SG11201908615RA - 6-6 fused bicyclic heteroaryl compounds and their use as lats inhibitors - Google Patents

6-6 fused bicyclic heteroaryl compounds and their use as lats inhibitors

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Publication number
SG11201908615RA
SG11201908615RA SG11201908615RA SG11201908615RA SG 11201908615R A SG11201908615R A SG 11201908615RA SG 11201908615R A SG11201908615R A SG 11201908615RA SG 11201908615R A SG11201908615R A SG 11201908615RA
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SG
Singapore
Prior art keywords
novartis
san diego
institute
california
functional genomics
Prior art date
Application number
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English (en)
Inventor
Dirk Behnke
Frada Berenshteyn
Xueshi Hao
Timothy Hoffman
Qihui Jin
Arnaud Lacoste
Cameron Lee
Jun Liu
Yahu Liu
Juergen Klaus Maibaum
Tingting Mo
Jianfeng Pan
Xin Qu
Jan Tchorz
Yun Feng Xie
Shanshan Yan
Yefen Zou
Original Assignee
Novartis Ag
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Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SG11201908615RA publication Critical patent/SG11201908615RA/en

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C12N5/0602—Vertebrate cells
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
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SG11201908615R 2017-04-28 2018-04-26 6-6 fused bicyclic heteroaryl compounds and their use as lats inhibitors SG11201908615RA (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201762491484P 2017-04-28 2017-04-28
US201762491526P 2017-04-28 2017-04-28
US201762491475P 2017-04-28 2017-04-28
US201762491573P 2017-04-28 2017-04-28
US201862650232P 2018-03-29 2018-03-29
PCT/IB2018/052919 WO2018198077A2 (en) 2017-04-28 2018-04-26 6-6 fused bicyclic heteroaryl compounds and their use as lats inhibitors

Publications (1)

Publication Number Publication Date
SG11201908615RA true SG11201908615RA (en) 2019-11-28

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SG11201908615R SG11201908615RA (en) 2017-04-28 2018-04-26 6-6 fused bicyclic heteroaryl compounds and their use as lats inhibitors

Country Status (24)

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US (2) US11458138B2 (es)
EP (1) EP3615537B1 (es)
JP (2) JP7247102B2 (es)
KR (1) KR20190142776A (es)
CN (3) CN110573511B (es)
AU (2) AU2018260495B2 (es)
BR (1) BR112019022512A2 (es)
CA (1) CA3056906A1 (es)
CL (1) CL2019003049A1 (es)
CO (1) CO2019011873A2 (es)
CR (1) CR20190483A (es)
CU (2) CU20200080A7 (es)
DO (1) DOP2019000273A (es)
EC (1) ECSP19076732A (es)
IL (2) IL269293B (es)
JO (1) JOP20190257A1 (es)
MA (1) MA49285A (es)
MX (1) MX2019012756A (es)
PE (1) PE20200292A1 (es)
PH (1) PH12019502436A1 (es)
SG (1) SG11201908615RA (es)
TW (1) TW201843140A (es)
UY (1) UY37703A (es)
WO (1) WO2018198077A2 (es)

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JP2023503970A (ja) * 2019-11-27 2023-02-01 ジェネンテック， インコーポレイテッド 治療用化合物
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CN111443068B (zh) * 2020-03-06 2023-06-27 天津大学 具有多重刺激响应特性的纯有机室温磷光材料及筛选方法和应用
JP2023522784A (ja) 2020-04-27 2023-05-31 ノバルティス アーゲー 眼細胞療法のための方法及び組成物
CN112305126A (zh) * 2020-11-02 2021-02-02 宁夏贝利特生物科技有限公司 一种硝酸胍含量的测定方法
CN115974868B (zh) * 2022-11-07 2024-04-12 安徽理工大学 一种尿嘧啶衍生物的合成方法及其抗肺纤维化方面的潜在应用

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US20180344738A1 (en) 2018-12-06
CR20190483A (es) 2019-11-20
TW201843140A (zh) 2018-12-16
EP3615537B1 (en) 2024-03-06
RU2019138304A3 (es) 2021-07-13
US11458138B2 (en) 2022-10-04
JP2020517698A (ja) 2020-06-18
CN114621222A (zh) 2022-06-14
IL269293A (en) 2019-11-28
CO2019011873A2 (es) 2020-01-17
JOP20190257A1 (ar) 2019-10-28
US20230190751A1 (en) 2023-06-22
ECSP19076732A (es) 2019-10-31
WO2018198077A2 (en) 2018-11-01
EP3615537A2 (en) 2020-03-04
WO2018198077A3 (en) 2019-02-14
RU2019138304A (ru) 2021-05-28
BR112019022512A2 (pt) 2020-06-16
CA3056906A1 (en) 2018-11-01
CN110573511B (zh) 2023-04-25
JP2022188056A (ja) 2022-12-20
CL2019003049A1 (es) 2020-02-07
MA49285A (fr) 2020-03-04
PE20200292A1 (es) 2020-02-05
CN110573511A (zh) 2019-12-13
CN114703144A (zh) 2022-07-05
IL269293B (en) 2022-06-01
PH12019502436A1 (en) 2020-07-20
AU2018260495A1 (en) 2019-10-17
CU20190086A7 (es) 2020-11-30
JP7247102B2 (ja) 2023-03-28
MX2019012756A (es) 2019-12-16
KR20190142776A (ko) 2019-12-27
DOP2019000273A (es) 2019-12-15
CU20200080A7 (es) 2021-05-12
AU2018260495B2 (en) 2021-09-16
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