SG10201608749UA - Methods of therapeutic monitoring of phenylacetic acid prodrugs - Google Patents

Methods of therapeutic monitoring of phenylacetic acid prodrugs

Info

Publication number: SG10201608749UA
Authority: SG; Singapore
Prior art keywords: methods; phenylacetic acid; therapeutic monitoring; acid prodrugs; prodrugs
Prior art date: 2012-04-20

Application number

SG10201608749UA

Other languages

English (en)

Inventor

Bruce Scharschmidt

Masoud Mokhtarani

Original Assignee

Horizon Therapeutics Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-04-20

Filing date

2012-09-11

Publication date

2016-12-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49380684&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201608749U(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2012-09-11 Application filed by Horizon Therapeutics Llc filed Critical Horizon Therapeutics Llc

2016-12-29 Publication of SG10201608749UA publication Critical patent/SG10201608749UA/en

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6806—Determination of free amino acids
- G01N33/6812—Assays for specific amino acids

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Physics & Mathematics (AREA)
Immunology (AREA)
Emergency Medicine (AREA)
Analytical Chemistry (AREA)
Microbiology (AREA)
Food Science & Technology (AREA)
Cell Biology (AREA)
Biochemistry (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Biotechnology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Bioinformatics & Computational Biology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Hospice & Palliative Care (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Gastroenterology & Hepatology (AREA)

SG10201608749UA 2012-04-20 2012-09-11 Methods of therapeutic monitoring of phenylacetic acid prodrugs SG10201608749UA (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US201261636256P	2012-04-20	2012-04-20

Publications (1)

Publication Number	Publication Date
SG10201608749UA true SG10201608749UA (en)	2016-12-29

Family

ID=49380684

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SG10201608749UA SG10201608749UA (en)	2012-04-20	2012-09-11	Methods of therapeutic monitoring of phenylacetic acid prodrugs
SG11201406745VA SG11201406745VA (en)	2012-04-20	2012-09-11	Methods of therapeutic monitoring of phenylacetic acid prodrugs

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
SG11201406745VA SG11201406745VA (en)	2012-04-20	2012-09-11	Methods of therapeutic monitoring of phenylacetic acid prodrugs

Country Status (25)

Country	Link
US (4)	US9561197B2 (hr)
EP (2)	EP2846791B1 (hr)
JP (3)	JP6234436B2 (hr)
KR (2)	KR20150013170A (hr)
CN (3)	CN104540507A (hr)
AU (3)	AU2012377389A1 (hr)
BR (1)	BR112014026138A2 (hr)
CL (2)	CL2014002807A1 (hr)
CY (1)	CY1118838T1 (hr)
DK (1)	DK2846791T3 (hr)
EC (1)	ECSP14024561A (hr)
ES (2)	ES2623470T3 (hr)
HK (2)	HK1208380A1 (hr)
HR (1)	HRP20170651T1 (hr)
HU (1)	HUE032726T2 (hr)
IL (2)	IL235127A (hr)
LT (1)	LT2846791T (hr)
MX (1)	MX365302B (hr)
PL (1)	PL2846791T3 (hr)
PT (1)	PT2846791T (hr)
RS (1)	RS55870B1 (hr)
SG (2)	SG10201608749UA (hr)
SI (1)	SI2846791T1 (hr)
WO (1)	WO2013158145A1 (hr)
ZA (1)	ZA201407597B (hr)

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KR20140094517A (ko)	2011-09-30	2014-07-30	하이페리온 쎄라퓨틱스, 인크.	질소 스캐빈징 약물들의 치료학적 모니터링 방법들
CN104540507A (zh) *	2012-04-20	2015-04-22	海波龙治疗公司	苯乙酸前药的治疗性监测方法
JP2016506378A (ja)	2012-11-21	2016-03-03	ハイペリオンセラピューティクス，インコーポレイテッド	肝性脳症の治療のための窒素除去薬の投与方法および評価方法
EP2986325B1 (en)	2013-10-14	2019-06-26	Immedica Pharma AB	Methods of treating urea cycle disorders
WO2015187641A1 (en) *	2014-06-04	2015-12-10	Horizon Therapeutics, Inc.	Methods for treating urea cycle disorders to prevent hyperammonemic crises by controlling blood ammonia levels
US9914692B2 (en)	2016-05-25	2018-03-13	Horizon Therapeutics, Llc	Procedure for the preparation of 4-phenyl butyrate and uses thereof
US20190076383A1 (en) *	2017-09-08	2019-03-14	Horizon Therapeutics, Llc	Methods for treating urea cycle disorders
US10668040B2 (en)	2017-09-11	2020-06-02	Horizon Therapeutics, Llc	Treatment of urea cycle disorders in neonates and infants

