SE9100799L - Rekombinant derivat av human faktor viii - Google Patents

Rekombinant derivat av human faktor viii

Info

Publication number
SE9100799L
SE9100799L SE9100799A SE9100799A SE9100799L SE 9100799 L SE9100799 L SE 9100799L SE 9100799 A SE9100799 A SE 9100799A SE 9100799 A SE9100799 A SE 9100799A SE 9100799 L SE9100799 L SE 9100799L
Authority
SE
Sweden
Prior art keywords
human factor
factor viii
dna segment
coding
segment coding
Prior art date
Application number
SE9100799A
Other languages
Unknown language ( )
English (en)
Other versions
SE468050B (sv
SE468050C (sv
SE9100799D0 (sv
Inventor
A B Almstedt
Original Assignee
Kabi Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Pharmacia Ab filed Critical Kabi Pharmacia Ab
Priority to SE9100799A priority Critical patent/SE468050C/sv
Publication of SE9100799D0 publication Critical patent/SE9100799D0/sv
Priority to EP92905708A priority patent/EP0533862B1/en
Priority to DE69230206T priority patent/DE69230206T2/de
Priority to AU13513/92A priority patent/AU650730B2/en
Priority to PCT/SE1992/000150 priority patent/WO1992016557A1/en
Priority to AT92905708T priority patent/ATE186055T1/de
Priority to ES92905708T priority patent/ES2137182T3/es
Priority to CA002081659A priority patent/CA2081659C/en
Priority to DK92905708T priority patent/DK0533862T3/da
Priority to JP4505642A priority patent/JP2655752B2/ja
Priority to ZA921882A priority patent/ZA921882B/xx
Priority to PT100245A priority patent/PT100245B/pt
Priority to IE081492A priority patent/IE920814A1/en
Priority to AR92321933A priority patent/AR247590A1/es
Publication of SE9100799L publication Critical patent/SE9100799L/sv
Publication of SE468050B publication Critical patent/SE468050B/sv
Priority to FI925131A priority patent/FI107539B/sv
Priority to NO924395A priority patent/NO308174B1/no
Priority to US08/462,917 priority patent/US5661008A/en
Publication of SE468050C publication Critical patent/SE468050C/sv
Priority to GR20000400162T priority patent/GR3032468T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SE9100799A 1991-03-15 1991-03-15 Rekombinant derivat av human faktor VIII SE468050C (sv)

Priority Applications (18)

Application Number Priority Date Filing Date Title
SE9100799A SE468050C (sv) 1991-03-15 1991-03-15 Rekombinant derivat av human faktor VIII
JP4505642A JP2655752B2 (ja) 1991-03-15 1992-03-11 組換えヒト第▲ｖｉｉｉ▼因子誘導体
DK92905708T DK0533862T3 (da) 1991-03-15 1992-03-11 Rekombinante human faktor VIII-derivater
DE69230206T DE69230206T2 (de) 1991-03-15 1992-03-11 Rekombinante derivate des menschlichen faktors viii
AU13513/92A AU650730B2 (en) 1991-03-15 1992-03-11 Recombinant human factor VIII derivatives
PCT/SE1992/000150 WO1992016557A1 (en) 1991-03-15 1992-03-11 Recombinant human factor viii derivatives
AT92905708T ATE186055T1 (de) 1991-03-15 1992-03-11 Rekombinante derivate des menschlichen faktors viii
ES92905708T ES2137182T3 (es) 1991-03-15 1992-03-11 Derivados recombinantes del factor viii humano.
CA002081659A CA2081659C (en) 1991-03-15 1992-03-11 Recombinant human factor viii derivatives
EP92905708A EP0533862B1 (en) 1991-03-15 1992-03-11 Recombinant human factor viii derivatives
AR92321933A AR247590A1 (es) 1991-03-15 1992-03-13 Una secuencia de adn que codifica derivados de factor viii humano recombinante y un procedimiento para su obtencion
ZA921882A ZA921882B (en) 1991-03-15 1992-03-13 Recombinant human factor viii derivatives
PT100245A PT100245B (pt) 1991-03-15 1992-03-13 Sequencia de adn que codifica um derivado de factor viii humano recombinante, biologicamente activo, vector de expressao recombinante, celula hospedeira, processo de producao de um derivado de factor vii e derivado de factor viii
IE081492A IE920814A1 (en) 1991-03-15 1992-03-13 Recombinant human factor viii derivatives
FI925131A FI107539B (sv) 1991-03-15 1992-11-11 Förfarande för framställning av rekombinant human-faktor-VIII-derivat och i förfarandet använda DNA-sekvens, vektor och värdcell
NO924395A NO308174B1 (no) 1991-03-15 1992-11-13 DNA-sekvens som koder for et biologisk aktivt rekombinant menneskefaktor VIII-derivat, rekombinant ekspresjonsvektor og vertscelle omfattende DNA-sekvensen, samt fremgangsmÕte for fremstilling av menneskefaktor VIII-derivat
US08/462,917 US5661008A (en) 1991-03-15 1995-06-05 Recombinant human factor VIII derivatives
GR20000400162T GR3032468T3 (en) 1991-03-15 2000-01-25 Recombinant human factor viii derivatives.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9100799A SE468050C (sv) 1991-03-15 1991-03-15 Rekombinant derivat av human faktor VIII

