SG11201505934XA - Spiro-lactam nmda receptor modulators and uses thereof - Google Patents
Spiro-lactam nmda receptor modulators and uses thereofInfo
- Publication number
- SG11201505934XA SG11201505934XA SG11201505934XA SG11201505934XA SG11201505934XA SG 11201505934X A SG11201505934X A SG 11201505934XA SG 11201505934X A SG11201505934X A SG 11201505934XA SG 11201505934X A SG11201505934X A SG 11201505934XA SG 11201505934X A SG11201505934X A SG 11201505934XA
- Authority
- SG
- Singapore
- Prior art keywords
- spiro
- nmda receptor
- receptor modulators
- lactam nmda
- lactam
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361757934P | 2013-01-29 | 2013-01-29 | |
PCT/US2014/013623 WO2014120786A1 (en) | 2013-01-29 | 2014-01-29 | Spiro-lactam nmda receptor modulators and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201505934XA true SG11201505934XA (en) | 2015-09-29 |
Family
ID=50071822
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201505934XA SG11201505934XA (en) | 2013-01-29 | 2014-01-29 | Spiro-lactam nmda receptor modulators and uses thereof |
Country Status (16)
Country | Link |
---|---|
US (2) | US9758525B2 (ru) |
EP (1) | EP2951184A1 (ru) |
JP (1) | JP6419087B2 (ru) |
KR (1) | KR20150110787A (ru) |
CN (1) | CN105229010A (ru) |
AU (1) | AU2014212487C1 (ru) |
BR (1) | BR112015018092A2 (ru) |
CA (1) | CA2898863A1 (ru) |
CL (1) | CL2015002123A1 (ru) |
EA (1) | EA031905B1 (ru) |
IL (1) | IL240166A0 (ru) |
MX (1) | MX2015009773A (ru) |
PE (1) | PE20151437A1 (ru) |
PH (1) | PH12015501595A1 (ru) |
SG (1) | SG11201505934XA (ru) |
WO (1) | WO2014120786A1 (ru) |
Families Citing this family (38)
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CN102186883B (zh) | 2008-09-18 | 2016-08-03 | 西北大学 | Nmda受体调节剂和其用途 |
CN107936076B (zh) | 2011-09-08 | 2021-10-15 | 萨奇治疗股份有限公司 | 神经活性类固醇、组合物、及其用途 |
CN105408336B (zh) | 2013-01-29 | 2018-06-26 | 阿普廷伊克斯股份有限公司 | 螺-内酰胺nmda受体调节剂及其用途 |
EP2951186B1 (en) | 2013-01-29 | 2018-07-25 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
CA2898861C (en) | 2013-01-29 | 2021-07-20 | Naurex, Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
AU2014212501A1 (en) | 2013-01-29 | 2015-07-30 | Aptinyx, Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
SG11201505934XA (en) | 2013-01-29 | 2015-09-29 | Naurex Inc | Spiro-lactam nmda receptor modulators and uses thereof |
JP6255082B2 (ja) | 2013-03-13 | 2017-12-27 | セージ セラピューティクス, インコーポレイテッド | 神経刺激性ステロイドおよびその使用方法 |
EP3157528B1 (en) | 2014-06-18 | 2023-09-13 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
KR20170065637A (ko) * | 2014-10-07 | 2017-06-13 | 세이지 테라퓨틱스, 인크. | 신경활성 화합물 및 그의 사용 방법 |
CN104326960A (zh) * | 2014-11-04 | 2015-02-04 | 崇州合瑞科技有限公司 | 一种制备Boc-L-脯氨酸的方法 |
CN104326943A (zh) * | 2014-11-04 | 2015-02-04 | 崇州合瑞科技有限公司 | 一种制备Boc-L-丝氨酸的方法 |
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KR20180026742A (ko) | 2015-07-06 | 2018-03-13 | 세이지 테라퓨틱스, 인크. | 옥시스테롤 및 그의 사용 방법 |
AU2016289965B2 (en) | 2015-07-06 | 2021-09-09 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
EP3411369A1 (en) * | 2016-02-01 | 2018-12-12 | Lupin Limited | Process for the preparation of ledipasvir and intermediates thereof |
BR112018070123A2 (pt) | 2016-04-01 | 2019-02-05 | Sage Therapeutics Inc | oxiesterós e métodos de uso dos mesmos |
CN105924402A (zh) * | 2016-05-06 | 2016-09-07 | 蚌埠中实化学技术有限公司 | 一种2-胺基甲基嘧啶盐酸盐的制备方法 |
WO2017193046A1 (en) | 2016-05-06 | 2017-11-09 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
JP6590226B2 (ja) * | 2016-05-11 | 2019-10-16 | 株式会社シード探索研究所 | オキサアジリジン化合物およびその製造方法 |
CA3024606C (en) | 2016-05-19 | 2019-09-03 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
WO2017201285A1 (en) * | 2016-05-19 | 2017-11-23 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
LT3481846T (lt) | 2016-07-07 | 2021-08-25 | Sage Therapeutics, Inc. | 11-pakeistieji 24-hidroksisteroliai, skirti naudoti gydant su nmda susijusias būkles |
WO2018026763A1 (en) | 2016-08-01 | 2018-02-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
EP3490990B1 (en) | 2016-08-01 | 2023-12-06 | Tenacia Biotechnology (Hong Kong) Co., Limited | Spiro-lactam nmda modulators and methods of using same |
