SI1699797T1 - Pirolotriazin spojine kot kinazni inhibitorji - Google Patents

Pirolotriazin spojine kot kinazni inhibitorji

Info

Publication number: SI1699797T1
Authority: SI; Slovenia
Prior art keywords: kinase inhibitors; pyrrolotriazine compounds; pyrrolotriazine; compounds; kinase
Prior art date: 2003-12-29

Application number

SI200431286T

Other languages

English (en)

Inventor

Brian E Fink

Ashvinikumar V Gavai

Gregory D Vite

Ping Chen

Harold Mastalerz

Derek J Norris

John S Tokarski

Yufen Zhao

Wen-Ching Han

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-12-29

Filing date

2004-12-23

Publication date

2010-04-30

2004-12-23 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2010-04-30 Publication of SI1699797T1 publication Critical patent/SI1699797T1/sl

Links

229940043355 kinase inhibitor Drugs 0.000 title 1
239000003757 phosphotransferase inhibitor Substances 0.000 title 1
150000003921 pyrrolotriazines Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

SI200431286T 2003-12-29 2004-12-23 Pirolotriazin spojine kot kinazni inhibitorji SI1699797T1 (sl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US53333503P	2003-12-29	2003-12-29
PCT/US2004/043169 WO2005066176A1 (en)	2003-12-29	2004-12-23	Pyrrolotriazine compounds as kinase inhibitors
EP04815269A EP1699797B1 (en)	2003-12-29	2004-12-23	Pyrrolotriazine compounds as kinase inhibitors

Publications (1)

Publication Number	Publication Date
SI1699797T1 true SI1699797T1 (sl)	2010-04-30

Family

ID=34748887

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI200431286T SI1699797T1 (sl)	2003-12-29	2004-12-23	Pirolotriazin spojine kot kinazni inhibitorji

Country Status (32)

Country	Link
US (4)	US7141571B2 (sl)
EP (2)	EP1699797B1 (sl)
JP (1)	JP4740878B2 (sl)
KR (1)	KR100839716B1 (sl)
CN (1)	CN1922182B (sl)
AR (1)	AR047076A1 (sl)
AT (1)	ATE443706T1 (sl)
AU (1)	AU2004312413C1 (sl)
BR (1)	BRPI0418231A (sl)
CA (1)	CA2552107C (sl)
CL (1)	CL2009001492A1 (sl)
CY (1)	CY1109662T1 (sl)
DE (1)	DE602004023324D1 (sl)
DK (1)	DK1699797T3 (sl)
ES (1)	ES2331842T3 (sl)
GE (1)	GEP20105081B (sl)
HK (1)	HK1088332A1 (sl)
HR (1)	HRP20090601T1 (sl)
IL (1)	IL176450A0 (sl)
MX (1)	MXPA06007038A (sl)
MY (1)	MY145634A (sl)
NO (1)	NO20062763L (sl)
NZ (2)	NZ573544A (sl)
PE (1)	PE20050679A1 (sl)
PL (1)	PL1699797T3 (sl)
PT (1)	PT1699797E (sl)
RU (1)	RU2373209C2 (sl)
SI (1)	SI1699797T1 (sl)
TW (1)	TWI332840B (sl)
UA (1)	UA89038C2 (sl)
WO (1)	WO2005066176A1 (sl)
ZA (1)	ZA200605160B (sl)

