DE69329195D1 - Rekombinante dna moleküle die aminopeptidase enzyme kodieren und ihre anwendung für die herstellung von impfstoffen gegen helminth infektionen - Google Patents
Rekombinante dna moleküle die aminopeptidase enzyme kodieren und ihre anwendung für die herstellung von impfstoffen gegen helminth infektionenInfo
- Publication number
- DE69329195D1 DE69329195D1 DE69329195T DE69329195T DE69329195D1 DE 69329195 D1 DE69329195 D1 DE 69329195D1 DE 69329195 T DE69329195 T DE 69329195T DE 69329195 T DE69329195 T DE 69329195T DE 69329195 D1 DE69329195 D1 DE 69329195D1
- Authority
- DE
- Germany
- Prior art keywords
- production
- application
- recombinant dna
- dna molecules
- vaccines against
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 244000000013 helminth Species 0.000 title abstract 3
- 102000004400 Aminopeptidases Human genes 0.000 title abstract 2
- 108090000915 Aminopeptidases Proteins 0.000 title abstract 2
- 108010034145 Helminth Proteins Proteins 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 108020004511 Recombinant DNA Proteins 0.000 title 1
- 208000015181 infectious disease Diseases 0.000 title 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0003—Invertebrate antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43536—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms
- C07K14/4354—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms from nematodes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929209993A GB9209993D0 (en) | 1992-05-08 | 1992-05-08 | Vaccines |
PCT/GB1993/000943 WO1993023542A1 (en) | 1992-05-08 | 1993-05-07 | Recombinant dna molecules encoding aminopeptidase enzymes and their use in the preparation of vaccines against helminth infections |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69329195D1 true DE69329195D1 (de) | 2000-09-14 |
DE69329195T2 DE69329195T2 (de) | 2001-04-05 |
Family
ID=10715227
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69329195T Expired - Fee Related DE69329195T2 (de) | 1992-05-08 | 1993-05-07 | Rekombinante dna moleküle die aminopeptidase enzyme kodieren und ihre anwendung für die herstellung von impfstoffen gegen helminth infektionen |
Country Status (25)
Country | Link |
---|---|
US (4) | US6066503A (de) |
EP (1) | EP0640133B1 (de) |
JP (1) | JPH07508879A (de) |
CN (1) | CN1053699C (de) |
AT (1) | ATE195346T1 (de) |
AU (1) | AU677582B2 (de) |
BG (1) | BG62700B1 (de) |
CA (1) | CA2134326A1 (de) |
CZ (1) | CZ274494A3 (de) |
DE (1) | DE69329195T2 (de) |
DK (1) | DK0640133T3 (de) |
ES (1) | ES2151506T3 (de) |
FI (1) | FI945221A0 (de) |
GB (1) | GB9209993D0 (de) |
GR (1) | GR3034766T3 (de) |
HU (1) | HU218041B (de) |
NO (1) | NO944245L (de) |
NZ (1) | NZ252221A (de) |
PL (1) | PL175900B1 (de) |
PT (1) | PT640133E (de) |
RO (1) | RO117709B1 (de) |
RU (1) | RU2140986C1 (de) |
SK (1) | SK132394A3 (de) |
WO (1) | WO1993023542A1 (de) |
ZA (1) | ZA933216B (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6099843A (en) * | 1991-02-12 | 2000-08-08 | Heska Corporation | Parasitic helminth PLA2 proteins |
US6156556A (en) * | 1991-12-13 | 2000-12-05 | Heska Corporation | Flea protease proteins, nucleic acid molecules, and uses thereof |
US6210920B1 (en) | 1991-12-13 | 2001-04-03 | Heska Corporation | Flea protease proteins, nucleic acid molecules, and uses thereof |
US6150125A (en) * | 1991-12-13 | 2000-11-21 | Heska Corporation | Flea protease proteins and uses thereof |
US6146870A (en) * | 1991-12-13 | 2000-11-14 | Heska Corporation | Flea protease proteins |
US6121035A (en) * | 1991-12-13 | 2000-09-19 | Heska Corporation | Flea aminopeptidase proteins and uses thereof |
US5972645A (en) * | 1991-12-13 | 1999-10-26 | Heska Corporation | Flea serine protease nucleic acid molecules |
GB9209993D0 (en) * | 1992-05-08 | 1992-06-24 | Munn Edward A | Vaccines |
GB9302302D0 (en) * | 1993-02-05 | 1993-03-24 | Pitman Moore Inc | Process |
GB9303681D0 (en) * | 1993-02-24 | 1993-04-14 | Pitman Moore Inc | Vaccines |
GB9322702D0 (en) | 1993-11-03 | 1993-12-22 | Agricultural & Food Res | Vaccines |
BR9305075A (pt) * | 1993-12-16 | 1995-08-08 | Fundacao Oswaldo Cruz | Antígeno para conferir imunidade protetora contra infecções helmínticas em humanos e animais,e processo de vacinação para aplicação na imunoprofilaxia de doenças helmintológicas de interesse veterinário e médico |
US6214579B1 (en) | 1994-10-18 | 2001-04-10 | Heska Corporation | Flea leucine aminopeptidase nucleic acid molecules and uses thereof |
US6204010B1 (en) | 1995-06-07 | 2001-03-20 | Heska Corporation | Flea protease proteins, nucleic acid molecules, and uses thereof |
