SK132394A3 - Recombinant dna molecules coding aminopeptidase enzymes and their use in the preparation of vaccines - Google Patents

Recombinant dna molecules coding aminopeptidase enzymes and their use in the preparation of vaccines Download PDF

Info

Publication number: SK132394A3
Authority: SK; Slovakia
Prior art keywords: ala; glu; thr; lys; phe
Prior art date: 1992-05-08

Application number

SK1323-94A

Other languages

English (en)

Slovak (sk)

Inventor

Margaret Graham

Trevor S Smith

Edward A Munn

David P Knox

Joanna J Oliver

Susan E Newton

Original Assignee

Biotech & Biolog Scien Res

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-05-08

Filing date

1993-05-07

Publication date

1995-07-11

1993-05-07 Application filed by Biotech & Biolog Scien Res filed Critical Biotech & Biolog Scien Res

1995-07-11 Publication of SK132394A3 publication Critical patent/SK132394A3/sk

Links

102000004400 Aminopeptidases Human genes 0.000 title claims abstract description 47
108090000915 Aminopeptidases Proteins 0.000 title claims abstract description 47
229960005486 vaccine Drugs 0.000 title claims abstract description 18
238000002360 preparation method Methods 0.000 title abstract description 17
108020004511 Recombinant DNA Proteins 0.000 title description 6
108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 60
102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 51
229920001184 polypeptide Polymers 0.000 claims abstract description 48
150000007523 nucleic acids Chemical class 0.000 claims abstract description 46
102000039446 nucleic acids Human genes 0.000 claims abstract description 27
108020004707 nucleic acids Proteins 0.000 claims abstract description 27
244000000013 helminth Species 0.000 claims abstract description 25
108010034145 Helminth Proteins Proteins 0.000 claims abstract description 13
230000000890 antigenic effect Effects 0.000 claims abstract description 11
108091028043 Nucleic acid sequence Proteins 0.000 claims abstract description 6
108090000623 proteins and genes Proteins 0.000 claims description 73
102000004169 proteins and genes Human genes 0.000 claims description 65
210000004027 cell Anatomy 0.000 claims description 45
238000000034 method Methods 0.000 claims description 38
241000243974 Haemonchus contortus Species 0.000 claims description 27
150000001413 amino acids Chemical class 0.000 claims description 25
241001465754 Metazoa Species 0.000 claims description 22
239000002773 nucleotide Substances 0.000 claims description 20
125000003729 nucleotide group Chemical group 0.000 claims description 20
241000282414 Homo sapiens Species 0.000 claims description 19
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 19
238000009396 hybridization Methods 0.000 claims description 13
229920001542 oligosaccharide Polymers 0.000 claims description 13
150000002482 oligosaccharides Chemical class 0.000 claims description 13
108010005233 alanylglutamic acid Proteins 0.000 claims description 12
238000004519 manufacturing process Methods 0.000 claims description 12
239000002131 composite material Substances 0.000 claims description 11
230000028993 immune response Effects 0.000 claims description 11
LQMHZERGCQJKAH-STQMWFEESA-N Met-Gly-Phe Chemical compound CSCC[C@H](N)C(=O)NCC(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 LQMHZERGCQJKAH-STQMWFEESA-N 0.000 claims description 10
241000700605 Viruses Species 0.000 claims description 10
239000011780 sodium chloride Substances 0.000 claims description 10
125000000010 L-asparaginyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C(=O)N([H])[H] 0.000 claims description 9
108010011559 alanylphenylalanine Proteins 0.000 claims description 9
108010064235 lysylglycine Proteins 0.000 claims description 9
125000003338 L-glutaminyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C([H])([H])C(=O)N([H])[H] 0.000 claims description 7