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US7102002B2 (en)	2004-06-16	2006-09-05	Bristol-Myers Squibb Company	Pyrrolotriazine kinase inhibitors
US7173031B2 (en) *	2004-06-28	2007-02-06	Bristol-Myers Squibb Company	Pyrrolotriazine kinase inhibitors
US7253167B2 (en) *	2004-06-30	2007-08-07	Bristol-Myers Squibb Company	Tricyclic-heteroaryl compounds useful as kinase inhibitors
TW200600513A (en) *	2004-06-30	2006-01-01	Bristol Myers Squibb Co	A method for preparing pyrrolotriazine compounds
US7504521B2 (en) *	2004-08-05	2009-03-17	Bristol-Myers Squibb Co.	Methods for the preparation of pyrrolotriazine compounds
US7148348B2 (en)	2004-08-12	2006-12-12	Bristol-Myers Squibb Company	Process for preparing pyrrolotriazine aniline compounds useful as kinase inhibitors
TW200635927A (en) *	2004-12-22	2006-10-16	Bristol Myers Squibb Co	Synthetic process
ES2319462T3 (es)	2005-03-28	2009-05-07	Bristol-Myers Squibb Company	Inhibidores competitivos de atp cinasas.
US20060235020A1 (en) *	2005-04-18	2006-10-19	Soojin Kim	Process for preparing salts of 4-[[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide and novel stable forms produced therein
MY150958A (en)	2005-06-16	2014-03-31	Astrazeneca Ab	Compounds for the treatment of multi-drug resistant bacterial infections
EP1957078B1 (en) *	2005-12-02	2013-08-28	Bayer HealthCare, LLC	Pyrrolotriazine derivatives useful for treating cancer through inhibition of aurora kinase
US8063208B2 (en) *	2006-02-16	2011-11-22	Bristol-Myers Squibb Company	Crystalline forms of (3R,4R)-4-amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-ol
EP2086549A1 (en) *	2006-11-01	2009-08-12	Bristol-Myers Squibb Company	Therapeutic combination of a panher/vegfr2 kinase inhibitor and a platinum compound
US7820421B2 (en)	2007-02-08	2010-10-26	Codexis, Inc.	Ketoreductases and uses thereof
US20090076034A1 (en) *	2007-09-14	2009-03-19	Protia, Llc	Deuterium-enriched bms-690514
PL2231662T3 (pl) *	2007-12-19	2011-11-30	Genentech Inc	8-anilinoimidazopirydyny oraz ich zastosowanie jako czynników przeciwnowotworowych i/lub przeciwzapalnych
JP2010209058A (ja) *	2008-09-29	2010-09-24	Sumitomo Chemical Co Ltd	１−置換−トランス−４−（置換アミノ）ピペリジン−３−オールの製造方法
US8445676B2 (en) *	2008-10-08	2013-05-21	Bristol-Myers Squibb Company	Pyrrolotriazine kinase inhibitors
WO2010071885A1 (en)	2008-12-19	2010-06-24	Cephalon, Inc.	Pyrrolotriazines as alk and jak2 inhibitors
CN102361863B (zh)	2009-01-21	2014-12-03	巴斯利尔药物股份公司	新的二环抗生素
US20120149902A1 (en) *	2009-07-28	2012-06-14	Ube Industries, Ltd.	Pyrrolo[2,3-d]pyrimidine derivative
US8431575B2 (en)	2010-02-18	2013-04-30	Transtech Pharma, Inc.	Phenyl-heteroaryl derivatives and methods of use thereof
BR112012033770A2 (pt)	2010-06-30	2016-11-22	Fujifilm Corp	novo derivado de nicotinamida ou sal do mesmo
CN102153558B (zh) *	2011-02-23	2012-11-21	扬州永济医药新技术有限公司	多靶点抗肿瘤抑制剂2-氨吡咯-三嗪的衍生物及其合成方法
DE102011119127A1 (de) *	2011-11-22	2013-05-23	Merck Patent Gmbh	3-Cyanaryl-1H-pyrrolo[2.3-b]pyridin-Derivate
US9724352B2 (en)	2012-05-31	2017-08-08	Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences	Pyrrolo[2,1-F[1,2,4]triazine compounds, preparation methods and applications thereof
CN103450204B (zh)	2012-05-31	2016-08-17	中国科学院上海药物研究所	吡咯[2，1-f][1，2，4]并三嗪类化合物，其制备方法及用途
TW201414737A (zh)	2012-07-13	2014-04-16	必治妥美雅史谷比公司	作爲激酶抑制劑之咪唑并三□甲腈
JP6473146B2 (ja)	2013-10-11	2019-02-20	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	ピロロトリアジンキナーゼ阻害剤
PT3466955T (pt) *	2014-01-13	2021-01-29	Aurigene Discovery Tech Ltd	Método de preparação de derivados de oxazolo[4,5-b] piridina e tiazolo[4,5-b] piridina como inibidores de irak-4 para o tratamento do cancro
WO2015175561A1 (en) *	2014-05-12	2015-11-19	Quest Diagnostics Investments Incorporated	Quantitation of tamoxifen and metabolites thereof by mass spectrometry
AR112027A1 (es)	2017-06-15	2019-09-11	Biocryst Pharm Inc	Inhibidores de alk 2 quinasa que contienen imidazol
WO2019214651A1 (zh) *	2018-05-08	2019-11-14	南京明德新药研发有限公司	作为选择性HER2抑制剂的吡咯并[2,1-f][1,2,4]三嗪类衍生物及其应用
WO2021088987A1 (zh) *	2019-11-08	2021-05-14	南京明德新药研发有限公司	作为选择性her2抑制剂的盐型、晶型及其应用