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US20050273359A1 (en)	2004-06-03	2005-12-08	Young David E	System and method of evaluating preoperative medical care and determining recommended tests based on patient health history and medical condition and nature of surgical procedure
SI2319581T1 (sl)	2004-11-26	2015-10-30	Ucl Business Plc	Pripravki, ki obsegajo ornitin in fenilacetat ali fenilbutirat za zdravljenje hepatične encefalopatije
US20060135612A1 (en)	2004-12-17	2006-06-22	U.S. Department Of Veterans Affairs	Method of ameliorating or abrogating the effects of a neurodegenerative disorder, such as amyotrophic lateral sclerosis (ALS), by using a HDAC inhibiting agent
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WO2007059031A2 (en)	2005-11-10	2007-05-24	Massachusetts Institute Of Technology	Methods and compositions for raising levels and release of gamma aminobutyric acid
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PL3133396T3 (pl)	2008-04-29	2019-03-29	Horizon Therapeutics, Llc	Sposób leczenia z zastosowaniem leków wychwytujących amoniak
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CN104540507A (zh)	2012-04-20	2015-04-22	海波龙治疗公司	苯乙酸前药的治疗性监测方法
JP2016506378A (ja)	2012-11-21	2016-03-03	ハイペリオンセラピューティクス，インコーポレイテッド	肝性脳症の治療のための窒素除去薬の投与方法および評価方法

2012
- 2012-09-11 CN CN201280074143.6A patent/CN104540507A/zh active Pending
- 2012-09-11 KR KR1020147032114A patent/KR20150013170A/ko not_active IP Right Cessation
- 2012-09-11 BR BR112014026138A patent/BR112014026138A2/pt not_active Application Discontinuation
- 2012-09-11 KR KR1020197029026A patent/KR102264579B1/ko active IP Right Grant
- 2012-09-11 US US13/610,580 patent/US9561197B2/en active Active
- 2012-09-11 LT LTEP12874745.8T patent/LT2846791T/lt unknown
- 2012-09-11 CN CN202111191403.5A patent/CN113995743A/zh active Pending
- 2012-09-11 SI SI201230933A patent/SI2846791T1/sl unknown
- 2012-09-11 EP EP12874745.8A patent/EP2846791B1/en active Active
- 2012-09-11 MX MX2014012694A patent/MX365302B/es active IP Right Grant
- 2012-09-11 AU AU2012377389A patent/AU2012377389A1/en not_active Abandoned
- 2012-09-11 HU HUE12874745A patent/HUE032726T2/en unknown
- 2012-09-11 CN CN202010449455.7A patent/CN111991383A/zh active Pending
- 2012-09-11 DK DK12874745.8T patent/DK2846791T3/en active
- 2012-09-11 SG SG10201608749UA patent/SG10201608749UA/en unknown
- 2012-09-11 RS RS20170421A patent/RS55870B1/sr unknown
- 2012-09-11 PT PT128747458T patent/PT2846791T/pt unknown
- 2012-09-11 PL PL12874745T patent/PL2846791T3/pl unknown
- 2012-09-11 WO PCT/US2012/054673 patent/WO2013158145A1/en active Application Filing
- 2012-09-11 SG SG11201406745VA patent/SG11201406745VA/en unknown
- 2012-09-11 ES ES12874745.8T patent/ES2623470T3/es active Active
- 2012-09-11 JP JP2015506953A patent/JP6234436B2/ja active Active
- 2012-09-11 ES ES17154858T patent/ES2807951T3/es active Active
- 2012-09-11 EP EP17154858.9A patent/EP3222275B1/en active Active
2014
- 2014-10-17 CL CL2014002807A patent/CL2014002807A1/es unknown
- 2014-10-19 IL IL235127A patent/IL235127A/en active IP Right Grant
- 2014-10-20 ZA ZA2014/07597A patent/ZA201407597B/en unknown
- 2014-10-27 EC ECIEPI201424561A patent/ECSP14024561A/es unknown
2015
- 2015-09-18 HK HK15109202.8A patent/HK1208380A1/xx unknown
2017
- 2017-01-10 US US15/402,780 patent/US20170266143A1/en not_active Abandoned
- 2017-04-20 CY CY20171100449T patent/CY1118838T1/el unknown
- 2017-04-27 HR HRP20170651TT patent/HRP20170651T1/hr unknown
- 2017-05-30 CL CL2017001375A patent/CL2017001375A1/es unknown
- 2017-08-25 US US15/687,136 patent/US20180015058A1/en not_active Abandoned
- 2017-10-24 JP JP2017204831A patent/JP6637941B2/ja active Active
- 2017-11-26 IL IL255918A patent/IL255918B/en active IP Right Grant
2018
- 2018-01-09 AU AU2018200163A patent/AU2018200163B2/en active Active
- 2018-03-15 HK HK18103625.7A patent/HK1243959A1/zh unknown
- 2018-05-15 US US15/980,431 patent/US20180263938A1/en not_active Abandoned
2019
- 2019-03-15 AU AU2019201811A patent/AU2019201811B2/en active Active
- 2019-08-19 JP JP2019149843A patent/JP2019219413A/ja active Pending

