SI1981863T1 - Postopek za pripravo aminokrotonilamino-substituiranih kinazolinskih derivatov - Google Patents
Postopek za pripravo aminokrotonilamino-substituiranih kinazolinskih derivatovInfo
- Publication number
- SI1981863T1 SI1981863T1 SI200731098T SI200731098T SI1981863T1 SI 1981863 T1 SI1981863 T1 SI 1981863T1 SI 200731098 T SI200731098 T SI 200731098T SI 200731098 T SI200731098 T SI 200731098T SI 1981863 T1 SI1981863 T1 SI 1981863T1
- Authority
- SI
- Slovenia
- Prior art keywords
- quinazoline derivatives
- substituted quinazoline
- aminocrotonylamino
- preparing
- preparing aminocrotonylamino
- Prior art date
Links
- -1 aminocrotonylamino-substituted quinazoline Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D293/00—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms
- C07D293/02—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms not condensed with other rings
- C07D293/04—Five-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06100914 | 2006-01-26 | ||
EP07704145A EP1981863B1 (en) | 2006-01-26 | 2007-01-25 | Process for preparing aminocrotonylamino-substituted quinazoline derivatives |
PCT/EP2007/050752 WO2007085638A1 (en) | 2006-01-26 | 2007-01-25 | Process for preparing aminocrotonylamino-substituted quinazoline derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
SI1981863T1 true SI1981863T1 (sl) | 2013-01-31 |
Family
ID=38180518
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200731098T SI1981863T1 (sl) | 2006-01-26 | 2007-01-25 | Postopek za pripravo aminokrotonilamino-substituiranih kinazolinskih derivatov |
Country Status (11)
Country | Link |
---|---|
US (3) | US7960546B2 (sl) |
EP (1) | EP1981863B1 (sl) |
JP (1) | JP5241513B2 (sl) |
CA (1) | CA2639936C (sl) |
CY (1) | CY1113778T1 (sl) |
DK (1) | DK1981863T3 (sl) |
ES (1) | ES2397181T3 (sl) |
PL (1) | PL1981863T3 (sl) |
PT (1) | PT1981863E (sl) |
SI (1) | SI1981863T1 (sl) |
WO (1) | WO2007085638A1 (sl) |
Families Citing this family (50)
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AU775285B2 (en) * | 1999-06-21 | 2004-07-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclic heterocycles, medicaments containing these compounds, their use and methods for the production thereof |
US7019012B2 (en) * | 2000-12-20 | 2006-03-28 | Boehringer Ingelheim International Pharma Gmbh & Co. Kg | Quinazoline derivatives and pharmaceutical compositions containing them |
US7197160B2 (en) | 2001-03-05 | 2007-03-27 | Digimarc Corporation | Geographic information systems using digital watermarks |
DE10221018A1 (de) * | 2002-05-11 | 2003-11-27 | Boehringer Ingelheim Pharma | Verwendung von Hemmern der EGFR-vermittelten Signaltransduktion zur Behandlung von gutartiger Prostatahyperplasie (BPH)/Prostatahypertrophie |
US20050043233A1 (en) * | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
DE10349113A1 (de) * | 2003-10-17 | 2005-05-12 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von Aminocrotonylverbindungen |
EP2340837B1 (en) * | 2005-11-11 | 2017-03-15 | Boehringer Ingelheim International GmbH | Combination treatment of cancer comprising egfr/her2 inhibitors |
US8404697B2 (en) | 2005-11-11 | 2013-03-26 | Boehringer Ingelheim International Gmbh | Quinazoline derivatives for the treatment of cancer diseases |
SI1981863T1 (sl) * | 2006-01-26 | 2013-01-31 | Boehringer Ingelheim International Gmbh | Postopek za pripravo aminokrotonilamino-substituiranih kinazolinskih derivatov |
PT2068880E (pt) * | 2006-09-18 | 2012-07-12 | Boehringer Ingelheim Int | Método para tratamento do cancro apresentando mutações no egfr |
PE20100252A1 (es) | 2008-06-06 | 2010-04-12 | Boehringer Ingelheim Int | Nuevas formulaciones farmaceuticas solidas que comprenden dimaleato de 4-[(3-cloro-4-fluorofenil) amino]-6-{[4-(n,n-dimetilamino)-1-oxo-2-buten-1-il] amino}-7-((s)-tetrahidrofuran-3-iloxi)-quinazolina |
WO2011002523A1 (en) * | 2009-07-02 | 2011-01-06 | Kanionusa Inc. | Phosphorus containing quinazoline compounds and methods of use |
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US8828391B2 (en) | 2011-05-17 | 2014-09-09 | Boehringer Ingelheim International Gmbh | Method for EGFR directed combination treatment of non-small cell lung cancer |
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CN105777655B (zh) * | 2014-12-25 | 2018-02-02 | 深圳海王医药科技研究院有限公司 | 萘普替尼对甲苯磺酸盐的α晶型及制备方法和含有其的药物组合物 |
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BR112018006873A2 (pt) | 2015-10-05 | 2018-11-06 | The Trustees Of Columbia University In The City Of New York | ativadores do fluxo autofágico e fosfolipase d e depuração de agregados de proteína incluindo tau e tratamento de proteinopatias |
