS INTERMEDIOS UTILES EN LA PRODUCCION DE PREGABALIN.
SV2001000295A 2000-01-27 2001-01-26 Sintesis asimetrica de pregabalin ref.pca76-01-ca/ 20133/bb SV2002000295A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17835900P 2000-01-27 2000-01-27
US19042700P 2000-03-17 2000-03-17

Publications (1)

Publication Number Publication Date
SV2002000295A true SV2002000295A (es) 2002-06-07

Family

ID=26874236

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2001000295A SV2002000295A (es) 2000-01-27 2001-01-26 Sintesis asimetrica de pregabalin ref.pca76-01-ca/ 20133/bb

Country Status (50)

Country Link
US (1) US6891059B2 (es)
EP (1) EP1250311B1 (es)
JP (2) JP4235384B2 (es)
KR (1) KR100549748B1 (es)
CN (1) CN1210253C (es)
AP (1) AP1438A (es)
AR (1) AR028499A1 (es)
AT (1) ATE261930T1 (es)
AU (1) AU777046B2 (es)
BG (1) BG65560B1 (es)
BR (1) BRPI0107863B8 (es)
CA (1) CA2396090C (es)
CO (1) CO5251411A1 (es)
CR (1) CR6703A (es)
CU (1) CU23221A3 (es)
CY (1) CY2004011I1 (es)
CZ (1) CZ302838B6 (es)
DE (1) DE60102356T2 (es)
DK (1) DK1250311T3 (es)
DZ (1) DZ3268A1 (es)
EA (1) EA004934B1 (es)
EE (1) EE05216B1 (es)
EG (1) EG24138A (es)
ES (1) ES2219493T3 (es)
GE (1) GEP20043236B (es)
HN (1) HN2001000010A (es)
HR (1) HRP20020627B1 (es)
HU (1) HU228815B1 (es)
IL (2) IL150633A0 (es)
IS (1) IS2038B (es)
MA (1) MA26869A1 (es)
ME (1) ME00921B (es)
MX (1) MXPA02007307A (es)
MY (1) MY127152A (es)
NO (1) NO327958B1 (es)
NZ (1) NZ519551A (es)
OA (1) OA12167A (es)
PA (1) PA8510501A1 (es)
PE (1) PE20011063A1 (es)
PL (1) PL203985B1 (es)
PT (1) PT1250311E (es)
RS (1) RS50257B (es)
SI (1) SI1250311T1 (es)
SK (1) SK287303B6 (es)
SV (1) SV2002000295A (es)
TN (1) TNSN01016A1 (es)
TR (1) TR200400953T4 (es)
TW (1) TWI288128B (es)
UA (1) UA75584C2 (es)
WO (1) WO2001055090A1 (es)

