SI9620012A - Process for the preparation of a dicarboxylic acid dichloride - Google Patents

Process for the preparation of a dicarboxylic acid dichloride Download PDF

Info

Publication number: SI9620012A
Authority: SI; Slovenia
Prior art keywords: benzenedicarboxylic acid; amino; process according; hydrocarbon; triiodo
Prior art date: 1995-05-23

Application number

SI9620012A

Other languages

English (en)

Slovenian (sl)

Inventor

Marina Mauro

Carlo Felice Viscardi

Massimo Gagna

Original Assignee

Fructamine Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-05-23

Filing date

1996-05-17

Publication date

1997-06-30

1995-05-23 Priority claimed from ITMI951044A external-priority patent/IT1274546B/it

1995-08-04 Priority claimed from IT95RM000550 external-priority patent/IT1281320B1/it

1996-05-17 Application filed by Fructamine Spa filed Critical Fructamine Spa

1997-06-30 Publication of SI9620012A publication Critical patent/SI9620012A/sl

Links

238000000034 method Methods 0.000 title claims abstract description 40
238000002360 preparation method Methods 0.000 title claims abstract description 7
OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 title description 2
238000006243 chemical reaction Methods 0.000 claims abstract description 26
SBZXBUIDTXKZTM-UHFFFAOYSA-N diglyme Chemical compound COCCOCCOC SBZXBUIDTXKZTM-UHFFFAOYSA-N 0.000 claims abstract description 24
229930195733 hydrocarbon Natural products 0.000 claims abstract description 15
150000002430 hydrocarbons Chemical class 0.000 claims abstract description 15
DKPFZGUDAPQIHT-UHFFFAOYSA-N butyl acetate Chemical compound CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 claims abstract description 12
FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 claims abstract description 12
FBJVWRITWDYUAC-UHFFFAOYSA-N 5-amino-2,4,6-triiodobenzene-1,3-dicarbonyl chloride Chemical compound NC1=C(I)C(C(Cl)=O)=C(I)C(C(Cl)=O)=C1I FBJVWRITWDYUAC-UHFFFAOYSA-N 0.000 claims abstract description 9
150000004945 aromatic hydrocarbons Chemical class 0.000 claims abstract description 8
UOCLXMDMGBRAIB-UHFFFAOYSA-N 1,1,1-trichloroethane Chemical compound CC(Cl)(Cl)Cl UOCLXMDMGBRAIB-UHFFFAOYSA-N 0.000 claims abstract description 7
JEZJSNULLBSYHV-UHFFFAOYSA-N 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid Chemical compound NC1=C(I)C(C(O)=O)=C(I)C(C(O)=O)=C1I JEZJSNULLBSYHV-UHFFFAOYSA-N 0.000 claims abstract description 6
239000002904 solvent Substances 0.000 claims abstract description 6
150000003512 tertiary amines Chemical class 0.000 claims abstract description 6
230000003197 catalytic effect Effects 0.000 claims abstract description 4
SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims description 38
IVSZLXZYQVIEFR-UHFFFAOYSA-N m-xylene Chemical group CC1=CC=CC(C)=C1 IVSZLXZYQVIEFR-UHFFFAOYSA-N 0.000 claims description 38
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
SJRJJKPEHAURKC-UHFFFAOYSA-N N-Methylmorpholine Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 claims description 15
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 12
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 9
