SE8203437L - Azabicyklohexaner, dess anvendningssett och framstellning - Google Patents

Azabicyklohexaner, dess anvendningssett och framstellning

Info

Publication number
SE8203437L
SE8203437L SE8203437A SE8203437A SE8203437L SE 8203437 L SE8203437 L SE 8203437L SE 8203437 A SE8203437 A SE 8203437A SE 8203437 A SE8203437 A SE 8203437A SE 8203437 L SE8203437 L SE 8203437L
Authority
SE
Sweden
Prior art keywords
formula
alkyl
optically active
compounds
hydroxyl
Prior art date
Application number
SE8203437A
Other languages
English (en)
Other versions
SE452610B (sv
Inventor
W J Fanshawe
J W Epstein
L S Crawley
C M Hofmann
S R Safir
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/809,341 external-priority patent/US4118393A/en
Priority claimed from US05/809,339 external-priority patent/US4131611A/en
Priority claimed from US05/809,340 external-priority patent/US4118417A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of SE8203437L publication Critical patent/SE8203437L/sv
Publication of SE452610B publication Critical patent/SE452610B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/40—Unsaturated compounds containing halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/36—Polyhydroxylic alcohols containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/28—Unsaturated compounds polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/34—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Claims (1)

PATENTKRAV satt att aterlosa en farening med formeln COOH COOH van i R betecknar \rate eller alkyl med 1 - 6 kolatomer och fenylgruppen är osubstituerad, mono- eller di-substituerad med vats, halogen, alkyl med 1 - 6 kolatomer, alkoxi med
1. - 6 kolatomer, trifluormetyl, nitro, amino, acetamido oiler hydroxi till deras (+) och (-)-isomerer, kdnnetecknat darav, att nifinnda forening far reagera med antingen (+) eller (-)-m-(1-nafty1)-etylamin, i ett organiskt losningsmedel for framstallning av en fast substans, att namnda fasta substans samlas, uPPslammas i vatten, installes pa basisk reaktion, extraheras med eter och surgares.
SE8203437A 1976-09-15 1982-06-03 Sett att spalta racemiska cis-1,2-cyklopropandikarboxylsyraderivat SE452610B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US72340276A 1976-09-15 1976-09-15
US05/809,341 US4118393A (en) 1977-06-23 1977-06-23 Phenyl azabicyclohexanones
US05/809,339 US4131611A (en) 1975-07-31 1977-06-23 Azabicyclohexanes
US05/809,340 US4118417A (en) 1977-06-23 1977-06-23 Process for resolving cis-1-substituted phenyl-1,2-cyclopropanedicarboxylic acids

Publications (2)

Publication Number Publication Date
SE8203437L true SE8203437L (sv) 1982-06-03
SE452610B SE452610B (sv) 1987-12-07

Family

ID=27505564

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7710367A SE435384B (sv) 1976-09-15 1977-09-15 Analogiforfarande for framstellning av 3-azabicyklo (3.1.0)alkaner
SE8203437A SE452610B (sv) 1976-09-15 1982-06-03 Sett att spalta racemiska cis-1,2-cyklopropandikarboxylsyraderivat

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7710367A SE435384B (sv) 1976-09-15 1977-09-15 Analogiforfarande for framstellning av 3-azabicyklo (3.1.0)alkaner

Country Status (16)

