SE447448B - Polymer diffusionsmatris for transdermal administrering av lekemedel - Google Patents

Polymer diffusionsmatris for transdermal administrering av lekemedel

Info

Publication number: SE447448B
Authority: SE; Sweden
Prior art keywords: diffusion matrix; molecular weight; polymer diffusion; matrix; drug
Prior art date: 1980-07-09

Application number

SE8201337A

Other languages

English (en)

Swedish (sv)

Other versions

SE8201337L (en

Inventor

A D Keith

W Snipes

Original Assignee

Key Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-07-09

Filing date

1982-03-04

Publication date

1986-11-17

1980-07-09 Priority claimed from US06/167,101 external-priority patent/US4294820A/en

1980-07-11 Priority claimed from US06/167,729 external-priority patent/US4291014A/en

1982-03-04 Application filed by Key Pharma filed Critical Key Pharma

1982-03-04 Publication of SE8201337L publication Critical patent/SE8201337L/xx

1986-11-17 Publication of SE447448B publication Critical patent/SE447448B/sv

Links

239000011159 matrix material Substances 0.000 title claims description 38
238000009792 diffusion process Methods 0.000 title claims description 29
229920000642 polymer Polymers 0.000 title claims description 9
229940126601 medicinal product Drugs 0.000 title 1
229940079593 drug Drugs 0.000 claims description 23
239000003814 drug Substances 0.000 claims description 23
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 21
239000004372 Polyvinyl alcohol Substances 0.000 claims description 10
229920002451 polyvinyl alcohol Polymers 0.000 claims description 10
229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 8
239000001267 polyvinylpyrrolidone Substances 0.000 claims description 8
235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 8
XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 claims description 6
229960000195 terbutaline Drugs 0.000 claims description 6
150000002159 estradiols Chemical class 0.000 claims description 4
DBAKFASWICGISY-BTJKTKAUSA-N Chlorpheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 DBAKFASWICGISY-BTJKTKAUSA-N 0.000 claims description 2
DLNKOYKMWOXYQA-UHFFFAOYSA-N dl-pseudophenylpropanolamine Natural products CC(N)C(O)C1=CC=CC=C1 DLNKOYKMWOXYQA-UHFFFAOYSA-N 0.000 claims description 2
229960002179 ephedrine Drugs 0.000 claims description 2
229960001802 phenylephrine Drugs 0.000 claims description 2
SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 claims description 2
229960000395 phenylpropanolamine Drugs 0.000 claims description 2
DLNKOYKMWOXYQA-APPZFPTMSA-N phenylpropanolamine Chemical compound C[C@@H](N)[C@H](O)C1=CC=CC=C1 DLNKOYKMWOXYQA-APPZFPTMSA-N 0.000 claims description 2
GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 claims 1
229960002896 clonidine Drugs 0.000 claims 1
230000037317 transdermal delivery Effects 0.000 claims 1
239000000203 mixture Substances 0.000 description 12
230000000694 effects Effects 0.000 description 6
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
230000004888 barrier function Effects 0.000 description 4
229960005309 estradiol Drugs 0.000 description 4
229930182833 estradiol Natural products 0.000 description 4
239000008240 homogeneous mixture Substances 0.000 description 4
-1 polyethylene Polymers 0.000 description 4
229940124630 bronchodilator Drugs 0.000 description 3
238000005266 casting Methods 0.000 description 3
150000002148 esters Chemical class 0.000 description 3
239000011521 glass Substances 0.000 description 3
229910001220 stainless steel Inorganic materials 0.000 description 3
239000010935 stainless steel Substances 0.000 description 3
238000003756 stirring Methods 0.000 description 3
KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 description 2
VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 2
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
239000000850 decongestant Substances 0.000 description 2
238000004090 dissolution Methods 0.000 description 2
150000002170 ethers Chemical class 0.000 description 2
230000035515 penetration Effects 0.000 description 2
239000000126 substance Substances 0.000 description 2
230000001225 therapeutic effect Effects 0.000 description 2
JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
NZJXADCEESMBPW-UHFFFAOYSA-N 1-methylsulfinyldecane Chemical compound CCCCCCCCCCS(C)=O NZJXADCEESMBPW-UHFFFAOYSA-N 0.000 description 1
GHIVDTCFLFLOBV-UHFFFAOYSA-N 2-(diethylamino)ethyl 2-acetyloxybenzoate Chemical compound CCN(CC)CCOC(=O)C1=CC=CC=C1OC(C)=O GHIVDTCFLFLOBV-UHFFFAOYSA-N 0.000 description 1
239000004698 Polyethylene Substances 0.000 description 1
229920001213 Polysorbate 20 Polymers 0.000 description 1
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
150000001241 acetals Chemical class 0.000 description 1
150000001408 amides Chemical class 0.000 description 1
230000001387 anti-histamine Effects 0.000 description 1
239000000739 antihistaminic agent Substances 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
210000003679 cervix uteri Anatomy 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
239000000470 constituent Substances 0.000 description 1
KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 description 1
239000003599 detergent Substances 0.000 description 1
230000006866 deterioration Effects 0.000 description 1
229960001760 dimethyl sulfoxide Drugs 0.000 description 1
239000002270 dispersing agent Substances 0.000 description 1
238000012377 drug delivery Methods 0.000 description 1
230000002708 enhancing effect Effects 0.000 description 1
239000004744 fabric Substances 0.000 description 1
238000001879 gelation Methods 0.000 description 1
239000007788 liquid Substances 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
239000000463 material Substances 0.000 description 1
238000000034 method Methods 0.000 description 1
239000000133 nasal decongestant Substances 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
239000002904 solvent Substances 0.000 description 1
230000008093 supporting effect Effects 0.000 description 1
229940070710 valerate Drugs 0.000 description 1
239000013598 vector Substances 0.000 description 1
210000000707 wrist Anatomy 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Reproductive Health (AREA)
Gynecology & Obstetrics (AREA)
Urology & Nephrology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