239000004215 Carbon black (E152) Substances 0.000 claims description 8
239000000243 solution Substances 0.000 claims description 7
238000005660 chlorination reaction Methods 0.000 claims description 6
DIOQZVSQGTUSAI-UHFFFAOYSA-N decane Chemical compound CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 claims description 6
TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 claims description 6
IUEVXLACZFKZSP-UHFFFAOYSA-L disodium;5-aminobenzene-1,3-dicarboxylate Chemical compound [Na+].[Na+].NC1=CC(C([O-])=O)=CC(C([O-])=O)=C1 IUEVXLACZFKZSP-UHFFFAOYSA-L 0.000 claims description 5
239000007864 aqueous solution Substances 0.000 claims description 4
SNRUBQQJIBEYMU-UHFFFAOYSA-N dodecane Chemical compound CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 claims description 4
229940094933 n-dodecane Drugs 0.000 claims description 4
239000007858 starting material Substances 0.000 claims description 4
COHDGTRFTKHYSJ-UHFFFAOYSA-N 2-Ethyl-5-methylpyridine Chemical compound CCC1=CC=C(C)C=N1 COHDGTRFTKHYSJ-UHFFFAOYSA-N 0.000 claims description 3
239000003350 kerosene Substances 0.000 claims description 3
239000011541 reaction mixture Substances 0.000 claims description 3
239000012266 salt solution Substances 0.000 claims description 3
NBDAHKQJXVLAID-UHFFFAOYSA-N 5-nitroisophthalic acid Chemical compound OC(=O)C1=CC(C(O)=O)=CC([N+]([O-])=O)=C1 NBDAHKQJXVLAID-UHFFFAOYSA-N 0.000 claims description 2
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 2
PSHKMPUSSFXUIA-UHFFFAOYSA-N n,n-dimethylpyridin-2-amine Chemical compound CN(C)C1=CC=CC=N1 PSHKMPUSSFXUIA-UHFFFAOYSA-N 0.000 claims description 2
238000000746 purification Methods 0.000 claims description 2
235000011149 sulphuric acid Nutrition 0.000 claims description 2
FVIAPYQJXFVGHJ-UHFFFAOYSA-N 2,4,6-triiodo-5-(sulfinylamino)benzene-1,3-dicarbonyl chloride Chemical compound ClC(=O)C1=C(I)C(N=S=O)=C(I)C(C(Cl)=O)=C1I FVIAPYQJXFVGHJ-UHFFFAOYSA-N 0.000 claims 1
238000009903 catalytic hydrogenation reaction Methods 0.000 claims 1
238000001914 filtration Methods 0.000 claims 1
230000026045 iodination Effects 0.000 claims 1
238000006192 iodination reaction Methods 0.000 claims 1
230000007935 neutral effect Effects 0.000 claims 1
239000000047 product Substances 0.000 description 17
239000000203 mixture Substances 0.000 description 10
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
239000007787 solid Substances 0.000 description 6
150000001875 compounds Chemical class 0.000 description 5
229910052757 nitrogen Inorganic materials 0.000 description 4
238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 3
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
150000001338 aliphatic hydrocarbons Chemical class 0.000 description 3
230000015572 biosynthetic process Effects 0.000 description 3
239000001257 hydrogen Substances 0.000 description 3
229910052739 hydrogen Inorganic materials 0.000 description 3
239000012299 nitrogen atmosphere Substances 0.000 description 3
239000002002 slurry Substances 0.000 description 3
238000001228 spectrum Methods 0.000 description 3
238000003756 stirring Methods 0.000 description 3
