DE69601525D1 - Verfahren zur herstellung von dicarbonsäurechlorid - Google Patents
Verfahren zur herstellung von dicarbonsäurechloridInfo
- Publication number
- DE69601525D1 DE69601525D1 DE69601525T DE69601525T DE69601525D1 DE 69601525 D1 DE69601525 D1 DE 69601525D1 DE 69601525 T DE69601525 T DE 69601525T DE 69601525 T DE69601525 T DE 69601525T DE 69601525 D1 DE69601525 D1 DE 69601525D1
- Authority
- DE
- Germany
- Prior art keywords
- producing
- acid chloride
- dicarbonic acid
- triiodo
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- ZFTFAPZRGNKQPU-UHFFFAOYSA-N dicarbonic acid Chemical compound OC(=O)OC(O)=O ZFTFAPZRGNKQPU-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- DKPFZGUDAPQIHT-UHFFFAOYSA-N butyl acetate Chemical compound CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- UOCLXMDMGBRAIB-UHFFFAOYSA-N 1,1,1-trichloroethane Chemical compound CC(Cl)(Cl)Cl UOCLXMDMGBRAIB-UHFFFAOYSA-N 0.000 abstract 1
- FBJVWRITWDYUAC-UHFFFAOYSA-N 5-amino-2,4,6-triiodobenzene-1,3-dicarbonyl chloride Chemical compound NC1=C(I)C(C(Cl)=O)=C(I)C(C(Cl)=O)=C1I FBJVWRITWDYUAC-UHFFFAOYSA-N 0.000 abstract 1
- JEZJSNULLBSYHV-UHFFFAOYSA-N 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid Chemical compound NC1=C(I)C(C(O)=O)=C(I)C(C(O)=O)=C1I JEZJSNULLBSYHV-UHFFFAOYSA-N 0.000 abstract 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- SBZXBUIDTXKZTM-UHFFFAOYSA-N diglyme Chemical compound COCCOCCOC SBZXBUIDTXKZTM-UHFFFAOYSA-N 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 150000003512 tertiary amines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
- C07C381/10—Compounds containing sulfur atoms doubly-bound to nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI951044A IT1274546B (it) | 1995-05-23 | 1995-05-23 | Processo per la preparazione del dicloruro dell'acido 5-ammino-2,4,- 6-triiodoisoftalico |
IT95RM000550 IT1281320B1 (it) | 1995-08-04 | 1995-08-04 | Procedimento di preparazione di dicloruro dell'acido 5-ammino-2,4,6- triiodo-1,3-benzendicarbossilico per reazione dell'acido |
PCT/EP1996/002103 WO1996037459A1 (en) | 1995-05-23 | 1996-05-17 | Process for the preparation of a dicarboxylic acid dichloride |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69601525D1 true DE69601525D1 (de) | 1999-03-25 |
DE69601525T2 DE69601525T2 (de) | 1999-06-24 |
Family
ID=26331277
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69601525T Expired - Lifetime DE69601525T2 (de) | 1995-05-23 | 1996-05-17 | Verfahren zur herstellung von dicarbonsäurechlorid |
DE0773924T Pending DE773924T1 (de) | 1995-05-23 | 1996-05-17 | Verfahren zur herstellung von dicarbonsäurechlorid |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE0773924T Pending DE773924T1 (de) | 1995-05-23 | 1996-05-17 | Verfahren zur herstellung von dicarbonsäurechlorid |
Country Status (22)
Country | Link |
---|---|
US (1) | US5616795A (de) |
EP (1) | EP0773924B1 (de) |
JP (1) | JP4012566B2 (de) |
KR (1) | KR100255914B1 (de) |
CN (1) | CN1157367C (de) |
AT (1) | ATE176663T1 (de) |
AU (1) | AU702895B2 (de) |
BR (1) | BR9606488A (de) |
CA (1) | CA2195636C (de) |
CZ (1) | CZ290345B6 (de) |
DE (2) | DE69601525T2 (de) |
DK (1) | DK0773924T3 (de) |
ES (1) | ES2103252T3 (de) |
GR (1) | GR970300027T1 (de) |
HU (1) | HU216548B (de) |
IL (1) | IL118359A (de) |
MX (1) | MX9700548A (de) |
NO (1) | NO313696B1 (de) |
PL (1) | PL182447B1 (de) |
SI (1) | SI9620012A (de) |
SK (1) | SK8797A3 (de) |
WO (1) | WO1996037459A1 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1271107B (it) * | 1994-11-29 | 1997-05-26 | Zambon Spa | Processo per la preparazione di un intermedio utile nella sintesi di composti organici |
IT1292037B1 (it) * | 1997-05-30 | 1999-01-25 | Bracco Spa | Processo per la preparazione di 5-(acetil 62,3-diidrossipropil)- ammino)-n,n'-bis(2,3-diidrossipropil)-2,4,6-triiodo-1,3-benzen- |
US7968745B2 (en) | 2005-12-19 | 2011-06-28 | Ge Healthcare As | Purification process of iodixanol |
GB0717189D0 (en) * | 2007-09-04 | 2007-10-17 | Syngenta Participations Ag | Novel processes and compounds |
WO2009091758A1 (en) | 2008-01-14 | 2009-07-23 | Mallinckrodt Inc. | Process for the preparation of iosimenol |
