SG11201907814SA - Methods and compositions for transducing and expanding lymphocytes and regulating the activity thereof - Google Patents

Methods and compositions for transducing and expanding lymphocytes and regulating the activity thereof

Info

Publication number
SG11201907814SA
SG11201907814SA SG11201907814SA SG11201907814SA SG11201907814SA SG 11201907814S A SG11201907814S A SG 11201907814SA SG 11201907814S A SG11201907814S A SG 11201907814SA SG 11201907814S A SG11201907814S A SG 11201907814SA SG 11201907814S A SG11201907814S A SG 11201907814SA
Authority
SG
Singapore
Prior art keywords
methods
international
pct
september
march
Prior art date
Application number
SG11201907814SA
Inventor
Gregory Ian Frost
James Joseph Onuffer
Ghiabe H Guibinga
Farzad Haerizadeh
Original Assignee
F1 Oncology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/462,855 external-priority patent/US10596274B2/en
Priority claimed from US15/644,778 external-priority patent/US11111505B2/en
Priority claimed from PCT/US2017/041277 external-priority patent/WO2018009923A1/en
Application filed by F1 Oncology Inc filed Critical F1 Oncology Inc
Publication of SG11201907814SA publication Critical patent/SG11201907814SA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1048—SELEX
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4631—Chimeric Antigen Receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A61K39/464411—Immunoglobulin superfamily
    • A61K39/464412—CD19 or B4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5418—IL-7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2302—Interleukin-2 (IL-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2307—Interleukin-7 (IL-7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/99—Coculture with; Conditioned medium produced by genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16045—Special targeting system for viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16051—Methods of production or purification of viral material
    • C12N2740/16052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/007—Vector systems having a special element relevant for transcription cell cycle specific enhancer/promoter combination

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 07 September 2018 (07.09.2018) WIP0 I PCT onion °nolo mu oloiloilooimmo oimIE (10) International Publication Number WO 2018/161064 Al (71) Applicant: Fl ONCOLOGY, INC. [US/US]; 625 N. Fla- gler Dr., Suite 625, West Palm Beach, Florida 33401 (US). (72) Inventors: FROST, Gregory Ian; 625 N. Flagler Dr., Suite 625, West Palm Beach, Florida 33401 (US). ONUFFER, James Joseph; 625 N. Flagler Dr., Suite 625, West Palm Beach, Florida 33401 (US). GUIBINGA, Ghiabe H.; 1613 Fort Stockton Drive, San Diego, California 92103 (US). HAERIZADEH, Farzad; 13954 Royal Dornoch Square, SAN DIEGO, California 92128 (US). (74) Agent: VACCHIANO, Emanuel J.; 8110 Woodside Lane, Burr Ridge, Illinois 60527 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (51) International Patent Classification: C12N 15/10 (2006.01) CO7K 14/705 (2006.01) C12N 15/867 (2006.01) CO7K 14/715 (2006.01) C12N 5/0783 (2010.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 15/86 (2006.01) CO7K 14/725 (2006.01) (21) International Application Number: PCT/US2018/020818 (22) International Filing Date: 03 March 2018 (03.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/467,039 03 March 2017 (03.03.2017) US 15/462,855 19 March 2017 (19.03.2017) US PCT/US2017/023112 19 March 2017 (19.03.2017) US 15/644,778 08 July 2017 (08.07.2017) US PCT/US2017/041277 08 July 2017 (08.07.2017) US 62/560,176 18 September 2017 (18.09.2017) US 62/564,253 27 September 2017 (27.09.2017) US 62/564,991 28 September 2017 (28.09.2017) US — (54) Title: METHODS AND COMPOSITIONS FOR TRANSDUCING AND EXPANDING LYMPHOCYTES AND REGULATING = THE ACTIVITY THEREOF W O 20 18/ 16 106 4 Al (57) : The present disclosure provides methods for genetically modify- ing lymphocytes and methods for performing adoptive cellular therapy that include transducing T cells and/or NK cells. The methods can include inhibitory RNA molecule(s) and/or engineered signaling polypeptides that can include a lymphopro- liferative element, and/or a chimeric antigen receptor (CAR), for example a microen- vironment restricted biologic CAR (MRB-CAR). Additional elements of such engi- neered signaling polypeptides are provided herein, such as those that drive prolifer- ation and regulatory elements therefor, as well as replication incompetent recombi- nant retroviral particles and packaging cell lines and methods of making the same. Numerous elements and methods for regulating transduced and/or genetically mod- ified T cells and/or NK cells are provided, such as, for example, those including ri- boswitches, MRB-CARs, recognition domains, and/or pH-modulating agents. [Continued on next page] WO 2018/161064 Al MIDEDIM01101 DIV IIMOU1111111111111111111111111111101111111110111111111111 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a))
SG11201907814SA 2017-03-03 2018-03-03 Methods and compositions for transducing and expanding lymphocytes and regulating the activity thereof SG11201907814SA (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201762467039P 2017-03-03 2017-03-03
US15/462,855 US10596274B2 (en) 2016-03-19 2017-03-19 Methods and compositions for transducing lymphocytes and regulated expansion thereof
PCT/US2017/023112 WO2017165245A2 (en) 2016-03-19 2017-03-19 Methods and compositions for transducing lymphocytes and regulated expansion thereof
US15/644,778 US11111505B2 (en) 2016-03-19 2017-07-08 Methods and compositions for transducing lymphocytes and regulating the activity thereof
PCT/US2017/041277 WO2018009923A1 (en) 2016-07-08 2017-07-08 Methods and compositions for transducing lymphocytes and regulating the activity thereof
US201762560176P 2017-09-18 2017-09-18
US201762564253P 2017-09-27 2017-09-27
US201762564991P 2017-09-28 2017-09-28
PCT/US2018/020818 WO2018161064A1 (en) 2017-03-03 2018-03-03 Methods and compositions for transducing and expanding lymphocytes and regulating the activity thereof