US6139840A (en) * | 1995-10-18 | 2000-10-31 | Heska Corporation | Methods of eliciting an antibody response using flea protease proteins and homologs thereof |
IL120704A0 (en) * | 1996-04-24 | 1998-04-05 | Heska Corp | Flea protease proteins nucleic acid molecules and uses thereof |
US20040006204A1 (en) | 2002-04-02 | 2004-01-08 | Miriam Tendler | Synthetic active peptide fragments |
US7951557B2 (en) | 2003-04-27 | 2011-05-31 | Protalix Ltd. | Human lysosomal proteins from plant cell culture |
BRPI0810343B1 (pt) | 2007-05-07 | 2021-03-30 | Protalix Ltd | Dispositivo descartável para o cultivo e colheita de tecidos vegetais e/ou células, método de cultivo e colheita de um tecido vegetal e/ou células vegetais em um volume maior do que 400 litros e sistema de cultivo da célula vegetal |
US20080294361A1 (en) * | 2007-05-24 | 2008-11-27 | Popp Shane M | Intelligent execution system for the monitoring and execution of vaccine manufacturing |
ES2325243B1 (es) | 2008-02-27 | 2011-05-04 | Universidad De Granada | Antigeno recombinante. |
US8277650B2 (en) | 2009-03-13 | 2012-10-02 | Terrasep, Llc | Methods and apparatus for centrifugal liquid chromatography |
CN112961848B (zh) * | 2021-02-24 | 2022-09-09 | 中国海洋大学 | 一种新型氨肽酶及其可溶性表达方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU584417B2 (en) | 1985-04-01 | 1989-05-25 | Lonza Group Ag | Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same |
GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
GB8619293D0 (en) * | 1986-08-07 | 1986-09-17 | Munn E A | Anthelmintic agents |
US4879213A (en) * | 1986-12-05 | 1989-11-07 | Scripps Clinic And Research Foundation | Synthetic polypeptides and antibodies related to Epstein-Barr virus early antigen-diffuse |
GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
GB8809129D0 (en) | 1988-04-18 | 1988-05-18 | Celltech Ltd | Recombinant dna methods vectors and host cells |
NZ230773A (en) * | 1988-09-26 | 1993-04-28 | Biotech Australia Pty Ltd | Nematode antigenic peptides and vaccines |
GB8906156D0 (en) * | 1989-03-17 | 1989-05-04 | Munn Edward A | Production and use of anthelmintic agents and protective immunogens |
NL9001832A (nl) * | 1990-08-16 | 1992-03-16 | Rijksuniversiteit | Specifieke sequenties van dna van een nematode die toegepast kunnen worden bij de diagnostiek van infektie met de nematode. |
US5795768A (en) * | 1991-02-12 | 1998-08-18 | Heska Corporation | Filariid nematode cysteine protease proteins, nucleic acid molecules and uses thereof |
GB9209993D0 (en) * | 1992-05-08 | 1992-06-24 | Munn Edward A | Vaccines |
GB9302302D0 (en) * | 1993-02-05 | 1993-03-24 | Pitman Moore Inc | Process |
-
1992
- 1992-05-08 GB GB929209993A patent/GB9209993D0/en active Pending
-
1993
- 1993-05-07 CA CA002134326A patent/CA2134326A1/en not_active Abandoned
- 1993-05-07 ES ES93910164T patent/ES2151506T3/es not_active Expired - Lifetime
- 1993-05-07 NZ NZ252221A patent/NZ252221A/en not_active IP Right Cessation
- 1993-05-07 PL PL93306028A patent/PL175900B1/pl unknown
- 1993-05-07 EP EP93910164A patent/EP0640133B1/de not_active Expired - Lifetime
- 1993-05-07 AT AT93910164T patent/ATE195346T1/de not_active IP Right Cessation
- 1993-05-07 ZA ZA933216A patent/ZA933216B/xx unknown
- 1993-05-07 DE DE69329195T patent/DE69329195T2/de not_active Expired - Fee Related
- 1993-05-07 AU AU40775/93A patent/AU677582B2/en not_active Ceased
- 1993-05-07 HU HU9403209A patent/HU218041B/hu not_active IP Right Cessation
- 1993-05-07 CZ CZ942744A patent/CZ274494A3/cs unknown
- 1993-05-07 US US08/335,844 patent/US6066503A/en not_active Expired - Fee Related
- 1993-05-07 RU RU94046017A patent/RU2140986C1/ru active
- 1993-05-07 DK DK93910164T patent/DK0640133T3/da active
- 1993-05-07 WO PCT/GB1993/000943 patent/WO1993023542A1/en not_active Application Discontinuation
- 1993-05-07 SK SK1323-94A patent/SK132394A3/sk unknown
- 1993-05-07 RO RO94-01794A patent/RO117709B1/ro unknown
- 1993-05-07 PT PT93910164T patent/PT640133E/pt unknown
- 1993-05-07 JP JP5519972A patent/JPH07508879A/ja active Pending
- 1993-05-08 CN CN93107081A patent/CN1053699C/zh not_active Expired - Fee Related
-
1994
- 1994-11-07 FI FI945221A patent/FI945221A0/fi unknown
- 1994-11-07 NO NO944245A patent/NO944245L/no not_active Application Discontinuation
- 1994-12-08 BG BG99246A patent/BG62700B1/bg unknown
-
1998
- 1998-08-05 US US09/129,366 patent/US6534638B1/en not_active Expired - Fee Related
-
2000
- 2000-11-07 GR GR20000402455T patent/GR3034766T3/el not_active IP Right Cessation
-
2002
- 2002-03-19 US US10/100,049 patent/US20030078398A1/en not_active Abandoned
-
2006
- 2006-11-02 US US11/591,569 patent/US20080145379A1/en not_active Abandoned
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |