IT1237327B - Matrice polimerica di diffusione per la somministrazione di farmaci. - Google Patents

Matrice polimerica di diffusione per la somministrazione di farmaci.

Info

Publication number: IT1237327B
Authority: IT; Italy
Prior art keywords: diffusion matrix; polymeric diffusion; administering drugs; matrix; drug
Prior art date: 1980-07-09

Application number

IT8219833A

Other languages

English (en)

Other versions

IT8219833A0 (it

Inventor

Alec D Keith

Wallace Snipes

Original Assignee

Key Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-07-09

Filing date

1982-02-24

Publication date

1993-05-31

1980-07-09 Priority claimed from US06/167,101 external-priority patent/US4294820A/en

1980-07-11 Priority claimed from US06/167,729 external-priority patent/US4291014A/en

1982-02-24 Application filed by Key Pharma filed Critical Key Pharma

1982-02-24 Publication of IT8219833A0 publication Critical patent/IT8219833A0/it

1993-05-31 Application granted granted Critical

1993-05-31 Publication of IT1237327B publication Critical patent/IT1237327B/it

Links

229940079593 drug Drugs 0.000 title abstract 5
239000003814 drug Substances 0.000 title abstract 5
239000011159 matrix material Substances 0.000 title abstract 3
238000009792 diffusion process Methods 0.000 title abstract 2
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 5
KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 abstract 2
235000011187 glycerol Nutrition 0.000 abstract 2
XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 abstract 1
FPXKNYVSOKOLKD-BTJKTKAUSA-N (z)-but-2-enedioic acid;n-chloroaniline Chemical compound OC(=O)\C=C/C(O)=O.ClNC1=CC=CC=C1 FPXKNYVSOKOLKD-BTJKTKAUSA-N 0.000 abstract 1
GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 abstract 1
239000004372 Polyvinyl alcohol Substances 0.000 abstract 1
229960002896 clonidine Drugs 0.000 abstract 1
KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 abstract 1
230000010339 dilation Effects 0.000 abstract 1
229960002179 ephedrine Drugs 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
ODLMAHJVESYWTB-UHFFFAOYSA-N ethylmethylbenzene Natural products CCCC1=CC=CC=C1 ODLMAHJVESYWTB-UHFFFAOYSA-N 0.000 abstract 1
229960001802 phenylephrine Drugs 0.000 abstract 1
SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 abstract 1
229920003023 plastic Polymers 0.000 abstract 1
229920002451 polyvinyl alcohol Polymers 0.000 abstract 1
229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
230000002035 prolonged effect Effects 0.000 abstract 1
229960000195 terbutaline Drugs 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Reproductive Health (AREA)
Gynecology & Obstetrics (AREA)
Urology & Nephrology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IT8219833A 1980-07-09 1982-02-24 Matrice polimerica di diffusione per la somministrazione di farmaci. IT1237327B (it)

Applications Claiming Priority (9)

Application Number	Priority Date	Filing Date	Title
US16700880A	1980-07-09	1980-07-09
US06/167,101 US4294820A (en)	1979-08-14	1980-07-09	Polymeric diffusion matrix containing phenylephrine
US06/167,010 US4292301A (en)	1979-08-14	1980-07-09	Polymeric diffusion matrix containing ephedrine
US06/167,106 US4292303A (en)	1979-08-14	1980-07-09	Polymeric diffusion matrix containing clonidine
US06/167,009 US4289749A (en)	1979-08-14	1980-07-09	Polymeric diffusion matrix containing phenylpropanolamine
US06/167,104 US4292302A (en)	1979-08-14	1980-07-09	Polymeric diffusion matrix containing terbutaline
US06/167,729 US4291014A (en)	1979-01-11	1980-07-11	Polymeric diffusion matrix containing estradiol diacetate
US06/217,400 US4321252A (en)	1979-08-14	1980-12-17	Polymeric diffusion matrix containing ester derivatives of estradiol
PCT/US1981/000893 WO1982000099A1 (en)	1980-07-09	1981-06-26	Polymeric diffusion matrix for administration of drugs

Publications (2)

Publication Number	Publication Date
IT8219833A0 IT8219833A0 (it)	1982-02-24
IT1237327B true IT1237327B (it)	1993-05-31

Family

ID=41698406

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT8219833A IT1237327B (it)	1980-07-09	1982-02-24	Matrice polimerica di diffusione per la somministrazione di farmaci.

