SI3077391T1 - Uporaba benzimidazol-prolinskih derivatov - Google Patents

Uporaba benzimidazol-prolinskih derivatov

Info

Publication number
SI3077391T1
SI3077391T1 SI201430931T SI201430931T SI3077391T1 SI 3077391 T1 SI3077391 T1 SI 3077391T1 SI 201430931 T SI201430931 T SI 201430931T SI 201430931 T SI201430931 T SI 201430931T SI 3077391 T1 SI3077391 T1 SI 3077391T1
Authority
SI
Slovenia
Prior art keywords
benzimidazole
proline derivatives
proline
derivatives
Prior art date
Application number
SI201430931T
Other languages
English (en)
Inventor
Christoph Boss
Catherine Roch
Christine Brotschi
Markus Gude
Bibia Heidmann
Francois Jenck
Thierry Sifferlen
Michel Steiner
Jodi T. Williams
Original Assignee
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idorsia Pharmaceuticals Ltd filed Critical Idorsia Pharmaceuticals Ltd
Publication of SI3077391T1 publication Critical patent/SI3077391T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SI201430931T 2013-12-04 2014-12-03 Uporaba benzimidazol-prolinskih derivatov SI3077391T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IB2013060630 2013-12-04
EP14827273.5A EP3077391B1 (en) 2013-12-04 2014-12-03 Use of benzimidazole-proline derivatives
PCT/IB2014/066548 WO2015083094A1 (en) 2013-12-04 2014-12-03 Use of benzimidazole-proline derivatives

Publications (1)

Publication Number Publication Date
SI3077391T1 true SI3077391T1 (sl) 2018-11-30

Family

ID=52347368

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201430931T SI3077391T1 (sl) 2013-12-04 2014-12-03 Uporaba benzimidazol-prolinskih derivatov

Country Status (29)

Country Link
US (1) US9914721B2 (sl)
EP (1) EP3077391B1 (sl)
JP (1) JP6421185B2 (sl)
KR (1) KR102330133B1 (sl)
CN (1) CN105873921B (sl)
AU (1) AU2014358766B2 (sl)
CA (1) CA2930053A1 (sl)
CL (1) CL2016001349A1 (sl)
CY (1) CY1121089T1 (sl)
DK (1) DK3077391T3 (sl)
EA (1) EA029725B1 (sl)
ES (1) ES2696708T3 (sl)
HK (1) HK1225734B (sl)
HR (1) HRP20181710T1 (sl)
HU (1) HUE040555T2 (sl)
IL (1) IL245914B (sl)
LT (1) LT3077391T (sl)
MA (1) MA39165A1 (sl)
MX (1) MX366642B (sl)
MY (1) MY179605A (sl)
PH (1) PH12016500985B1 (sl)
PL (1) PL3077391T3 (sl)
PT (1) PT3077391T (sl)
SA (1) SA516371253B1 (sl)
SI (1) SI3077391T1 (sl)
TR (1) TR201815342T4 (sl)
UA (1) UA116053C2 (sl)
WO (1) WO2015083094A1 (sl)
ZA (1) ZA201604502B (sl)

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UA119151C2 (uk) 2013-12-03 2019-05-10 Ідорсія Фармасьютікалз Лтд КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА
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CN106349228B (zh) 2015-07-17 2019-07-09 广东东阳光药业有限公司 取代的喹唑啉酮类化合物及其制备方法和用途
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KR20230004670A (ko) 2020-04-19 2023-01-06 이도르시아 파마슈티컬스 리미티드 다리도렉산트의 의학적 용도
EP4289834A1 (en) * 2021-02-02 2023-12-13 Medshine Discovery Inc. Tetrahydropyrrolocyclic compound and application thereof
WO2023160004A1 (zh) * 2022-02-25 2023-08-31 南京知和医药科技有限公司 具有镇痛活性的稠环化合物及其制备方法与用途

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UA119151C2 (uk) 2013-12-03 2019-05-10 Ідорсія Фармасьютікалз Лтд КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА
JP6421185B2 (ja) 2013-12-04 2018-11-07 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ ベンゾイミダゾール−プロリン誘導体の使用

Also Published As

Publication number Publication date
LT3077391T (lt) 2018-10-25
UA116053C2 (uk) 2018-01-25
CL2016001349A1 (es) 2017-01-27
AU2014358766B2 (en) 2019-01-17
CN105873921B (zh) 2019-03-15
PL3077391T3 (pl) 2019-01-31
EA029725B1 (ru) 2018-05-31
KR20160093686A (ko) 2016-08-08
NZ721697A (en) 2021-09-24
CN105873921A (zh) 2016-08-17
EA201600434A1 (ru) 2016-11-30
WO2015083094A1 (en) 2015-06-11
JP6421185B2 (ja) 2018-11-07
PH12016500985A1 (en) 2016-06-20
KR102330133B1 (ko) 2021-11-23
EP3077391A1 (en) 2016-10-12
US20170001985A1 (en) 2017-01-05
TR201815342T4 (tr) 2018-11-21
PT3077391T (pt) 2018-11-26
IL245914B (en) 2019-09-26
SA516371253B1 (ar) 2018-07-24
AU2014358766A1 (en) 2016-07-21
CA2930053A1 (en) 2015-06-11
MY179605A (en) 2020-11-11
MX2016007313A (es) 2016-09-07
US9914721B2 (en) 2018-03-13
HUE040555T2 (hu) 2019-03-28
IL245914A0 (en) 2016-08-02
PH12016500985B1 (en) 2016-06-20
ES2696708T3 (es) 2019-01-17
EP3077391B1 (en) 2018-08-15
MA39165A1 (fr) 2017-10-31
CY1121089T1 (el) 2019-12-11
JP2016539157A (ja) 2016-12-15
DK3077391T3 (en) 2018-10-22
HRP20181710T1 (hr) 2018-12-28
HK1225734B (zh) 2017-09-15
MX366642B (es) 2019-07-17
ZA201604502B (en) 2019-07-31

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