SE7606736L - BESTATIN ASSOCIATIONS AND METHODS OF PREPARING THEREOF - Google Patents
BESTATIN ASSOCIATIONS AND METHODS OF PREPARING THEREOFInfo
- Publication number
- SE7606736L SE7606736L SE7606736A SE7606736A SE7606736L SE 7606736 L SE7606736 L SE 7606736L SE 7606736 A SE7606736 A SE 7606736A SE 7606736 A SE7606736 A SE 7606736A SE 7606736 L SE7606736 L SE 7606736L
- Authority
- SE
- Sweden
- Prior art keywords
- formula
- image
- optionally
- compounds
- bestatin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
For preparing the novel bestatin compounds of the formula <IMAGE> having R1 and R2 in accordance with the preceding Patent Claim 1, an alpha -hydroxybeta -amino acid of the formula <IMAGE> is used as the starting material. The latter is condensed, optionally after having protected the functional groups which are not to participate in the subsequent reaction, with a beta -amino acid of the formula <IMAGE> using a peptide-linking method. Protective groups which may optionally be present are subsequently removed. The optically pure diastereoisomers can be readily obtained from the compounds of the formula (III). The alpha -hydroxybeta -amino acids can be prepared by hydrolysing a corresponding cyanohydrin whose amino group is optionally protected. The novel compounds inhibit certain enzymes which decompose bleomycin and in this way amplify the anti-tumour activity of the bleomycins.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB30632/75A GB1510477A (en) | 1975-07-22 | 1975-07-22 | Peptides and to amino acid intermediates thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7606736L true SE7606736L (en) | 1977-01-23 |
| SE431642B SE431642B (en) | 1984-02-20 |
Family
ID=10310676
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7606736A SE431642B (en) | 1975-07-22 | 1976-06-14 | PROCEDURE FOR THE PREPARATION OF BESTATIN SOCIETIES |
| SE8001959A SE452318B (en) | 1975-07-22 | 1980-03-13 | AMINO ACIDS FOR USE AS INTERMEDIATES IN THE PRODUCTION OF BESTATIN |
| SE8306145A SE8306145L (en) | 1975-07-22 | 1983-11-09 | PROCEDURE FOR THE PREPARATION OF BESTATE ASSOCIATIONS |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8001959A SE452318B (en) | 1975-07-22 | 1980-03-13 | AMINO ACIDS FOR USE AS INTERMEDIATES IN THE PRODUCTION OF BESTATIN |
| SE8306145A SE8306145L (en) | 1975-07-22 | 1983-11-09 | PROCEDURE FOR THE PREPARATION OF BESTATE ASSOCIATIONS |
Country Status (12)
| Country | Link |
|---|---|
| JP (2) | JPS52136118A (en) |
| AU (1) | AU506003B2 (en) |
| CA (1) | CA1104156A (en) |
| CH (1) | CH630892A5 (en) |
| CS (2) | CS201034B2 (en) |
| DE (2) | DE2660626C2 (en) |
| DK (1) | DK149110C (en) |
| FR (1) | FR2318863A1 (en) |
| GB (1) | GB1510477A (en) |
| HU (1) | HU183048B (en) |
| NL (1) | NL7608064A (en) |
| SE (3) | SE431642B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2725732C2 (en) | 1977-06-07 | 1983-01-05 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Tokyo | Bestatin analogs, processes for their preparation and pharmaceutical preparations containing these compounds |
| DE2760007C2 (en) * | 1977-06-07 | 1988-10-06 | Microbial Chem Res Found | |
| JPS6026099B2 (en) * | 1977-09-21 | 1985-06-21 | 財団法人微生物化学研究会 | Peptide, its acid salt and its production method |
| AR227636A1 (en) * | 1978-11-25 | 1982-11-30 | Nippon Kayaku Kk | PROCEDURE TO PRODUCE TREO-3-AMINO-2-HYDROXIBUTANOYL AMINOACETIC ACID INTERMEDIARIES TO PREPARE IT AND PROCEDURE TO PREPARE INTERMEDIARIES |