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Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU775285B2 (en) | 1999-06-21 | 2004-07-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclic heterocycles, medicaments containing these compounds, their use and methods for the production thereof |
US7019012B2 (en) | 2000-12-20 | 2006-03-28 | Boehringer Ingelheim International Pharma Gmbh & Co. Kg | Quinazoline derivatives and pharmaceutical compositions containing them |
DE10063435A1 (de) * | 2000-12-20 | 2002-07-04 | Boehringer Ingelheim Pharma | Chinazolinderviate,diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
DE10221018A1 (de) | 2002-05-11 | 2003-11-27 | Boehringer Ingelheim Pharma | Verwendung von Hemmern der EGFR-vermittelten Signaltransduktion zur Behandlung von gutartiger Prostatahyperplasie (BPH)/Prostatahypertrophie |
US20030225079A1 (en) | 2002-05-11 | 2003-12-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Use of inhibitors of the EGFR-mediated signal transduction for the treatment of benign prostatic hyperplasia (BPH)/prostatic hypertrophy |
US7223749B2 (en) | 2003-02-20 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them |
DE10307165A1 (de) | 2003-02-20 | 2004-09-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, ihre Verwendung und Verfahren zu ihrer Herstellung |
US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
DE10349113A1 (de) | 2003-10-17 | 2005-05-12 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von Aminocrotonylverbindungen |
US20060058311A1 (en) | 2004-08-14 | 2006-03-16 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
US8404697B2 (en) | 2005-11-11 | 2013-03-26 | Boehringer Ingelheim International Gmbh | Quinazoline derivatives for the treatment of cancer diseases |
EP2340837B1 (en) | 2005-11-11 | 2017-03-15 | Boehringer Ingelheim International GmbH | Combination treatment of cancer comprising egfr/her2 inhibitors |
SI1981863T1 (sl) | 2006-01-26 | 2013-01-31 | Boehringer Ingelheim International Gmbh | Postopek za pripravo aminokrotonilamino-substituiranih kinazolinskih derivatov |
PT2068880E (pt) | 2006-09-18 | 2012-07-12 | Boehringer Ingelheim Int | Método para tratamento do cancro apresentando mutações no egfr |
PE20100252A1 (es) | 2008-06-06 | 2010-04-12 | Boehringer Ingelheim Int | Nuevas formulaciones farmaceuticas solidas que comprenden dimaleato de 4-[(3-cloro-4-fluorofenil) amino]-6-{[4-(n,n-dimetilamino)-1-oxo-2-buten-1-il] amino}-7-((s)-tetrahidrofuran-3-iloxi)-quinazolina |
EP2387401A1 (en) | 2009-01-14 | 2011-11-23 | Boehringer Ingelheim International GmbH | Method for treating colorectal cancer |
ES2731901T3 (es) | 2009-07-06 | 2019-11-19 | Boehringer Ingelheim Int | Proceso para el secado de BIBW2992, de sus sales y de formulaciones farmacéuticas sólidas que comprenden este ingrediente activo |
-
2007
- 2007-01-25 SI SI200731098T patent/SI1981863T1/sl unknown
- 2007-01-25 WO PCT/EP2007/050752 patent/WO2007085638A1/en active Application Filing
- 2007-01-25 ES ES07704145T patent/ES2397181T3/es active Active
- 2007-01-25 CA CA2639936A patent/CA2639936C/en active Active
- 2007-01-25 DK DK07704145.7T patent/DK1981863T3/da active
- 2007-01-25 EP EP07704145A patent/EP1981863B1/en active Active
- 2007-01-25 JP JP2008551791A patent/JP5241513B2/ja active Active
- 2007-01-25 US US12/162,037 patent/US7960546B2/en active Active
- 2007-01-25 PT PT77041457T patent/PT1981863E/pt unknown
- 2007-01-25 PL PL07704145T patent/PL1981863T3/pl unknown
-
2011
- 2011-05-05 US US13/101,195 patent/US8188274B2/en active Active
- 2011-05-05 US US13/101,198 patent/US8067593B2/en active Active
-
2013
- 2013-01-07 CY CY20131100010T patent/CY1113778T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
US20110207929A1 (en) | 2011-08-25 |
WO2007085638A1 (en) | 2007-08-02 |
PT1981863E (pt) | 2012-12-07 |
US8188274B2 (en) | 2012-05-29 |
CY1113778T1 (el) | 2016-07-27 |
DK1981863T3 (da) | 2013-01-02 |
EP1981863A1 (en) | 2008-10-22 |
US7960546B2 (en) | 2011-06-14 |
CA2639936A1 (en) | 2008-08-02 |
PL1981863T3 (pl) | 2013-03-29 |
EP1981863B1 (en) | 2012-10-10 |
US20110207932A1 (en) | 2011-08-25 |
JP2009528981A (ja) | 2009-08-13 |
JP5241513B2 (ja) | 2013-07-17 |
US20090306378A1 (en) | 2009-12-10 |
ES2397181T3 (es) | 2013-03-05 |
CA2639936C (en) | 2014-06-17 |
US8067593B2 (en) | 2011-11-29 |
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