Publications (1)

Publication Number Publication Date
SG11201907814SA true SG11201907814SA (en) 2019-09-27

Family

ID=63371106

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201907814SA SG11201907814SA (en) 2017-03-03 2018-03-03 Methods and compositions for transducing and expanding lymphocytes and regulating the activity thereof
SG10202109571P SG10202109571PA (en) 2017-03-03 2018-03-03 Methods and compositions for transducing and expanding lymphocytes and regulating the activity thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10202109571P SG10202109571PA (en) 2017-03-03 2018-03-03 Methods and compositions for transducing and expanding lymphocytes and regulating the activity thereof

Country Status (12)

Country Link
EP (1) EP3589733A1 (en)
KR (1) KR20200003370A (en)
CN (1) CN110892070A (en)
AU (1) AU2018226884A1 (en)
BR (1) BR112019018288A2 (en)
CA (1) CA3054064A1 (en)
CU (1) CU24645B1 (en)
IL (1) IL268739A (en)
MX (1) MX2019010445A (en)
SG (2) SG11201907814SA (en)
TW (1) TW201839127A (en)
WO (1) WO2018161064A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020047527A2 (en) 2018-09-02 2020-03-05 F1 Bioventures, Llc Methods and compositions for genetically modifying lymphocytes in blood or in enriched pbmcs
US11111505B2 (en) 2016-03-19 2021-09-07 Exuma Biotech, Corp. Methods and compositions for transducing lymphocytes and regulating the activity thereof
US11325948B2 (en) 2016-03-19 2022-05-10 Exuma Biotech Corp. Methods and compositions for genetically modifying lymphocytes to express polypeptides comprising the intracellular domain of MPL
EP3781177A4 (en) * 2018-04-19 2022-03-02 Baylor College of Medicine Reprogramming cd4 t cells into cytotoxic cd8 cells by forced expression of cd8ab and class 1 restricted t cell receptors
WO2020160419A1 (en) * 2019-02-01 2020-08-06 The Trustees Of Dartmouth College Signaling platforms for chimeric antigen receptor t cells
US20220096549A1 (en) * 2019-02-08 2022-03-31 Seattle Children's Hospital (dba Seattle Children's Research Institute) Chimeric cytokine receptors
EP3931208A1 (en) 2019-03-01 2022-01-05 Allogene Therapeutics, Inc. Chimeric cytokine receptors bearing a pd-1 ectodomain
EP3715368A1 (en) * 2019-03-28 2020-09-30 Albert-Ludwigs-Universität Freiburg Chimeric antigen receptors, vectors coding for such receptors and their use in the modification of t cells
CN110244612B (en) * 2019-06-06 2020-05-26 西安交通大学 Binary digital communication system based on chemical diffusion mechanism
CN112500492B (en) * 2019-09-13 2023-08-04 中国科学院分子细胞科学卓越创新中心 Chimeric antigen receptor and application thereof
CN114616239B (en) * 2019-10-17 2023-08-11 北京门罗生物科技有限公司 Chimeric antigen receptor and T cell expressing chimeric antigen receptor therein
WO2021108677A1 (en) * 2019-11-27 2021-06-03 Board Of Regents, The University Of Texas System Natural killer cell immunotherapy for the treatment of glioblastoma and other cancers
US20230111159A1 (en) * 2020-03-05 2023-04-13 Exuma Biotech Corp Methods and compositions for the delivery of modified lymphocyte aggregates
CN111662900B (en) * 2020-05-13 2023-06-27 重庆师范大学 Sulfadimidine aptamer screening method, kit and application
CN111549044B (en) * 2020-07-13 2020-10-23 北京市肿瘤防治研究所 Preparation method and application of targeted TRBC1 CAR-T cell
CA3204357A1 (en) * 2021-01-28 2022-08-04 Todd LUMAN Methods for transducing immune cells
WO2022187289A1 (en) 2021-03-01 2022-09-09 Exuma Biotech Corp. Methods and compositions for the delivery of retroviral particles
WO2023168305A1 (en) 2022-03-01 2023-09-07 Exuma Biotech Corp. Viral particles with membrane-bound hyaluronidase
CN117683139A (en) * 2022-09-09 2024-03-12 信达细胞制药(苏州)有限公司 Constitutive chimeric cytokine receptor, immune cell expressing same and application thereof