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KR100491282B1 (ko) 1996-07-24 2005-05-24 워너-램버트 캄파니 엘엘씨 통증 치료용 이소부틸가바 및 그의 유도체
BRPI0107863B8 (pt) * 2000-01-27 2017-04-25 Warner-Lambert Company método para preparar um derivado do ácido (s)-3- ciano-5-metilhexanoico, composto intermediário, seu método de preparação e método para preparar a pregabalina
US6687187B2 (en) * 2000-08-11 2004-02-03 Phonak Ag Method for directional location and locating system
EP1543831A1 (en) * 2003-12-18 2005-06-22 Pfizer GmbH Arzneimittelwerk Gödecke Pregabalin composition
BRPI0508615A (pt) * 2004-03-12 2007-07-31 Warner Lambert Co lingandos de bisfosfina c1-simétrica e seu emprego na sìntese assimétrica de pregabalina
UA82292C2 (uk) * 2004-04-14 2008-03-25 Пфайзер Продактс Инк. Спосіб стереоселективного біоперетворення аліфатичних динітрилів в ціанокарбонові кислоти (варіанти)
AU2005256945B2 (en) * 2004-06-21 2008-11-13 Upjohn Us 1 Llc Preparation of pregabalin and related compounds
CA2603129A1 (en) * 2005-04-06 2006-10-12 Teva Pharmaceutical Industries Ltd. Crystalline forms of pregabalin
US20070066846A1 (en) * 2005-04-11 2007-03-22 Asher Maymon Process for making (S)-Pregabalin
US7488846B2 (en) * 2005-04-11 2009-02-10 Teva Pharmaceuical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
MX2007000524A (es) 2005-05-10 2007-03-28 Teva Pharma Metodo para la preparacion de pregabalina y sales de ella.
US20070043241A1 (en) * 2005-05-10 2007-02-22 Lilach Hedvati Optical resolution of 3-carbamoylmethyl-5-methylhexanoic acid
CA2604600A1 (en) * 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Pregabalin free of isobutylglutaric acid and a process for preparation thereof
US20060270871A1 (en) * 2005-05-30 2006-11-30 Khanduri Chandra H Polymorphic form i of pregabalin and processes for its preparation
CN100410242C (zh) * 2005-06-23 2008-08-13 江苏恩华药业股份有限公司 普瑞巴林中间体及其制备方法
US7563923B2 (en) * 2005-09-19 2009-07-21 Teva Pharmaceutical Industries Ltd. Chiral 3-carbamoylmethyl-5-methyl hexanoic acids, key intermediates for the synthesis of (S)-Pregabalin
NL2000281C2 (nl) * 2005-11-02 2007-08-07 Pfizer Prod Inc Vaste farmaceutische samenstellingen die pregabaline bevatten.
BRPI0702865A2 (pt) * 2006-04-24 2012-08-07 Teva Pharma processos para preparaÇço do Ácido 3-isobutilglutÁrico e de (s)- pregabalin, a partir de combinaÇÕes de composiÇÕes com fàrmulas especÍficas para uso na dita preparaÇço
WO2007139933A2 (en) 2006-05-24 2007-12-06 Teva Pharmaceutical Industries Ltd. Processes for the preparation of r-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof
CA2649117A1 (en) * 2006-05-31 2007-12-13 Teva Pharmaceutical Industries Ltd. The use of enzymatic resolution for the preparation of intermediates of pregabalin
US20080015385A1 (en) * 2006-05-31 2008-01-17 Lilach Hedvati Preparation of (S)-pregabalin-nitrile
EP1903027A1 (en) * 2006-09-13 2008-03-26 Novartis AG Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of NEP inhibitors
US8097754B2 (en) * 2007-03-22 2012-01-17 Teva Pharmaceutical Industries Ltd. Synthesis of (S)-(+)-3-(aminomethyl)-5-methyl hexanoic acid
US8168828B2 (en) 2007-06-25 2012-05-01 Msn Laboratories, Limited Process for the preparation of pregabalin
KR100846419B1 (ko) * 2007-08-10 2008-07-15 한국과학기술원 프레가발린의 신규한 제조 방법
US20090137842A1 (en) * 2007-10-03 2009-05-28 Vollerner Yuri Pregabalin -4-eliminate, pregabalin 5-eliminate, their use as reference marker and standard, and method to produce pregabalin containing low levels thereof
EP2053040A1 (en) * 2007-10-26 2009-04-29 Chemo Ibérica, S.A. Pregabalin intermediates and process for preparing them and Pregabalin
WO2009087674A2 (en) * 2007-12-18 2009-07-16 Watson Pharma Private Limited Improved process for the preparation of (s)-pregabalin
CA2710152A1 (en) * 2007-12-26 2009-07-02 Generics (Uk) Limited Processes to pregabalin
US8263797B2 (en) * 2008-01-10 2012-09-11 Sumitomo Chemical Company, Limited Method for producing cyclopropane carboxylic acid compound and intermediate therefor
EP2110372A1 (en) 2008-04-16 2009-10-21 Chemo Ibérica, S.A. Intermediates for the preparation of Pregabalin and process for their preparation
JP2010043063A (ja) 2008-05-09 2010-02-25 Agency For Science Technology & Research 川崎病の診断及び治療
CA2724828C (en) 2008-05-21 2016-01-12 Sandoz Ag Process for the stereoselective enzymatic hydrolysis of 5-methyl-3-nitromethyl-hexanoic acid ester
KR20100107500A (ko) * 2008-06-23 2010-10-05 테바 파마슈티컬 인더스트리즈 리미티드 (ｓ) 또는 (ｒ)-이소-부틸-글루타릭 에스테르의 입체선택적 효소 합성방법
WO2010070593A2 (en) 2008-12-19 2010-06-24 Pfizer Ireland Pharmaceuticals Malonate esters
CN101987826A (zh) * 2009-08-04 2011-03-23 铜陵凯顺生物科技有限公司 一种(3s)-3-氨甲基-5-甲基己酸的合成方法
WO2011141923A2 (en) 2010-05-14 2011-11-17 Lupin Limited Improved synthesis of optically pure (s) - 3-cyano-5-methyl-hexanoic acid alkyl ester, an intermediate of (s)- pregabalin
US8212072B2 (en) 2010-08-13 2012-07-03 Divi's Laboratories, Ltd. Process for the preparation of pregabalin
WO2012025861A1 (en) * 2010-08-23 2012-03-01 Pfizer Manufacturing Ireland Process for the preparation of ( s ) - 3 - cyano - 5 - methylhexanoic acid derivatives adn of pregabalin
CN102464594B (zh) * 2010-11-17 2014-06-25 凯瑞斯德生化(苏州)有限公司 普瑞巴林的中间体化合物的制备方法
WO2014181359A1 (en) 2013-05-09 2014-11-13 Council Of Scientific & Industrial Research A process for the preparation of an anticonvulsant agent pregabalin hydrochloride
WO2016075082A1 (en) 2014-11-10 2016-05-19 Sandoz Ag Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam
WO2017019791A1 (en) 2015-07-27 2017-02-02 Teva Pharmaceuticals International Gmbh Synthesis of (s)-pregabalin