Publications (4)

Publication Number Publication Date
SE9100799D0 SE9100799D0 (sv) 1991-03-15
SE9100799L true SE9100799L (sv) 1992-09-16
SE468050B SE468050B (sv) 1992-10-26
SE468050C SE468050C (sv) 1998-04-27

Family

ID=20382191

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9100799A SE468050C (sv) 1991-03-15 1991-03-15 Rekombinant derivat av human faktor VIII

Country Status (17)

Country Link
EP (1) EP0533862B1 (sv)
JP (1) JP2655752B2 (sv)
AR (1) AR247590A1 (sv)
AT (1) ATE186055T1 (sv)
AU (1) AU650730B2 (sv)
CA (1) CA2081659C (sv)
DE (1) DE69230206T2 (sv)
DK (1) DK0533862T3 (sv)
ES (1) ES2137182T3 (sv)
FI (1) FI107539B (sv)
GR (1) GR3032468T3 (sv)
IE (1) IE920814A1 (sv)
NO (1) NO308174B1 (sv)
PT (1) PT100245B (sv)
SE (1) SE468050C (sv)
WO (1) WO1992016557A1 (sv)
ZA (1) ZA921882B (sv)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5595886A (en) * 1986-01-27 1997-01-21 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
US6060447A (en) * 1987-05-19 2000-05-09 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
US5663060A (en) * 1992-04-07 1997-09-02 Emory University Hybrid human/animal factor VIII
US5888974A (en) * 1992-04-07 1999-03-30 Emory University Hybrid human/animal factor VIII
US5364771A (en) * 1992-04-07 1994-11-15 Emory University Hybrid human/porcine factor VIII
US5744446A (en) * 1992-04-07 1998-04-28 Emory University Hybrid human/animal factor VIII
CA2141427C (en) 1992-07-31 2008-07-22 Mohammed Anjam Khan Expression of recombinant fusion proteins in attenuated bacteria
SE9300509D0 (sv) * 1993-02-16 1993-02-16 Kabi Pharmacia Ab Peg treatment
SE504074C2 (sv) * 1993-07-05 1996-11-04 Pharmacia Ab Proteinberedning för subkutan, intramuskulär eller intradermal administrering
GB9401787D0 (en) * 1994-01-31 1994-03-23 Medeva Holdings Bv Vaccine compositions
SE9303601D0 (sv) * 1993-11-01 1993-11-01 Kabi Pharmacia Ab Improved cell cultivation method and medium
SE9403915D0 (sv) * 1994-11-14 1994-11-14 Annelie Almstedt Process A
US6221349B1 (en) 1998-10-20 2001-04-24 Avigen, Inc. Adeno-associated vectors for expression of factor VIII by target cells
US6200560B1 (en) 1998-10-20 2001-03-13 Avigen, Inc. Adeno-associated virus vectors for expression of factor VIII by target cells
US6197526B1 (en) * 1999-01-04 2001-03-06 Dyax Corp. Polypeptides for binding human factor VIII and fragments of human factor VIII
US7112438B2 (en) 1999-01-04 2006-09-26 Dyax Corp. Binding molecules for human factor VIII and factor VIII-like proteins
EP1038959A1 (en) * 1999-03-17 2000-09-27 Aventis Behring Gesellschaft mit beschränkter Haftung Factor VIII without B-domain, comprising one or more insertions of a truncated intron I of factor IX
EP1048726B1 (en) * 1999-04-27 2006-07-26 Négrier, Claude Modified factor VIII cDNA
SE9901379D0 (sv) 1999-04-19 1999-04-19 Pharmacia & Upjohn Ab Receptor structures
EP1233064A1 (en) * 2001-02-09 2002-08-21 Aventis Behring Gesellschaft mit beschränkter Haftung Modified factor VIII cDNA and its use for the production of factor VIII
EP1284290A1 (en) * 2001-08-08 2003-02-19 Aventis Behring GmbH Increase of the expression levels of factor VIII by insertion of spliceable nucleotide sequences into factor VIII cDNA
EP1283263A1 (en) * 2001-08-08 2003-02-12 Aventis Behring GmbH Modified cDNA for high expression levels of factor VIII and its derivatives
CA2939103C (en) 2003-09-30 2020-03-24 The Trustees Of The University Of Pennsylvania Adeno-associated virus (aav) clades, sequences, vectors containing same, and uses therefor
ES2428218T3 (es) 2005-04-07 2013-11-06 The Trustees Of The University Of Pennsylvania Cápsides de AAV rh48 modificadas, composiciones que las contienen y usos de las mismas
EP1874815A1 (en) * 2005-04-14 2008-01-09 CSL Behring GmbH Modified coagulation factor viii with enhanced stability and its derivates
SG183929A1 (en) 2010-03-29 2012-10-30 Univ Pennsylvania Pharmacologically induced transgene ablation system
US9315825B2 (en) 2010-03-29 2016-04-19 The Trustees Of The University Of Pennsylvania Pharmacologically induced transgene ablation system
BRPI1105317A2 (pt) 2011-01-24 2013-04-30 Fundacco Hemoct De Ribeirco Preto produÇço estÁvel e em larga escala de fviii humano em linhagem celular humana sk-hep-1
SG10201601110VA (en) 2011-02-17 2016-03-30 Univ Pennsylvania Compositions and methods for altering tissue specificity and improving aav9-mediated gene transfer
WO2015012924A2 (en) 2013-04-29 2015-01-29 The Trustees Of The University Of Pennsylvania Tissue preferential codon modified expression cassettes, vectors containing same, and use thereof
CN105017410B (zh) * 2014-04-18 2018-06-08 北京诺思兰德生物技术股份有限公司 一种b区部分缺失型重组人凝血因子ⅷ
CN115074366A (zh) 2015-04-16 2022-09-20 埃默里大学 用于肝脏中蛋白质表达的重组启动子和载体及其用途
EP3521428A4 (en) * 2016-10-03 2020-06-24 Daiichi Sankyo Company, Limited PROMOTER OF THE HSPA5 GENE
KR20230042754A (ko) 2020-08-07 2023-03-29 아미쿠스 세라퓨틱스, 인코포레이티드 소포 표적화 단백질 및 이의 용도