238000003786 synthesis reaction Methods 0.000 description 3
238000005160 1H NMR spectroscopy Methods 0.000 description 2
VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 2
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
239000012467 final product Substances 0.000 description 2
238000004128 high performance liquid chromatography Methods 0.000 description 2
238000002955 isolation Methods 0.000 description 2
UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 2
239000000725 suspension Substances 0.000 description 2
BHKKSKOHRFHHIN-MRVPVSSYSA-N 1-[[2-[(1R)-1-aminoethyl]-4-chlorophenyl]methyl]-2-sulfanylidene-5H-pyrrolo[3,2-d]pyrimidin-4-one Chemical compound N[C@H](C)C1=C(CN2C(NC(C3=C2C=CN3)=O)=S)C=CC(=C1)Cl BHKKSKOHRFHHIN-MRVPVSSYSA-N 0.000 description 1
HIXDQWDOVZUNNA-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxychromen-4-one Chemical compound C=1C(OC)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(OC)C(OC)=C1 HIXDQWDOVZUNNA-UHFFFAOYSA-N 0.000 description 1
KBZFDRWPMZESDI-UHFFFAOYSA-N 5-aminobenzene-1,3-dicarboxylic acid Chemical compound NC1=CC(C(O)=O)=CC(C(O)=O)=C1 KBZFDRWPMZESDI-UHFFFAOYSA-N 0.000 description 1
229940126062 Compound A Drugs 0.000 description 1
230000005526 G1 to G0 transition Effects 0.000 description 1
NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 1
238000005481 NMR spectroscopy Methods 0.000 description 1
CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 1
238000003556 assay Methods 0.000 description 1
239000012298 atmosphere Substances 0.000 description 1
150000001555 benzenes Chemical group 0.000 description 1
238000007664 blowing Methods 0.000 description 1
LSDKXERJHVJDEO-UHFFFAOYSA-N butyl acetate;hydrochloride Chemical compound Cl.CCCCOC(C)=O LSDKXERJHVJDEO-UHFFFAOYSA-N 0.000 description 1
239000003054 catalyst Substances 0.000 description 1
239000003610 charcoal Substances 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
238000001816 cooling Methods 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
230000008025 crystallization Effects 0.000 description 1
238000000354 decomposition reaction Methods 0.000 description 1
238000001035 drying Methods 0.000 description 1
238000000921 elemental analysis Methods 0.000 description 1
238000010828 elution Methods 0.000 description 1
RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
238000011049 filling Methods 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
229940116559 iodinated x-ray contrast media Drugs 0.000 description 1
PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
238000002156 mixing Methods 0.000 description 1
JEDHEXUPBRMUMB-UHFFFAOYSA-N n,n-dimethylpyridin-3-amine Chemical compound CN(C)C1=CC=CN=C1 JEDHEXUPBRMUMB-UHFFFAOYSA-N 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
239000008237 rinsing water Substances 0.000 description 1
235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 description 1
238000000825 ultraviolet detection Methods 0.000 description 1
239000008096 xylene Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
- C07C381/10—Compounds containing sulfur atoms doubly-bound to nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