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JP4623483B2 (ja) *	1999-08-23	2011-02-02	塩野義製薬株式会社	ｓＰＬＡ２阻害作用を有するピロロトリアジン誘導体
US6867300B2 (en) *	2000-11-17	2005-03-15	Bristol-Myers Squibb Company	Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors
US6670357B2 (en) *	2000-11-17	2003-12-30	Bristol-Myers Squibb Company	Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors
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2004
- 2004-12-09 MY MYPI20045093A patent/MY145634A/en unknown
- 2004-12-22 TW TW093140035A patent/TWI332840B/zh not_active IP Right Cessation
- 2004-12-22 US US11/019,901 patent/US7141571B2/en active Active
- 2004-12-23 UA UAA200608400A patent/UA89038C2/ru unknown
- 2004-12-23 AT AT04815269T patent/ATE443706T1/de active
- 2004-12-23 KR KR1020067012936A patent/KR100839716B1/ko not_active IP Right Cessation
- 2004-12-23 GE GEAP20049544A patent/GEP20105081B/en unknown
- 2004-12-23 EP EP04815269A patent/EP1699797B1/en active Active
- 2004-12-23 CN CN2004800421984A patent/CN1922182B/zh not_active Expired - Fee Related
- 2004-12-23 PL PL04815269T patent/PL1699797T3/pl unknown
- 2004-12-23 PT PT04815269T patent/PT1699797E/pt unknown
- 2004-12-23 NZ NZ573544A patent/NZ573544A/en unknown
- 2004-12-23 MX MXPA06007038A patent/MXPA06007038A/es active IP Right Grant
- 2004-12-23 DE DE602004023324T patent/DE602004023324D1/de active Active
- 2004-12-23 SI SI200431286T patent/SI1699797T1/sl unknown
- 2004-12-23 NZ NZ548070A patent/NZ548070A/en unknown
- 2004-12-23 CA CA2552107A patent/CA2552107C/en not_active Expired - Fee Related
- 2004-12-23 WO PCT/US2004/043169 patent/WO2005066176A1/en active Application Filing
- 2004-12-23 BR BRPI0418231-6A patent/BRPI0418231A/pt not_active IP Right Cessation
- 2004-12-23 ES ES04815269T patent/ES2331842T3/es active Active
- 2004-12-23 JP JP2006547328A patent/JP4740878B2/ja not_active Expired - Fee Related
- 2004-12-23 DK DK04815269T patent/DK1699797T3/da active
- 2004-12-23 AU AU2004312413A patent/AU2004312413C1/en not_active Ceased
- 2004-12-23 EP EP09153694A patent/EP2058314A1/en not_active Withdrawn
- 2004-12-23 RU RU2006127396/04A patent/RU2373209C2/ru not_active IP Right Cessation
- 2004-12-29 AR ARP040104947A patent/AR047076A1/es not_active Application Discontinuation
2005
- 2005-01-03 PE PE2005000015A patent/PE20050679A1/es not_active Application Discontinuation
2006
- 2006-06-13 NO NO20062763A patent/NO20062763L/no not_active Application Discontinuation
- 2006-06-20 IL IL176450A patent/IL176450A0/en unknown
- 2006-06-22 ZA ZA200605160A patent/ZA200605160B/en unknown
- 2006-06-26 US US11/426,479 patent/US7297695B2/en active Active
- 2006-09-19 HK HK06110373.0A patent/HK1088332A1/xx not_active IP Right Cessation
2008
- 2008-09-24 US US11/869,910 patent/US7846931B2/en active Active
2009
- 2009-06-26 CL CL2009001492A patent/CL2009001492A1/es unknown
- 2009-11-09 HR HR20090601T patent/HRP20090601T1/hr unknown
- 2009-12-21 CY CY20091101326T patent/CY1109662T1/el unknown
2010
- 2010-10-25 US US12/911,299 patent/US20110039838A1/en not_active Abandoned

