SG11201807965YA - Combinations of lsd1 inhibitors for use in the treatment of solid tumors - Google Patents

Combinations of lsd1 inhibitors for use in the treatment of solid tumors

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Publication number
SG11201807965YA
SG11201807965YA SG11201807965YA SG11201807965YA SG11201807965YA SG 11201807965Y A SG11201807965Y A SG 11201807965YA SG 11201807965Y A SG11201807965Y A SG 11201807965YA SG 11201807965Y A SG11201807965Y A SG 11201807965YA SG 11201807965Y A SG11201807965Y A SG 11201807965YA
Authority
SG
Singapore
Prior art keywords
international
roche
combinations
tcrc
alexandria
Prior art date
Application number
SG11201807965YA
Inventor
Mark Demario
William Pierceall
Fiona Mack
Tamara Maes
Serena Lunardi
Original Assignee
Oryzon Genomics Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oryzon Genomics Sa filed Critical Oryzon Genomics Sa
Publication of SG11201807965YA publication Critical patent/SG11201807965YA/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
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    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization M1111101110101011111 HO 11111 01E3 100 111110101110 11n III 11 International Bureau 0.. .... .. (10) International Publication Number ..... ..or::,„, (43) International Publication Date WO 2017/157825 Al 21 September 2017 (21.09.2017) WIP0 I PCT (51) International Patent Classification: Life Science, New York, NY 10016 (US). MAES, A61K 31/12 (2006.01) A61K 31/475 (2006.01) Tamara; c/o Oryzon Genomics S.A., C. Sant Ferran 74, A61K 31/135 (2006.01) A61K 31/495 (2006.01) 08940 Cornelia de Llobregat (ES). LUNARDI, Serena; A61K 31/19 (2006.01) A61K 31/519 (2006.01) c/o Oryzon Genomics S.A., C. Sant Ferran 74, 08940 Cor- A61K 31/282 (2006.01) A61K 31/555 (2006.01) nella de Llobregat (ES). A61K 31/337 (2006.01) A61K 31/704 (2006.01) A61K 31/4045 (2006.01) A61K 31/7068 (2006.01) (74) Agent: MUELLER-AFRAZ, Simona; Grenzacherstrasse A61K 31/4745 (2006.01) A61P 35/00 (2006.01) 124, 4070 Basel (CH). (21) International Application Number: (81) Designated States (unless otherwise indicated, for every PCT/EP2017/055784 kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (22) International Filing Date: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, 13 March 2017 (13.03.2017) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (25) Filing Language: English HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (26) Publication Language: English MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (30) Priority Data: RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, 62/308,529 15 March 2016 (15.03.2016) US TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (71) Applicant (for all designated States except US): F. HOFF- ZA, ZM, ZW. MANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse (84) Designated States (unless otherwise indicated, for every 124, 4070 Basel (CH). kind of regional protection available): ARIPO (BW, GH, Applicant (for US only): HOFFMANN-LA ROCHE GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, INC. [US/US]; Overlook at Great Notch, 150 Clove Road TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, 8th Floor, Suite 8 - Legal Department, Little Falls, NJ TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, 07424 (US). DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (71) = (72) Inventors: DEMARIO, Mark; c/o Roche TCRC, Inc. East SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, 29th Street, Alexandria Center for Life Science, New York, GW, KM, ML, MR, NE, SN, TD, TG). = = NY 10016 (US). PIERCEALL, William; c/o Roche TCRC, Inc. East 29th Street, Alexandria Center for Life Published: — — Science, New York, NY 10016 (US). MACK, Fiona; c/o — with international search report (Art. 21(3)) Roche TCRC, Inc. East 29th Street, Alexandria Center for = = = = = = = Il kin ei cc IN kin ,-1 IN ,-1 © (54) Title: COMBINATIONS OF LSD1 INHIBITORS FOR USE IN THE TREATMENT OF SOLID TUMORS ei 0 (57) : The instant invention relates to therapeutic combinations of LSD1 inhibitors and one or more other active pharma- ceutical ingredient(s) or pharmaceutically acceptable salts thereof. The combinations are particularly useful for treating neoplastic diseases, such as cancer, particularly small cell lung cancer (SCLC).
SG11201807965YA 2016-03-15 2017-03-13 Combinations of lsd1 inhibitors for use in the treatment of solid tumors SG11201807965YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662308529P 2016-03-15 2016-03-15
PCT/EP2017/055784 WO2017157825A1 (en) 2016-03-15 2017-03-13 Combinations of lsd1 inhibitors for use in the treatment of solid tumors

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