SI9620012A 1995-05-23 1996-05-17 Process for the preparation of a dicarboxylic acid dichloride SI9620012A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ITMI951044A IT1274546B (it)	1995-05-23	1995-05-23	Processo per la preparazione del dicloruro dell'acido 5-ammino-2,4,- 6-triiodoisoftalico
IT95RM000550 IT1281320B1 (it)	1995-08-04	1995-08-04	Procedimento di preparazione di dicloruro dell'acido 5-ammino-2,4,6- triiodo-1,3-benzendicarbossilico per reazione dell'acido

Publications (1)

Publication Number	Publication Date
SI9620012A true SI9620012A (en)	1997-06-30

Family

ID=26331277

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI9620012A SI9620012A (en)	1995-05-23	1996-05-17	Process for the preparation of a dicarboxylic acid dichloride

Country Status (22)

Country	Link
US (1)	US5616795A (es)
EP (1)	EP0773924B1 (es)
JP (1)	JP4012566B2 (es)
KR (1)	KR100255914B1 (es)
CN (1)	CN1157367C (es)
AT (1)	ATE176663T1 (es)
AU (1)	AU702895B2 (es)
BR (1)	BR9606488A (es)
CA (1)	CA2195636C (es)
CZ (1)	CZ290345B6 (es)
DE (2)	DE69601525T2 (es)
DK (1)	DK0773924T3 (es)
ES (1)	ES2103252T3 (es)
GR (1)	GR970300027T1 (es)
HU (1)	HU216548B (es)
IL (1)	IL118359A (es)
MX (1)	MX9700548A (es)
NO (1)	NO313696B1 (es)
PL (1)	PL182447B1 (es)
SI (1)	SI9620012A (es)
SK (1)	SK8797A3 (es)
WO (1)	WO1996037459A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1271107B (it) *	1994-11-29	1997-05-26	Zambon Spa	Processo per la preparazione di un intermedio utile nella sintesi di composti organici
IT1292037B1 (it) *	1997-05-30	1999-01-25	Bracco Spa	Processo per la preparazione di 5-(acetil 62,3-diidrossipropil)- ammino)-n,n'-bis(2,3-diidrossipropil)-2,4,6-triiodo-1,3-benzen-
US7968745B2 (en)	2005-12-19	2011-06-28	Ge Healthcare As	Purification process of iodixanol
GB0717189D0 (en) *	2007-09-04	2007-10-17	Syngenta Participations Ag	Novel processes and compounds
WO2009091758A1 (en)	2008-01-14	2009-07-23	Mallinckrodt Inc.	Process for the preparation of iosimenol
EP2230227A1 (en)	2009-03-20	2010-09-22	Bracco Imaging S.p.A	Process for the preparation of triiodinated carboxylic aromatic derivatives
EP2243767A1 (en)	2009-04-21	2010-10-27	Bracco Imaging S.p.A	Process for the iodination of aromatic compounds
US7999134B2 (en)	2009-07-21	2011-08-16	Ge Healthcare As	Crystallization of iodixanol using milling
US7999135B2 (en)	2009-07-21	2011-08-16	Ge Healthcare As	Crystallization of iodixanol using ultrasound
CN102725249B (zh)	2009-11-26	2014-12-10	好利安中国控股有限公司	碘克沙醇的制备和纯化
EP2394984A1 (en)	2010-06-10	2011-12-14	Bracco Imaging S.p.A	Process for the iodination of phenolic derivatives
WO2014090650A1 (en)	2012-12-11	2014-06-19	Bracco Imaging Spa	Continuous process for the preparation of (s)-2-acetyloxypropionic acid chloride
PL3066071T3 (pl)	2013-11-05	2018-09-28	Bracco Imaging S.P.A	Sposób otrzymywania jopamidolu
BR112016027507B1 (pt)	2014-06-10	2020-11-24	Bracco Imaging Spa	método para a preparação de ácido (s)-2-acetiloxipropiônico e seus derivados
CN104230731B (zh) *	2014-09-24	2016-01-20	武汉理工大学	造影剂中间体三碘异酞酰氯的制备方法
US10836710B2 (en)	2016-12-05	2020-11-17	Bracco Imaging Spa	Mechanochemical synthesis of radiographic agents intermediates

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH608189A5 (es) *	1974-12-13	1978-12-29	Savac Ag
IT1193211B (it) *	1979-08-09	1988-06-15	Bracco Ind Chimica Spa	Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono
IT1207226B (it) *	1979-08-09	1989-05-17	Bracco Ind Chimica Spa	Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
US4396598A (en) *	1982-01-11	1983-08-02	Mallinckrodt, Inc.	Triiodoisophthalamide X-ray contrast agent
FR2541676A1 (fr) *	1983-02-25	1984-08-31	Guerbet Sa	Composes non-ioniques a structures benzenique iodee ou bromee et produits opacifiants en contenant
US5075502A (en) *	1989-12-13	1991-12-24	Mallinckrodt, Inc.	Nonionic x-ray contrast agents, compositions and methods
US5191120A (en) *	1989-12-13	1993-03-02	Mallinckrodt Medical, Inc.	Process for preparing nonionic X-ray contrast agents
IT1271107B (it) *	1994-11-29	1997-05-26	Zambon Spa	Processo per la preparazione di un intermedio utile nella sintesi di composti organici

