HK1218418A1 - 螺-內酰胺 受體調節劑及其用途 - Google Patents
螺-內酰胺 受體調節劑及其用途Info
- Publication number
- HK1218418A1 HK1218418A1 HK16106443.2A HK16106443A HK1218418A1 HK 1218418 A1 HK1218418 A1 HK 1218418A1 HK 16106443 A HK16106443 A HK 16106443A HK 1218418 A1 HK1218418 A1 HK 1218418A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- nmda
- spiro
- lactam
- receptor modulators
- nmda receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361757920P | 2013-01-29 | 2013-01-29 | |
PCT/US2014/013621 WO2014120784A1 (en) | 2013-01-29 | 2014-01-29 | Spiro-lactam nmda receptor modulators and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1218418A1 true HK1218418A1 (zh) | 2017-02-17 |
Family
ID=50069346
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK16106443.2A HK1218418A1 (zh) | 2013-01-29 | 2016-06-06 | 螺-內酰胺 受體調節劑及其用途 |
Country Status (17)
Country | Link |
---|---|
US (5) | US9828384B2 (zh) |
EP (1) | EP2951182B1 (zh) |
JP (1) | JP6531042B2 (zh) |
KR (1) | KR102410989B1 (zh) |
CN (1) | CN105408336B (zh) |
AU (1) | AU2014212485C1 (zh) |
BR (1) | BR112015018089B1 (zh) |
CA (1) | CA2898774C (zh) |
CL (1) | CL2015002122A1 (zh) |
EA (1) | EA032153B1 (zh) |
HK (1) | HK1218418A1 (zh) |
IL (1) | IL240162B (zh) |
MX (1) | MX2015009772A (zh) |
PE (1) | PE20151427A1 (zh) |
PH (1) | PH12015501596A1 (zh) |
SG (1) | SG11201505942YA (zh) |
WO (1) | WO2014120784A1 (zh) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102186883B (zh) | 2008-09-18 | 2016-08-03 | 西北大学 | Nmda受体调节剂和其用途 |
AU2014212501A1 (en) | 2013-01-29 | 2015-07-30 | Aptinyx, Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
EP2951186B1 (en) | 2013-01-29 | 2018-07-25 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
CA2898861C (en) | 2013-01-29 | 2021-07-20 | Naurex, Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
SG11201505934XA (en) | 2013-01-29 | 2015-09-29 | Naurex Inc | Spiro-lactam nmda receptor modulators and uses thereof |
CN105408336B (zh) | 2013-01-29 | 2018-06-26 | 阿普廷伊克斯股份有限公司 | 螺-内酰胺nmda受体调节剂及其用途 |
CA3024606C (en) | 2016-05-19 | 2019-09-03 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
WO2017201285A1 (en) | 2016-05-19 | 2017-11-23 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
CA3031539C (en) | 2016-08-01 | 2023-11-28 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
PE20190503A1 (es) * | 2016-08-01 | 2019-04-10 | Aptinyx Inc | Moduladores del receptor nmda espiro-lactam y uso de los mismos |
WO2018026763A1 (en) | 2016-08-01 | 2018-02-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
BR112019001926A2 (pt) | 2016-08-01 | 2019-08-06 | Aptinyx Inc | moduladores do receptor nmda espiro-lactama e bis-espiro-lactama e usos destes |
EP3490990B1 (en) | 2016-08-01 | 2023-12-06 | Tenacia Biotechnology (Hong Kong) Co., Limited | Spiro-lactam nmda modulators and methods of using same |
PE20210455A1 (es) | 2018-01-31 | 2021-03-08 | Aptinyx Inc | Moduladores del receptor nmda espiro-lactama y usos de los mismos |
WO2019152685A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and methods of using same |
WO2019152696A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
WO2019152681A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof |
WO2019152688A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
SG11202007251XA (en) * | 2018-01-31 | 2020-08-28 | Aptinyx Inc | Spiro-lactam nmda receptor modulators and uses thereof |
