SG11201709634QA - Nitrogen-containing tricyclic derivative having hiv replication inhibitory activity - Google Patents

Nitrogen-containing tricyclic derivative having hiv replication inhibitory activity

Info

Publication number
SG11201709634QA
SG11201709634QA SG11201709634QA SG11201709634QA SG11201709634QA SG 11201709634Q A SG11201709634Q A SG 11201709634QA SG 11201709634Q A SG11201709634Q A SG 11201709634QA SG 11201709634Q A SG11201709634Q A SG 11201709634QA SG 11201709634Q A SG11201709634Q A SG 11201709634QA
Authority
SG
Singapore
Prior art keywords
nitrogen
inhibitory activity
hiv replication
tricyclic derivative
containing tricyclic
Prior art date
Application number
SG11201709634QA
Other languages
English (en)
Inventor
Yoshinori Tamura
Takashi Kawasuji
Shuichi Sugiyama
Akira Matsumura
Toshiyuki Akiyama
Yutaka Tomida
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of SG11201709634QA publication Critical patent/SG11201709634QA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
SG11201709634QA 2015-05-29 2016-05-27 Nitrogen-containing tricyclic derivative having hiv replication inhibitory activity SG11201709634QA (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2015109547 2015-05-29
JP2015170222 2015-08-31
JP2015223036 2015-11-13
JP2016054215 2016-03-17
PCT/JP2016/065702 WO2016194806A1 (ja) 2015-05-29 2016-05-27 Ｈｉｖ複製阻害作用を有する含窒素３環性誘導体

Publications (1)

Publication Number Publication Date
SG11201709634QA true SG11201709634QA (en) 2017-12-28

Family

ID=57442245

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201709634QA SG11201709634QA (en) 2015-05-29 2016-05-27 Nitrogen-containing tricyclic derivative having hiv replication inhibitory activity

Country Status (16)

Country Link
US (2) US10494380B2 (zh)
EP (1) EP3305789A4 (zh)
JP (2) JP6614585B2 (zh)
KR (1) KR20180011267A (zh)
CN (2) CN107922423B (zh)
AU (1) AU2016271762B2 (zh)
BR (1) BR112017025367A2 (zh)
CA (1) CA2987384A1 (zh)
HK (1) HK1253539A1 (zh)
IL (1) IL255580B (zh)
MA (1) MA43120A (zh)
MX (1) MX2017015256A (zh)
RU (1) RU2720145C2 (zh)
SG (1) SG11201709634QA (zh)
TW (1) TWI700284B (zh)
WO (1) WO2016194806A1 (zh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112015022942B1 (pt) 2013-03-15 2022-02-22 Incyte Holdings Corporation Compostos heterocíciclos tricíclicos, método para inibir proteína bet in vitro e composição farmacêutica compreendendo os referidos compostos
JP2016523964A (ja) 2013-07-08 2016-08-12 インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ Ｂｅｔタンパク質阻害剤としての三環式複素環
WO2015081203A1 (en) 2013-11-26 2015-06-04 Incyte Corporation Bicyclic heterocycles as bet protein inhibitors
WO2015095492A1 (en) 2013-12-19 2015-06-25 Incyte Corporation Tricyclic heterocycles as bet protein inhibitors
NZ763740A (en) 2014-04-23 2023-06-30 Incyte Holdings Corp 1h-pyrrolo[2,3-c]pyridin-7(6h)-ones and pyrazolo[3,4-c]pyridin-7(6h)-ones as inhibitors of bet proteins
JP6599979B2 (ja) 2014-09-15 2019-10-30 インサイト・コーポレイション Ｂｅｔタンパク質阻害剤として用いるための三環式複素環化合物
WO2017075377A1 (en) 2015-10-29 2017-05-04 Incyte Corporation Amorphous solid form of a bet protein inhibitor
FI3472157T3 (fi) 2016-06-20 2023-06-01 Incyte Corp Bet-inhibiittorin kiteisiä kiinteitä muotoja
US20220009894A1 (en) * 2019-01-23 2022-01-13 Abbisko Therapeutics Co., Ltd. 1,2,3,4-tetrahydroquinoxaline derivative, preparation method therefor and application thereof
JPWO2021107066A1 (zh) 2019-11-28 2021-06-03
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms
CN112409493B (zh) * 2020-08-12 2022-09-30 浙江工业大学 一种重组融合酶及其在乙醛酸甲酯合成中的应用
CN114075212B (zh) * 2020-08-14 2023-05-12 江苏恒瑞医药股份有限公司 稠合三环类衍生物、其制备方法及其在医药上的应用