KOSRFJWDECSPRO-UHFFFAOYSA-N alpha-L-glutamyl-L-glutamic acid Natural products OC(=O)CCC(N)C(=O)NC(CCC(O)=O)C(O)=O KOSRFJWDECSPRO-UHFFFAOYSA-N 0.000 claims description 7
108010040443 aspartyl-aspartic acid Proteins 0.000 claims description 7
108010049041 glutamylalanine Proteins 0.000 claims description 7
108010003700 lysyl aspartic acid Proteins 0.000 claims description 7
FUSPCLTUKXQREV-ACZMJKKPSA-N Ala-Glu-Ala Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(O)=O FUSPCLTUKXQREV-ACZMJKKPSA-N 0.000 claims description 6
KXEVYGKATAMXJJ-ACZMJKKPSA-N Ala-Glu-Asp Chemical compound C[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(O)=O KXEVYGKATAMXJJ-ACZMJKKPSA-N 0.000 claims description 6
125000002435 L-phenylalanyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims description 6
UGCIQUYEJIEHKX-GVXVVHGQSA-N Lys-Val-Glu Chemical compound [H]N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(O)=O UGCIQUYEJIEHKX-GVXVVHGQSA-N 0.000 claims description 6
LMMDEZPNUTZJAY-GCJQMDKQSA-N Thr-Asp-Ala Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(O)=O LMMDEZPNUTZJAY-GCJQMDKQSA-N 0.000 claims description 6
108010008685 alanyl-glutamyl-aspartic acid Proteins 0.000 claims description 6
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230000004936 stimulating effect Effects 0.000 claims description 6
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YLTKNGYYPIWKHZ-ACZMJKKPSA-N Ala-Ala-Glu Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@H](C(O)=O)CCC(O)=O YLTKNGYYPIWKHZ-ACZMJKKPSA-N 0.000 claims description 5
125000003580 L-valyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(C([H])([H])[H])(C([H])([H])[H])[H] 0.000 claims description 5
IAJFFZORSWOZPQ-SRVKXCTJSA-N Leu-Leu-Asn Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(O)=O IAJFFZORSWOZPQ-SRVKXCTJSA-N 0.000 claims description 5
CIOWSLJGLSUOME-BQBZGAKWSA-N Lys-Asp Chemical compound NCCCC[C@H](N)C(=O)N[C@H](C(O)=O)CC(O)=O CIOWSLJGLSUOME-BQBZGAKWSA-N 0.000 claims description 5
210000003527 eukaryotic cell Anatomy 0.000 claims description 5
239000013604 expression vector Substances 0.000 claims description 5
210000001236 prokaryotic cell Anatomy 0.000 claims description 5
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NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 5
LBYMZCVBOKYZNS-CIUDSAMLSA-N Ala-Leu-Asp Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O LBYMZCVBOKYZNS-CIUDSAMLSA-N 0.000 claims description 4
YCRAFFCYWOUEOF-DLOVCJGASA-N Ala-Phe-Ser Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)C)CC1=CC=CC=C1 YCRAFFCYWOUEOF-DLOVCJGASA-N 0.000 claims description 4
VAWNQIGQPUOPQW-ACZMJKKPSA-N Asp-Glu-Ala Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(O)=O VAWNQIGQPUOPQW-ACZMJKKPSA-N 0.000 claims description 4
UTKUTMJSWKKHEM-WDSKDSINSA-N Glu-Ala-Gly Chemical compound OC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)CCC(O)=O UTKUTMJSWKKHEM-WDSKDSINSA-N 0.000 claims description 4
PMSMKNYRZCKVMC-DRZSPHRISA-N Glu-Phe-Ala Chemical compound C[C@@H](C(=O)O)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CCC(=O)O)N PMSMKNYRZCKVMC-DRZSPHRISA-N 0.000 claims description 4
JSIQVRIXMINMTA-ZDLURKLDSA-N Glu-Thr Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@@H](N)CCC(O)=O JSIQVRIXMINMTA-ZDLURKLDSA-N 0.000 claims description 4
AIQWYVFNBNNOLU-RHYQMDGZSA-N Leu-Thr-Val Chemical compound [H]N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(O)=O AIQWYVFNBNNOLU-RHYQMDGZSA-N 0.000 claims description 4
IGRMTQMIDNDFAA-UWVGGRQHSA-N Lys-His Chemical compound NCCCC[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CN=CN1 IGRMTQMIDNDFAA-UWVGGRQHSA-N 0.000 claims description 4
ATIPDCIQTUXABX-UWVGGRQHSA-N Lys-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@@H](N)CCCCN ATIPDCIQTUXABX-UWVGGRQHSA-N 0.000 claims description 4