JP2023525860A (ja) * | 2020-05-12 | 2023-06-19 | ベイジン・グレートウェイ・ファーマシューティカル・テクノロジー・カンパニー・リミテッド | Nmda受容体の活性を調節する化合物、その医薬組成物及び使用 |
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SG11201505934XA (en) | 2013-01-29 | 2015-09-29 | Naurex Inc | Spiro-lactam nmda receptor modulators and uses thereof |
EP2951186B1 (en) | 2013-01-29 | 2018-07-25 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
CA2898861C (en) | 2013-01-29 | 2021-07-20 | Naurex, Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
AU2014212501A1 (en) | 2013-01-29 | 2015-07-30 | Aptinyx, Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
CN105408336B (zh) | 2013-01-29 | 2018-06-26 | 阿普廷伊克斯股份有限公司 | 螺-内酰胺nmda受体调节剂及其用途 |
-
2014
- 2014-01-29 CN CN201480018643.7A patent/CN105408336B/zh active Active
- 2014-01-29 KR KR1020157023289A patent/KR102410989B1/ko active IP Right Grant
- 2014-01-29 MX MX2015009772A patent/MX2015009772A/es active IP Right Grant
- 2014-01-29 EA EA201591402A patent/EA032153B1/ru unknown
- 2014-01-29 BR BR112015018089-2A patent/BR112015018089B1/pt active IP Right Grant
- 2014-01-29 WO PCT/US2014/013621 patent/WO2014120784A1/en active Application Filing
- 2014-01-29 CA CA2898774A patent/CA2898774C/en active Active
- 2014-01-29 SG SG11201505942YA patent/SG11201505942YA/en unknown
- 2014-01-29 US US14/764,402 patent/US9828384B2/en active Active
- 2014-01-29 PE PE2015001568A patent/PE20151427A1/es unknown
- 2014-01-29 EP EP14703247.8A patent/EP2951182B1/en active Active
- 2014-01-29 JP JP2015556099A patent/JP6531042B2/ja active Active
- 2014-01-29 AU AU2014212485A patent/AU2014212485C1/en active Active
-
2015
- 2015-07-20 PH PH12015501596A patent/PH12015501596A1/en unknown
- 2015-07-27 IL IL240162A patent/IL240162B/en active IP Right Grant
- 2015-07-29 CL CL2015002122A patent/CL2015002122A1/es unknown
-
2016
- 2016-06-06 HK HK16106443.2A patent/HK1218418A1/zh unknown
-
2017
- 2017-08-08 US US15/671,409 patent/US20180179218A1/en not_active Abandoned
-
2018
- 2018-03-28 US US15/938,040 patent/US20180215767A1/en not_active Abandoned
- 2018-05-02 US US15/968,976 patent/US20180244680A1/en not_active Abandoned
-
2020
- 2020-07-02 US US16/919,438 patent/US20210155632A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP2951182B1 (en) | 2020-03-18 |
US20150368252A1 (en) | 2015-12-24 |
BR112015018089B1 (pt) | 2022-09-20 |
EA201591402A1 (ru) | 2015-12-30 |
AU2014212485A1 (en) | 2015-07-30 |
US20180215767A1 (en) | 2018-08-02 |
CL2015002122A1 (es) | 2015-12-18 |
CA2898774A1 (en) | 2014-08-07 |
NZ709872A (en) | 2020-09-25 |
CA2898774C (en) | 2021-07-13 |
BR112015018089A2 (pt) | 2017-07-18 |
IL240162B (en) | 2020-08-31 |
IL240162A0 (en) | 2015-09-24 |
JP6531042B2 (ja) | 2019-06-12 |
KR20150110788A (ko) | 2015-10-02 |
US9828384B2 (en) | 2017-11-28 |
AU2014212485B2 (en) | 2018-04-19 |
WO2014120784A1 (en) | 2014-08-07 |
CN105408336B (zh) | 2018-06-26 |
US20180179218A1 (en) | 2018-06-28 |
AU2014212485C1 (en) | 2018-10-25 |
US20180244680A1 (en) | 2018-08-30 |
PH12015501596A1 (en) | 2015-10-19 |
EP2951182A1 (en) | 2015-12-09 |
CN105408336A (zh) | 2016-03-16 |
EA032153B1 (ru) | 2019-04-30 |
SG11201505942YA (en) | 2015-08-28 |
JP2016506959A (ja) | 2016-03-07 |
KR102410989B1 (ko) | 2022-06-17 |
PE20151427A1 (es) | 2015-10-10 |
US20210155632A1 (en) | 2021-05-27 |
MX2015009772A (es) | 2016-05-31 |
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