SG11201805186VA - Compositions and methods for immune cell modulation in adoptive immunotherapies - Google Patents
Compositions and methods for immune cell modulation in adoptive immunotherapiesInfo
- Publication number
- SG11201805186VA SG11201805186VA SG11201805186VA SG11201805186VA SG11201805186VA SG 11201805186V A SG11201805186V A SG 11201805186VA SG 11201805186V A SG11201805186V A SG 11201805186VA SG 11201805186V A SG11201805186V A SG 11201805186VA SG 11201805186V A SG11201805186V A SG 11201805186VA
- Authority
- SG
- Singapore
- Prior art keywords
- suite
- international
- san diego
- california
- fate
- Prior art date
Links
- 210000002865 immune cell Anatomy 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 238000009169 immunotherapy Methods 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 210000000822 natural killer cell Anatomy 0.000 abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 230000003044 adaptive effect Effects 0.000 abstract 1
- 238000011467 adoptive cell therapy Methods 0.000 abstract 1
- 210000001228 classical NK T cell Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 210000003071 memory t lymphocyte Anatomy 0.000 abstract 1
- 210000000581 natural killer T-cell Anatomy 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 210000000130 stem cell Anatomy 0.000 abstract 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- C12N5/06—Animal cells or tissues; Human cells or tissues
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- C12N5/0636—T lymphocytes
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- C12N5/0634—Cells from the blood or the immune system
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
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- A61K2239/59—Reproductive system, e.g. uterus, ovaries, cervix or testes
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- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2086—IL-13 to IL-16
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- C—CHEMISTRY; METALLURGY
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- C12N2501/2315—Interleukin-15 (IL-15)
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- C12N2501/24—Interferons [IFN]
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- C12N2501/70—Enzymes
- C12N2501/72—Transferases (EC 2.)
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- C12N2503/00—Use of cells in diagnostics
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- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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- Medicinal Chemistry (AREA)
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- Public Health (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Urology & Nephrology (AREA)
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662281064P | 2016-01-20 | 2016-01-20 | |
US201662336339P | 2016-05-13 | 2016-05-13 | |
PCT/US2017/014408 WO2017127729A1 (en) | 2016-01-20 | 2017-01-20 | Compositions and methods for immune cell modulation in adoptive immunotherapies |
Publications (1)
Publication Number | Publication Date |
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SG11201805186VA true SG11201805186VA (en) | 2018-07-30 |
Family
ID=59362673
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201805186VA SG11201805186VA (en) | 2016-01-20 | 2017-01-20 | Compositions and methods for immune cell modulation in adoptive immunotherapies |
Country Status (9)
Country | Link |
---|---|
US (2) | US11096964B2 (zh) |
EP (1) | EP3405567A4 (zh) |
JP (2) | JP2019502722A (zh) |
KR (1) | KR20180096707A (zh) |
CN (2) | CN108473959B (zh) |
AU (3) | AU2017210031C1 (zh) |
CA (1) | CA3010236A1 (zh) |
SG (1) | SG11201805186VA (zh) |
