SE468050C - Rekombinant derivat av human faktor VIII - Google Patents

Rekombinant derivat av human faktor VIII

Info

Publication number: SE468050C
Authority: SE; Sweden
Prior art keywords: factor viii; kda; dna; amino acid; encoding
Prior art date: 1991-03-15

Application number

SE9100799A

Other languages

English (en)

Swedish (sv)

Other versions

SE468050B (sv

SE9100799L (sv

SE9100799D0 (sv

Inventor

Anneli B Almstedt

Eva Maria Hellstroem

Peter Lind

Catherine Ljung

Helena Inga Sandberg

Jack Spira

Mona Sydow-Baeckman

Helena Wiman

Original Assignee

Pharmacia & Upjohn Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-03-15

Filing date

1991-03-15

Publication date

1998-04-27

1991-03-15 Application filed by Pharmacia & Upjohn Ab filed Critical Pharmacia & Upjohn Ab

1991-03-15 Priority to SE9100799A priority Critical patent/SE468050C/sv

1991-03-15 Publication of SE9100799D0 publication Critical patent/SE9100799D0/xx

1992-03-11 Priority to EP92905708A priority patent/EP0533862B1/en

1992-03-11 Priority to PCT/SE1992/000150 priority patent/WO1992016557A1/en

1992-03-11 Priority to DE69230206T priority patent/DE69230206T2/de

1992-03-11 Priority to CA002081659A priority patent/CA2081659C/en

1992-03-11 Priority to DK92905708T priority patent/DK0533862T3/da

1992-03-11 Priority to ES92905708T priority patent/ES2137182T3/es

1992-03-11 Priority to AU13513/92A priority patent/AU650730B2/en

1992-03-11 Priority to JP4505642A priority patent/JP2655752B2/ja

1992-03-11 Priority to AT92905708T priority patent/ATE186055T1/de

1992-03-13 Priority to PT100245A priority patent/PT100245B/pt

1992-03-13 Priority to AR92321933A priority patent/AR247590A1/es

1992-03-13 Priority to ZA921882A priority patent/ZA921882B/xx

1992-03-13 Priority to IE081492A priority patent/IE920814A1/en

1992-09-16 Publication of SE9100799L publication Critical patent/SE9100799L/

1992-10-26 Publication of SE468050B publication Critical patent/SE468050B/sv

1992-11-11 Priority to FI925131A priority patent/FI107539B/fi

1992-11-13 Priority to NO924395A priority patent/NO308174B1/no

1995-06-05 Priority to US08/462,917 priority patent/US5661008A/en

1998-04-27 Publication of SE468050C publication Critical patent/SE468050C/sv

2000-01-25 Priority to GR20000400162T priority patent/GR3032468T3/el

Links

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Hematology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Gastroenterology & Hepatology (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Biophysics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

SE9100799A 1991-03-15 1991-03-15 Rekombinant derivat av human faktor VIII SE468050C (sv)

Priority Applications (18)