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU710876B2 (en) 1996-02-21 1999-09-30 Darwin Discovery Limited Quinolones and their therapeutic use
US5792774A (en) 1996-02-21 1998-08-11 Chiroscience Limited Quinolones and their therapeutic use
AU710825B2 (en) * 1996-02-21 1999-09-30 Darwin Discovery Limited Quinolones and their therapeutic use
DE19946289A1 (de) 1999-09-28 2001-03-29 Basf Ag Benzodiazepin-Derivate, deren Herstellung und Anwendung
MXPA03000753A (es) * 2000-08-08 2003-10-15 Sanofi Synthelabo Derivados de benzimidazola, su preparacion y su aplicacion terapeutica.
US7026311B2 (en) 2002-01-10 2006-04-11 Abbott Gmbh & Co., Kg Dibenzodiazepine derivatives, their preparation and use
JP2004256531A (ja) 2003-02-07 2004-09-16 Takeda Chem Ind Ltd 三環性化合物、その製造法および用途
US20060178359A1 (en) 2003-02-07 2006-08-10 Mitsuru Shiraishi Tricyclic compound, process for producing the same, and use
TW200637862A (en) 2005-01-10 2006-11-01 Tibotec Pharm Ltd 1,5,6-substituted-2-oxo-3-cyano-1,6a-diaza-tetrahydro-fluoranthenes
CA2616020A1 (en) * 2005-08-05 2007-02-15 Astrazeneca Ab Tricyclic benzimidazoles and their use as metabotropic glutamate receptor modulators
US7939545B2 (en) 2006-05-16 2011-05-10 Boehringer Ingelheim International Gmbh Inhibitors of human immunodeficiency virus replication
EP2220095B1 (en) 2007-11-15 2013-01-02 Gilead Sciences, Inc. Inhibitors of human immunodeficiency virus replication
JP5269086B2 (ja) 2007-11-15 2013-08-21 ギリアード サイエンシス インコーポレーテッド ヒト免疫不全ウイルスの複製阻害薬
EP2220084B1 (en) 2007-11-16 2014-02-19 Gilead Sciences, Inc. Inhibitors of human immunodeficiency virus replication
UA100250C2 (uk) 2007-11-16 2012-12-10 Гілеад Сайнсіз, Інк. Інгібітори реплікації вірусу імунодефіциту людини
US8338441B2 (en) 2009-05-15 2012-12-25 Gilead Sciences, Inc. Inhibitors of human immunodeficiency virus replication
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
SG10201408512RA (en) 2009-12-23 2015-02-27 Univ Leuven Kath Novel antiviral compounds
CA2802308C (en) 2010-07-02 2018-08-28 Lianhong Xu Napht-2-ylacetic acid derivatives to treat aids
JP5806735B2 (ja) 2010-07-02 2015-11-10 ギリアード サイエンシーズ， インコーポレイテッド Ｈｉｖ抗ウイルス化合物としての２−キノリニル−酢酸誘導体
US8633200B2 (en) 2010-09-08 2014-01-21 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
JP2013542243A (ja) 2010-11-15 2013-11-21 カトリーケ ウニヴェルシテイト ルーヴェン 新規な抗ウイルス性化合物
BR112013011991A2 (pt) 2010-11-15 2016-08-30 Viiv Healthcare Uk Ltd composto, composição farmacêutica, uso de um composto, método de tratamento, produto, e kit.
WO2012102985A1 (en) 2011-01-24 2012-08-02 Glaxosmithkline Llc Isoquinoline compounds and methods for treating hiv
EP2508511A1 (en) 2011-04-07 2012-10-10 Laboratoire Biodim Inhibitors of viral replication, their process of preparation and their therapeutical uses
EP2511273B8 (en) * 2011-04-15 2019-06-26 Hivih Inhibitors of viral replication, their process of preparation and their therapeutical uses
MX2013012266A (es) 2011-04-21 2013-11-22 Gilead Sciences Inc Compuestos de benzotiazol y su uso farmaceutico.
WO2013002357A1 (ja) 2011-06-30 2013-01-03 塩野義製薬株式会社 Ｈｉｖ複製阻害剤
WO2013012649A1 (en) 2011-07-15 2013-01-24 Glaxosmithkline Llc Azaindole compounds and methods for treating hiv