EP2230227A1 (de) | 2009-03-20 | 2010-09-22 | Bracco Imaging S.p.A | Verfahren zur Herstellung von aromatischen Trijodid-Carboxyl- Derivaten |
EP2243767A1 (de) | 2009-04-21 | 2010-10-27 | Bracco Imaging S.p.A | Verfahren zur Iodierung aromatischer Verbindungen |
US7999134B2 (en) | 2009-07-21 | 2011-08-16 | Ge Healthcare As | Crystallization of iodixanol using milling |
US7999135B2 (en) | 2009-07-21 | 2011-08-16 | Ge Healthcare As | Crystallization of iodixanol using ultrasound |
CN102725249B (zh) | 2009-11-26 | 2014-12-10 | 好利安中国控股有限公司 | 碘克沙醇的制备和纯化 |
EP2394984A1 (de) | 2010-06-10 | 2011-12-14 | Bracco Imaging S.p.A | Verfahren zur Iodinierung von Phenol-Derivaten |
WO2014090650A1 (en) | 2012-12-11 | 2014-06-19 | Bracco Imaging Spa | Continuous process for the preparation of (s)-2-acetyloxypropionic acid chloride |
PL3066071T3 (pl) | 2013-11-05 | 2018-09-28 | Bracco Imaging S.P.A | Sposób otrzymywania jopamidolu |
BR112016027507B1 (pt) | 2014-06-10 | 2020-11-24 | Bracco Imaging Spa | método para a preparação de ácido (s)-2-acetiloxipropiônico e seus derivados |
CN104230731B (zh) * | 2014-09-24 | 2016-01-20 | 武汉理工大学 | 造影剂中间体三碘异酞酰氯的制备方法 |
US10836710B2 (en) | 2016-12-05 | 2020-11-17 | Bracco Imaging Spa | Mechanochemical synthesis of radiographic agents intermediates |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH608189A5 (de) * | 1974-12-13 | 1978-12-29 | Savac Ag | |
IT1193211B (it) * | 1979-08-09 | 1988-06-15 | Bracco Ind Chimica Spa | Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono |
IT1207226B (it) * | 1979-08-09 | 1989-05-17 | Bracco Ind Chimica Spa | Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono. |
US4396598A (en) * | 1982-01-11 | 1983-08-02 | Mallinckrodt, Inc. | Triiodoisophthalamide X-ray contrast agent |
FR2541676A1 (fr) * | 1983-02-25 | 1984-08-31 | Guerbet Sa | Composes non-ioniques a structures benzenique iodee ou bromee et produits opacifiants en contenant |
US5075502A (en) * | 1989-12-13 | 1991-12-24 | Mallinckrodt, Inc. | Nonionic x-ray contrast agents, compositions and methods |
US5191120A (en) * | 1989-12-13 | 1993-03-02 | Mallinckrodt Medical, Inc. | Process for preparing nonionic X-ray contrast agents |
IT1271107B (it) * | 1994-11-29 | 1997-05-26 | Zambon Spa | Processo per la preparazione di un intermedio utile nella sintesi di composti organici |
-
1996
- 1996-05-17 US US08/650,094 patent/US5616795A/en not_active Expired - Lifetime
- 1996-05-17 SI SI9620012A patent/SI9620012A/sl unknown
- 1996-05-17 JP JP53534596A patent/JP4012566B2/ja not_active Expired - Lifetime
- 1996-05-17 CN CNB961905271A patent/CN1157367C/zh not_active Expired - Lifetime
- 1996-05-17 DE DE69601525T patent/DE69601525T2/de not_active Expired - Lifetime
- 1996-05-17 AT AT96916098T patent/ATE176663T1/de active
- 1996-05-17 EP EP96916098A patent/EP0773924B1/de not_active Expired - Lifetime
- 1996-05-17 CA CA002195636A patent/CA2195636C/en not_active Expired - Lifetime
- 1996-05-17 HU HU9700188A patent/HU216548B/hu unknown
- 1996-05-17 ES ES96916098T patent/ES2103252T3/es not_active Expired - Lifetime
- 1996-05-17 BR BR9606488A patent/BR9606488A/pt not_active Application Discontinuation
- 1996-05-17 DK DK96916098T patent/DK0773924T3/da active
- 1996-05-17 CZ CZ1997187A patent/CZ290345B6/cs not_active IP Right Cessation
- 1996-05-17 WO PCT/EP1996/002103 patent/WO1996037459A1/en active IP Right Grant
- 1996-05-17 AU AU58978/96A patent/AU702895B2/en not_active Expired
- 1996-05-17 DE DE0773924T patent/DE773924T1/de active Pending
- 1996-05-17 SK SK87-97A patent/SK8797A3/sk unknown
- 1996-05-17 PL PL96318311A patent/PL182447B1/pl unknown
- 1996-05-17 MX MX9700548A patent/MX9700548A/es unknown
- 1996-05-17 KR KR1019970700402A patent/KR100255914B1/ko not_active IP Right Cessation
- 1996-05-22 IL IL11835996A patent/IL118359A/xx not_active IP Right Cessation
-
1997
- 1997-01-21 NO NO19970261A patent/NO313696B1/no not_active IP Right Cessation
- 1997-09-30 GR GR970300027T patent/GR970300027T1/el unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: BRACCO IMAGING S.P.A., MAILAND/MILANO, IT |