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Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2948544A4 (en) | 2013-01-28 | 2016-08-03 | St Jude Childrens Res Hospital | CHIMERIC RECEPTOR WITH NKG2D SPECIFICITY FOR CELL THERAPY AGAINST CANCER AND INFECTION DISEASES |
ES2839089T3 (es) | 2014-05-15 | 2021-07-05 | Nat Univ Singapore | Linfocitos citolíticos naturales modificados y usos de los mismos |
JP6921759B2 (ja) | 2015-06-04 | 2021-08-18 | クリティテック・インコーポレイテッド | 捕集装置および使用法 |
US11413309B2 (en) | 2016-01-20 | 2022-08-16 | Fate Therapeutics, Inc. | Compositions and methods for immune cell modulation in adoptive immunotherapies |
DK3439635T3 (da) | 2016-04-04 | 2021-03-08 | Crititech Inc | Formuleringer til behandling af fast tumor |
US11932870B2 (en) | 2016-12-05 | 2024-03-19 | Fate Therapeutics, Inc. | Compositions and methods for immune cell modulation in adoptive immunotherapies |
WO2018148462A1 (en) | 2017-02-09 | 2018-08-16 | Indapta Therapeutics, Inc. | Engineered natural killer (nk) cells and compositions and methods thereof |
WO2018170335A1 (en) * | 2017-03-15 | 2018-09-20 | Orca Biosystems Inc. | Compositions and methods for hematopoietic stem cell transplants |
US11365236B2 (en) | 2017-03-27 | 2022-06-21 | Nkarta, Inc. | Truncated NKG2D chimeric receptors and uses thereof in natural killer cell immunotherapy |
BR112019020001A2 (pt) | 2017-03-27 | 2020-04-28 | Nat Univ Singapore | linhagens celulares estimuladoras para expansão ex vivo e ativação de células exterminadoras naturais |
SG11201909840TA (en) | 2017-06-09 | 2019-11-28 | Crititech Inc | Treatment of epithelial cysts by intracystic injection of antineoplastic particles |
BR112019022720A2 (pt) | 2017-06-14 | 2020-05-12 | Crititech, Inc. | Métodos para tratar distúrbios pulmonares |
CN111278436A (zh) | 2017-10-03 | 2020-06-12 | 克里蒂泰克公司 | 局部递送抗肿瘤颗粒与全身递送免疫治疗剂相结合用于治疗癌症 |
CA3083162A1 (en) * | 2017-11-20 | 2019-05-23 | Prospect CharterCare RWMC, LLC d/b/a Roger Williams Medical Center | Compositions for improving car-t cell functionality and use thereof |
SG11202007543TA (en) * | 2018-02-09 | 2020-09-29 | Immatics Us Inc | Methods for manufacturing t cells |
BR112020021437A2 (pt) * | 2018-05-31 | 2021-01-19 | Crititech, Inc. | Métodos para isolar células imunes específicas de tumor de um sujeito para terapia celular adotiva e vacinas contra o câncer |
JP2022516389A (ja) * | 2018-05-31 | 2022-02-28 | ワシントン・ユニバーシティ | 血液悪性腫瘍を治療するためのゲノム編集インバリアントナチュラルキラーT(iNKT)細胞 |
CN109136276A (zh) * | 2018-09-30 | 2019-01-04 | 北京鼎成肽源生物技术有限公司 | 一种rfft2细胞的构建方法 |
US11596692B1 (en) * | 2018-11-21 | 2023-03-07 | Incyte Corporation | PD-L1/STING conjugates and methods of use |
KR20210099601A (ko) * | 2018-12-02 | 2021-08-12 | 페이트 세러퓨틱스, 인코포레이티드 | 향상된 iPSC 유래 효과기 세포를 사용한 면역요법 |
SG11202109057XA (en) | 2019-03-05 | 2021-09-29 | Nkarta Inc | Cd19-directed chimeric antigen receptors and uses thereof in immunotherapy |
JP2022525928A (ja) * | 2019-03-21 | 2022-05-20 | ガミダ セル リミテッド | 併用療法における移植に適したnk細胞画分の増殖及び増殖nk細胞画分の使用 |
CN113874490A (zh) * | 2019-04-17 | 2021-12-31 | 车比奥泰有限公司 | 一种抗癌活性增加的自然杀伤细胞以及其免疫治疗用途 |
KR102300846B1 (ko) * | 2019-11-01 | 2021-09-09 | 서울대학교산학협력단 | 면역 활성 개선용 조성물 및 이의 방법 |
AU2021223336A1 (en) | 2020-02-19 | 2022-10-06 | Nammi Therapeutics, Inc. | Formulated and/or co-formulated liposome compositions containing TGFB antagonist prodrugs useful in the treatment of cancer and methods thereof |
WO2022046675A1 (en) * | 2020-08-23 | 2022-03-03 | Applied Stemcell, Inc. | Hla-f-modified cells and methods |
EP4251741A1 (en) | 2020-11-30 | 2023-10-04 | CRISPR Therapeutics AG | Gene-edited natural killer cells |