US8791108B2 (en) 2011-08-18 2014-07-29 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
WO2013043553A1 (en) 2011-09-22 2013-03-28 Glaxosmithkline Llc Pyrrolopyridinone compounds and methods for treating hiv
US9199959B2 (en) 2011-10-25 2015-12-01 Shionogi & Co., Ltd. HIV replication inhibitor
WO2013073875A1 (ko) 2011-11-15 2013-05-23 한국화학연구원 신규한 항바이러스성 피롤로피리딘 유도체 및 이의 제조방법
US9284323B2 (en) 2012-01-04 2016-03-15 Gilead Sciences, Inc. Naphthalene acetic acid derivatives against HIV infection
WO2013103724A1 (en) 2012-01-04 2013-07-11 Gilead Sciences, Inc. 2- (tert - butoxy) -2- (7 -methylquinolin- 6 - yl) acetic acid derivatives for treating aids
US8629276B2 (en) 2012-02-15 2014-01-14 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
US9034882B2 (en) 2012-03-05 2015-05-19 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
US9006235B2 (en) 2012-03-06 2015-04-14 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
WO2013157622A1 (ja) 2012-04-19 2013-10-24 塩野義製薬株式会社 Ｈｉｖ複製阻害剤
MD20140063A2 (ro) 2012-04-20 2014-12-31 Gilead Sciences, Inc. Derivaţi de acid benzotiazol-6-il acetic şi utilizarea acestora pentru tratarea unei infecţii HIV
EP2877468B1 (en) * 2012-07-12 2017-08-23 ViiV Healthcare UK Limited Compounds and methods for treating hiv
US8906929B2 (en) 2012-08-16 2014-12-09 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
EP2716632A1 (en) 2012-10-05 2014-04-09 Laboratoire Biodim Inhibitors of viral replication, their process of preparation and their therapeutical uses
EP2716639A1 (en) 2012-10-05 2014-04-09 Laboratoire Biodim Inhibitors of viral replication, their process of preparation and their therapeutical uses
EP2719685A1 (en) 2012-10-11 2014-04-16 Laboratoire Biodim Inhibitors of viral replication, their process of preparation and their therapeutical uses
TW201441197A (zh) 2013-01-31 2014-11-01 Shionogi & Co Ｈｉｖ複製抑制劑
EP2970273B1 (en) 2013-03-13 2017-03-01 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication
US9580431B2 (en) 2013-03-13 2017-02-28 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication
WO2014159959A1 (en) 2013-03-14 2014-10-02 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
WO2015126765A1 (en) 2014-02-19 2015-08-27 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
WO2015147247A1 (ja) * 2014-03-28 2015-10-01 塩野義製薬株式会社 Ｈｉｖ複製阻害作用を有する３環性誘導体
JP6579549B2 (ja) 2014-05-16 2019-09-25 塩野義製薬株式会社 Ｈｉｖ複製阻害作用を有する３環性複素環誘導体
WO2015179448A1 (en) 2014-05-21 2015-11-26 Gilead Sciences, Inc. Therapeutic compounds
WO2016005878A1 (en) 2014-07-08 2016-01-14 Viiv Healthcare Uk Limited Isoindoline derivatives for use in the treatment of a viral infection
US10118894B2 (en) 2014-07-22 2018-11-06 Viiv Healthcare Uk Limited Isoindolinone derivatives useful as antiviral agents
KR20170045308A (ko) 2014-08-27 2017-04-26 비브 헬스케어 유케이 (넘버5) 리미티드 인간 면역결핍 바이러스 복제의 억제제로서 이미다조[1,2-a]피리딘 유도체
TW201720798A (zh) 2015-09-17 2017-06-16 Ｖｉｉｖ醫療保健英國有限公司 苯并氮呯衍生物
JP2018536000A (ja) 2015-12-04 2018-12-06 ヴィーブ ヘルスケア ユーケー リミテッド イソインドリン誘導体
EP3383866A1 (en) 2015-12-04 2018-10-10 ViiV Healthcare UK Limited Tetrahydroisoquinoline derivatives
JP2018535993A (ja) 2015-12-04 2018-12-06 ヴィーブ ヘルスケア ユーケー リミテッド イソインドリン誘導体
WO2017093937A1 (en) 2015-12-04 2017-06-08 Viiv Healthcare Uk Limited Isoindoline derivatives