Application Number	Priority Date	Filing Date	Title
SE9100799A SE468050C (sv)	1991-03-15	1991-03-15	Rekombinant derivat av human faktor VIII
AT92905708T ATE186055T1 (de)	1991-03-15	1992-03-11	Rekombinante derivate des menschlichen faktors viii
JP4505642A JP2655752B2 (ja)	1991-03-15	1992-03-11	組換えヒト第▲ｖｉｉｉ▼因子誘導体
PCT/SE1992/000150 WO1992016557A1 (en)	1991-03-15	1992-03-11	Recombinant human factor viii derivatives
DE69230206T DE69230206T2 (de)	1991-03-15	1992-03-11	Rekombinante derivate des menschlichen faktors viii
CA002081659A CA2081659C (en)	1991-03-15	1992-03-11	Recombinant human factor viii derivatives
DK92905708T DK0533862T3 (da)	1991-03-15	1992-03-11	Rekombinante human faktor VIII-derivater
ES92905708T ES2137182T3 (es)	1991-03-15	1992-03-11	Derivados recombinantes del factor viii humano.
AU13513/92A AU650730B2 (en)	1991-03-15	1992-03-11	Recombinant human factor VIII derivatives
EP92905708A EP0533862B1 (en)	1991-03-15	1992-03-11	Recombinant human factor viii derivatives
IE081492A IE920814A1 (en)	1991-03-15	1992-03-13	Recombinant human factor viii derivatives
PT100245A PT100245B (pt)	1991-03-15	1992-03-13	Sequencia de adn que codifica um derivado de factor viii humano recombinante, biologicamente activo, vector de expressao recombinante, celula hospedeira, processo de producao de um derivado de factor vii e derivado de factor viii
AR92321933A AR247590A1 (es)	1991-03-15	1992-03-13	Una secuencia de adn que codifica derivados de factor viii humano recombinante y un procedimiento para su obtencion
ZA921882A ZA921882B (en)	1991-03-15	1992-03-13	Recombinant human factor viii derivatives
FI925131A FI107539B (fi)	1991-03-15	1992-11-11	Menetelmä yhdistelmä-humaani-hyytymistekijä VIII:n johdannaisen valmistamiseksi ja menetelmässä käytettävä DNA-jakso, vektori ja isäntäsolu
NO924395A NO308174B1 (no)	1991-03-15	1992-11-13	DNA-sekvens som koder for et biologisk aktivt rekombinant menneskefaktor VIII-derivat, rekombinant ekspresjonsvektor og vertscelle omfattende DNA-sekvensen, samt fremgangsmÕte for fremstilling av menneskefaktor VIII-derivat
US08/462,917 US5661008A (en)	1991-03-15	1995-06-05	Recombinant human factor VIII derivatives
GR20000400162T GR3032468T3 (en)	1991-03-15	2000-01-25	Recombinant human factor viii derivatives.

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE9100799A SE468050C (sv)	1991-03-15	1991-03-15	Rekombinant derivat av human faktor VIII

Publications (4)

Publication Number	Publication Date
SE9100799D0 SE9100799D0 (sv)	1991-03-15
SE9100799L SE9100799L (sv)	1992-09-16
SE468050B SE468050B (sv)	1992-10-26
SE468050C true SE468050C (sv)	1998-04-27

Family

ID=20382191

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE9100799A SE468050C (sv)	1991-03-15	1991-03-15	Rekombinant derivat av human faktor VIII

Country Status (17)

Country	Link
EP (1)	EP0533862B1 (xx)
JP (1)	JP2655752B2 (xx)
AR (1)	AR247590A1 (xx)
AT (1)	ATE186055T1 (xx)
AU (1)	AU650730B2 (xx)
CA (1)	CA2081659C (xx)
DE (1)	DE69230206T2 (xx)
DK (1)	DK0533862T3 (xx)
ES (1)	ES2137182T3 (xx)
FI (1)	FI107539B (xx)
GR (1)	GR3032468T3 (xx)
IE (1)	IE920814A1 (xx)
NO (1)	NO308174B1 (xx)
PT (1)	PT100245B (xx)
SE (1)	SE468050C (xx)
WO (1)	WO1992016557A1 (xx)
ZA (1)	ZA921882B (xx)