WO2022187280A1 (en) * | 2021-03-01 | 2022-09-09 | Dana-Farber Cancer Institute, Inc. | Personalized redirection and reprogramming of t cells for precise targeting of tumors |
CN114807044B (zh) * | 2021-04-30 | 2023-09-08 | 四川大学华西医院 | 一种具有高nkt细胞比例的car-cik细胞制备方法及应用 |
WO2023278893A1 (en) * | 2021-07-02 | 2023-01-05 | Case Western Reserve University | Adoptive immunotherapy compositions and methods of tracking |
WO2024084518A1 (en) * | 2022-10-20 | 2024-04-25 | Microcrispr Pvt Ltd. | Attenuation of cytokine release syndrome in immunotherapy |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE277895T1 (de) | 1997-07-01 | 2004-10-15 | Warner Lambert Co | 4-brom or 4-iod-phenylamino- benzhydroxamsäurederivate und ihre anwendung als mek-inhibitoren |
KR20020022798A (ko) | 1999-08-13 | 2002-03-27 | 후미에 사토 | 프로스타글란딘 유도체 |
US20020013294A1 (en) | 2000-03-31 | 2002-01-31 | Delong Mitchell Anthony | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
DK1301472T3 (da) | 2000-07-19 | 2014-04-07 | Warner Lambert Co | Oxygenerede estere af 4-iod-phenylamino-benzhydroxamsyrer |
KR100984613B1 (ko) | 2002-03-13 | 2010-09-30 | 어레이 바이오파마 인크. | Mek 억제제로서의 n3 알킬화 벤즈이미다졸 유도체 |
US20050075276A1 (en) * | 2003-03-14 | 2005-04-07 | Christopher Rudd | Use of inhibitors of glycogen synthase-3 to augment CD28 dependent -T-cell responses |
EP1689387B1 (en) | 2003-11-19 | 2011-09-14 | Array Biopharma, Inc. | Bicyclic inhibitors of mek and methods of synthesis thereof |
EP1991663A2 (en) * | 2006-03-06 | 2008-11-19 | Government of the United States of America, Represented by the Secretary, Department of Health and Human Services | Autologous natural killer cells and lymphodepleting chemotherapy for the treatment of cancer |
WO2008071974A2 (en) | 2006-12-14 | 2008-06-19 | Medical Research Council | Use of pi3k m-tor and akt inhibitors to induce f0xp3 expression and generate regulatory t cells |
EP3409762A1 (en) * | 2008-03-17 | 2018-12-05 | The Scripps Research Institute | Combined chemical and genetic approaches for generation of induced pluripotent stem cells |
EP2375897A4 (en) * | 2009-01-14 | 2013-05-15 | Health Research Inc | METHOD AND COMPOSITIONS USING MTOR-INHIBITORS FOR IMPROVING IMMUNE REACTIONS |
EP2638896A1 (en) * | 2012-03-14 | 2013-09-18 | Bioneer A/S | Cationic liposomal drug delivery system for specific targeting of human cd14+ monocytes in whole blood |
CA2945263A1 (en) * | 2014-04-09 | 2015-10-15 | Christopher Rudd | Use of gsk-3 inhibitors or activators which modulate pd-1 or t-bet expression to modulate t cell immunity |
SI3151672T1 (sl) * | 2014-06-06 | 2021-03-31 | Bluebird Bio, Inc. | Izboljšani T-celični sestavki |
EP3770252A1 (en) | 2015-01-26 | 2021-01-27 | Fate Therapeutics, Inc. | Cells with increased immuno-regulatory properties and methods for their use and manufacture |
EP3292200A4 (en) * | 2015-05-05 | 2018-10-31 | Fate Therapeutics, Inc. | Modulation of t lymphocytes |
US11413309B2 (en) * | 2016-01-20 | 2022-08-16 | Fate Therapeutics, Inc. | Compositions and methods for immune cell modulation in adoptive immunotherapies |
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CN108473959B (zh) | 2023-04-21 |
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AU2017210031A1 (en) | 2018-07-26 |
CN116376826A (zh) | 2023-07-04 |
AU2017210031C1 (en) | 2020-11-26 |
CA3010236A1 (en) | 2017-07-27 |
AU2023201552A1 (en) | 2023-04-13 |
AU2020204267A1 (en) | 2020-07-16 |
CN108473959A (zh) | 2018-08-31 |
US11096964B2 (en) | 2021-08-24 |
US20210393695A1 (en) | 2021-12-23 |
JP2019502722A (ja) | 2019-01-31 |
EP3405567A4 (en) | 2019-10-30 |
AU2017210031B2 (en) | 2020-04-02 |
EP3405567A1 (en) | 2018-11-28 |
AU2020204267B2 (en) | 2022-12-15 |
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