SMP201000116B - Inibitori di diacetilasi B a base di idrossamato - Google Patents
Inibitori di diacetilasi B a base di idrossamatoInfo
- Publication number
- SMP201000116B SMP201000116B SM201000116T SM201000116T SMP201000116B SM P201000116 B SMP201000116 B SM P201000116B SM 201000116 T SM201000116 T SM 201000116T SM 201000116 T SM201000116 T SM 201000116T SM P201000116 B SMP201000116 B SM P201000116B
- Authority
- SM
- San Marino
- Prior art keywords
- diacetylase
- hydroxamate
- inhibitors
- based diacetylase
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3967408P | 2008-03-26 | 2008-03-26 | |
PCT/EP2009/053421 WO2009118305A1 (en) | 2008-03-26 | 2009-03-24 | Hydroxamate-based inhibitors of deacetylases b |
Publications (2)
Publication Number | Publication Date |
---|---|
SMAP201000116A SMAP201000116A (it) | 2011-01-19 |
SMP201000116B true SMP201000116B (it) | 2011-09-09 |
Family
ID=40591831
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SM201000116T SMP201000116B (it) | 2008-03-26 | 2010-10-26 | Inibitori di diacetilasi B a base di idrossamato |
Country Status (33)
Country | Link |
---|---|
US (2) | US7943652B2 (it) |
EP (2) | EP2628726A1 (it) |
JP (1) | JP5330498B2 (it) |
KR (1) | KR101252349B1 (it) |
CN (1) | CN102036955B (it) |
AR (1) | AR071072A1 (it) |
AU (1) | AU2009228778B2 (it) |
BR (1) | BRPI0909159A2 (it) |
CA (1) | CA2719477C (it) |
CL (1) | CL2009000727A1 (it) |
CO (1) | CO6531501A2 (it) |
CR (1) | CR11680A (it) |
DO (1) | DOP2010000283A (it) |
EA (1) | EA019033B1 (it) |
EC (1) | ECSP10010497A (it) |
ES (1) | ES2519474T3 (it) |
GE (1) | GEP20125708B (it) |
IL (1) | IL208212A0 (it) |
MA (1) | MA32240B1 (it) |
MX (1) | MX2010010502A (it) |
MY (1) | MY150437A (it) |
NI (1) | NI201000157A (it) |
NZ (1) | NZ588069A (it) |
PA (1) | PA8821301A1 (it) |
PE (1) | PE20091736A1 (it) |
PL (1) | PL2260020T3 (it) |
PT (1) | PT2260020E (it) |
SM (1) | SMP201000116B (it) |
SV (1) | SV2010003677A (it) |
TW (1) | TWI510467B (it) |
UY (1) | UY31738A (it) |
WO (1) | WO2009118305A1 (it) |
ZA (1) | ZA201006474B (it) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120101099A1 (en) * | 2009-07-07 | 2012-04-26 | Anthem Biosciences Private Limited | Histone deacetylase inhibitors |
EP2566333A4 (en) | 2010-05-07 | 2014-04-02 | Univ Leland Stanford Junior | IDENTIFICATION OF STABILIZERS OF MULTIMEDER PROTEINS |
CN104136410A (zh) * | 2011-12-29 | 2014-11-05 | 药品循环公司 | 作为组蛋白脱乙酰酶8抑制剂的肉桂酸羟基酰胺 |
FR2992317B1 (fr) | 2012-06-22 | 2016-05-13 | Diverchim | Procede de preparation de peptides chiraux |
WO2016025129A1 (en) | 2014-08-14 | 2016-02-18 | Alhamadsheh Mamoun M | Conjugation of pharmaceutically active agents with transthyretin ligands through adjustable linkers to increase serum half-life |
CN104910074B (zh) * | 2015-03-11 | 2017-07-14 | 常州大学 | 一类含有羟肟酸基团的吡唑类衍生物及其制备方法及用途 |
US9745253B2 (en) * | 2015-03-13 | 2017-08-29 | Forma Therapeutics, Inc. | Alpha-cinnamide compounds and compositions as HDAC8 inhibitors |
CN106854189A (zh) * | 2015-12-08 | 2017-06-16 | 湖南华腾制药有限公司 | 一种哌嗪化合物的合成方法 |
US20170273307A1 (en) * | 2016-03-28 | 2017-09-28 | Trent University | Silane-based antimicrobial coatings and methods of making and using the same |
MA47511A (fr) | 2017-02-17 | 2019-12-25 | Eidos Therapeutics Inc | Procédés de préparation d'ag-10, de ses intermédiaires et de sels correspondants |
KR20200135996A (ko) | 2018-03-23 | 2020-12-04 | 에이도스 테라퓨틱스, 인코포레이티드 | Ag10을 사용하여 ttr 아밀로이드증을 치료하는 방법 |
WO2020037189A1 (en) | 2018-08-17 | 2020-02-20 | Eidos Therapeutics, Inc. | Formulations of ag10 |
CN113956182B (zh) * | 2021-10-11 | 2023-11-17 | 杭州师范大学 | Hdac/mao-b双重抑制剂及其制备和应用 |