| US4370318A (en) * | 1980-07-07 | 1983-01-25 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Bestatin-related compounds as immunopotentiator |
| JPS5767516A (en) * | 1980-09-24 | 1982-04-24 | Microbial Chem Res Found | Novel analgesic agent |
| JPH0810855Y2 (en) * | 1989-07-20 | 1996-03-29 | タナシン電機株式会社 | Auto-reverse type tape recorder |
| DE69420524T2 (en) * | 1993-06-29 | 2000-02-17 | Kaneka Corp | METHOD FOR PRODUCING DERIVATIVES OF 3-AMINE-2-HYDROXY-4-PHENYLBUTTERIC ACID AND 1-NITRO-4-PHENYL-2-BUTANOL INTERMEDIATE PRODUCTS |
| ATE284863T1 (en) * | 1996-02-08 | 2005-01-15 | Nippon Kayaku Kk | METHOD FOR PRODUCING OPTICALLY ACTIVE CYANOHYDRINS |
| US6242494B1 (en) | 1998-05-01 | 2001-06-05 | Abbott Laboratories | Substituted β-amino acid inhibitors of methionine aminopeptidase-2 |
| WO1999057098A2 (en) * | 1998-05-01 | 1999-11-11 | Abbott Laboratories | Substituted beta-amino acid inhibitors of methionine aminopeptidase-2 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5439477B2 (en) * | 1974-07-01 | 1979-11-28 |
-
1975
- 1975-07-22 GB GB30632/75A patent/GB1510477A/en not_active Expired
-
1976
- 1976-06-14 SE SE7606736A patent/SE431642B/en not_active IP Right Cessation
- 1976-07-15 AU AU15912/76A patent/AU506003B2/en not_active Expired
- 1976-07-16 CS CS793519A patent/CS201034B2/en unknown
- 1976-07-16 CS CS764736A patent/CS201033B2/en unknown
- 1976-07-19 DE DE2660626A patent/DE2660626C2/en not_active Expired
- 1976-07-19 DE DE2632396A patent/DE2632396C2/en not_active Expired
- 1976-07-20 CA CA257,393A patent/CA1104156A/en not_active Expired
- 1976-07-21 CH CH933676A patent/CH630892A5/en not_active IP Right Cessation
- 1976-07-21 NL NL7608064A patent/NL7608064A/en not_active Application Discontinuation
- 1976-07-21 JP JP8599276A patent/JPS52136118A/en active Granted
- 1976-07-21 FR FR7622279A patent/FR2318863A1/en active Granted
- 1976-07-22 DK DK331276A patent/DK149110C/en not_active IP Right Cessation
- 1976-07-22 HU HU76ZA395A patent/HU183048B/en unknown
-
1980
- 1980-03-13 SE SE8001959A patent/SE452318B/en unknown
-
1982
- 1982-04-22 JP JP57066233A patent/JPS6050780B2/en not_active Expired
-
1983
- 1983-11-09 SE SE8306145A patent/SE8306145L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| GB1510477A (en) | 1978-05-10 |
| SE452318B (en) | 1987-11-23 |
| DE2632396C2 (en) | 1982-11-25 |
| SE8306145D0 (en) | 1983-11-09 |
| JPS6050780B2 (en) | 1985-11-11 |
| JPS5823654A (en) | 1983-02-12 |
| DK149110C (en) | 1986-09-08 |
| NL7608064A (en) | 1977-01-25 |
| DE2632396A1 (en) | 1977-02-03 |
| SE431642B (en) | 1984-02-20 |
| HU183048B (en) | 1984-04-28 |
| SE8306145L (en) | 1983-11-09 |
| CH630892A5 (en) | 1982-07-15 |
| JPS5758338B2 (en) | 1982-12-09 |
| JPS52136118A (en) | 1977-11-14 |
| SE8001959L (en) | 1980-03-13 |
| CS201034B2 (en) | 1980-10-31 |
| FR2318863B1 (en) | 1980-10-31 |
| AU506003B2 (en) | 1979-12-13 |
| FR2318863A1 (en) | 1977-02-18 |
| DE2660626C2 (en) | 1985-07-11 |
| AU1591276A (en) | 1978-01-19 |
| DK149110B (en) | 1986-01-27 |
| CS201033B2 (en) | 1980-10-31 |
| DK331276A (en) | 1977-01-23 |
| CA1104156A (en) | 1981-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
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| NUG | Patent has lapsed |
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