MX2018011102A - Combinations of lsd1 inhibitors for use in the treatment of solid tumors. - Google Patents

Combinations of lsd1 inhibitors for use in the treatment of solid tumors.

Info

Publication number
MX2018011102A
MX2018011102A MX2018011102A MX2018011102A MX2018011102A MX 2018011102 A MX2018011102 A MX 2018011102A MX 2018011102 A MX2018011102 A MX 2018011102A MX 2018011102 A MX2018011102 A MX 2018011102A MX 2018011102 A MX2018011102 A MX 2018011102A
Authority
MX
Mexico
Prior art keywords
combinations
treatment
lsd1 inhibitors
solid tumors
cancer
Prior art date
Application number
MX2018011102A
Other languages
Spanish (es)
Inventor
Maes Tamara
Demario Mark
Pierceall William
MACK Fiona
Lunardi Serena
Original Assignee
Oryzon Genomics Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oryzon Genomics Sa filed Critical Oryzon Genomics Sa
Publication of MX2018011102A publication Critical patent/MX2018011102A/en

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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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Abstract

The instant invention relates to therapeutic combinations of LSD1 inhibitors and one or more other active pharmaceutical ingredient(s) or pharmaceutically acceptable salts thereof. The combinations are particularly useful for treating neoplastic diseases, such as cancer, particularly small cell lung cancer (SCLC).
MX2018011102A 2016-03-15 2017-03-13 Combinations of lsd1 inhibitors for use in the treatment of solid tumors. MX2018011102A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662308529P 2016-03-15 2016-03-15
PCT/EP2017/055784 WO2017157825A1 (en) 2016-03-15 2017-03-13 Combinations of lsd1 inhibitors for use in the treatment of solid tumors

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MX2018011102A true MX2018011102A (en) 2019-01-10

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MX2018011102A MX2018011102A (en) 2016-03-15 2017-03-13 Combinations of lsd1 inhibitors for use in the treatment of solid tumors.
MX2021004639A MX2021004639A (en) 2016-03-15 2018-09-13 Combinations of lsd1 inhibitors for use in the treatment of solid tumors.

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US (2) US10265279B2 (en)
EP (1) EP3429571A1 (en)
JP (2) JP7158023B2 (en)
KR (2) KR20230042756A (en)
CN (1) CN109195593A (en)
AR (1) AR107871A1 (en)
AU (2) AU2017233898B2 (en)
BR (1) BR112018068565A2 (en)
CA (1) CA3017411A1 (en)
EA (1) EA201892075A1 (en)
IL (1) IL261721B (en)
MX (2) MX2018011102A (en)
SG (2) SG11201807965YA (en)
WO (1) WO2017157825A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3736265A1 (en) 2011-10-20 2020-11-11 Oryzon Genomics, S.A. (hetero)aryl cyclopropylamine compounds as lsd1 inhibitors
EP3090998A1 (en) 2015-05-06 2016-11-09 F. Hoffmann-La Roche AG Solid forms
MX2018011102A (en) 2016-03-15 2019-01-10 Oryzon Genomics Sa Combinations of lsd1 inhibitors for use in the treatment of solid tumors.