RMOKGALPSPOYKE-KATARQTJSA-N Lys-Thr-Ser Chemical compound [H]N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(O)=O RMOKGALPSPOYKE-KATARQTJSA-N 0.000 claims description 4
BCRQJDMZQUHQSV-STQMWFEESA-N Met-Gly-Tyr Chemical compound [H]N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O BCRQJDMZQUHQSV-STQMWFEESA-N 0.000 claims description 4
AFFKUNVPPLQUGA-DCAQKATOSA-N Met-Leu-Ala Chemical compound [H]N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(O)=O AFFKUNVPPLQUGA-DCAQKATOSA-N 0.000 claims description 4
IRVONVRHHJXWTK-RWMBFGLXSA-N Met-Lys-Pro Chemical compound CSCC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)O)N IRVONVRHHJXWTK-RWMBFGLXSA-N 0.000 claims description 4
LCPUWQLULVXROY-RHYQMDGZSA-N Met-Lys-Thr Chemical compound CSCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O LCPUWQLULVXROY-RHYQMDGZSA-N 0.000 claims description 4
SITLTJHOQZFJGG-UHFFFAOYSA-N N-L-alpha-glutamyl-L-valine Natural products CC(C)C(C(O)=O)NC(=O)C(N)CCC(O)=O SITLTJHOQZFJGG-UHFFFAOYSA-N 0.000 claims description 4
ONWMQORSVZYVNH-UWVGGRQHSA-N Tyr-Asn Chemical compound NC(=O)C[C@@H](C(O)=O)NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 ONWMQORSVZYVNH-UWVGGRQHSA-N 0.000 claims description 4
JHORGUYURUBVOM-KKUMJFAQSA-N Tyr-His-Ser Chemical compound [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(O)=O JHORGUYURUBVOM-KKUMJFAQSA-N 0.000 claims description 4
108010068265 aspartyltyrosine Proteins 0.000 claims description 4
108010055341 glutamyl-glutamic acid Proteins 0.000 claims description 4
108010009298 lysylglutamic acid Proteins 0.000 claims description 4
108010022588 methionyl-lysyl-proline Proteins 0.000 claims description 4
COEXAQSTZUWMRI-STQMWFEESA-N (2s)-1-[2-[[(2s)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]pyrrolidine-2-carboxylic acid Chemical compound C([C@H](N)C(=O)NCC(=O)N1[C@@H](CCC1)C(O)=O)C1=CC=C(O)C=C1 COEXAQSTZUWMRI-STQMWFEESA-N 0.000 claims description 3
BFMIRJBURUXDRG-DLOVCJGASA-N Ala-Phe-Asp Chemical compound OC(=O)C[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)C)CC1=CC=CC=C1 BFMIRJBURUXDRG-DLOVCJGASA-N 0.000 claims description 3
BUQICHWNXBIBOG-LMVFSUKVSA-N Ala-Thr Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@H](C)N BUQICHWNXBIBOG-LMVFSUKVSA-N 0.000 claims description 3
SPWXXPFDTMYTRI-IUKAMOBKSA-N Asp-Ile-Thr Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(O)=O SPWXXPFDTMYTRI-IUKAMOBKSA-N 0.000 claims description 3
108091026890 Coding region Proteins 0.000 claims description 3
SITLTJHOQZFJGG-XPUUQOCRSA-N Glu-Val Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@@H](N)CCC(O)=O SITLTJHOQZFJGG-XPUUQOCRSA-N 0.000 claims description 3
QOOWRKBDDXQRHC-BQBZGAKWSA-N L-lysyl-L-alanine Chemical compound OC(=O)[C@H](C)NC(=O)[C@@H](N)CCCCN QOOWRKBDDXQRHC-BQBZGAKWSA-N 0.000 claims description 3
125000002842 L-seryl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])O[H] 0.000 claims description 3
125000000769 L-threonyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])[C@](O[H])(C([H])([H])[H])[H] 0.000 claims description 3
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IUVYJBMTHARMIP-PCBIJLKTSA-N Phe-Asp-Ile Chemical compound [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O IUVYJBMTHARMIP-PCBIJLKTSA-N 0.000 claims description 3
IWNOFCGBMSFTBC-CIUDSAMLSA-N Pro-Ala-Glu Chemical compound [H]N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(O)=O IWNOFCGBMSFTBC-CIUDSAMLSA-N 0.000 claims description 3
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- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0003—Invertebrate antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43536—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms
- C07K14/4354—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms from nematodes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
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- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