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Also Published As

Publication number Publication date
HUP0204307A2 (hu) 2003-06-28
DZ3268A1 (fr) 2001-08-02
DE60102356D1 (de) 2004-04-22
CR6703A (es) 2003-06-24
SK10782002A3 (sk) 2002-11-06
ES2219493T3 (es) 2004-12-01
BR0107863B1 (pt) 2013-06-18
CA2396090A1 (en) 2001-08-02
BR0107863A (pt) 2002-11-05
BRPI0107863B8 (pt) 2017-04-25
CA2396090C (en) 2006-01-10
CZ302838B6 (cs) 2011-12-07
SK287303B6 (sk) 2010-06-07
BG106849A (en) 2003-03-31
MY127152A (en) 2006-11-30
YU56202A (sh) 2006-01-16
MA26869A1 (fr) 2004-12-20
ATE261930T1 (de) 2004-04-15
OA12167A (en) 2006-05-08
DK1250311T3 (da) 2004-08-16
JP2003520841A (ja) 2003-07-08
JP2009073841A (ja) 2009-04-09
ME00921B (me) 2012-06-20
CY2004011I1 (el) 2010-07-28
CZ20022520A3 (cs) 2002-10-16
AU2213801A (en) 2001-08-07
BG65560B1 (bg) 2008-12-30
IL150633A (en) 2009-08-03
AP1438A (en) 2005-05-23
JP4886753B2 (ja) 2012-02-29
US20030212290A1 (en) 2003-11-13
CN1396905A (zh) 2003-02-12
NO327958B1 (no) 2009-10-26
EP1250311A1 (en) 2002-10-23
TNSN01016A1 (fr) 2005-11-10
GEP20043236B (en) 2004-05-25
KR20020073187A (ko) 2002-09-19
EG24138A (en) 2008-08-06
CO5251411A1 (es) 2003-02-28
HRP20020627A2 (en) 2004-08-31
IS6430A (is) 2002-06-19
PE20011063A1 (es) 2001-10-18
NZ519551A (en) 2004-02-27
EE200200403A (et) 2003-10-15
PL203985B1 (pl) 2009-11-30
JP4235384B2 (ja) 2009-03-11
EE05216B1 (et) 2009-10-15
HN2001000010A (es) 2001-06-13
AU777046B2 (en) 2004-09-30
PT1250311E (pt) 2004-07-30
DE60102356T2 (de) 2005-02-17
PL357077A1 (en) 2004-07-12
RS50257B (sr) 2009-07-15
IL150633A0 (en) 2003-02-12
NO20023582D0 (no) 2002-07-26
UA75584C2 (uk) 2006-05-15
TR200400953T4 (tr) 2004-07-21
CU23221A3 (es) 2007-07-20
HU228815B1 (en) 2013-05-28
TWI288128B (en) 2007-10-11
HUP0204307A3 (en) 2003-07-28
IS2038B (is) 2005-08-15
SI1250311T1 (en) 2004-10-31
MXPA02007307A (es) 2002-11-29
EA200200642A1 (ru) 2002-12-26
NO20023582L (no) 2002-09-02
CN1210253C (zh) 2005-07-13
HRP20020627B1 (en) 2011-01-31
AP2002002588A0 (en) 2002-09-30
WO2001055090A1 (en) 2001-08-02
AR028499A1 (es) 2003-05-14
US6891059B2 (en) 2005-05-10
PA8510501A1 (es) 2002-02-21
EA004934B1 (ru) 2004-10-28
KR100549748B1 (ko) 2006-02-08
EP1250311B1 (en) 2004-03-17

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