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US5744446A (en) *	1992-04-07	1998-04-28	Emory University	Hybrid human/animal factor VIII
US5364771A (en) *	1992-04-07	1994-11-15	Emory University	Hybrid human/porcine factor VIII
US5663060A (en) *	1992-04-07	1997-09-02	Emory University	Hybrid human/animal factor VIII
US5888974A (en) *	1992-04-07	1999-03-30	Emory University	Hybrid human/animal factor VIII
AU4719393A (en)	1992-07-31	1994-03-03	Medeva Holdings B.V.	Expression of recombinant fusion proteins in attenuated bacteria
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SE504074C2 (sv) *	1993-07-05	1996-11-04	Pharmacia Ab	Proteinberedning för subkutan, intramuskulär eller intradermal administrering
GB9401787D0 (en) *	1994-01-31	1994-03-23	Medeva Holdings Bv	Vaccine compositions
SE9303601D0 (sv) *	1993-11-01	1993-11-01	Kabi Pharmacia Ab	Improved cell cultivation method and medium
SE9403915D0 (sv) *	1994-11-14	1994-11-14	Annelie Almstedt	Process A
US6200560B1 (en)	1998-10-20	2001-03-13	Avigen, Inc.	Adeno-associated virus vectors for expression of factor VIII by target cells
US6221349B1 (en)	1998-10-20	2001-04-24	Avigen, Inc.	Adeno-associated vectors for expression of factor VIII by target cells
US6197526B1 (en) *	1999-01-04	2001-03-06	Dyax Corp.	Polypeptides for binding human factor VIII and fragments of human factor VIII
US7112438B2 (en)	1999-01-04	2006-09-26	Dyax Corp.	Binding molecules for human factor VIII and factor VIII-like proteins
EP1048726B1 (en) *	1999-04-27	2006-07-26	Négrier, Claude	Modified factor VIII cDNA
EP1038959A1 (en) *	1999-03-17	2000-09-27	Aventis Behring Gesellschaft mit beschränkter Haftung	Factor VIII without B-domain, comprising one or more insertions of a truncated intron I of factor IX
SE9901379D0 (sv)	1999-04-19	1999-04-19	Pharmacia & Upjohn Ab	Receptor structures
EP1233064A1 (en) *	2001-02-09	2002-08-21	Aventis Behring Gesellschaft mit beschränkter Haftung	Modified factor VIII cDNA and its use for the production of factor VIII
EP1284290A1 (en) *	2001-08-08	2003-02-19	Aventis Behring GmbH	Increase of the expression levels of factor VIII by insertion of spliceable nucleotide sequences into factor VIII cDNA
EP1283263A1 (en) *	2001-08-08	2003-02-12	Aventis Behring GmbH	Modified cDNA for high expression levels of factor VIII and its derivatives
PL2292780T3 (pl)	2003-09-30	2018-05-30	The Trustees Of The University Of Pennsylvania	Klady wirusów związanych z adenowirusami (AAV), sekwencje, wektory je zawierające i ich zastosowania
ES2580044T3 (es)	2005-04-07	2016-08-18	The Trustees Of The University Of Pennsylvania	Método de incremento de la función de un vector de AAV
AU2006233638A1 (en) *	2005-04-14	2006-10-19	Csl Behring Gmbh	Modified coagulation Factor VIII with enhanced stability and its derivates
KR20130040844A (ko)	2010-03-29	2013-04-24	더 트러스티스 오브 더 유니버시티 오브 펜실바니아	약학적으로 유발된 전이유전자 제거 시스템
US9315825B2 (en)	2010-03-29	2016-04-19	The Trustees Of The University Of Pennsylvania	Pharmacologically induced transgene ablation system
BRPI1105317A2 (pt)	2011-01-24	2013-04-30	Fundacco Hemoct De Ribeirco Preto	produÇço estÁvel e em larga escala de fviii humano em linhagem celular humana sk-hep-1
TR201908020T4 (tr)	2011-02-17	2019-06-21	Univ Pennsylvania	Doku özgüllüğünü değiştirmek ve aav9-aracılı gen transferini geliştirmek için bileşimler ve yöntemler.
WO2015012924A2 (en)	2013-04-29	2015-01-29	The Trustees Of The University Of Pennsylvania	Tissue preferential codon modified expression cassettes, vectors containing same, and use thereof
CN105017410B (zh) *	2014-04-18	2018-06-08	北京诺思兰德生物技术股份有限公司	一种b区部分缺失型重组人凝血因子ⅷ
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EP3521428A4 (en)	2016-10-03	2020-06-24	Daiichi Sankyo Company, Limited	PROMOTER OF THE HSPA5 GENE
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IL83192A (en) *	1986-07-18	1992-11-15	Gist Brocades Nv	Method for the preparation of proteins with factor viii activity by microbial host cells;expression vectors,host cells,antibodies
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DE3720246A1 (de) *	1987-06-19	1988-12-29	Behringwerke Ag	Faktor viii:c-aehnliches molekuel mit koagulationsaktivitaet
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SE465222C5 (sv) *	1989-12-15	1998-02-10	Pharmacia & Upjohn Ab	Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
CA2078721A1 (en) *	1991-09-24	1993-03-25	Hiroshi Yonemura	Process for preparing human coagulation factor viii protein complex

