SI3705488T1 - Nevroaktivni steroidi, sestavki in uporaba le-teh - Google Patents

Nevroaktivni steroidi, sestavki in uporaba le-teh

Info

Publication number
SI3705488T1
SI3705488T1 SI201531879T SI201531879T SI3705488T1 SI 3705488 T1 SI3705488 T1 SI 3705488T1 SI 201531879 T SI201531879 T SI 201531879T SI 201531879 T SI201531879 T SI 201531879T SI 3705488 T1 SI3705488 T1 SI 3705488T1
Authority
SI
Slovenia
Prior art keywords
compositions
neuroactive steroids
neuroactive
steroids
Prior art date
Application number
SI201531879T
Other languages
English (en)
Inventor
Gabriel Martinez Botella
Boyd L. Harrison
Albert Jean Robichaud
Francesco G. Salituro
Richard Thomas Beresis
Original Assignee
Sage Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sage Therapeutics, Inc. filed Critical Sage Therapeutics, Inc.
Publication of SI3705488T1 publication Critical patent/SI3705488T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
    • C07J7/007—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/009—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by only one oxygen atom doubly bound
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hospice & Palliative Care (AREA)
SI201531879T 2014-05-29 2015-05-29 Nevroaktivni steroidi, sestavki in uporaba le-teh SI3705488T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2014078820 2014-05-29
EP20171670.1A EP3705488B1 (en) 2014-05-29 2015-05-29 Neuroactive steroids, compositions and uses thereof

Publications (1)

Publication Number Publication Date
SI3705488T1 true SI3705488T1 (sl) 2022-10-28

Family

ID=54698130

Family Applications (2)

Application Number Title Priority Date Filing Date
SI201531879T SI3705488T1 (sl) 2014-05-29 2015-05-29 Nevroaktivni steroidi, sestavki in uporaba le-teh
SI201531252T SI3149018T1 (sl) 2014-05-29 2015-05-29 Nevroaktivni steroidi, sestavki in uporaba le-teh

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI201531252T SI3149018T1 (sl) 2014-05-29 2015-05-29 Nevroaktivni steroidi, sestavki in uporaba le-teh

Country Status (26)

Country Link
US (5) US20180179247A1 (sl)
EP (3) EP3705488B1 (sl)
JP (4) JP6652934B2 (sl)
KR (2) KR102494061B1 (sl)
CN (3) CN106661078A (sl)
AR (2) AR100691A1 (sl)
AU (4) AU2015266447A1 (sl)
CA (1) CA2949720A1 (sl)
CY (1) CY1124109T1 (sl)
DK (2) DK3705488T3 (sl)
ES (2) ES2805598T3 (sl)
HR (2) HRP20221294T1 (sl)
HU (2) HUE059829T2 (sl)
IL (3) IL292461B2 (sl)
JO (1) JO3691B1 (sl)
LT (2) LT3705488T (sl)
MX (4) MX2016015532A (sl)
PH (1) PH12016502342A1 (sl)
PL (2) PL3705488T3 (sl)
PT (2) PT3705488T (sl)
RS (2) RS60529B1 (sl)
RU (2) RU2699359C2 (sl)
SG (2) SG11201609813XA (sl)
SI (2) SI3705488T1 (sl)
TW (1) TW201625661A (sl)
WO (1) WO2015180679A1 (sl)