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Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
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Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

SK1323-94A 1992-05-08 1993-05-07 Recombinant dna molecules coding aminopeptidase enzymes and their use in the preparation of vaccines SK132394A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB929209993A GB9209993D0 (en)	1992-05-08	1992-05-08	Vaccines
PCT/GB1993/000943 WO1993023542A1 (en)	1992-05-08	1993-05-07	Recombinant dna molecules encoding aminopeptidase enzymes and their use in the preparation of vaccines against helminth infections

Publications (1)

Publication Number	Publication Date
SK132394A3 true SK132394A3 (en)	1995-07-11

Family

ID=10715227

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1323-94A SK132394A3 (en)	1992-05-08	1993-05-07	Recombinant dna molecules coding aminopeptidase enzymes and their use in the preparation of vaccines

Country Status (25)

Country	Link
US (4)	US6066503A (de)
EP (1)	EP0640133B1 (de)
JP (1)	JPH07508879A (de)
CN (1)	CN1053699C (de)
AT (1)	ATE195346T1 (de)
AU (1)	AU677582B2 (de)
BG (1)	BG62700B1 (de)
CA (1)	CA2134326A1 (de)
CZ (1)	CZ274494A3 (de)
DE (1)	DE69329195T2 (de)
DK (1)	DK0640133T3 (de)
ES (1)	ES2151506T3 (de)
FI (1)	FI945221A0 (de)
GB (1)	GB9209993D0 (de)
GR (1)	GR3034766T3 (de)
HU (1)	HU218041B (de)
NO (1)	NO944245L (de)
NZ (1)	NZ252221A (de)
PL (1)	PL175900B1 (de)
PT (1)	PT640133E (de)
RO (1)	RO117709B1 (de)
RU (1)	RU2140986C1 (de)
SK (1)	SK132394A3 (de)
WO (1)	WO1993023542A1 (de)
ZA (1)	ZA933216B (de)

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US6099843A (en) *	1991-02-12	2000-08-08	Heska Corporation	Parasitic helminth PLA2 proteins
US6156556A (en) *	1991-12-13	2000-12-05	Heska Corporation	Flea protease proteins, nucleic acid molecules, and uses thereof
US5972645A (en) *	1991-12-13	1999-10-26	Heska Corporation	Flea serine protease nucleic acid molecules
US6210920B1 (en)	1991-12-13	2001-04-03	Heska Corporation	Flea protease proteins, nucleic acid molecules, and uses thereof
US6150125A (en)	1991-12-13	2000-11-21	Heska Corporation	Flea protease proteins and uses thereof
US6121035A (en) *	1991-12-13	2000-09-19	Heska Corporation	Flea aminopeptidase proteins and uses thereof
US6146870A (en) *	1991-12-13	2000-11-14	Heska Corporation	Flea protease proteins
GB9209993D0 (en) *	1992-05-08	1992-06-24	Munn Edward A	Vaccines
GB9302302D0 (en) *	1993-02-05	1993-03-24	Pitman Moore Inc	Process
GB9303681D0 (en) *	1993-02-24	1993-04-14	Pitman Moore Inc	Vaccines
GB9322702D0 (en)	1993-11-03	1993-12-22	Agricultural & Food Res	Vaccines
BR9305075A (pt) *	1993-12-16	1995-08-08	Fundacao Oswaldo Cruz	Antígeno para conferir imunidade protetora contra infecções helmínticas em humanos e animais,e processo de vacinação para aplicação na imunoprofilaxia de doenças helmintológicas de interesse veterinário e médico
US6214579B1 (en)	1994-10-18	2001-04-10	Heska Corporation	Flea leucine aminopeptidase nucleic acid molecules and uses thereof
US6204010B1 (en)	1995-06-07	2001-03-20	Heska Corporation	Flea protease proteins, nucleic acid molecules, and uses thereof
US6139840A (en) *	1995-10-18	2000-10-31	Heska Corporation	Methods of eliciting an antibody response using flea protease proteins and homologs thereof
IL120704A0 (en) *	1996-04-24	1998-04-05	Heska Corp	Flea protease proteins nucleic acid molecules and uses thereof
US20040006204A1 (en)	2002-04-02	2004-01-08	Miriam Tendler	Synthetic active peptide fragments
US7951557B2 (en)	2003-04-27	2011-05-31	Protalix Ltd.	Human lysosomal proteins from plant cell culture
CA2685701C (en)	2007-05-07	2019-01-15	Protalix Ltd.	Large scale disposable bioreactor
US20080294361A1 (en) *	2007-05-24	2008-11-27	Popp Shane M	Intelligent execution system for the monitoring and execution of vaccine manufacturing
ES2325243B1 (es)	2008-02-27	2011-05-04	Universidad De Granada	Antigeno recombinante.
US8277651B2 (en)	2009-03-13	2012-10-02	Terrasep, Llc	Methods and apparatus for centrifugal liquid chromatography
CN112961848B (zh) *	2021-02-24	2022-09-09	中国海洋大学	一种新型氨肽酶及其可溶性表达方法