SE8201337A 1980-07-09 1982-03-04 Polymer diffusionsmatris for transdermal administrering av lekemedel SE447448B (sv)

Applications Claiming Priority (9)

Application Number	Priority Date	Filing Date	Title
US16700880A	1980-07-09	1980-07-09
US06/167,101 US4294820A (en)	1979-08-14	1980-07-09	Polymeric diffusion matrix containing phenylephrine
US06/167,010 US4292301A (en)	1979-08-14	1980-07-09	Polymeric diffusion matrix containing ephedrine
US06/167,106 US4292303A (en)	1979-08-14	1980-07-09	Polymeric diffusion matrix containing clonidine
US06/167,009 US4289749A (en)	1979-08-14	1980-07-09	Polymeric diffusion matrix containing phenylpropanolamine
US06/167,104 US4292302A (en)	1979-08-14	1980-07-09	Polymeric diffusion matrix containing terbutaline
US06/167,729 US4291014A (en)	1979-01-11	1980-07-11	Polymeric diffusion matrix containing estradiol diacetate
US06/217,400 US4321252A (en)	1979-08-14	1980-12-17	Polymeric diffusion matrix containing ester derivatives of estradiol
PCT/US1981/000893 WO1982000099A1 (en)	1980-07-09	1981-06-26	Polymeric diffusion matrix for administration of drugs

Publications (2)

Publication Number	Publication Date
SE8201337L SE8201337L (en)	1982-03-04
SE447448B true SE447448B (sv)	1986-11-17

Family

ID=41698406

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE8201337A SE447448B (sv)	1980-07-09	1982-03-04	Polymer diffusionsmatris for transdermal administrering av lekemedel

Country Status (13)

Country	Link
JP (1)	JPS57500980A (it)
AU (1)	AU7415181A (it)
BE (1)	BE889549A (it)
CA (1)	CA1163559A (it)
CH (1)	CH658597A5 (it)
DE (1)	DE3152182A1 (it)
FR (1)	FR2486397A1 (it)
GB (1)	GB2089210B (it)
IT (1)	IT1237327B (it)
NL (1)	NL8120270A (it)
NO (1)	NO153638C (it)
SE (1)	SE447448B (it)
WO (1)	WO1982000099A1 (it)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS58206751A (ja) *	1982-05-26	1983-12-02	日石三菱株式会社	創傷被覆材
FR2532546B1 (fr) *	1982-09-07	1985-12-27	Biotrol Sa Lab	Pate pour la protection de la peau
FR2548021B1 (fr) *	1983-06-29	1986-02-28	Dick P R	Compositions pharmaceutiques dermiques a action prolongee et continue a base d'acides gras essentiels
DE3409079A1 (de) *	1984-03-13	1985-09-19	Bayer Ag, 5090 Leverkusen	Medizinische pflaster
SE457326B (sv) *	1986-02-14	1988-12-19	Lejus Medical Ab	Foerfarande foer framstaellning av en snabbt soenderfallande kaerna innehaallande bl a mikrokristallin cellulosa
US4860543A (en) *	1986-08-08	1989-08-29	Helix Technology Corporation	Vibration isolation system for a linear reciprocating machine
SU1705319A1 (ru) *	1987-10-23	1992-01-15	Всесоюзный Научно-Исследовательский Институт Биотехнологии	Состав полимерной диффузионной матрицы дл трансдермального введени лекарственных веществ
IT1261305B (it) *	1993-06-22	1996-05-14	Gevipi Ag	Dispositivo smorzatore di vibrazioni e di rumore, per impianti idraulici
DE4429667C2 (de) *	1994-08-20	1996-07-11	Lohmann Therapie Syst Lts	Estradiol-TTS mit wasserbindenden Zusätzen und Verfahren zu seiner Herstellung
EP1239846A2 (en) *	1999-12-16	2002-09-18	Dermatrends, Inc.	Transdermal administration of phenylpropanolamine
US6602912B2 (en)	2000-06-30	2003-08-05	Dermatrends, Inc.	Transdermal administration of phenylpropanolamine
US6719997B2 (en)	2000-06-30	2004-04-13	Dermatrends, Inc.	Transdermal administration of pharmacologically active amines using hydroxide-releasing agents as permeation enhancers
US6673363B2 (en)	1999-12-16	2004-01-06	Dermatrends, Inc.	Transdermal and topical administration of local anesthetic agents using basic enhancers