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WO2014169836A1 (en) 2013-04-17 2014-10-23 Sage Therapeutics, Inc. 19-nor neuroactive steroids and methods of use thereof
US9725481B2 (en) 2013-04-17 2017-08-08 Sage Therapeutics, Inc. 19-nor C3, 3-disubstituted C21-C-bound heteroaryl steroids and methods of use thereof
KR20230172622A (ko) 2013-04-17 2023-12-22 세이지 테라퓨틱스, 인크. 19-노르 c3,3-이치환된 c21-n-피라졸릴 스테로이드 및 그의 사용 방법
HUE051403T2 (hu) 2013-04-17 2021-03-01 Sage Therapeutics Inc Neuroaktív 19-nor-szteroidok kezelési eljárásokhoz
PT3021852T (pt) 2013-07-19 2021-04-21 Sage Therapeutics Inc Esteroides neuroativos, composições e utilizações das mesmas
CA2921512A1 (en) 2013-08-23 2015-02-26 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
HRP20221294T1 (hr) * 2014-05-29 2023-03-03 Sage Therapeutics, Inc. Neuroaktivni steroidi, njihovi pripravci i uporabe
WO2015195962A1 (en) 2014-06-18 2015-12-23 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
US10577390B2 (en) 2014-10-16 2020-03-03 Sage Therapeutics, Inc. Compositions and methods for treating CNS disorders
HUE051488T2 (hu) 2014-10-16 2021-03-01 Sage Therapeutics Inc Készítmények és eljárások központi idegrendszeri rendellenességek kezelésére
EP3719029A1 (en) 2014-11-27 2020-10-07 Sage Therapeutics, Inc. Compositions for inducing sedation
DK3250210T3 (da) 2015-01-26 2021-03-08 Sage Therapeutics Inc Sammensætninger og fremgangsmåder til behandling af cns-forstyrrelser
US10329320B2 (en) 2015-02-20 2019-06-25 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
US10780099B2 (en) 2015-10-16 2020-09-22 Marinus Pharmaceuticals, Inc. Injectable neurosteroid formulations containing nanoparticles
MA43815A (fr) * 2016-03-08 2021-04-07 Sage Therapeutics Inc Stéroïdes neuroactifs, compositions, et leurs utilisations
AU2017296295B2 (en) * 2016-07-11 2022-02-24 Sage Therapeutics, Inc. C7, C12, and C16 substituted neuroactive steroids and their methods of use
RU2019103590A (ru) * 2016-07-11 2021-02-11 Сейдж Терапьютикс, Инк. С17-, с20- и с21-замещенные нейроактивные стероиды и способы их применения
KR20230050474A (ko) 2016-08-11 2023-04-14 오비드 테라퓨틱스 인크. 간질 장애의 치료를 위한 방법 및 조성물
US10391105B2 (en) 2016-09-09 2019-08-27 Marinus Pharmaceuticals Inc. Methods of treating certain depressive disorders and delirium tremens
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CN109503694A (zh) * 2018-11-21 2019-03-22 苏州闻天医药科技有限公司 一种新型gabaa受体调节剂及其用途
US11266662B2 (en) 2018-12-07 2022-03-08 Marinus Pharmaceuticals, Inc. Ganaxolone for use in prophylaxis and treatment of postpartum depression
KR20210116523A (ko) * 2019-01-14 2021-09-27 베이징 슈안이 파마사이언시스 컴퍼니, 리미티드 테트라졸론 치환된 스테로이드 및 이의 용도
JP2022534424A (ja) 2019-05-31 2022-07-29 セージ セラピューティクス， インコーポレイテッド 神経刺激性ステロイド及びその組成物
JP2022543837A (ja) 2019-08-05 2022-10-14 マリナス ファーマシューティカルズ， インコーポレイテッド てんかん重積状態の治療に使用するためのガナキソロン
KR20220066262A (ko) 2019-08-07 2022-05-24 상하이 한서 바이오메디컬 컴퍼니 리미티드 스테로이드 유도체 조절제의 염 및 결정형
US10857163B1 (en) 2019-09-30 2020-12-08 Athenen Therapeutics, Inc. Compositions that preferentially potentiate subtypes of GABAA receptors and methods of use thereof
JP2023503928A (ja) 2019-12-06 2023-02-01 マリナス ファーマシューティカルズ， インコーポレイテッド 結節性硬化症の治療での使用のためのガナキソロン
WO2022165017A1 (en) 2021-01-28 2022-08-04 Sage Therapeutics, Inc. Use of neuroactive steroids for treatment of sexual dysfunction
KR20240037975A (ko) 2021-07-28 2024-03-22 세이지 테라퓨틱스, 인크. 신경활성 스테로이드의 결정질 형태
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HRP20221294T1 (hr) * 2014-05-29 2023-03-03 Sage Therapeutics, Inc. Neuroaktivni steroidi, njihovi pripravci i uporabe
HUE051488T2 (hu) * 2014-10-16 2021-03-01 Sage Therapeutics Inc Készítmények és eljárások központi idegrendszeri rendellenességek kezelésére