Also Published As

Publication number	Publication date
US9561197B2 (en)	2017-02-07
DK2846791T3 (en)	2017-03-27
RS55870B1 (sr)	2017-08-31
JP2018039830A (ja)	2018-03-15
US20180263938A1 (en)	2018-09-20
CN111991383A (zh)	2020-11-27
JP6637941B2 (ja)	2020-01-29
MX2014012694A (es)	2015-06-03
EP3222275B1 (en)	2020-06-24
IL255918A (en)	2018-01-31
SI2846791T1 (sl)	2017-06-30
AU2018200163B2 (en)	2018-12-20
PL2846791T3 (pl)	2017-07-31
ES2807951T3 (es)	2021-02-24
AU2018200163A1 (en)	2018-02-01
JP2019219413A (ja)	2019-12-26
IL255918B (en)	2019-06-30
US20170266143A1 (en)	2017-09-21
KR20150013170A (ko)	2015-02-04
KR20190116552A (ko)	2019-10-14
JP2015514757A (ja)	2015-05-21
CL2017001375A1 (es)	2018-01-05
EP2846791A4 (en)	2015-08-19
PT2846791T (pt)	2017-05-25
EP2846791B1 (en)	2017-02-08
CY1118838T1 (el)	2018-01-10
IL235127A (en)	2017-12-31
AU2019201811A1 (en)	2019-04-04
CL2014002807A1 (es)	2015-02-27
AU2019201811B2 (en)	2020-07-09
EP2846791A1 (en)	2015-03-18
MX365302B (es)	2019-05-29
ES2623470T3 (es)	2017-07-11
US20180015058A1 (en)	2018-01-18
WO2013158145A1 (en)	2013-10-24
SG11201406745VA (en)	2014-12-30
US20130281530A1 (en)	2013-10-24
ECSP14024561A (es)	2015-09-30
CN104540507A (zh)	2015-04-22
JP6234436B2 (ja)	2017-11-22
AU2012377389A1 (en)	2014-10-30
BR112014026138A2 (pt)	2017-06-27
HUE032726T2 (en)	2017-10-30
HK1208380A1 (en)	2016-03-04
HK1243959A1 (zh)	2018-07-27
ZA201407597B (en)	2017-05-31
EP3222275A1 (en)	2017-09-27
HRP20170651T1 (hr)	2017-06-30
LT2846791T (lt)	2017-04-10
KR102264579B1 (ko)	2021-06-11
WO2013158145A9 (en)	2014-05-01
CN113995743A (zh)	2022-02-01

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