PE20190503A1 (es) * | 2016-08-01 | 2019-04-10 | Aptinyx Inc | Moduladores del receptor nmda espiro-lactam y uso de los mismos |
CA3031539C (en) | 2016-08-01 | 2023-11-28 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
BR112019001926A2 (pt) * | 2016-08-01 | 2019-08-06 | Aptinyx Inc | moduladores do receptor nmda espiro-lactama e bis-espiro-lactama e usos destes |
MA46351A (fr) | 2016-09-30 | 2021-06-02 | Sage Therapeutics Inc | Oxystérols substitués en c7 et procédés en tant que modulateurs nmda |
CN115181153A (zh) | 2016-10-18 | 2022-10-14 | 萨奇治疗股份有限公司 | 氧甾醇及其使用方法 |
KR20230051723A (ko) | 2016-10-18 | 2023-04-18 | 세이지 테라퓨틱스, 인크. | 옥시스테롤 및 그의 사용 방법 |
CN107602436A (zh) * | 2017-09-29 | 2018-01-19 | 新发药业有限公司 | 一种n‑取代‑l‑焦谷氨酸酯的绿色制备方法 |
WO2019152696A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
WO2019152685A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and methods of using same |
SG11202007251XA (en) * | 2018-01-31 | 2020-08-28 | Aptinyx Inc | Spiro-lactam nmda receptor modulators and uses thereof |
PE20210455A1 (es) | 2018-01-31 | 2021-03-08 | Aptinyx Inc | Moduladores del receptor nmda espiro-lactama y usos de los mismos |
EP3986400A4 (en) * | 2019-06-24 | 2023-05-17 | Naurex Inc. | METHODS AND INTERMEDIATES FOR THE PRODUCTION OF DIAZASPIROLACTAM COMPOUNDS |
KR20220061088A (ko) * | 2019-06-24 | 2022-05-12 | 노렉스, 인크. | 고체 형태의 tert-부틸 (S)-2-((2S,3R)-1-아미노-3-히드록시-1-옥소부탄-2-일)-1-옥소-2,5-디아자스피로[3.4]옥탄-5-카르복실레이트 및 제조 방법 |
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AU2014212501A1 (en) * | 2013-01-29 | 2015-07-30 | Aptinyx, Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
EP2951186B1 (en) * | 2013-01-29 | 2018-07-25 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
CA2898861C (en) | 2013-01-29 | 2021-07-20 | Naurex, Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
SG11201505934XA (en) | 2013-01-29 | 2015-09-29 | Naurex Inc | Spiro-lactam nmda receptor modulators and uses thereof |
-
2014
- 2014-01-29 SG SG11201505934XA patent/SG11201505934XA/en unknown
- 2014-01-29 PE PE2015001570A patent/PE20151437A1/es not_active Application Discontinuation
- 2014-01-29 MX MX2015009773A patent/MX2015009773A/es unknown
- 2014-01-29 AU AU2014212487A patent/AU2014212487C1/en active Active
- 2014-01-29 US US14/764,411 patent/US9758525B2/en active Active
- 2014-01-29 WO PCT/US2014/013623 patent/WO2014120786A1/en active Application Filing
- 2014-01-29 CA CA2898863A patent/CA2898863A1/en not_active Abandoned
- 2014-01-29 CN CN201480018641.8A patent/CN105229010A/zh active Pending
- 2014-01-29 EA EA201591403A patent/EA031905B1/ru not_active IP Right Cessation
- 2014-01-29 KR KR1020157023288A patent/KR20150110787A/ko not_active Application Discontinuation
- 2014-01-29 EP EP14703748.5A patent/EP2951184A1/en not_active Withdrawn
- 2014-01-29 JP JP2015556100A patent/JP6419087B2/ja active Active
- 2014-01-29 BR BR112015018092A patent/BR112015018092A2/pt not_active Application Discontinuation
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2015
- 2015-07-20 PH PH12015501595A patent/PH12015501595A1/en unknown
- 2015-07-27 IL IL240166A patent/IL240166A0/en unknown
- 2015-07-29 CL CL2015002123A patent/CL2015002123A1/es unknown
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2017
- 2017-08-02 US US15/667,014 patent/US10273239B2/en active Active
Also Published As
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WO2014120786A1 (en) | 2014-08-07 |
CA2898863A1 (en) | 2014-08-07 |
EP2951184A1 (en) | 2015-12-09 |
JP6419087B2 (ja) | 2018-11-07 |
US20180179217A1 (en) | 2018-06-28 |
PH12015501595B1 (en) | 2015-10-19 |
EA031905B1 (ru) | 2019-03-29 |
PH12015501595A1 (en) | 2015-10-19 |
AU2014212487A1 (en) | 2015-07-30 |
MX2015009773A (es) | 2016-08-05 |
BR112015018092A2 (pt) | 2017-07-18 |
US9758525B2 (en) | 2017-09-12 |
AU2014212487C1 (en) | 2018-10-25 |
KR20150110787A (ko) | 2015-10-02 |
US10273239B2 (en) | 2019-04-30 |
PE20151437A1 (es) | 2015-10-10 |
EA201591403A1 (ru) | 2017-05-31 |
IL240166A0 (en) | 2015-09-24 |
JP2016506960A (ja) | 2016-03-07 |
CL2015002123A1 (es) | 2015-12-04 |
AU2014212487B2 (en) | 2018-04-19 |
US20150368253A1 (en) | 2015-12-24 |
CN105229010A (zh) | 2016-01-06 |
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