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WO1986005807A1 (en)	1985-04-01	1986-10-09	Celltech Limited	Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same
GB8601597D0 (en)	1986-01-23	1986-02-26	Wilson R H	Nucleotide sequences
GB8619293D0 (en) *	1986-08-07	1986-09-17	Munn E A	Anthelmintic agents
US4879213A (en) *	1986-12-05	1989-11-07	Scripps Clinic And Research Foundation	Synthetic polypeptides and antibodies related to Epstein-Barr virus early antigen-diffuse
GB8717430D0 (en)	1987-07-23	1987-08-26	Celltech Ltd	Recombinant dna product
GB8809129D0 (en)	1988-04-18	1988-05-18	Celltech Ltd	Recombinant dna methods vectors and host cells
WO1990003433A1 (en) *	1988-09-26	1990-04-05	Biotechnology Australia Pty. Ltd.	Vaccine
GB8906156D0 (en) *	1989-03-17	1989-05-04	Munn Edward A	Production and use of anthelmintic agents and protective immunogens
NL9001832A (nl) *	1990-08-16	1992-03-16	Rijksuniversiteit	Specifieke sequenties van dna van een nematode die toegepast kunnen worden bij de diagnostiek van infektie met de nematode.
US5795768A (en) *	1991-02-12	1998-08-18	Heska Corporation	Filariid nematode cysteine protease proteins, nucleic acid molecules and uses thereof
GB9209993D0 (en) *	1992-05-08	1992-06-24	Munn Edward A	Vaccines
GB9302302D0 (en) *	1993-02-05	1993-03-24	Pitman Moore Inc	Process

1992
- 1992-05-08 GB GB929209993A patent/GB9209993D0/en active Pending
1993
- 1993-05-07 EP EP93910164A patent/EP0640133B1/de not_active Expired - Lifetime
- 1993-05-07 HU HU9403209A patent/HU218041B/hu not_active IP Right Cessation
- 1993-05-07 RU RU94046017A patent/RU2140986C1/ru active
- 1993-05-07 NZ NZ252221A patent/NZ252221A/en not_active IP Right Cessation
- 1993-05-07 PL PL93306028A patent/PL175900B1/pl unknown
- 1993-05-07 CZ CZ942744A patent/CZ274494A3/cs unknown
- 1993-05-07 JP JP5519972A patent/JPH07508879A/ja active Pending
- 1993-05-07 US US08/335,844 patent/US6066503A/en not_active Expired - Fee Related
- 1993-05-07 ZA ZA933216A patent/ZA933216B/xx unknown
- 1993-05-07 CA CA002134326A patent/CA2134326A1/en not_active Abandoned
- 1993-05-07 SK SK1323-94A patent/SK132394A3/sk unknown
- 1993-05-07 ES ES93910164T patent/ES2151506T3/es not_active Expired - Lifetime
- 1993-05-07 DK DK93910164T patent/DK0640133T3/da active
- 1993-05-07 PT PT93910164T patent/PT640133E/pt unknown
- 1993-05-07 AU AU40775/93A patent/AU677582B2/en not_active Ceased
- 1993-05-07 WO PCT/GB1993/000943 patent/WO1993023542A1/en not_active Application Discontinuation
- 1993-05-07 DE DE69329195T patent/DE69329195T2/de not_active Expired - Fee Related
- 1993-05-07 AT AT93910164T patent/ATE195346T1/de not_active IP Right Cessation
- 1993-05-07 RO RO94-01794A patent/RO117709B1/ro unknown
- 1993-05-08 CN CN93107081A patent/CN1053699C/zh not_active Expired - Fee Related
1994
- 1994-11-07 NO NO944245A patent/NO944245L/no not_active Application Discontinuation
- 1994-11-07 FI FI945221A patent/FI945221A0/fi unknown
- 1994-12-08 BG BG99246A patent/BG62700B1/bg unknown
1998
- 1998-08-05 US US09/129,366 patent/US6534638B1/en not_active Expired - Fee Related
2000
- 2000-11-07 GR GR20000402455T patent/GR3034766T3/el not_active IP Right Cessation
2002
- 2002-03-19 US US10/100,049 patent/US20030078398A1/en not_active Abandoned
2006
- 2006-11-02 US US11/591,569 patent/US20080145379A1/en not_active Abandoned

