SG10201500258WA - Process for the preparation of compounds useful as inhibitors of sglt2 - Google Patents

Process for the preparation of compounds useful as inhibitors of sglt2

Info

Publication number
SG10201500258WA
SG10201500258WA SG10201500258WA SG10201500258WA SG10201500258WA SG 10201500258W A SG10201500258W A SG 10201500258WA SG 10201500258W A SG10201500258W A SG 10201500258WA SG 10201500258W A SG10201500258W A SG 10201500258WA SG 10201500258W A SG10201500258W A SG 10201500258WA
Authority
SG
Singapore
Prior art keywords
sglt2
inhibitors
preparation
compounds useful
compounds
Prior art date
Application number
SG10201500258WA
Inventor
Vittorio Farina
Sebastien Francois Emmanuel Lemaire
Ioannis N Houpis
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43127364&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201500258W(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of SG10201500258WA publication Critical patent/SG10201500258WA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic System
    • C07F3/06—Zinc compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
SG10201500258WA 2009-10-14 2010-10-14 Process for the preparation of compounds useful as inhibitors of sglt2 SG10201500258WA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25137809P 2009-10-14 2009-10-14

Publications (1)

Publication Number Publication Date
SG10201500258WA true SG10201500258WA (en) 2015-03-30

Family

ID=43127364

Family Applications (1)

Application Number Title Priority Date Filing Date
SG10201500258WA SG10201500258WA (en) 2009-10-14 2010-10-14 Process for the preparation of compounds useful as inhibitors of sglt2

Country Status (29)

Country Link
US (1) US9174971B2 (en)
EP (1) EP2488515B1 (en)
JP (1) JP5833011B2 (en)
KR (1) KR101730920B1 (en)
CN (1) CN102648196B (en)
AU (1) AU2010306797B2 (en)
BR (1) BR112012008939B1 (en)
CA (1) CA2777528C (en)
CL (1) CL2012000929A1 (en)
CY (1) CY1118777T1 (en)
DK (1) DK2488515T3 (en)
EA (1) EA024368B1 (en)
ES (1) ES2620469T3 (en)
HK (1) HK1170241A1 (en)
HR (1) HRP20170446T1 (en)
HU (1) HUE031375T2 (en)
IL (1) IL219094A (en)
IN (1) IN2012DN03299A (en)
LT (1) LT2488515T (en)
ME (1) ME02634B (en)
MX (1) MX340214B (en)
NZ (1) NZ599306A (en)
PL (1) PL2488515T3 (en)
PT (1) PT2488515T (en)
RS (1) RS55909B1 (en)
SG (1) SG10201500258WA (en)
SI (1) SI2488515T1 (en)
UA (1) UA109883C2 (en)
WO (1) WO2011047113A1 (en)

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US9024009B2 (en) * 2007-09-10 2015-05-05 Janssen Pharmaceutica N.V. Process for the preparation of compounds useful as inhibitors of SGLT
US9056850B2 (en) * 2008-10-17 2015-06-16 Janssen Pharmaceutica N.V. Process for the preparation of compounds useful as inhibitors of SGLT
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JO3577B1 (en) 2010-05-11 2020-07-05 Janssen Pharmaceutica Nv Pharmaceutical formulations comprising 1-(beta-d-glucopyranosyl)-2-thienylmethylbenzene derivatives as inhibitors of sglt
WO2012140120A1 (en) * 2011-04-13 2012-10-18 Janssen Pharmaceutica Nv Process for the preparation of compounds useful as inhibitors of sglt2
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CN103980261B (en) * 2014-04-01 2016-06-29 天津大学 The A crystal formation of canagliflozin and crystallization preparation method thereof
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US20170247359A1 (en) * 2014-09-05 2017-08-31 Mylan Laboratories Ltd. Process for the preparation of canagliflozin
CN104402946B (en) * 2014-11-17 2018-01-02 连云港恒运药业有限公司 Canagliflozin intermediate and its unbodied preparation method
CN104530023A (en) * 2014-12-25 2015-04-22 重庆医药工业研究院有限责任公司 Crystal form I of Canagliflozin and preparation method thereof
CN104557895B (en) * 2015-01-27 2017-10-31 江苏嘉逸医药有限公司 The synthesis technique of 1 (β D glycopyranosyls) 4 methyl 3 [5 (4 fluorophenyl) 2 thienyl methyls] benzene
US10508128B2 (en) 2015-02-09 2019-12-17 Indoco Remedies Limited Process for the preparation of SGLT inhibitor compounds
US20170071970A1 (en) 2015-09-15 2017-03-16 Janssen Pharmaceutica Nv Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders
CN105153137A (en) * 2015-09-17 2015-12-16 上海应用技术学院 Preparation method of empagliflozin
CZ2015729A3 (en) 2015-10-13 2017-04-26 Zentiva, K.S. Preparation of intermediates for the synthesis of Canagliflozin and Dapagliflozin
US11198703B2 (en) 2017-05-09 2021-12-14 Piramal Enterprises Limited Process for the preparation of SGLT2 inhibitors and intermediates thereof
CN110054657B (en) * 2018-01-18 2021-06-29 亚宝药业集团股份有限公司 Glucopyranosyl substituted pyrazole compound and preparation method thereof
CN112206216B (en) * 2020-10-15 2023-03-17 江西华士药业有限公司 Preparation method of sustained-release dapagliflozin

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