MY197785A (en) 2016-03-15 2023-07-13 Oryzon Genomics Sa Combinations of lsd1 inhibitors for the treatment of hematological malignancies
ES2732669T3 (en) 2016-06-10 2019-11-25 Oryzon Genomics Sa Multiple sclerosis treatment
US11685782B2 (en) 2017-10-23 2023-06-27 Children's Medical Center Corporation Methods of treating cancer using LSD1 inhibitors in combination with immunotherapy
WO2019108789A1 (en) * 2017-11-29 2019-06-06 The Trustees Of Columbia University In The City Of New York Combination therapy of lymphoma
WO2019211491A1 (en) * 2018-05-04 2019-11-07 Oryzon Genomics, S.A. Stable pharmaceutical formulation
CA3099479A1 (en) * 2018-05-06 2019-11-14 Ayala Pharmaceuticals Inc. Combination compositions comprising bisfluoroalkyl-1,4- benzodiazepinone compounds and methods of use thereof
CN109265462B (en) * 2018-10-31 2020-06-02 郑州大学 Pyrimido 1,2, 4-triazole compound and preparation method and application thereof
EP3994280A1 (en) * 2019-07-05 2022-05-11 Oryzon Genomics, S.A. Biomarkers and methods for personalized treatment of small cell lung cancer using kdm1a inhibitors
CN110863047B (en) * 2019-11-15 2022-09-13 西安交通大学医学院第一附属医院 Application of human CCDC154 gene and related product
AU2021213131B2 (en) * 2020-01-28 2023-02-02 PAIGE.AI, Inc. Systems and methods for processing electronic images for biomarker localization
WO2021228146A1 (en) * 2020-05-12 2021-11-18 石药集团中奇制药技术（石家庄）有限公司 Use of lsd1 inhibitor
WO2023067058A1 (en) 2021-10-20 2023-04-27 Queen Mary University Of London Sequential treatments and biomarkers to reverse resistance to kinase inhibitors
GB202115017D0 (en) 2021-10-20 2021-12-01 Univ London Queen Mary Sequential treatments and biomarkers to reverse resistance to kinase inhibitors

Family Cites Families (136)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2802005A (en) 1957-08-06 S-eluorourace
US2331725A (en) 1941-01-31 1943-10-12 Lederle Lab Inc Preparation of 2-methyl-1,4-naphthoquinone
US3205220A (en) 1961-10-26 1965-09-07 Lilly Co Eli Leurosidine and leurocristine and their production
CH514578A (en) 1968-02-27 1971-10-31 Sandoz Ag Process for the production of glucosides
GB1457632A (en) 1974-03-22 1976-12-08 Farmaceutici Italia Adriamycins
DD159877A1 (en) 1981-06-12 1983-04-13 Wolfgang Krueger PROCESS FOR PREPARING 4- [1-METHYL-5-BIS (2-CHLOROETHYL) AMINO-BENZIMIDAZOLYL-2] BUTTERIC ACID
OA07174A (en) 1981-08-24 1984-04-30 May & Baker Ltd New imidazotetrazionones, their preparation and medicines containing them.
US4526988A (en) 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
ES8604088A1 (en) 1985-06-14 1986-01-16 Espanola Farma Therapeut Platinum complex with cyclobutane di:carboxylic acid
FR2601675B1 (en) 1986-07-17 1988-09-23 Rhone Poulenc Sante TAXOL DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2601676B1 (en) 1986-07-17 1988-09-23 Rhone Poulenc Sante PROCESS FOR THE PREPARATION OF TAXOL AND DESACETYL-10 TAXOL
US5004758A (en) 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
IL96531A (en) 1989-12-11 1995-08-31 Univ Princeton N-(disubstituted-1h-pyrrolo [2,3-d] pyrimidin-3-ylacyl)-glutamic acid derivatives their preparation and pharmaceutical compositions containing them
US5369108A (en) 1991-10-04 1994-11-29 Sloan-Kettering Institute For Cancer Research Potent inducers of terminal differentiation and methods of use thereof
WO1994006802A1 (en) 1992-09-18 1994-03-31 Yoshitomi Pharmaceutical Industries, Ltd. Thienodiazepine compound and medicinal use thereof
IL117684A (en) 1995-04-07 2002-02-10 Pharmacia & Upjohn Inc Intermediates and process for the manufacture of camptothesin derivatives (cpt-11) and related compounds
US6174905B1 (en) 1996-09-30 2001-01-16 Mitsui Chemicals, Inc. Cell differentiation inducer
JP3354090B2 (en) 1996-09-30 2002-12-09 シエーリング アクチエンゲゼルシャフト Differentiation inducer
RS49779B (en) 1998-01-12 2008-06-05 Glaxo Group Limited, Byciclic heteroaromatic compounds as protein tyrosine kinase inhibitors
PE20020354A1 (en) 2000-09-01 2002-06-12 Novartis Ag HYDROXAMATE COMPOUNDS AS HISTONE-DESACETILASE (HDA) INHIBITORS
GB0108591D0 (en) 2001-04-05 2001-05-23 Merck Sharp & Dohme Therapeutic agents
MXPA05012799A (en) 2003-05-30 2006-02-22 Gemin X Biotechnologies Inc Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases.