Also Published As

Publication number	Publication date
WO1993023542A1 (en)	1993-11-25
US6534638B1 (en)	2003-03-18
AU4077593A (en)	1993-12-13
JPH07508879A (ja)	1995-10-05
GB9209993D0 (en)	1992-06-24
EP0640133A1 (de)	1995-03-01
AU677582B2 (en)	1997-05-01
NZ252221A (en)	1996-12-20
ZA933216B (en)	1994-06-14
CA2134326A1 (en)	1993-11-25
EP0640133B1 (de)	2000-08-09
US20080145379A1 (en)	2008-06-19
PT640133E (pt)	2000-12-29
RU2140986C1 (ru)	1999-11-10
DK0640133T3 (da)	2000-12-18
RO117709B1 (ro)	2002-06-28
FI945221A (fi)	1994-11-07
DE69329195T2 (de)	2001-04-05
NO944245L (no)	1995-01-06
US6066503A (en)	2000-05-23
CN1053699C (zh)	2000-06-21
HUT71847A (en)	1996-02-28
ATE195346T1 (de)	2000-08-15
HU218041B (hu)	2000-05-28
DE69329195D1 (de)	2000-09-14
ES2151506T3 (es)	2001-01-01
US20030078398A1 (en)	2003-04-24
CZ274494A3 (en)	1995-08-16
CN1084563A (zh)	1994-03-30
BG62700B1 (bg)	2000-05-31
BG99246A (bg)	1995-07-28
FI945221A0 (fi)	1994-11-07
RU94046017A (ru)	1997-03-20
NO944245D0 (no)	1994-11-07
PL175900B1 (pl)	1999-03-31
GR3034766T3 (en)	2001-02-28

Publication	Publication Date	Title
US6534638B1 (en)	2003-03-18	Recombinant DNA molecules encoding aminopeptidase enzymes and their use in the preparation of vaccines against helminth infections
Trottein et al.	1992	Inter-species variation of schistosome 28-kDa glutathione S-transferases
US7396909B2 (en)	2008-07-08	Toxoplasma gondii proteins
US10314900B2 (en)	2019-06-11	Lutzomyia longipalpis polypeptides and methods of use
KR20000065266A (ko)	2000-11-06	말라리아 원충 msp-1의 c-말단 단편을 함유하는 재조합 단백질
JPH07196690A (ja)	1995-08-01	コクシジウム症家禽ワクチン
SK130598A3 (en)	1999-06-11	Nucleic acid and amino acid sequences relating to helicobacter pylori and vaccine compositions thereof
KR20000065265A (ko)	2000-11-06	말라리아 원충 msp-1의 c-말단 단편을 함유하는 재조합 단백질
US20040171821A1 (en)	2004-09-02	Anti-arthropod vector vaccines method of selecting and uses thereof
US6413521B1 (en)	2002-07-02	Helminth parasite antigen with aminopeptidase-like activity
JPH11507820A (ja)	1999-07-13	新規なフィラリア線虫システインプロテアーゼタンパク質、核酸分子、およびこれらの使用
WO2000056763A1 (en)	2000-09-28	A novel polypeptide and its derivatives, homologues and analogues