Country Status (13)

Country	Link
JP (1)	JPS57500980A (it)
AU (1)	AU7415181A (it)
BE (1)	BE889549A (it)
CA (1)	CA1163559A (it)
CH (1)	CH658597A5 (it)
DE (1)	DE3152182A1 (it)
FR (1)	FR2486397A1 (it)
GB (1)	GB2089210B (it)
IT (1)	IT1237327B (it)
NL (1)	NL8120270A (it)
NO (1)	NO153638C (it)
SE (1)	SE447448B (it)
WO (1)	WO1982000099A1 (it)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS58206751A (ja) *	1982-05-26	1983-12-02	日石三菱株式会社	創傷被覆材
FR2532546B1 (fr) *	1982-09-07	1985-12-27	Biotrol Sa Lab	Pate pour la protection de la peau
FR2548021B1 (fr) *	1983-06-29	1986-02-28	Dick P R	Compositions pharmaceutiques dermiques a action prolongee et continue a base d'acides gras essentiels
DE3409079A1 (de) *	1984-03-13	1985-09-19	Bayer Ag, 5090 Leverkusen	Medizinische pflaster
SE457326B (sv) *	1986-02-14	1988-12-19	Lejus Medical Ab	Foerfarande foer framstaellning av en snabbt soenderfallande kaerna innehaallande bl a mikrokristallin cellulosa
US4860543A (en) *	1986-08-08	1989-08-29	Helix Technology Corporation	Vibration isolation system for a linear reciprocating machine
SU1705319A1 (ru) *	1987-10-23	1992-01-15	Всесоюзный Научно-Исследовательский Институт Биотехнологии	Состав полимерной диффузионной матрицы дл трансдермального введени лекарственных веществ
IT1261305B (it) *	1993-06-22	1996-05-14	Gevipi Ag	Dispositivo smorzatore di vibrazioni e di rumore, per impianti idraulici
DE4429667C2 (de) *	1994-08-20	1996-07-11	Lohmann Therapie Syst Lts	Estradiol-TTS mit wasserbindenden Zusätzen und Verfahren zu seiner Herstellung
EP1239846A2 (en) *	1999-12-16	2002-09-18	Dermatrends, Inc.	Transdermal administration of phenylpropanolamine
US6602912B2 (en)	2000-06-30	2003-08-05	Dermatrends, Inc.	Transdermal administration of phenylpropanolamine
US6719997B2 (en)	2000-06-30	2004-04-13	Dermatrends, Inc.	Transdermal administration of pharmacologically active amines using hydroxide-releasing agents as permeation enhancers
US6673363B2 (en)	1999-12-16	2004-01-06	Dermatrends, Inc.	Transdermal and topical administration of local anesthetic agents using basic enhancers

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2693438A (en) *	1951-02-21	1954-11-02	Norwich Pharma Co	Preformed, nonadherent films for application to open lesions
US2804073A (en) *	1953-01-26	1957-08-27	Protective Teatments Inc	Fluid surgical dressing
BE638231A (it) *	1962-03-16
US3214338A (en) *	1964-07-31	1965-10-26	Ehrlich Joseph Ronald	Medicament releasing film-forming ointments and process of making
SU219116A1 (ru) *	1965-11-26	1973-03-20	А. А. Вишневский, Т. Т. Даурова, М. И. Долгина, И. А. Паников, Ф. П. Сидельковска , М. И. Шрайбер	Пленка для первичной обработки ожоговой поверхности
DE1617282A1 (de) *	1965-11-30	1975-02-06	Astra Pharma Prod	Vorrichtung zur lokalanaesthetisierung durch oertliche aufbringung und verfahren zur herstellung dieser vorrichtung
GB1213295A (en) *	1967-04-27	1970-11-25	Boots Pure Drug Co Ltd	Improvements in therapeutic compositions for topical application
FR2047874A6 (it) *	1969-06-10	1971-03-19	Nouvel Lucien
US3577516A (en) *	1969-12-02	1971-05-04	Nat Patent Dev Corp	Preparation of spray on bandage
DE2012775C3 (de) *	1970-03-18	1973-10-04	V.P. Variopharm Gmbh Herstellung Und Vertrieb Pharmazeutischer, Kosmetischer Und Chemischer Erzeugnisse, 6656 Einoed	Salbenfohe und Verfahren zu ihrer Herstellung
US3892905A (en) *	1970-08-12	1975-07-01	Du Pont	Cold water soluble plastic films
US4210633A (en) *	1978-10-20	1980-07-01	Eli Lilly And Company	Flurandrenolide film formulation
IL59063A (en) *	1979-01-11	1983-12-30	Key Pharma	Polymeric diffusion matrix for release of pharmaceutical dosage