WO2005049593A2 (en) 2003-11-13 2005-06-02 Abbott Laboratories N-acylsulfonamide apoptosis promoters
SI1730119T1 (en) 2004-03-23 2008-10-31 Pfizer Prod Inc Imidazole compounds for the treatment of neurodegenerative disorders
US7893278B2 (en) 2004-06-17 2011-02-22 Hoffman-La Roche Inc. CIS-imidazolines
GB0512324D0 (en) 2005-06-16 2005-07-27 Novartis Ag Organic compounds
US8557812B2 (en) 2004-08-20 2013-10-15 The Regents Of The University Of Michigan Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof
US7888364B2 (en) 2004-09-02 2011-02-15 Curis, Inc. Pyridyl inhibitors of hedgehog signalling
ATE554184T1 (en) 2004-12-16 2012-05-15 Harvard College HISTONE DEMETHYLATION MEDIATED BY THE NUCLEAR AMINO OXIDASE HOMOLOGUE LSD1
EP1704859B1 (en) 2005-02-18 2010-08-11 Universitätsklinikum Freiburg Androgen receptor-dependent gene expression control by inhibiting the amine oxidase activity of lysine-specific demethylase (LSD1)
RS51616B (en) 2005-03-29 2011-08-31 Icos Corporation Heteroaryl urea derivatives useful for inhibiting ghk1
TWI375673B (en) 2005-04-11 2012-11-01 Abbott Lab 1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors
EP2757099B1 (en) 2005-05-12 2017-08-23 AbbVie Bahamas Limited Apoptosis promoters
WO2007015632A1 (en) 2005-08-04 2007-02-08 Cgk Co., Ltd. Atm and atr inhibitor
CA2619005A1 (en) 2005-08-10 2007-02-22 Johns Hopkins University Polyamines useful as anti-parasitic and anti-cancer therapeutics and as lysine-specific demethylase inhibitors
NL2000613C2 (en) 2006-05-11 2007-11-20 Pfizer Prod Inc Triazole pyrazine derivatives.
CL2007003244A1 (en) 2006-11-16 2008-04-04 Millennium Pharm Inc COMPOUNDS DERIVED FROM PIRIMIDO [5,4-D] [2] BENZAZEPINA; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUND; AND USE OF THE COMPOUND FOR THE TREATMENT OF CANCER.
EP2142287A4 (en) 2007-04-13 2012-05-23 Univ Johns Hopkins Lysine-specific demethylase inhibitors
JP2010540426A (en) 2007-09-25 2010-12-24 トポターゲット ユーケー リミテッド Method for synthesizing specific hydroxamic acid compounds
EP2317992A2 (en) 2008-07-24 2011-05-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Preventing or treating viral infection using an inhibitor of the lsd1 protein, a mao inhibitor or an inhibitor of lsd1 and a mao inhibitor
AU2009293444B2 (en) 2008-09-17 2012-03-15 Sun Pharmaceutical Industries Limited Salts of N-[6-cis-2,6-dimethylmorpholin-4yl)pyridine-3yl]-2-methyl-4'- (trifluoromethoxy)[1,1'-biphenyl]-3-carboxamide
WO2010043721A1 (en) 2008-10-17 2010-04-22 Oryzon Genomics, S.A. Oxidase inhibitors and their use
US8993808B2 (en) 2009-01-21 2015-03-31 Oryzon Genomics, S.A. Phenylcyclopropylamine derivatives and their medical use
KR20190086591A (en) 2009-05-26 2019-07-22 애브비 아일랜드 언리미티드 컴퍼니 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8389580B2 (en) 2009-06-02 2013-03-05 Duke University Arylcyclopropylamines and methods of use
EP2258865A1 (en) 2009-06-05 2010-12-08 Universitätsklinikum Freiburg Lysine-specific demethylase 1 (LSD1) is a biomarker for breast cancer
WO2010143582A1 (en) 2009-06-11 2010-12-16 公立大学法人名古屋市立大学 Phenylcyclopropylamine derivatives and lsd1 inhibitors
AR077014A1 (en) 2009-06-19 2011-07-27 Lilly Co Eli COMPOUND DERIVED FROM FTALAZINE 1,4-DISPOSED, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND USE TO PREPARE A USEFUL MEDICINAL PRODUCT FOR THE TREATMENT OF CANCER
EP2467359A4 (en) 2009-08-18 2013-01-09 Univ Johns Hopkins (bis) urea and (bis) thiourea compounds as epigenic modulators of lysine-specific demethylase 1 and methods of treating disorders