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5677425A (en) 1987-09-04 1997-10-14 Celltech Therapeutics Limited Recombinant antibody
US5585362A (en) 1989-08-22 1996-12-17 The Regents Of The University Of Michigan Adenovirus vectors for gene therapy
CA2115742A1 (en) 1991-08-20 1993-03-04 Ronald G. Crystal Adenovirus mediated transfer of genes to the gastrointestinal tract
US5252479A (en) 1991-11-08 1993-10-12 Research Corporation Technologies, Inc. Safe vector for gene therapy
FR2688514A1 (en) 1992-03-16 1993-09-17 Centre Nat Rech Scient Defective recombinant adenoviruses expressing cytokines and antitumour drugs containing them
CA2592997A1 (en) 1992-12-03 1994-06-09 Genzyme Corporation Pseudo-adenovirus vectors
US5310903A (en) 1993-03-05 1994-05-10 Merck & Co., Inc. Imidazolidyl rapamycin derivatives
ES2249761T3 (en) 1993-06-24 2006-04-01 Advec Inc. ADENOVIRUS VECTORS FOR GENE THERAPY.
EP2113569A1 (en) 1993-10-25 2009-11-04 CANJI, Inc. Recombinant adenoviral vector and methods of use
US5527907A (en) 1993-11-19 1996-06-18 Abbott Laboratories Macrolide immunomodulators
US5525610A (en) 1994-03-31 1996-06-11 American Home Products Corporation 42-Epi-rapamycin and pharmaceutical compositions thereof
US5362718A (en) 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
US20030036654A1 (en) 1994-08-18 2003-02-20 Holt Dennis A. Synthetic multimerizing agents
PT889120E (en) 1994-12-09 2002-09-30 Microscience Ltd VIRULENCE GENES IN SALMONELLA VGC2 GROUP
WO1996041865A1 (en) 1995-06-07 1996-12-27 Ariad Gene Therapeutics, Inc. Rapamcycin-based regulation of biological events
KR20000076157A (en) 1997-03-11 2000-12-26 리전츠 오브 더 유니버스티 오브 미네소타 Dna-based transposon system for the introduction of nucleic acid into dna of a cell
WO1999036553A2 (en) 1998-01-15 1999-07-22 Ariad Gene Therapeutics, Inc. Regulation of biological events using multimeric chimeric proteins
IL147803A0 (en) 1999-08-24 2002-08-14 Ariad Gene Therapeutics Inc 28-epirapalogs
US20040005561A1 (en) * 2000-03-01 2004-01-08 Corixa Corporation Compositions and methods for the detection, diagnosis and therapy of hematological malignancies
US6916846B2 (en) 2000-05-12 2005-07-12 Merck & Co. Inc. Coumermycin analogs as chemical dimerizers of chimeric proteins
GB0105924D0 (en) 2001-03-09 2001-04-25 Microscience Ltd Promoter
US7387896B2 (en) 2003-03-26 2008-06-17 The Regents Of The University Of Michigan MicroRNA vectors
CN1897977A (en) * 2003-10-20 2007-01-17 Ns基因公司 In vivo gene therapy of parkinson's disease
WO2006007539A1 (en) * 2004-07-01 2006-01-19 Virxsys Corporation Vector packaging cell line
KR20070111448A (en) 2004-11-08 2007-11-21 예일 유니버시티 Riboswitches, structure-based compound design with riboswitches, and methods and compositions for use of and with riboswitches
US8236925B1 (en) 2005-08-26 2012-08-07 University Of Minnesota Protein nanorings
US20100260739A1 (en) 2009-03-09 2010-10-14 Bioatla, Llc Mirac Proteins
ES2717629T3 (en) 2009-11-03 2019-06-24 Hope City Truncated epidermal growth factor receptor (EGFRt) for selection of transduced T cells
CN103582699B (en) * 2011-04-08 2017-03-22 贝勒医学院 Reversing the effects of the tumor microenvironment using chimeric cytokine receptors
DK2997134T3 (en) * 2013-05-14 2020-09-28 Univ Texas HUMAN USE OF GENANIZED CHIMARY ANTIGEN RECEPTOR (CAR) T CELLS
JP7286267B2 (en) 2014-08-28 2023-06-05 バイオアトラ インコーポレイテッド Conditionally active chimeric antigen receptor for modified T cells
GB201503500D0 (en) * 2015-03-02 2015-04-15 Ucl Business Plc Cell
MX2018011345A (en) * 2016-03-19 2019-05-27 F1 Oncology Inc Methods and compositions for transducing lymphocytes and regulated expansion thereof.
AU2017292936C1 (en) * 2016-07-08 2024-05-02 Exuma Biotech, Corp. Methods and compositions for transducing lymphocytes and regulating the activity thereof
GB201614093D0 (en) * 2016-08-17 2016-09-28 Autolus Ltd Vector