Also Published As

Publication number	Publication date
RU2373209C2 (ru)	2009-11-20
PT1699797E (pt)	2009-12-29
NZ548070A (en)	2009-02-28
NO20062763L (no)	2006-09-11
EP2058314A1 (en)	2009-05-13
BRPI0418231A (pt)	2007-04-27
KR20060107828A (ko)	2006-10-16
AR047076A1 (es)	2006-01-04
DE602004023324D1 (de)	2009-11-05
RU2006127396A (ru)	2008-02-10
CL2009001492A1 (es)	2010-01-15
ATE443706T1 (de)	2009-10-15
GEP20105081B (en)	2010-09-27
DK1699797T3 (da)	2010-01-04
CA2552107C (en)	2011-10-18
JP2007518721A (ja)	2007-07-12
MY145634A (en)	2012-03-15
CN1922182A (zh)	2007-02-28
US20110039838A1 (en)	2011-02-17
US7846931B2 (en)	2010-12-07
AU2004312413B2 (en)	2010-07-22
HK1088332A1 (en)	2006-11-03
AU2004312413C1 (en)	2011-01-27
AU2004312413A1 (en)	2005-07-21
NZ573544A (en)	2010-04-30
TWI332840B (en)	2010-11-11
TW200526226A (en)	2005-08-16
EP1699797A1 (en)	2006-09-13
UA89038C2 (en)	2009-12-25
US20050182058A1 (en)	2005-08-18
KR100839716B1 (ko)	2008-06-19
MXPA06007038A (es)	2006-08-31
US20090048244A1 (en)	2009-02-19
ZA200605160B (en)	2007-12-27
IL176450A0 (en)	2006-10-05
HRP20090601T1 (hr)	2009-12-31
CY1109662T1 (el)	2014-08-13
PL1699797T3 (pl)	2010-02-26
PE20050679A1 (es)	2005-09-25
EP1699797B1 (en)	2009-09-23
ES2331842T3 (es)	2010-01-18
WO2005066176A1 (en)	2005-07-21
US7297695B2 (en)	2007-11-20
CN1922182B (zh)	2010-08-18
US7141571B2 (en)	2006-11-28
US20060264438A1 (en)	2006-11-23
JP4740878B2 (ja)	2011-08-03
CA2552107A1 (en)	2005-07-21

Publication	Publication Date	Title
HK1088332A1 (en)	2006-11-03	Pyrrolotriazine compounds as kinase inhibitors
IL173381A0 (en)	2006-06-11	2-aminophenyl-4-phenylpyrimidines as kinase inhibitors
ZA200408541B (en)	2006-01-25	Pyrrolotriazine aniline compounds useful as kinase inhibitors
EP1543009A4 (en)	2007-08-08	Pyrrolotriazine KINASE INHIBITORS
EP1761268A4 (en)	2009-07-08	KINASE INHIBITORS BASED ON PYRROLOTRIAZINE
EP1773837A4 (en)	2009-07-15	Pyrrolotriazine KINASE INHIBITORS
AP2048A (en)	2009-09-24	Diazepinoindole derivatives as kinase inhibitors
AU2003271566A8 (en)	2004-03-03	Pyrrolopyrazines as kinase inhibitors
HK1072056A1 (en)	2005-08-12	Imidazopyrazines as cyclin dependent kinase inhibitors
EP1507780A4 (en)	2006-08-02	PYRAZOLO-PYRIMIDINANILINE COMPOUND SUITABLE AS KINASEINHIBITORS
AP2006003620A0 (en)	2006-06-30	Imidazopyrazine tyroshine kinase inhibitors
IL172132A0 (en)	2006-04-10	Thienopyridone derivatives as kinase inhibitors
HK1071570A1 (en)	2005-07-22	Pyrazolopyrimidines as cyclin dependent kinase inhibitors
HK1071569A1 (en)	2005-07-22	Pyrazolopyrimidines as cyclin dependent kinase inhibitors
PL373371A1 (en)	2005-08-22	Aryl ketone pyrrolo-triazine compounds useful as kinase inhibitors
HK1071572A1 (en)	2005-07-22	PyrazoloÄ1,5-AÜpyrimidine compounds as cyclin dependent kinase inhibitors
HK1071757A1 (en)	2005-07-29	Imidazopyridines as cyclin dependent kinase inhibitors
ZA200606683B (en)	2008-01-30	Pyrazolotriazines as kinase inhibitors
EP1778693A4 (en)	2009-11-11	AS KINASEINHIBITORS USEFUL COMPOUNDS OF TRICYCLIC HETEROARYL
IL165515A0 (en)	2006-01-15	Bisindolyl-maleimid derivatives as kinase inhibitors
AU2005310968A1 (en)	2006-06-08	Bicyclic amides as kinase inhibitors
HK1096385A1 (en)	2007-06-01	Indazole compounds useful as protein kinase inhibitors
AU2003254051A8 (en)	2004-02-09	Pyrazolopyrimidines as kinase inhibitors
EP1713793A4 (en)	2009-09-02	PYRIMIDINONE COMPOUNDS SUITED AS KINASEINHIBITORS
PL378121A1 (pl)	2006-03-06	Sposób wytwarzania pirolotriazynowych inhibitorów kinazy