JP5699152B2 (en) 2009-09-25 2015-04-08 オリゾン・ジェノミックス・ソシエダッド・アノニマＯｒｙｚｏｎ Ｇｅｎｏｍｉｃｓ Ｓ．Ａ． Lysine-specific demethylase-1 inhibitors and uses thereof
EP2486002B1 (en) 2009-10-09 2019-03-27 Oryzon Genomics, S.A. Substituted heteroaryl- and aryl- cyclopropylamine acetamides and their use
GB0919432D0 (en) 2009-11-05 2009-12-23 Glaxosmithkline Llc Use
BR112012018246B1 (en) 2010-01-22 2020-10-06 Acetylon Pharmaceuticals, Inc REVERSE AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS, PHARMACEUTICAL COMPOSITION UNDERSTANDING THOSE COMPOUNDS, KIT AND USES OF THE SAME
WO2011106105A2 (en) 2010-02-24 2011-09-01 Oryzon Genomics, S.A. Inhibitors for antiviral use
US9186337B2 (en) 2010-02-24 2015-11-17 Oryzon Genomics S.A. Lysine demethylase inhibitors for diseases and disorders associated with Hepadnaviridae
US20130197088A1 (en) 2010-03-12 2013-08-01 Robert A. Casero, JR. Compositions and Methods for Combinations of Oligoamines with 2-Difluoromethylornithine (DFMO)
US8722743B2 (en) 2010-04-19 2014-05-13 Oryzon Genomics S.A. Lysine specific demethylase-1 inhibitors and their use
JP5934184B2 (en) 2010-04-20 2016-06-15 ウニヴェルシタ・デグリ・ストゥディ・ディ・ローマ・ラ・サピエンツァ Tranylcypromine derivatives as inhibitors of histone demethylase LSD1 and / or LSD2
US8846935B2 (en) 2010-05-07 2014-09-30 Glaxosmithkline Llc Indazoles
LT2566327T (en) 2010-05-07 2017-05-25 Glaxosmithkline Llc Indoles
JP5913292B2 (en) 2010-05-14 2016-04-27 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド Compositions and methods for modulating metabolism
NO2598482T3 (en) 2010-07-29 2018-09-01
EP2598480B1 (en) 2010-07-29 2019-04-24 Oryzon Genomics, S.A. Cyclopropylamine derivatives useful as lsd1 inhibitors
US9527805B2 (en) 2010-09-10 2016-12-27 Robert A. Casero Small molecules as epigenetic modulators of lysine-specific demethylase 1 and methods of treating disorders
US20130303545A1 (en) 2010-09-30 2013-11-14 Tamara Maes Cyclopropylamine derivatives useful as lsd1 inhibitors
US9061966B2 (en) 2010-10-08 2015-06-23 Oryzon Genomics S.A. Cyclopropylamine inhibitors of oxidases
GB201112607D0 (en) 2011-07-22 2011-09-07 Glaxo Group Ltd Novel compounds
WO2012072713A2 (en) 2010-11-30 2012-06-07 Oryzon Genomics, S.A. Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae
KR101923746B1 (en) 2010-12-03 2018-11-29 에피자임, 인코포레이티드 Substituted purine and 7-deazapurine compounds as modulators of epigenetic enzymes
WO2012107498A1 (en) 2011-02-08 2012-08-16 Oryzon Genomics S.A. Lysine demethylase inhibitors for myeloproliferative disorders
US20140163041A1 (en) 2011-02-08 2014-06-12 Oryzon Genomics S.A. Lysine demethylase inhibitors for myeloproliferative or lymphoproliferative diseases or disorders
US20140066410A1 (en) 2011-02-23 2014-03-06 Icahn School Of Medicine At Mount Sinai Inhibitors of bromodomains as modulators of gene expression
WO2012118812A2 (en) 2011-02-28 2012-09-07 Epizyme, Inc. Substituted 6,5-fused bicyclic heteroaryl compounds
TWI530489B (en) 2011-03-22 2016-04-21 必治妥美雅史谷比公司 Bis(fluoroalkyl)-1,4-benzodiazepinone compounds
PE20141322A1 (en) 2011-03-25 2014-10-05 Glaxosmithkline Intellectual Property (N 2) Limited CYCLOPROPYLAMINES AS INHIBITORS OF LYSINE-SPECIFIC DESMETILASE 1
JO3438B1 (en) 2011-04-13 2019-10-20 Epizyme Inc Aryl- or heteroaryl-substituted benzene compounds
WO2012156531A2 (en) 2011-05-19 2012-11-22 Oryzon Genomics, S.A. Lysine demethylase inhibitors for inflammatory diseases or conditions
US20140296255A1 (en) 2011-05-19 2014-10-02 Oryzong Genomics, S.A. Lysine demethylase inhibitors for thrombosis and cardiovascular diseases
AR087107A1 (en) 2011-07-27 2014-02-12 Lilly Co Eli INHIBITOR COMPOUND OF THE SIGNALING OF THE NOTCH TRAJECTORY