WO2023114844A1 (en) * | 2021-12-15 | 2023-06-22 | Delix Therapeutics, Inc. | Imidazopyridine psychoplastogens and uses thereof |
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JP2004345953A (ja) | 2003-01-16 | 2004-12-09 | Hiroki Koma | 抗菌活性を有する新規な第四級アンモニウム塩化合物およびその製造方法 |
JP2007501775A (ja) | 2003-08-07 | 2007-02-01 | ノバルティス アクチエンゲゼルシャフト | 免疫抑制剤としてのヒストンデアセチラーゼ阻害剤 |
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WO2007030454A2 (en) | 2005-09-07 | 2007-03-15 | Novartis Ag | Mutations and polymorphisms of hdac9 |
WO2007030455A2 (en) | 2005-09-07 | 2007-03-15 | Novartis Ag | Mutations and polymorphisms of hdac10 |
MX2008010035A (es) * | 2006-02-07 | 2008-10-17 | Astellas Pharma Inc | Compuestos de n-hidroxiacrilamida. |
US7783564B2 (en) | 2006-07-25 | 2010-08-24 | Visa U.S.A. Inc. | Compliance control in a card based program |
AU2007328281B2 (en) | 2006-12-04 | 2011-03-31 | Novartis Ag | Combination of an HDAC inhibitor and an antimetabolite |
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2009
- 2009-03-24 CN CN2009801187972A patent/CN102036955B/zh not_active Expired - Fee Related
- 2009-03-24 GE GEAP200911949A patent/GEP20125708B/en unknown
- 2009-03-24 CA CA2719477A patent/CA2719477C/en not_active Expired - Fee Related
- 2009-03-24 EP EP13158259.5A patent/EP2628726A1/en not_active Withdrawn
- 2009-03-24 JP JP2011501196A patent/JP5330498B2/ja not_active Expired - Fee Related
- 2009-03-24 MY MYPI20104315 patent/MY150437A/en unknown
- 2009-03-24 AU AU2009228778A patent/AU2009228778B2/en not_active Ceased
- 2009-03-24 EP EP09725624.2A patent/EP2260020B1/en active Active
- 2009-03-24 WO PCT/EP2009/053421 patent/WO2009118305A1/en active Application Filing
- 2009-03-24 MX MX2010010502A patent/MX2010010502A/es active IP Right Grant
- 2009-03-24 NZ NZ588069A patent/NZ588069A/en not_active IP Right Cessation
- 2009-03-24 PT PT97256242T patent/PT2260020E/pt unknown
- 2009-03-24 PL PL09725624T patent/PL2260020T3/pl unknown
- 2009-03-24 ES ES09725624.2T patent/ES2519474T3/es active Active
- 2009-03-24 KR KR1020107023785A patent/KR101252349B1/ko not_active IP Right Cessation
- 2009-03-24 BR BRPI0909159A patent/BRPI0909159A2/pt not_active Application Discontinuation
- 2009-03-24 EA EA201001524A patent/EA019033B1/ru not_active IP Right Cessation
- 2009-03-25 CL CL2009000727A patent/CL2009000727A1/es unknown
- 2009-03-25 TW TW098109789A patent/TWI510467B/zh not_active IP Right Cessation
- 2009-03-25 AR ARP090101062A patent/AR071072A1/es not_active Application Discontinuation
- 2009-03-25 PE PE2009000451A patent/PE20091736A1/es not_active Application Discontinuation
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- 2009-03-26 PA PA20098821301A patent/PA8821301A1/es unknown
- 2009-03-26 US US12/411,715 patent/US7943652B2/en not_active Expired - Fee Related
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2010
- 2010-09-09 ZA ZA2010/06474A patent/ZA201006474B/en unknown
- 2010-09-16 IL IL208212A patent/IL208212A0/en unknown
- 2010-09-21 CR CR11680A patent/CR11680A/es not_active Application Discontinuation
- 2010-09-22 DO DO2010000283A patent/DOP2010000283A/es unknown
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- 2010-09-24 EC EC2010010497A patent/ECSP10010497A/es unknown
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- 2010-09-29 CO CO10120813A patent/CO6531501A2/es not_active Application Discontinuation
- 2010-10-18 MA MA33262A patent/MA32240B1/fr unknown
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2011
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