UY37616A - COMBINATION OF QUINASA ATR INHIBITORS WITH RADIO SALT-223 - Google Patents

COMBINATION OF QUINASA ATR INHIBITORS WITH RADIO SALT-223

Info

Publication number
UY37616A
UY37616A UY0001037616A UY37616A UY37616A UY 37616 A UY37616 A UY 37616A UY 0001037616 A UY0001037616 A UY 0001037616A UY 37616 A UY37616 A UY 37616A UY 37616 A UY37616 A UY 37616A
Authority
UY
Uruguay
Prior art keywords
radio
component
salt
quinasa
combination
Prior art date
Application number
UY0001037616A
Other languages
Spanish (es)
Inventor
Arne Scholz Dr
Antje Margret Wengner Dr
Original Assignee
Bayer Ag
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Bayer Pharma AG filed Critical Bayer Ag
Publication of UY37616A publication Critical patent/UY37616A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

La presente invención abarca combinaciones de por lo menos dos componentes, el componente A y el componente B, donde el componente A es un inhibidor de quinasa ATR, y el componente B que es radio-223, particularmente una sal aceptable desde el punto de vista farmacéutico de radio-223. Otro aspecto adicional de la presente invención abarca el uso de dichas combinaciones como se describe en este documento para la preparación de un medicamento para el tratamiento o la profilaxis de una enfermedad hiperproliferativa, particularmente para el tratamiento del cáncer de próstata como también su metástasis ósea.The present invention encompasses combinations of at least two components, component A and component B, wherein component A is an ATR kinase inhibitor, and component B which is radio-223, particularly a salt acceptable from the point of view. radio pharmacist-223. Another additional aspect of the present invention encompasses the use of such combinations as described herein for the preparation of a medicament for the treatment or prophylaxis of a hyperproliferative disease, particularly for the treatment of prostate cancer as well as its bone metastasis.

UY0001037616A 2017-02-24 2018-02-22 COMBINATION OF QUINASA ATR INHIBITORS WITH RADIO SALT-223 UY37616A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17157764 2017-02-24

Publications (1)

Publication Number Publication Date
UY37616A true UY37616A (en) 2018-09-28

Family

ID=58185318

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001037616A UY37616A (en) 2017-02-24 2018-02-22 COMBINATION OF QUINASA ATR INHIBITORS WITH RADIO SALT-223

Country Status (4)

Country Link
AR (1) AR110995A1 (en)
TW (1) TW201840319A (en)
UY (1) UY37616A (en)
WO (1) WO2018153969A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI700283B (en) 2014-08-04 2020-08-01 德商拜耳製藥公司 2-(morpholin-4-yl)-1,7-naphthyridines
EP3402795B1 (en) 2016-01-14 2019-10-30 Bayer Pharma Aktiengesellschaft 5-substituted 2-(morpholin-4-yl)-1,7-naphthyridines
MA54928A (en) * 2019-02-11 2021-12-22 Bayer Ag BAY1895344 ATR KINASE INHIBITOR FOR USE IN THE TREATMENT OF A HYPER-PROLIFERATIVE DISEASE
CN112773805A (en) * 2019-11-11 2021-05-11 中国科学院脑科学与智能技术卓越创新中心 Novel therapeutic agent for ischemic brain injury
CN114081848A (en) * 2021-11-19 2022-02-25 上海琪维生物科技有限公司 Composition for skin care and application thereof

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JP2014528419A (en) 2011-09-30 2014-10-27 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Compounds useful as ATR kinase inhibitors
WO2013071094A1 (en) 2011-11-09 2013-05-16 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
JP2015502925A (en) 2011-11-09 2015-01-29 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Pyrazine compounds useful as inhibitors of ATR kinase
EP2776420A1 (en) 2011-11-09 2014-09-17 Vertex Pharmaceuticals Incorporated Pyrazine compounds useful as inhibitors of atr kinase
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US8841337B2 (en) 2011-11-09 2014-09-23 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
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JP2016512815A (en) 2013-03-15 2016-05-09 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Condensed pyrazolopyrimidine derivatives useful as inhibitors of ATR kinase
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TWI700283B (en) 2014-08-04 2020-08-01 德商拜耳製藥公司 2-(morpholin-4-yl)-1,7-naphthyridines

Also Published As

Publication number Publication date
WO2018153969A1 (en) 2018-08-30
AR110995A1 (en) 2019-05-22
TW201840319A (en) 2018-11-16

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Effective date: 20231026