Also Published As

Publication number Publication date
KR20200003370A (en) 2020-01-09
CU20190075A7 (en) 2020-04-02
AU2018226884A1 (en) 2019-10-10
CA3054064A1 (en) 2018-09-07
SG10202109571PA (en) 2021-10-28
IL268739A (en) 2019-10-31
CU24645B1 (en) 2023-02-13
MX2019010445A (en) 2019-10-24
WO2018161064A1 (en) 2018-09-07
TW201839127A (en) 2018-11-01
EP3589733A1 (en) 2020-01-08
BR112019018288A2 (en) 2020-03-31
WO2018161064A9 (en) 2019-07-18
CN110892070A (en) 2020-03-17

Similar Documents

Publication Publication Date Title
SG11201907814SA (en) Methods and compositions for transducing and expanding lymphocytes and regulating the activity thereof
SG11201807286WA (en) Methods and compositions for transducing lymphocytes and regulated expansion thereof
SG11201906468TA (en) Chimeric antigen receptors against axl or ror2 and methods of use thereof
SG11201805784PA (en) Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases
SG11201805186VA (en) Compositions and methods for immune cell modulation in adoptive immunotherapies
SG11201903454VA (en) Immunologically discernible cell surface variants for use in cell therapy
SG11201809649WA (en) Macromolecule analysis employing nucleic acid encoding
SG11201909395TA (en) Antibody agents directed against lymphocyte activation gene-3 (lag-3) and uses thereof
SG11201903882VA (en) Il-2 variants for the treatment of autoimmune diseases
SG11201908658TA (en) Nucleobase editors comprising nucleic acid programmable dna binding proteins
SG11201810132WA (en) Ferroelectric memory cell recovery
SG11201908391XA (en) Methods for modulating an immune response
SG11201903857UA (en) Antibodies to pd-1 and uses thereof
SG11201809700YA (en) Gdf15 fusion proteins and uses thereof
SG11201811405QA (en) Improved differentiation method
SG11201805268XA (en) T cell receptors specific for the ny-eso-1 tumor antigen-hla-a*02 complex
SG11201808797XA (en) T cell receptors
SG11201810525XA (en) Anti-gitr antibodies and uses thereof
SG11201807538PA (en) Crispr-cpf1-related methods, compositions and components for cancer immunotherapy
SG11201906885TA (en) Methods for the administration of certain vmat2 inhibitors
SG11201900201YA (en) Methods for quantitating individual antibodies from a mixture
SG11201907653QA (en) Compositions and methods for enhanced gene expression
SG11201407579QA (en) Interleukin-2 fusion proteins and uses thereof
SG11201907319QA (en) Gamma delta t cells and a method of augmenting the tumoricidal activity of the same
SG11201909728XA (en) Constructs specifically recognizing glypican 3 and uses thereof