1991
- 1991-03-15 SE SE9100799A patent/SE468050C/sv not_active IP Right Cessation
1992
- 1992-03-11 JP JP4505642A patent/JP2655752B2/ja not_active Expired - Lifetime
- 1992-03-11 DE DE69230206T patent/DE69230206T2/de not_active Expired - Lifetime
- 1992-03-11 DK DK92905708T patent/DK0533862T3/da active
- 1992-03-11 AU AU13513/92A patent/AU650730B2/en not_active Expired
- 1992-03-11 CA CA002081659A patent/CA2081659C/en not_active Expired - Lifetime
- 1992-03-11 AT AT92905708T patent/ATE186055T1/de active
- 1992-03-11 WO PCT/SE1992/000150 patent/WO1992016557A1/en active IP Right Grant
- 1992-03-11 ES ES92905708T patent/ES2137182T3/es not_active Expired - Lifetime
- 1992-03-11 EP EP92905708A patent/EP0533862B1/en not_active Expired - Lifetime
- 1992-03-13 AR AR92321933A patent/AR247590A1/es active
- 1992-03-13 IE IE081492A patent/IE920814A1/en not_active IP Right Cessation
- 1992-03-13 ZA ZA921882A patent/ZA921882B/xx unknown
- 1992-03-13 PT PT100245A patent/PT100245B/pt not_active IP Right Cessation
- 1992-11-11 FI FI925131A patent/FI107539B/fi not_active IP Right Cessation
- 1992-11-13 NO NO924395A patent/NO308174B1/no not_active IP Right Cessation
2000
- 2000-01-25 GR GR20000400162T patent/GR3032468T3/el unknown

Also Published As

Publication number	Publication date
GR3032468T3 (en)	2000-05-31
JPH05507420A (ja)	1993-10-28
CA2081659A1 (en)	1992-09-16
NO308174B1 (no)	2000-08-07
FI925131A (fi)	1992-11-11
JP2655752B2 (ja)	1997-09-24
FI107539B (fi)	2001-08-31
WO1992016557A1 (en)	1992-10-01
PT100245B (pt)	1999-08-31
PT100245A (pt)	1993-07-30
AU650730B2 (en)	1994-06-30
AR247590A1 (es)	1995-01-31
ZA921882B (en)	1992-11-25
EP0533862B1 (en)	1999-10-27
ATE186055T1 (de)	1999-11-15
DE69230206D1 (de)	1999-12-02
NO924395D0 (no)	1992-11-13
SE468050B (sv)	1992-10-26
DE69230206T2 (de)	2000-05-18
SE9100799L (sv)	1992-09-16
ES2137182T3 (es)	1999-12-16
FI925131A0 (fi)	1992-11-11
CA2081659C (en)	2002-06-25
IE920814A1 (en)	1992-09-23
EP0533862A1 (en)	1993-03-31
AU1351392A (en)	1992-10-21
NO924395L (no)	1993-01-13
DK0533862T3 (da)	2000-01-17
SE9100799D0 (sv)	1991-03-15

Legal Events

Date	Code	Title	Description
2011-05-03	NUG	Patent has lapsed

Publication	Publication Date	Title
SE468050C (sv)	1998-04-27	Rekombinant derivat av human faktor VIII
US5661008A (en)	1997-08-26	Recombinant human factor VIII derivatives
EP0506757B2 (en)	2005-10-26	A recombinant human factor viii derivative
US6060447A (en)	2000-05-09	Protein complexes having Factor VIII:C activity and production thereof
US5451521A (en)	1995-09-19	Procoagulant proteins
US6228620B1 (en)	2001-05-08	Protein complexes having factor VIII:C activity and production thereof
CA2068728A1 (en)	1991-05-18	Protein complexes having factor viii:c activity and production thereof
WO1993016709A1 (en)	1993-09-02	Therapeutic domains of von willebrand factor
AU606925B2 (en)	1991-02-21	A method for producing factor viii in high yield
US6130203A (en)	2000-10-10	Hybrid proteins with modified activity
AU2004283833A1 (en)	2005-05-06	Modified cDNA for high expression levels of factor VIII and its derivatives