Also Published As

Publication number Publication date
AU2023285755A1 (en) 2024-01-18
US20200165291A1 (en) 2020-05-28
HRP20201126T1 (hr) 2020-12-11
DK3149018T3 (da) 2020-07-20
MX2021005106A (es) 2021-06-15
MX2021005099A (es) 2021-06-15
JP7386204B2 (ja) 2023-11-24
AU2015266447A1 (en) 2016-12-01
HUE059829T2 (hu) 2022-12-28
AU2019279910A1 (en) 2020-01-16
CA2949720A1 (en) 2015-12-03
RS60529B1 (sr) 2020-08-31
LT3149018T (lt) 2020-08-10
IL248948A0 (en) 2017-01-31
EP3705488B1 (en) 2022-08-03
SG11201609813XA (en) 2016-12-29
AU2021204410A1 (en) 2021-07-22
RU2016151727A (ru) 2018-07-02
PT3149018T (pt) 2020-07-21
ES2805598T3 (es) 2021-02-12
AR121661A2 (es) 2022-06-29
HRP20221294T1 (hr) 2023-03-03
AU2021204410B2 (en) 2023-09-21
IL304033A (en) 2023-08-01
PH12016502342A1 (en) 2017-02-13
PL3149018T3 (pl) 2021-01-25
EP3149018B1 (en) 2020-04-29
TW201625661A (zh) 2016-07-16
NZ764921A (en) 2023-11-24
RU2016151727A3 (sl) 2018-12-03
US20210061850A1 (en) 2021-03-04
MX2016015532A (es) 2017-02-27
CN106661078A (zh) 2017-05-10
TW202231652A (zh) 2022-08-16
KR20230021165A (ko) 2023-02-13
EP3149018A4 (en) 2017-12-06
CN114369135A (zh) 2022-04-19
AR100691A1 (es) 2016-10-26
JP2023123878A (ja) 2023-09-05
CY1124109T1 (el) 2022-03-24
LT3705488T (lt) 2022-09-26
RU2699359C2 (ru) 2019-09-05
MX2023004352A (es) 2023-05-08
JP2021130696A (ja) 2021-09-09
CN114133423A (zh) 2022-03-04
NZ726260A (en) 2023-11-24
EP3705488A1 (en) 2020-09-09
JO3691B1 (ar) 2020-08-27
JP2017516793A (ja) 2017-06-22
IL292461B1 (en) 2023-11-01
KR20240066304A (ko) 2024-05-14
BR112016027508A2 (pt) 2018-06-26
ES2927007T3 (es) 2022-10-31
PL3705488T3 (pl) 2022-12-05
PT3705488T (pt) 2022-09-30
IL248948B (en) 2022-09-01
IL292461B2 (en) 2024-03-01
JP6652934B2 (ja) 2020-02-26
JP6892936B2 (ja) 2021-06-23
JP2020073577A (ja) 2020-05-14
SG10201803812TA (en) 2018-06-28
DK3705488T3 (da) 2022-10-03
SI3149018T1 (sl) 2020-10-30
HUE050028T2 (hu) 2021-12-28
NZ764941A (en) 2023-11-24
WO2015180679A1 (en) 2015-12-03
EP3149018A1 (en) 2017-04-05
US20210061849A1 (en) 2021-03-04
RS63554B1 (sr) 2022-09-30
KR20170003706A (ko) 2017-01-09
KR102494061B1 (ko) 2023-01-31
US20180179247A1 (en) 2018-06-28
AU2019279910B2 (en) 2021-07-22
RU2019126637A (ru) 2019-10-03
US20240076310A1 (en) 2024-03-07
EP4144746A1 (en) 2023-03-08
IL292461A (en) 2022-06-01

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