Also Published As

Publication number Publication date
RU2017145082A3 (zh) 2019-10-24
AU2016271762A1 (en) 2017-11-30
JP6797464B2 (ja) 2020-12-09
US10494380B2 (en) 2019-12-03
EP3305789A4 (en) 2018-11-21
MX2017015256A (es) 2018-02-19
US20200055873A1 (en) 2020-02-20
BR112017025367A2 (pt) 2018-08-07
CN107922423A (zh) 2018-04-17
JP6614585B2 (ja) 2019-12-04
KR20180011267A (ko) 2018-01-31
MA43120A (fr) 2018-09-05
JPWO2016194806A1 (ja) 2018-03-22
CN107922423B (zh) 2020-10-27
RU2720145C2 (ru) 2020-04-24
TW201706275A (zh) 2017-02-16
IL255580B (en) 2020-11-30
US10870661B2 (en) 2020-12-22
CN111138458A (zh) 2020-05-12
AU2016271762B2 (en) 2020-01-23
TWI700284B (zh) 2020-08-01
IL255580A (en) 2018-01-31
JP2020097568A (ja) 2020-06-25
RU2017145082A (ru) 2019-07-01
US20180162876A1 (en) 2018-06-14
EP3305789A1 (en) 2018-04-11
CA2987384A1 (en) 2016-12-08
WO2016194806A1 (ja) 2016-12-08
HK1253539A1 (zh) 2019-06-21

Similar Documents

Publication Publication Date Title
HK1253539A1 (zh) 具有hiv複製抑制作用的含氮三環性衍生物
IL291598A (en) History of benzodiazepine cytotoxicity
HK1245253A1 (zh) Parg抑制化合物
EP3193667A4 (en) Modular shelving
GB2529856B (en) Modular furniture system
ZA201900019B (en) Pharmaceutical combinations
IL257808B (en) decarboxylation without water
HK1253011A1 (zh) 聯合hiv療法
EP3144311A4 (en) Tricyclic heterocyclic derivative having hiv replication-inhibiting effect
PL3310784T3 (pl) Związki tricykliczne i ich zastosowanie jako inhibitory fosfodiesterazy
PL3531872T3 (pl) Mebel
HK1245796A1 (zh) 黃嘌呤衍生物
PT3187071T (pt) Gaveta
GB201612404D0 (en) Vdu
GB201607978D0 (en) Inhibitory compounds
AU201613667S (en) Log splitter
GB201610579D0 (en) Furniture
AU2015904138A0 (en) Saddle Shelving
GB201517291D0 (en) Modular furniture system
EP3174864A4 (en) Vmat inhibitory compounds
GB201509287D0 (en) Modular furniture system
GB201402369D0 (en) Pair Pursuit