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2693438A (en) *	1951-02-21	1954-11-02	Norwich Pharma Co	Preformed, nonadherent films for application to open lesions
US2804073A (en) *	1953-01-26	1957-08-27	Protective Teatments Inc	Fluid surgical dressing
BE638231A (it) *	1962-03-16
US3214338A (en) *	1964-07-31	1965-10-26	Ehrlich Joseph Ronald	Medicament releasing film-forming ointments and process of making
SU219116A1 (ru) *	1965-11-26	1973-03-20	А. А. Вишневский, Т. Т. Даурова, М. И. Долгина, И. А. Паников, Ф. П. Сидельковска , М. И. Шрайбер	Пленка для первичной обработки ожоговой поверхности
DE1617282A1 (de) *	1965-11-30	1975-02-06	Astra Pharma Prod	Vorrichtung zur lokalanaesthetisierung durch oertliche aufbringung und verfahren zur herstellung dieser vorrichtung
GB1213295A (en) *	1967-04-27	1970-11-25	Boots Pure Drug Co Ltd	Improvements in therapeutic compositions for topical application
FR2047874A6 (it) *	1969-06-10	1971-03-19	Nouvel Lucien
US3577516A (en) *	1969-12-02	1971-05-04	Nat Patent Dev Corp	Preparation of spray on bandage
DE2012775C3 (de) *	1970-03-18	1973-10-04	V.P. Variopharm Gmbh Herstellung Und Vertrieb Pharmazeutischer, Kosmetischer Und Chemischer Erzeugnisse, 6656 Einoed	Salbenfohe und Verfahren zu ihrer Herstellung
US3892905A (en) *	1970-08-12	1975-07-01	Du Pont	Cold water soluble plastic films
US4210633A (en) *	1978-10-20	1980-07-01	Eli Lilly And Company	Flurandrenolide film formulation
IL59063A (en) *	1979-01-11	1983-12-30	Key Pharma	Polymeric diffusion matrix for release of pharmaceutical dosage

1981
- 1981-06-24 CA CA000380505A patent/CA1163559A/en not_active Expired
- 1981-06-26 AU AU74151/81A patent/AU7415181A/en not_active Abandoned
- 1981-06-26 WO PCT/US1981/000893 patent/WO1982000099A1/en active Application Filing
- 1981-06-26 JP JP56502416A patent/JPS57500980A/ja active Pending
- 1981-06-26 CH CH1456/82A patent/CH658597A5/de not_active IP Right Cessation
- 1981-06-26 DE DE813152182T patent/DE3152182A1/de not_active Withdrawn
- 1981-06-26 GB GB8206466A patent/GB2089210B/en not_active Expired
- 1981-06-26 NL NL8120270A patent/NL8120270A/nl unknown
- 1981-07-08 BE BE0/205347A patent/BE889549A/fr not_active IP Right Cessation
- 1981-07-09 FR FR8113518A patent/FR2486397A1/fr active Pending
1982
- 1982-02-24 IT IT8219833A patent/IT1237327B/it active
- 1982-03-04 SE SE8201337A patent/SE447448B/sv not_active IP Right Cessation
- 1982-03-08 NO NO820722A patent/NO153638C/no unknown

Also Published As

Publication number	Publication date
NO153638C (no)	1986-05-07
CA1163559A (en)	1984-03-13
WO1982000099A1 (en)	1982-01-21
GB2089210B (en)	1984-09-05
FR2486397A1 (fr)	1982-01-15
AU7415181A (en)	1982-02-02
JPS57500980A (it)	1982-06-03
DE3152182A1 (de)	1983-02-10
NO820722L (no)	1982-03-08
IT8219833A0 (it)	1982-02-24
GB2089210A (en)	1982-06-23
CH658597A5 (de)	1986-11-28
NO153638B (no)	1986-01-20
SE8201337L (en)	1982-03-04
NL8120270A (en)	1982-06-01
BE889549A (fr)	1981-11-03
IT1237327B (it)	1993-05-31

Legal Events

Date

Code

Title

Description

1995-01-31

NUG

Patent has lapsed

Ref document number: 8201337-6

Effective date: 19890725

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JPH02149514A (ja)	1990-06-08	医薬部材
JPS58501034A (ja)	1983-06-30	プロプラノロ−ル含有高分子拡散マトリツクス
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