1981
- 1981-06-24 CA CA000380505A patent/CA1163559A/en not_active Expired
- 1981-06-26 AU AU74151/81A patent/AU7415181A/en not_active Abandoned
- 1981-06-26 WO PCT/US1981/000893 patent/WO1982000099A1/en active Application Filing
- 1981-06-26 JP JP56502416A patent/JPS57500980A/ja active Pending
- 1981-06-26 CH CH1456/82A patent/CH658597A5/de not_active IP Right Cessation
- 1981-06-26 DE DE813152182T patent/DE3152182A1/de not_active Withdrawn
- 1981-06-26 GB GB8206466A patent/GB2089210B/en not_active Expired
- 1981-06-26 NL NL8120270A patent/NL8120270A/nl unknown
- 1981-07-08 BE BE0/205347A patent/BE889549A/fr not_active IP Right Cessation
- 1981-07-09 FR FR8113518A patent/FR2486397A1/fr active Pending
1982
- 1982-02-24 IT IT8219833A patent/IT1237327B/it active
- 1982-03-04 SE SE8201337A patent/SE447448B/sv not_active IP Right Cessation
- 1982-03-08 NO NO820722A patent/NO153638C/no unknown

Also Published As

Publication number	Publication date
NO153638C (no)	1986-05-07
CA1163559A (en)	1984-03-13
WO1982000099A1 (en)	1982-01-21
GB2089210B (en)	1984-09-05
FR2486397A1 (fr)	1982-01-15
AU7415181A (en)	1982-02-02
JPS57500980A (it)	1982-06-03
DE3152182A1 (de)	1983-02-10
NO820722L (no)	1982-03-08
IT8219833A0 (it)	1982-02-24
GB2089210A (en)	1982-06-23
CH658597A5 (de)	1986-11-28
NO153638B (no)	1986-01-20
SE8201337L (en)	1982-03-04
NL8120270A (en)	1982-06-01
BE889549A (fr)	1981-11-03
SE447448B (sv)	1986-11-17

Publication	Publication Date	Title
IT1237327B (it)	1993-05-31	Matrice polimerica di diffusione per la somministrazione di farmaci.
FI78389C (fi)	1989-08-10	Vaginalring.
US4781714A (en)	1988-11-01	Dispenser for delivering thermo-responsive composition
NO891680D0 (no)	1989-04-24	Osmotisk kontinuerlig avgivende oralt avgivelsessystem inneholdende et farmasoeytisk akseptabelt aktivt middel som har forbedrede kjernemembran-adhesjonsegenskaper.
DE3484165D1 (de)	1991-04-04	Vernetzte poroese polymere fuer eine kontrollierte wirkstoffabgabe.
ES2053981T3 (es)	1994-08-01	Composicion de revestimiento farmaceutica de base acuosa para formas de dosificacion.
ES8608864A1 (es)	1986-07-16	Un procedimiento para producir un preparado a modo de hojas
CA2313642A1 (en)	1999-06-17	Pharmaceutical hydrogel formulations, drug delivery devices and methods
PT88854A (pt)	1989-07-31	Sistema para a libertacao controlada dum medicamento benefico
ATE251895T1 (de)	2003-11-15	Hydrophobe arzneistoffabgabesysteme
DE3864543D1 (de)	1991-10-10	Vorrichtung zur arzneistoffabgabe und verfahren zu ihrer herstellung.
HUP9801526A2 (hu)	1998-10-28	Inhaláló berendezés albuterol adagolására mért dózisban
DE3865631D1 (de)	1991-11-21	Darreichungsform mit kontrollierter freigabe.
NO171004C (no)	1993-01-13	Fremgangsmaate for fremstilling av en utleveringsanordningsom i naervaer av en opploesningsvaeske frigir en biologisk aktiv bestanddel ved en i praksis konstant hastighet under en utvidet tidsperiode
FI973452A0 (fi)	1997-08-22	Nauhoitettu annosmuoto aktiivisen aineen pidennettyyn jakamiseen
ATE63059T1 (de)	1991-05-15	Vorrichtung mit zwei schichten zur freisetzung von arzneimitteln.
JPS61103820A (ja)	1986-05-22	結腸一治療系
ES8607008A1 (es)	1986-06-16	Procedimiento para la preparar una tableta farmaceutica para procurar una liberacion sostenidad de medicamento.
SE8701479L (sv)	1988-10-10	Metod foer inneslutning av biologiskt verksamma preparat samt anvaendning daerav
SE8803822D0 (sv)	1988-10-26	Novel dosage form
NZ512194A (en)	2002-09-27	A pharmaceutical composition comprising cyclosporin in a lipid carrier
DE3772954D1 (de)	1991-10-17	Arzneimittel mit verzoegerter wirkstoffabgabe.
DK595987A (da)	1988-05-15	Osmotisk kontinuerligt dispenserende oralt afgivelsessystem indeholdende et moderat vandoploeseligt metoprololsalt