Country Link
JP (1) JPS5337656A (sv)
AR (2) AR220684A1 (sv)
AT (2) AT367036B (sv)
AU (1) AU519620B2 (sv)
BE (1) BE858683A (sv)
CH (2) CH637929A5 (sv)
DD (1) DD133943A5 (sv)
DE (1) DE2740562A1 (sv)
DK (3) DK146245C (sv)
FR (1) FR2375212A1 (sv)
GR (1) GR72713B (sv)
HU (1) HU177531B (sv)
NL (1) NL189041C (sv)
PL (1) PL115869B1 (sv)
SE (2) SE435384B (sv)
YU (2) YU39499B (sv)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4183857A (en) * 1978-07-06 1980-01-15 Shell Oil Company 3-Benzyl-3-azabicyclo(3.1.0)hexane-2,4-dione
IL65843A (en) * 1977-08-11 1986-12-31 American Cyanamid Co Pharmaceutical compositions for the treatment of depression containing 3-aza-bicyclo(3.1.0)hexane derivatives and certain novel compounds of this type
CA1117127A (en) * 1978-06-27 1982-01-26 Janet A. Day Derivatives of 3-azabicyclo(3.1.0)hexane and a process for their preparation
US4225499A (en) * 1978-07-06 1980-09-30 Shell Oil Company Process for preparing 3-azabicyclo(3.1.0)hexane-2-carbonitrile
JPS6332100A (ja) * 1986-07-25 1988-02-10 東京電力株式会社 シ−ルド掘進機
JPH0658037B2 (ja) * 1989-09-01 1994-08-03 日本鋼管株式会社 シールド掘進装置
US6372919B1 (en) 2001-01-11 2002-04-16 Dov Pharmaceutical, Inc. (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent
US6569887B2 (en) 2001-08-24 2003-05-27 Dov Pharmaceuticals Inc. (−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake
US20080081834A1 (en) 2002-07-31 2008-04-03 Lippa Arnold S Methods and compositions employing bicifadine for treating disability or functional impairment associated with acute pain, chronic pain, or neuropathic disorders
AU2005266997A1 (en) * 2004-07-22 2006-02-02 Wyeth Method for treating nervous system disorders and conditions
RU2007102292A (ru) * 2004-07-22 2008-08-27 Вайет (Us) Способ лечения расстройств и заболеваний нервной системы
US20070043100A1 (en) 2005-08-16 2007-02-22 Hagen Eric J Novel polymorphs of azabicyclohexane
AU2006275870B2 (en) 2005-07-27 2013-01-10 Otsuka America Pharmaceutical, Inc. Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
US20080045725A1 (en) 2006-04-28 2008-02-21 Murry Jerry A Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
US8138377B2 (en) 2006-11-07 2012-03-20 Dov Pharmaceutical, Inc. Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
US9133159B2 (en) 2007-06-06 2015-09-15 Neurovance, Inc. 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
US20140206740A1 (en) 2011-07-30 2014-07-24 Neurovance, Inc. Use Of (1R,5S)-(+)-(Napthalen-2-yl)-3-Azabicyclo[3.1.0]Hexane In The Treatment Of Conditions Affected By Monoamine Neurotransmitters

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1351754A (en) * 1970-07-02 1974-05-01 Allen & Hanburys Ltd Indenopyrrole derivatives

Also Published As

Publication number Publication date
CH637929A5 (en) 1983-08-31
YU217477A (en) 1983-01-21
JPS6129341B2 (sv) 1986-07-05
DK407577A (da) 1978-03-16
JPS5337656A (en) 1978-04-06
GR72713B (sv) 1983-12-01
FR2375212A1 (fr) 1978-07-21
SE435384B (sv) 1984-09-24
DE2740562A1 (de) 1978-03-23
PL115869B1 (en) 1981-05-30
SE7710367L (sv) 1978-03-16
AT367036B (de) 1982-05-25
AU2844177A (en) 1979-03-08
DD133943A5 (de) 1979-01-31
ATA288280A (de) 1981-10-15
SE452610B (sv) 1987-12-07
AT367037B (de) 1982-05-25
HU177531B (en) 1981-11-28
ATA661577A (de) 1981-10-15
NL189041B (nl) 1992-07-16
YU43523B (en) 1989-08-31
YU188582A (en) 1985-03-20
YU39499B (en) 1984-12-31
NL189041C (nl) 1992-12-16
AR227507A1 (es) 1982-11-15
AU519620B2 (en) 1981-12-17
DK146245C (da) 1984-01-16
BE858683A (fr) 1978-03-14
PL200831A1 (sv) 1980-02-11
FR2375212B1 (sv) 1981-07-31
DK146245B (da) 1983-08-08
AR220684A1 (es) 1980-11-28
CH637931A5 (en) 1983-08-31
DE2740562C2 (sv) 1989-05-03
NL7709691A (nl) 1978-03-17
DK438580A (da) 1980-10-16
DK438480A (da) 1980-10-16

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