SK287333B6 - Derivát piperazinylkarbonylchinolínu alebo piperazinylkarbonylizochinolínu, spôsob jeho prípravy, jeho použitie a farmaceutický prostriedok s jeho obsahom - Google Patents

Derivát piperazinylkarbonylchinolínu alebo piperazinylkarbonylizochinolínu, spôsob jeho prípravy, jeho použitie a farmaceutický prostriedok s jeho obsahom Download PDF

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Publication number
SK287333B6
SK287333B6 SK865-2003A SK8652003A SK287333B6 SK 287333 B6 SK287333 B6 SK 287333B6 SK 8652003 A SK8652003 A SK 8652003A SK 287333 B6 SK287333 B6 SK 287333B6
Authority
SK
Slovakia
Prior art keywords
piperazinylcarbonylquinoline
piperazinylcarbonylisoquinoline
formula
derivative
disease
Prior art date
Application number
SK865-2003A
Other languages
English (en)
Slovak (sk)
Other versions
SK8652003A3 (en
Inventor
Henning B�Ttcher
Gerd Bartoszyk
J�Rgen Harting
Amsterdam Christoph Van
Christoph Seyfried
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of SK8652003A3 publication Critical patent/SK8652003A3/sk
Publication of SK287333B6 publication Critical patent/SK287333B6/sk

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Addiction (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SK865-2003A 2001-01-17 2001-12-24 Derivát piperazinylkarbonylchinolínu alebo piperazinylkarbonylizochinolínu, spôsob jeho prípravy, jeho použitie a farmaceutický prostriedok s jeho obsahom SK287333B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10102053A DE10102053A1 (de) 2001-01-17 2001-01-17 Piperazinylcarbonylchinoline und -isochinoline
PCT/EP2001/015311 WO2002057256A1 (en) 2001-01-17 2001-12-24 Piperazinylcarbonylquinolines and -isoquinolines

Publications (2)

Publication Number Publication Date
SK8652003A3 SK8652003A3 (en) 2003-11-04
SK287333B6 true SK287333B6 (sk) 2010-07-07

Family

ID=7670921

Family Applications (1)

Application Number Title Priority Date Filing Date
SK865-2003A SK287333B6 (sk) 2001-01-17 2001-12-24 Derivát piperazinylkarbonylchinolínu alebo piperazinylkarbonylizochinolínu, spôsob jeho prípravy, jeho použitie a farmaceutický prostriedok s jeho obsahom

Country Status (23)

Country Link
US (1) US7329749B2 (de)
EP (1) EP1366039B1 (de)
JP (1) JP4417624B2 (de)
KR (1) KR100854481B1 (de)
CN (1) CN1249055C (de)
AR (1) AR035682A1 (de)
AT (1) ATE304010T1 (de)
BR (1) BR0116774A (de)
CA (1) CA2434773C (de)
CZ (1) CZ304144B6 (de)
DE (2) DE10102053A1 (de)
DK (1) DK1366039T3 (de)
ES (1) ES2248230T3 (de)
HK (1) HK1061849A1 (de)
HU (1) HU230250B1 (de)
MX (1) MXPA03006360A (de)
MY (1) MY127293A (de)
PL (1) PL212087B1 (de)
RU (1) RU2280034C2 (de)
SI (1) SI1366039T1 (de)
SK (1) SK287333B6 (de)
WO (1) WO2002057256A1 (de)
ZA (1) ZA200306331B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1630720A (zh) * 2001-01-18 2005-06-22 默克专利有限公司 具有葡糖脑苷脂酶活性的双功能融合蛋白
ATE404200T1 (de) * 2002-04-22 2008-08-15 Univ Johns Hopkins Med Modulatoren von hedgehog signalpfaden, zusammensetzungen und verwandte verwendungen
PL375527A1 (en) * 2002-06-29 2005-11-28 Zentaris Gmbh Arylcarbonylpiperazines and heteroarylcarbonylpiperazines and the use thereof for treating benign and malignant tumour diseases
EP1774326A2 (de) * 2004-07-29 2007-04-18 Bayer HealthCare AG Diagnostika und therapeutika für mit 5-hydroxytryptamin 2a rezeptor (5ht2a) assoziierten krankheiten
JP5916730B2 (ja) * 2010-09-06 2016-05-11 グアンジョウ インスティテュート オブ バイオメディスン アンド ヘルス,チャイニーズ アカデミー オブ サイエンスィズ アミド化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4970714A (en) * 1989-01-05 1990-11-13 International Business Machines Corp. Adaptive data link protocol
PT957100E (pt) * 1997-07-07 2005-02-28 Kowa Co Derivados de diamina e farmaceuticos que os contem
EP1107758A2 (de) * 1998-08-28 2001-06-20 Scios Inc. Verwendung von piperidinen und/oder piperazinen als hemmer der p38-alpha kinase
DE19934433A1 (de) * 1999-07-22 2001-01-25 Merck Patent Gmbh N-(Indolcarbonyl-)piperazinderivate

Also Published As

Publication number Publication date
EP1366039B1 (de) 2005-09-07
MXPA03006360A (es) 2003-10-06
US7329749B2 (en) 2008-02-12
KR100854481B1 (ko) 2008-08-26
WO2002057256A9 (en) 2005-12-08
JP4417624B2 (ja) 2010-02-17
US20040077657A1 (en) 2004-04-22
DE60113300D1 (de) 2005-10-13
PL361741A1 (en) 2004-10-04
HUP0401038A2 (hu) 2004-08-30
HUP0401038A3 (en) 2011-08-29
KR20030068579A (ko) 2003-08-21
HK1061849A1 (en) 2004-10-08
ES2248230T3 (es) 2006-03-16
JP2004517145A (ja) 2004-06-10
CN1249055C (zh) 2006-04-05
CZ20031861A3 (cs) 2003-09-17
CA2434773C (en) 2011-10-04
DK1366039T3 (da) 2006-01-02
MY127293A (en) 2006-11-30
HU230250B1 (hu) 2015-11-30
ZA200306331B (en) 2005-01-26
ATE304010T1 (de) 2005-09-15
SK8652003A3 (en) 2003-11-04
RU2003124077A (ru) 2005-01-10
DE60113300T2 (de) 2006-06-29
CA2434773A1 (en) 2002-07-25
DE10102053A1 (de) 2002-07-18
PL212087B1 (pl) 2012-08-31
BR0116774A (pt) 2004-01-06
CN1486308A (zh) 2004-03-31
CZ304144B6 (cs) 2013-11-20
EP1366039A1 (de) 2003-12-03
SI1366039T1 (sl) 2006-02-28
AR035682A1 (es) 2004-06-23
RU2280034C2 (ru) 2006-07-20
WO2002057256A1 (en) 2002-07-25

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SK287333B6 (sk) Derivát piperazinylkarbonylchinolínu alebo piperazinylkarbonylizochinolínu, spôsob jeho prípravy, jeho použitie a farmaceutický prostriedok s jeho obsahom
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MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20171224