SI1678166T1 - Inhibitorji proteinske kinaze - Google Patents
Inhibitorji proteinske kinazeInfo
- Publication number
- SI1678166T1 SI1678166T1 SI200431206T SI200431206T SI1678166T1 SI 1678166 T1 SI1678166 T1 SI 1678166T1 SI 200431206 T SI200431206 T SI 200431206T SI 200431206 T SI200431206 T SI 200431206T SI 1678166 T1 SI1678166 T1 SI 1678166T1
- Authority
- SI
- Slovenia
- Prior art keywords
- protein kinase
- kinase inhibitors
- disclosed
- cycl1
- cycl2
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51148603P | 2003-10-14 | 2003-10-14 | |
US51148903P | 2003-10-14 | 2003-10-14 | |
US60852904P | 2004-09-09 | 2004-09-09 | |
EP04795080A EP1678166B1 (en) | 2003-10-14 | 2004-10-14 | Protein kinase inhibitors |
PCT/US2004/033870 WO2005037825A2 (en) | 2003-10-14 | 2004-10-14 | Protein kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
SI1678166T1 true SI1678166T1 (sl) | 2009-10-31 |
Family
ID=34468370
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200431206T SI1678166T1 (sl) | 2003-10-14 | 2004-10-14 | Inhibitorji proteinske kinaze |
Country Status (14)
Country | Link |
---|---|
US (4) | US7326712B2 (sl) |
EP (1) | EP1678166B1 (sl) |
JP (1) | JP4845736B2 (sl) |
AT (1) | ATE437872T1 (sl) |
AU (1) | AU2004282179B2 (sl) |
CA (1) | CA2542076C (sl) |
CY (1) | CY1110504T1 (sl) |
DE (1) | DE602004022318D1 (sl) |
DK (1) | DK1678166T3 (sl) |
ES (1) | ES2344007T3 (sl) |
PL (1) | PL1678166T3 (sl) |
PT (1) | PT1678166E (sl) |
SI (1) | SI1678166T1 (sl) |
WO (1) | WO2005037825A2 (sl) |
Families Citing this family (79)
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US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
NZ544472A (en) * | 2003-07-03 | 2009-04-30 | Myriad Genetics Inc | Compounds and therapeutical use thereof |
US20080051414A1 (en) * | 2003-10-14 | 2008-02-28 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Protein Kinase Inhibitors |
US20090099165A1 (en) * | 2003-10-14 | 2009-04-16 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Protein Kinase Inhibitors |
US20090143399A1 (en) * | 2003-10-14 | 2009-06-04 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Protein Kinase Inhibitors |
US20070244114A1 (en) * | 2004-07-06 | 2007-10-18 | Myriad Genetics, Incorporated | Compounds and therapeutical use thereof |
EP1812439B2 (en) | 2004-10-15 | 2017-12-06 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
CA2586316A1 (en) * | 2004-11-11 | 2006-05-18 | Argenta Discovery Ltd. | Pyrimidine compounds as histamine modulators |
EP1776982A1 (en) * | 2005-10-18 | 2007-04-25 | Argenta Discovery Limited | Pyrimidine compounds as histamine modulators |
CA2592900A1 (en) * | 2005-01-03 | 2006-07-13 | Myriad Genetics Inc. | Nitrogen containing bicyclic compounds and therapeutical use thereof |
US8258145B2 (en) * | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
CN101189239A (zh) * | 2005-04-28 | 2008-05-28 | 休普基因公司 | 蛋白激酶抑制剂 |
US20070004660A1 (en) * | 2005-06-10 | 2007-01-04 | Baumann Christian A | Synergistic Modulation of Flt3 Kinase Using Alkylquinolines and Alkylquinazolines |
US7825244B2 (en) * | 2005-06-10 | 2010-11-02 | Janssen Pharmaceutica Nv | Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis |
US20070004763A1 (en) * | 2005-06-10 | 2007-01-04 | Nand Baindur | Aminoquinoline and aminoquinazoline kinase modulators |
US20060281771A1 (en) * | 2005-06-10 | 2006-12-14 | Baumann Christian A | Synergistic modulation of flt3 kinase using aminoquinoline and aminoquinazoline kinase modulators |