CA2844525A1 (en) 2011-08-09 2013-02-14 Takeda Pharmaceutical Company Limited Cyclopropaneamine compound
AU2012296639B2 (en) 2011-08-15 2016-06-09 University Of Utah Research Foundation Substituted (E)-N'-(1-phenylethylidene) benzohydrazide analogs as histone demethylase inhibitors
EP3736265A1 (en) 2011-10-20 2020-11-11 Oryzon Genomics, S.A. (hetero)aryl cyclopropylamine compounds as lsd1 inhibitors
JP6046154B2 (en) 2011-10-20 2016-12-14 オリソン ヘノミクス エセ． アー． (Hetero) arylcyclopropylamine compounds as LSD1 inhibitors
US9085583B2 (en) 2012-02-10 2015-07-21 Constellation—Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
WO2013178821A1 (en) 2012-06-01 2013-12-05 Leibniz-Institut für Altersforschung - Fritz-Lipmann-Institut e.V. (FLI) Inhibitors of the notch signalling pathway and secretion for use in medicine
WO2014058071A1 (en) 2012-10-12 2014-04-17 武田薬品工業株式会社 Cyclopropanamine compound and use thereof
WO2014084298A1 (en) 2012-11-28 2014-06-05 京都府公立大学法人 Lsd1-selective inhibitor having lysine structure
US9144555B2 (en) 2012-11-30 2015-09-29 Darlene E. McCord Hydroxytyrosol and oleuropein compositions for induction of DNA damage, cell death and LSD1 inhibition
EP2740474A1 (en) 2012-12-05 2014-06-11 Instituto Europeo di Oncologia S.r.l. Cyclopropylamine derivatives useful as inhibitors of histone demethylases kdm1a
AU2014223990A1 (en) 2013-02-28 2015-09-10 Washington University Methods of treatment of human cytomegalovirus infection and diseases with bromodomain inhibitors
WO2014164867A1 (en) 2013-03-11 2014-10-09 Imago Biosciences Kdm1a inhibitors for the treatment of disease
JP2016517434A (en) 2013-03-14 2016-06-16 エピザイム，インコーポレイティド Combination therapy to treat cancer
WO2014194280A2 (en) 2013-05-30 2014-12-04 The Board of Regents of the Nevada System of Higher Education on behalf of the University of Novel suicidal lsd1 inhibitors targeting sox2-expressing cancer cells
KR102288648B1 (en) 2013-06-19 2021-08-12 유니버시티 오브 유타 리서치 파운데이션 Substituted (e)-n'-(1-phenylethylidene)benzohydrazide analogs as histone demethylase inhibitors
EP2829284A1 (en) * 2013-07-22 2015-01-28 Deutsches Krebsforschungszentrum Cancer therapy with a parvovirus combined with a Bcl-2 inhibitor
KR102255778B1 (en) 2013-08-06 2021-05-24 이마고 바이오사이언시즈 인코포레이티드 Kdm1a inhibitors for the treatment of disease
US9556170B2 (en) 2013-08-30 2017-01-31 University Of Utah Research Foundation Substituted-1H-benzo[d]imidazole series compounds as lysine-specific demethylase 1 (LSD1) inhibitors
CN105873592B (en) * 2013-12-06 2023-01-31 Epizyme股份有限公司 Combination therapy for the treatment of cancer
CA3161836A1 (en) 2013-12-11 2015-06-18 Celgene Quanticel Research, Inc. Inhibitors of lysine specific demethylase-1
WO2015120281A1 (en) 2014-02-07 2015-08-13 Musc Foundation For Research Development Aminotriazole- and aminotetrazole-based kdm1a inhibitors as epigenetic modulators
ES2672797T3 (en) 2014-02-13 2018-06-18 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
US9527835B2 (en) 2014-02-13 2016-12-27 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
EP3105218B1 (en) 2014-02-13 2019-09-25 Incyte Corporation Cyclopropylamines as lsd1 inhibitors
RS59534B1 (en) 2014-02-13 2019-12-31 Incyte Corp Cyclopropylamines as lsd1 inhibitors
JP2017508798A (en) 2014-03-07 2017-03-30 ザ ジョンズ ホプキンス ユニバーシティ Inhibitors of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC)
US10053456B2 (en) 2014-04-11 2018-08-21 Takeda Pharmaceutical Company Limited Cyclopropanamine compound and use thereof
CN106659914B (en) 2014-05-01 2020-06-19 赛尔基因昆蒂赛尔研究公司 Inhibitors of lysine-specific demethylase-1
