SG11201900551WA - Spiro-lactam nmda receptor modulators and uses thereof - Google Patents

Spiro-lactam nmda receptor modulators and uses thereof

Info

Publication number
SG11201900551WA
SG11201900551WA SG11201900551WA SG11201900551WA SG11201900551WA SG 11201900551W A SG11201900551W A SG 11201900551WA SG 11201900551W A SG11201900551W A SG 11201900551WA SG 11201900551W A SG11201900551W A SG 11201900551WA SG 11201900551W A SG11201900551W A SG 11201900551WA
Authority
SG
Singapore
Prior art keywords
international
pct
compounds
nmda receptor
spiro
Prior art date
Application number
SG11201900551WA
Inventor
M Khan
Original Assignee
Aptinyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aptinyx Inc filed Critical Aptinyx Inc
Publication of SG11201900551WA publication Critical patent/SG11201900551WA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/499—Spiro-condensed pyrazines or piperazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 February 2018 (08.02.2018) WIP0 I PCT 01E1°1°1a °nolo III olomiooinoinio ow (10) International Publication Number WO 2018/026782 Al (51) International Patent Classification: CO7D 487/10 (2006.01) A61K 31/499 (2006.01) CO7D 498/10 (2006.01) A61P 25/00 (2006.01) A61K 31/5386 (2006.01) (21) International Application Number: PCT/US2017/044841 (22) International Filing Date: 01 August 2017 (01.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/369,456 01 August 2016 (01.08.2016) US (71) Applicant: APTINYX INC. [US/US]; 1801 Maple Av- enue, Suite 4300, Evanston, IL 60201 (US). (72) Inventor: KHAN, M., Amin; 720 Oakton Street, #3A, Evanston, IL 60202 (US). (74) Agent: BRODOWSKI, Michael, H. et al.; Goodwin Proc- ter LLP, 100 Northern Avenue, Boston, MA 02210 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) 1-1 00 N © (54) Title: SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF (57) : Disclosed are compounds having potency in the modulation of NMDA receptor activity. Such compounds can be O used in the treatment of conditions such as depression and related disorders. Orally delivered formulations and other pharmaceutically N acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.
SG11201900551WA 2016-08-01 2017-08-01 Spiro-lactam nmda receptor modulators and uses thereof SG11201900551WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662369456P 2016-08-01 2016-08-01
PCT/US2017/044841 WO2018026782A1 (en) 2016-08-01 2017-08-01 Spiro-lactam nmda receptor modulators and uses thereof

Publications (1)

Publication Number Publication Date
SG11201900551WA true SG11201900551WA (en) 2019-02-27

Family

ID=59593191

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201900551WA SG11201900551WA (en) 2016-08-01 2017-08-01 Spiro-lactam nmda receptor modulators and uses thereof

Country Status (16)

Country Link
US (3) US10918637B2 (en)
EP (1) EP3490993B1 (en)
JP (1) JP7032378B2 (en)
KR (1) KR102465757B1 (en)
CN (1) CN109890825B (en)
AU (1) AU2017305240B2 (en)
CA (1) CA3031539C (en)
CL (1) CL2019000247A1 (en)
CO (1) CO2019000943A2 (en)
EA (1) EA201990428A1 (en)
IL (2) IL264495B (en)
MX (1) MX2019001321A (en)
PE (1) PE20190504A1 (en)
PH (1) PH12019500206A1 (en)
SG (1) SG11201900551WA (en)
WO (1) WO2018026782A1 (en)

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US20210322406A1 (en) 2021-10-21
PH12019500206A1 (en) 2019-06-17
US10918637B2 (en) 2021-02-16
MX2019001321A (en) 2019-07-04
WO2018026782A1 (en) 2018-02-08
EP3490993A1 (en) 2019-06-05
US11376250B2 (en) 2022-07-05
CA3031539C (en) 2023-11-28
JP7032378B2 (en) 2022-03-08
CN109890825B (en) 2022-03-11
CL2019000247A1 (en) 2019-06-21
US20230131402A1 (en) 2023-04-27
CN109890825A (en) 2019-06-14
CO2019000943A2 (en) 2019-02-08
EP3490993C0 (en) 2023-12-06
IL286107A (en) 2021-10-31
AU2017305240B2 (en) 2021-12-09
PE20190504A1 (en) 2019-04-10
KR102465757B1 (en) 2022-11-09
EP3490993B1 (en) 2023-12-06
IL264495B (en) 2021-09-30
EA201990428A1 (en) 2019-08-30
US20190175588A1 (en) 2019-06-13
JP2019527234A (en) 2019-09-26
CA3031539A1 (en) 2018-02-08
KR20190033594A (en) 2019-03-29
AU2017305240A1 (en) 2019-02-28

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