US8071768B2 (en) | 2005-06-10 | 2011-12-06 | Janssen Pharmaceutica, N.V. | Alkylquinoline and alkylquinazoline kinase modulators |
US20070249640A1 (en) * | 2005-06-16 | 2007-10-25 | Myriad Genetics, Incorporated | Pharmaceutical compositions and use thereof |
EP1767537A1 (en) * | 2005-09-21 | 2007-03-28 | Cellzome (UK) Ltd. | Pyrimidine compounds for the treatment of inflammatory disorders |
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US8119655B2 (en) * | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
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FR2903387B1 (fr) * | 2006-07-05 | 2008-08-29 | Alcatel Sa | Actionneur pour systemes de guidage d'equipements spatiaux a taux de rotation variable |
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WO2008055233A1 (en) * | 2006-10-31 | 2008-05-08 | Supergen, Inc. | Protein kinase inhibitors |
JP5492565B2 (ja) | 2006-12-22 | 2014-05-14 | インサイト・コーポレイション | Janusキナーゼ阻害剤としての置換複素環 |
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WO2009023876A1 (en) * | 2007-08-16 | 2009-02-19 | Myriad Genetics, Inc. | Method of treating non-small cell lung cancer |
US7960400B2 (en) | 2007-08-27 | 2011-06-14 | Duquesne University Of The Holy Ghost | Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof |
US7982035B2 (en) | 2007-08-27 | 2011-07-19 | Duquesne University Of The Holy Spirit | Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof |
JP2011514881A (ja) * | 2007-11-09 | 2011-05-12 | ザ ソルク インスティテュート フォー バイオロジカル スタディーズ | 免疫増強剤としてのtam受容体阻害剤の使用および免疫抑制剤としてのtam活性化剤の使用 |
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JP5502072B2 (ja) * | 2008-04-30 | 2014-05-28 | ナショナル ヘルス リサーチ インスティテューツ | オーロラキナーゼ阻害剤としての縮合二環式ピリミジン化合物 |
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EP2807165B1 (en) | 2012-01-27 | 2019-05-15 | Université de Montréal | Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells |
WO2013115167A1 (ja) * | 2012-01-31 | 2013-08-08 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | アムバチニブ誘導体 |
KR20210156333A (ko) | 2012-05-15 | 2021-12-24 | 캔써 리서치 테크놀로지 리미티드 | 5-[[4-[[모르폴린-2-일]메틸아미노]-5-(트리플루오로메틸)-2-피리딜]아미노]피라진-2-카보니트릴 및 그의 치료적 용도 |
CN102690274A (zh) * | 2012-05-24 | 2012-09-26 | 盛世泰科生物医药技术(苏州)有限公司 | 4-氯-2-甲基嘧啶苯并呋喃合成工艺 |
AR091273A1 (es) | 2012-06-08 | 2015-01-21 | Biogen Idec Inc | Inhibidores de pirimidinil tirosina quinasa |
WO2014043272A1 (en) * | 2012-09-12 | 2014-03-20 | Trius Therapeutics Inc. | Tricyclic gyrase inhibitors for use as antibacterial agents |
CN102875558A (zh) * | 2012-11-05 | 2013-01-16 | 贵州大学 | 2-氯-4-取代-8-硝基苯并呋喃[3,2-d]嘧啶类化合物及其制备方法和用途 |
CN104045642B (zh) * | 2013-03-14 | 2016-08-24 | 上海医药工业研究院 | 含嘧啶或吡啶的稠环化合物及其作为抗肿瘤药物的应用 |
CN109616572B (zh) * | 2013-03-26 | 2023-01-17 | 株式会社半导体能源研究所 | 发光装置 |
US10385055B2 (en) | 2013-09-11 | 2019-08-20 | Merck Sharp & Dohme Corp. | Tricyclic gyrase inhibitors |
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WO2016191879A1 (en) | 2015-06-05 | 2016-12-08 | Héma-Québec | Methods for culturing and/or differentiating hematopoietic stem cells into progenitors and uses thereof |
CN108431010B (zh) | 2015-12-25 | 2021-10-15 | 株式会社半导体能源研究所 | 化合物、发光元件、显示装置、电子设备及照明装置 |
CN105461728A (zh) * | 2015-12-29 | 2016-04-06 | 中山大学 | 一种4-取代胺基-6-甲氧羰基苯并呋喃并[2,3-d]嘧啶类化合物及制备方法 |
JOP20180114B1 (ar) * | 2016-06-22 | 2022-09-15 | Univ Vanderbilt | عوامل تعديل متباينة التجاسم موجبة من مستقبل الأسيتيل كولين المسكاريني m4 |