AU2015265820C1 (en) 2014-05-30 2020-01-16 Ieo - Istituto Europeo Di Oncologia S.R.L. Cyclopropylamine compounds as histone demethylase inhibitors
HUE050564T2 (en) 2014-06-27 2020-12-28 Celgene Quanticel Res Inc Inhibitors of lysine specific demethylase-1
RS63074B1 (en) 2014-07-03 2022-04-29 Celgene Quanticel Research Inc Inhibitors of lysine specific demethylase-1
WO2016004105A1 (en) 2014-07-03 2016-01-07 Quanticel Pharmaceuticals, Inc. Inhibitors of lysine specific demethylase-1
US9758523B2 (en) 2014-07-10 2017-09-12 Incyte Corporation Triazolopyridines and triazolopyrazines as LSD1 inhibitors
WO2016007722A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
WO2016007736A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Imidazopyrazines as lsd1 inhibitors
WO2016007731A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Imidazopyridines and imidazopyrazines as lsd1 inhibitors
WO2016025635A2 (en) * 2014-08-13 2016-02-18 Epizyme, Inc. Combination therapy for treating cancer
EP2993175A1 (en) 2014-09-05 2016-03-09 IEO - Istituto Europeo di Oncologia Srl Thienopyrroles as histone demethylase inhibitors
JP6692350B2 (en) 2014-09-05 2020-05-13 セルジーン クオンティセル リサーチ，インク． Lysine-specific demethylase-1 inhibitor
WO2016123387A1 (en) 2015-01-30 2016-08-04 Genentech, Inc. Therapeutic compounds and uses thereof
MX2017010291A (en) 2015-02-12 2017-12-07 Imago Biosciences Inc Kdm1a inhibitors for the treatment of disease.
CN106146361A (en) 2015-03-16 2016-11-23 四川大学 Indenes-1-subunit sulfonyl benzoyl hydrazine derivant and its production and use
MX2017012699A (en) 2015-04-03 2018-02-09 Incyte Corp Heterocyclic compounds as lsd1 inhibitors.
CN106045862B (en) 2015-04-10 2019-04-23 上海迪诺医药科技有限公司 Cyclopropyl amine spiral shell (miscellaneous) cycle compound, its pharmaceutical composition and application
WO2016172496A1 (en) 2015-04-23 2016-10-27 Constellation Pharmaceuticals, Inc. Lsd1 inhibitors and uses thereof
EP3090998A1 (en) 2015-05-06 2016-11-09 F. Hoffmann-La Roche AG Solid forms
SG10201911989SA (en) 2015-06-12 2020-02-27 Oryzon Genomics Sa Biomarkers associated with lsd1 inhibitors and uses thereof
US20170001970A1 (en) 2015-07-02 2017-01-05 University Of Utah Research Foundation Substituted benzohydrazide analogs as histone demethylase inhibitors
WO2017013061A1 (en) 2015-07-17 2017-01-26 Oryzon Genomics, S.A. Biomarkers associated with lsd1 inhibitors and uses thereof
MA42606A (en) 2015-08-12 2018-06-20 Incyte Corp SALTS OF LSD1 INHIBITOR
CN105233292B (en) * 2015-10-19 2018-03-13 中国科学院北京基因组研究所 The combined radiotherapies of ORY 1001 and chemotherapy are used for the purposes for treating people's triple negative breast cancer
CN105541806A (en) 2015-12-25 2016-05-04 中国药科大学 Barbiturate compound, preparing method and application thereof
CN105924362B (en) 2016-02-05 2018-08-17 上海龙翔生物医药开发有限公司 Aromatic rings allylamine compound, its pharmaceutically acceptable salt, Its Preparation Method And Use
MY197785A (en) 2016-03-15 2023-07-13 Oryzon Genomics Sa Combinations of lsd1 inhibitors for the treatment of hematological malignancies
MX2018011102A (en) 2016-03-15 2019-01-10 Oryzon Genomics Sa Combinations of lsd1 inhibitors for use in the treatment of solid tumors.
JP2019512546A (en) 2016-03-16 2019-05-16 オリゾン・ゲノミクス・ソシエダッド・アノニマ Methods for determining KDM1A target association, and chemical probes useful therefor
CN106045881B (en) 2016-05-26 2017-10-31 新乡医学院 Resveratrol derivative, its preparation method and the application as LSD1 inhibitor

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