1996
- 1996-05-17 US US08/650,094 patent/US5616795A/en not_active Expired - Lifetime
- 1996-05-17 SI SI9620012A patent/SI9620012A/sl unknown
- 1996-05-17 JP JP53534596A patent/JP4012566B2/ja not_active Expired - Lifetime
- 1996-05-17 CN CNB961905271A patent/CN1157367C/zh not_active Expired - Lifetime
- 1996-05-17 DE DE69601525T patent/DE69601525T2/de not_active Expired - Lifetime
- 1996-05-17 AT AT96916098T patent/ATE176663T1/de active
- 1996-05-17 EP EP96916098A patent/EP0773924B1/en not_active Expired - Lifetime
- 1996-05-17 CA CA002195636A patent/CA2195636C/en not_active Expired - Lifetime
- 1996-05-17 HU HU9700188A patent/HU216548B/hu unknown
- 1996-05-17 ES ES96916098T patent/ES2103252T3/es not_active Expired - Lifetime
- 1996-05-17 BR BR9606488A patent/BR9606488A/pt not_active Application Discontinuation
- 1996-05-17 DK DK96916098T patent/DK0773924T3/da active
- 1996-05-17 CZ CZ1997187A patent/CZ290345B6/cs not_active IP Right Cessation
- 1996-05-17 WO PCT/EP1996/002103 patent/WO1996037459A1/en active IP Right Grant
- 1996-05-17 AU AU58978/96A patent/AU702895B2/en not_active Expired
- 1996-05-17 DE DE0773924T patent/DE773924T1/de active Pending
- 1996-05-17 SK SK87-97A patent/SK8797A3/sk unknown
- 1996-05-17 PL PL96318311A patent/PL182447B1/pl unknown
- 1996-05-17 MX MX9700548A patent/MX9700548A/es unknown
- 1996-05-17 KR KR1019970700402A patent/KR100255914B1/ko not_active IP Right Cessation
- 1996-05-22 IL IL11835996A patent/IL118359A/xx not_active IP Right Cessation
1997
- 1997-01-21 NO NO19970261A patent/NO313696B1/no not_active IP Right Cessation
- 1997-09-30 GR GR970300027T patent/GR970300027T1/el unknown

Also Published As

Publication number	Publication date
ES2103252T1 (es)	1997-09-16
NO970261D0 (no)	1997-01-21
PL318311A1 (en)	1997-06-09
AU702895B2 (en)	1999-03-11
EP0773924B1 (en)	1999-02-10
KR100255914B1 (ko)	2000-05-01
NO970261L (no)	1997-05-02
BR9606488A (pt)	1997-11-25
CN1157367C (zh)	2004-07-14
CN1154689A (zh)	1997-07-16
CA2195636C (en)	2007-10-30
WO1996037459A1 (en)	1996-11-28
JPH10508874A (ja)	1998-09-02
PL182447B1 (pl)	2002-01-31
CA2195636A1 (en)	1996-11-28
AU5897896A (en)	1996-12-11
IL118359A (en)	2000-10-31
IL118359A0 (en)	1996-09-12
EP0773924A1 (en)	1997-05-21
ES2103252T3 (es)	1999-04-01
HUP9700188A3 (en)	1998-03-02
US5616795A (en)	1997-04-01
ATE176663T1 (de)	1999-02-15
CZ290345B6 (cs)	2002-07-17
MX9700548A (es)	1997-05-31
JP4012566B2 (ja)	2007-11-21
DE69601525T2 (de)	1999-06-24
HU216548B (hu)	1999-07-28
HUP9700188A1 (hu)	1998-01-28
SK8797A3 (en)	1997-08-06
CZ18797A3 (en)	1997-07-16
DE773924T1 (de)	1997-12-18
NO313696B1 (no)	2002-11-18
GR970300027T1 (en)	1997-09-30
DE69601525D1 (de)	1999-03-25
DK0773924T3 (da)	1999-09-20

Legal Events

Date	Code	Title	Description
2005-01-10	IF	Valid on the event date

Publication	Publication Date	Title
SI9620012A (en)	1997-06-30	Process for the preparation of a dicarboxylic acid dichloride
CZ25399A3 (cs)	1999-07-14	Způsob výroby trijodbenzendikarboxamidových derivátů
JPH11508601A (ja)	1999-07-27	アミン酸塩化合物とその製造プロセス
US11472767B2 (en)	2022-10-18	Process for the monotopic preparation of intermediate organo-iodinated compounds for the synthesis of ioversol
AU707177B2 (en)	1999-07-01	Process for the preparation of a halosubstituted aromatic acid
SI9620010A (en)	1997-06-30	Process for the preparation of a dicarboxylic acid dichloride
KR930005446B1 (ko)	1993-06-22	2-알콕시-n-(1-아자비사이클로[2.2.2]옥탄-3-일)아미노 벤즈아미드의 제조방법
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