CA3031443A1 (en) | 2016-07-21 | 2018-01-25 | Biogen Ma Inc. | Succinate of pyrimidinyl derivatives and solid forms thereof as bruton's tyrosine kinase inhibitors |
WO2018085808A1 (en) | 2016-11-07 | 2018-05-11 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor m4 |
CN116041365A (zh) | 2016-11-07 | 2023-05-02 | 范德比尔特大学 | 毒蕈碱型乙酰胆碱受体m4的正向别构调节剂 |
EP3534901B1 (en) | 2016-11-07 | 2022-06-22 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor m4 |
TW201930311A (zh) | 2017-12-05 | 2019-08-01 | 泛德比爾特大學 | 蕈毒鹼型乙醯膽鹼受體m4之正向別構調節劑 |
JP2021505581A (ja) | 2017-12-05 | 2021-02-18 | ヴァンダービルト ユニヴァーシティ | ムスカリン性アセチルコリンレセプターm4のポジティブアロステリック調節因子 |
BR112020020246A8 (pt) | 2018-04-05 | 2022-10-18 | Sumitomo Dainippon Pharma Oncology Inc | Inibidores de cinase axl e uso dos mesmos |
CA3127502A1 (en) | 2019-02-12 | 2020-08-20 | Sumitomo Dainippon Pharma Oncology, Inc. | Formulations comprising heterocyclic protein kinase inhibitors |
CN114920704B (zh) * | 2019-07-26 | 2023-11-03 | 暨南大学 | 一种苯基哌嗪喹唑啉类化合物或其药学上可接受的盐、制法与用途 |
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UA82058C2 (uk) | 2001-12-24 | 2008-03-11 | Астразенека Аб | Заміщені похідні хіназоліну як інгібітори ауроракінази, спосіб їх одержання, фармацевтична композиція на їх основі |
GB0313766D0 (en) * | 2003-06-13 | 2003-07-23 | Xenova Ltd | Pharmaceutical compounds |
-
2004
- 2004-10-14 PL PL04795080T patent/PL1678166T3/pl unknown
- 2004-10-14 DK DK04795080T patent/DK1678166T3/da active
- 2004-10-14 SI SI200431206T patent/SI1678166T1/sl unknown
- 2004-10-14 JP JP2006535644A patent/JP4845736B2/ja not_active Expired - Fee Related
- 2004-10-14 AT AT04795080T patent/ATE437872T1/de active
- 2004-10-14 EP EP04795080A patent/EP1678166B1/en not_active Not-in-force
- 2004-10-14 CA CA2542076A patent/CA2542076C/en not_active Expired - Fee Related
- 2004-10-14 PT PT04795080T patent/PT1678166E/pt unknown
- 2004-10-14 WO PCT/US2004/033870 patent/WO2005037825A2/en active Application Filing
- 2004-10-14 US US10/965,313 patent/US7326712B2/en not_active Expired - Fee Related
- 2004-10-14 DE DE602004022318T patent/DE602004022318D1/de active Active
- 2004-10-14 ES ES04795080T patent/ES2344007T3/es active Active
- 2004-10-14 AU AU2004282179A patent/AU2004282179B2/en not_active Ceased
-
2005
- 2005-03-29 US US11/092,168 patent/US7312226B2/en not_active Expired - Fee Related
- 2005-03-29 US US11/092,809 patent/US7326713B2/en not_active Expired - Fee Related
- 2005-03-29 US US11/092,863 patent/US7335662B2/en not_active Expired - Fee Related
-
2009
- 2009-10-13 CY CY20091101047T patent/CY1110504T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
US7312226B2 (en) | 2007-12-25 |
US20050239794A1 (en) | 2005-10-27 |
EP1678166A2 (en) | 2006-07-12 |
US20050239793A1 (en) | 2005-10-27 |
PT1678166E (pt) | 2009-10-30 |
ES2344007T3 (es) | 2010-08-16 |
US7326712B2 (en) | 2008-02-05 |
DK1678166T3 (da) | 2009-11-09 |
WO2005037825A3 (en) | 2006-03-30 |
PL1678166T3 (pl) | 2009-12-31 |
US20050227992A1 (en) | 2005-10-13 |
US7335662B2 (en) | 2008-02-26 |
AU2004282179A1 (en) | 2005-04-28 |
CY1110504T1 (el) | 2015-04-29 |
AU2004282179B2 (en) | 2011-05-19 |
EP1678166B1 (en) | 2009-07-29 |
US20050277658A1 (en) | 2005-12-15 |
JP2007510627A (ja) | 2007-04-26 |
DE602004022318D1 (de) | 2009-09-10 |
JP4845736B2 (ja) | 2011-12-28 |
WO2005037825A2 (en) | 2005-04-28 |
CA2542076C (en) | 2013-02-26 |
CA2542076A1 (en) | 2005-04-28 |
US7326713B2 (en) | 2008-02-05 |
ATE437872T1 (de) | 2009-08-15 |
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