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1200773A (en) * 1980-02-29 1986-02-18 William J. Rutter Expression linkers
JPS62181786A (ja) * 1985-08-12 1987-08-10 シンテツクス（ユ−・エス・エイ）インコ−ポレイテツド 融合蛋白質の製造法
US4935233A (en) * 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
US5451521A (en) * 1986-05-29 1995-09-19 Genetics Institute, Inc. Procoagulant proteins
NO872932L (no) * 1986-07-18 1988-01-19 Gist Brocades Nv Fremgangsmaate for fremstilling av proteiner med faktorviiiaktivitet ved hjelp av mikrobielle vertsceller, eksprimeringsvektorer, vertsceller, antibiotika.
NZ219516A (en) * 1987-02-10 1991-02-26 Wellcome Found Fusion proteins of hbcag (hepatitis b virus core antigen)
DE3720246A1 (de) * 1987-06-19 1988-12-29 Behringwerke Ag Faktor viii:c-aehnliches molekuel mit koagulationsaktivitaet
ZA909167B (en) * 1989-11-17 1993-10-15 Chiron Corp Protein complexes having Factor VIII:C activity and production thereof
SE465222C5 (sv) * 1989-12-15 1998-02-10 Pharmacia & Upjohn Ab Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
CA2078721A1 (en) * 1991-09-24 1993-03-25 Hiroshi Yonemura Process for preparing human coagulation factor viii protein complex

Also Published As

Publication number Publication date
NO308174B1 (no) 2000-08-07
NO924395D0 (no) 1992-11-13
SE468050B (sv) 1992-10-26
NO924395L (no) 1993-01-13
CA2081659A1 (en) 1992-09-16
ATE186055T1 (de) 1999-11-15
SE468050C (sv) 1998-04-27
PT100245A (pt) 1993-07-30
EP0533862A1 (en) 1993-03-31
SE9100799D0 (sv) 1991-03-15
IE920814A1 (en) 1992-09-23
EP0533862B1 (en) 1999-10-27
GR3032468T3 (en) 2000-05-31
JP2655752B2 (ja) 1997-09-24
ZA921882B (en) 1992-11-25
PT100245B (pt) 1999-08-31
WO1992016557A1 (en) 1992-10-01
FI925131A (fi) 1992-11-11
ES2137182T3 (es) 1999-12-16
FI107539B (sv) 2001-08-31
AU1351392A (en) 1992-10-21
JPH05507420A (ja) 1993-10-28
CA2081659C (en) 2002-06-25
DE69230206T2 (de) 2000-05-18
DK0533862T3 (da) 2000-01-17
AU650730B2 (en) 1994-06-30
AR247590A1 (es) 1995-01-31
DE69230206D1 (de) 1999-12-02
FI925131A0 (fi) 1992-11-11

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