AU2001264932A1 - Oxo-imidazopyrimidine-carboxamides and their use as gaba brain receptor ligands - Google Patents

Oxo-imidazopyrimidine-carboxamides and their use as gaba brain receptor ligands

Info

Publication number
AU2001264932A1
AU2001264932A1 AU2001264932A AU6493201A AU2001264932A1 AU 2001264932 A1 AU2001264932 A1 AU 2001264932A1 AU 2001264932 A AU2001264932 A AU 2001264932A AU 6493201 A AU6493201 A AU 6493201A AU 2001264932 A1 AU2001264932 A1 AU 2001264932A1
Authority
AU
Australia
Prior art keywords
imidazopyrimidine
carboxamides
oxo
receptor ligands
brain receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001264932A
Inventor
Pamela Albaugh
Guolin Cai
Kenneth Shaw
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neurogen Corp
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of AU2001264932A1 publication Critical patent/AU2001264932A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2001264932A 2000-05-26 2001-05-24 Oxo-imidazopyrimidine-carboxamides and their use as gaba brain receptor ligands Abandoned AU2001264932A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20985500P 2000-05-26 2000-05-26
US60209855 2000-05-26
PCT/US2001/016884 WO2001092257A1 (en) 2000-05-26 2001-05-24 Oxo-imidazopyrimidine-carboxamides and their use as gaba brain receptor ligands

Publications (1)

Publication Number Publication Date
AU2001264932A1 true AU2001264932A1 (en) 2001-12-11

Family

ID=22780592

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001264932A Abandoned AU2001264932A1 (en) 2000-05-26 2001-05-24 Oxo-imidazopyrimidine-carboxamides and their use as gaba brain receptor ligands

Country Status (3)

Country Link
US (1) US6723332B2 (en)
AU (1) AU2001264932A1 (en)
WO (1) WO2001092257A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2441926A1 (en) 2001-03-27 2002-10-03 Neurogen Corporation (oxo-pyrazolo[1,5a]pyrimidin-2-yl)alkyl-carboxamides
CA2954376C (en) 2006-10-16 2019-06-11 Bionomics Limited Novel anxiolytic compounds
US10954231B2 (en) 2006-10-16 2021-03-23 Bionomics Limited Anxiolytic compounds
SI2516433T1 (en) * 2009-12-21 2014-09-30 Array Biopharma, Inc. Substituted n-(1h-indazol-4-yl)imidazoš1, 2-aćpyridine-3- carboxamide compounds as cfms inhibitors
SG184073A1 (en) 2010-03-18 2012-10-30 Pasteur Institut Korea Anti-infective compounds
JP2014510065A (en) 2011-03-02 2014-04-24 バイオノミックス リミテッド Novel small molecules as therapeutic agents
EP2707367B1 (en) 2011-05-12 2019-10-09 Bionomics Limited Methods for preparing naphthyridines
WO2012178125A1 (en) 2011-06-22 2012-12-27 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
SI2941432T1 (en) 2012-12-07 2018-07-31 Vertex Pharmaceuticals Incorporated 2-amino-6-fluoro-n-(5-fluoro-4-(4-(4-(oxetan-3-yl)piperazine-1-carbonyl)piperidin-1-yl)pyridin-3-yl)pyrazolo(1,5alpha)pyrimidine-3-carboxamide as inhibitor of atr kinase
EP2970288A1 (en) 2013-03-15 2016-01-20 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
JP2016512239A (en) 2013-03-15 2016-04-25 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Compounds useful as inhibitors of ATR kinase
WO2014143240A1 (en) 2013-03-15 2014-09-18 Vertex Pharmaceuticals Incorporated Fused pyrazolopyrimidine derivatives useful as inhibitors of atr kinase
RU2720408C2 (en) 2013-12-06 2020-04-29 Вертекс Фармасьютикалз Инкорпорейтед Method of producing atr kinase inhibitors (embodiments)
RU2719583C2 (en) 2014-06-05 2020-04-21 Вертекс Фармасьютикалз Инкорпорейтед Radiolabelled 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]-pyrazolo [1, 5-a] pyrimidine-3-carboxamide derivatives used as atr kinase inhibitor, preparations based thereon compounds and various solid forms thereof
CA2950780C (en) 2014-06-17 2023-05-16 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of chk1 and atr inhibitors
JP7187308B2 (en) 2015-09-30 2022-12-12 バーテックス ファーマシューティカルズ インコーポレイテッド Methods for treating cancer using combinations of DNA damaging agents and ATR inhibitors
US20220370461A1 (en) * 2019-10-21 2022-11-24 Sk Biopharmaceuticals Co., Ltd. Use of imidazopyrimidine or imidazotriazine compounds for prevention, alleviation, or treatment of cognitive disorders, or for improving cognitive function
WO2024117205A1 (en) * 2022-11-30 2024-06-06 北興化学工業株式会社 Bicyclic pyridine derivative and salt thereof, and harmful organism control agent characterized by containing said derivative or salt thereof as active ingredient

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2492382A1 (en) * 1980-10-22 1982-04-23 Synthelabo IMIDAZO (1,2-A) PYRIDINE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF
US5750702A (en) * 1993-10-27 1998-05-12 Neurogen Corporation Certain pyrrolo pyridine-3-carboxamides; a new class of GABA brain receptor ligands
US5804686A (en) * 1996-01-19 1998-09-08 Neurogen Corporation fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
EP0888300A1 (en) 1996-03-22 1999-01-07 Neurogen Corporation Certain fused pyrrolecarboxamides as gaba brain receptor ligands
ES2221996T3 (en) 1997-10-07 2005-01-16 Ortho-Mcneil Pharmaceutical, Inc. DERIVATIVES OF DIPIRIDO-IMIDAZOL USEFUL FOR THE TREATMENT OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM.
GB9801538D0 (en) 1998-01-23 1998-03-25 Merck Sharp & Dohme Pharmaceutical product
GB9805559D0 (en) 1998-03-16 1998-05-13 Merck Sharp & Dohme A combination of therapeutic agents
GB9805561D0 (en) 1998-03-16 1998-05-13 Merck Sharp & Dohme A combination of therapeutic agents
GB9805557D0 (en) 1998-03-16 1998-05-13 Merck Sharp & Dohme A combination of therapeutic agents
EE200200111A (en) 1999-08-31 2003-06-16 Neurogen Corporation Condensed pyrrole carboxamides: brain GABA receptor ligands

Also Published As

Publication number Publication date
US6723332B2 (en) 2004-04-20
WO2001092257A1 (en) 2001-12-06
US20020035120A1 (en) 2002-03-21

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