SA518391864B1 - مشتقات باي بيرازوليل مفيدة لمعالجة أمراض المناعة الذاتية - Google Patents
مشتقات باي بيرازوليل مفيدة لمعالجة أمراض المناعة الذاتيةInfo
- Publication number
- SA518391864B1 SA518391864B1 SA518391864A SA518391864A SA518391864B1 SA 518391864 B1 SA518391864 B1 SA 518391864B1 SA 518391864 A SA518391864 A SA 518391864A SA 518391864 A SA518391864 A SA 518391864A SA 518391864 B1 SA518391864 B1 SA 518391864B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- treatment
- bipyrazolyl
- autoimmune diseases
- derivatives useful
- compounds
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Abstract
يتعلق الاختراع الحالي بمركبات بالصيغة (I) (I)، حيث تم تعريف R1، Cy وY في هذه الوثيقة، والتي تكون مناسبة لمعالجة أمراض متعلقة بكيناز تيروسين Bruton Bruton's tyrosine kinase (BTK)، وعمليات لتحضير تلك المركبات، والمستحضرات الصيدلانية pharmaceutical preparations التي تحتوي على تلك المركبات، وطرق للاستخدام. شكل 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562268278P | 2015-12-16 | 2015-12-16 | |
| US201662431008P | 2016-12-07 | 2016-12-07 | |
| PCT/US2016/066799 WO2017106429A2 (en) | 2015-12-16 | 2016-12-15 | Heteroaromatic compounds as btk inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SA518391864B1 true SA518391864B1 (ar) | 2021-12-13 |
Family
ID=58737849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SA518391864A SA518391864B1 (ar) | 2015-12-16 | 2018-06-23 | مشتقات باي بيرازوليل مفيدة لمعالجة أمراض المناعة الذاتية |
Country Status (31)
| Country | Link |
|---|---|
| US (6) | US9975882B2 (ar) |
| EP (1) | EP3390390B1 (ar) |
| JP (1) | JP6976947B2 (ar) |
| KR (1) | KR20180095655A (ar) |
| CN (1) | CN108368086B (ar) |
| AU (1) | AU2016370743B2 (ar) |
| BR (1) | BR112018011969B1 (ar) |
| CA (1) | CA3005268A1 (ar) |
| CL (1) | CL2018001569A1 (ar) |
| CO (1) | CO2018005954A2 (ar) |
| CY (1) | CY1124749T1 (ar) |
| DK (1) | DK3390390T3 (ar) |
| EA (1) | EA034561B1 (ar) |
| ES (1) | ES2897910T3 (ar) |
| HK (1) | HK1256795A1 (ar) |
| HR (1) | HRP20211845T1 (ar) |
| HU (1) | HUE056877T2 (ar) |
| IL (1) | IL259281B (ar) |
| LT (1) | LT3390390T (ar) |
| MX (1) | MX2018007333A (ar) |
| MY (1) | MY197440A (ar) |
| PE (1) | PE20181074A1 (ar) |
| PH (1) | PH12018501248A1 (ar) |
| PL (1) | PL3390390T3 (ar) |
| PT (1) | PT3390390T (ar) |
| RS (1) | RS62525B1 (ar) |
| SA (1) | SA518391864B1 (ar) |
| SG (1) | SG11201804890TA (ar) |
| SI (1) | SI3390390T1 (ar) |
| TW (1) | TWI726017B (ar) |
| WO (1) | WO2017106429A2 (ar) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112015002590A2 (pt) | 2012-08-10 | 2019-08-06 | Boehringer Ingelheim Int | compostos heteroaromáticos como inibidores de tirosina cinase de bruton (btk) |
| EA034561B1 (ru) * | 2015-12-16 | 2020-02-20 | Бёрингер Ингельхайм Интернациональ Гмбх | Бипиразолильные производные, пригодные для лечения аутоиммунных заболеваний |
| LT3390395T (lt) | 2015-12-16 | 2020-11-25 | Loxo Oncology, Inc. | Junginiai, naudingi kaip kinazės inhibitoriai |
| US10570118B2 (en) | 2016-01-13 | 2020-02-25 | Boehringer Ingelheim International Gmbh | Isoquinolones as BTK inhibitors |
| JP7166331B2 (ja) * | 2017-08-01 | 2022-11-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 中間体化合物及び方法 |
| KR102653681B1 (ko) | 2018-07-31 | 2024-04-03 | 록쏘 온콜로지, 인코포레이티드 | (s)-5-아미노-3-(4-((5-플루오로-2-메톡시벤즈아미도)메틸)페닐)-1-(1,1,1-트리플루오로프로판-2-일)-1h-피라졸-4-카르복스아미드의분무-건조된 분산물 및 제제 |
| AU2020242287A1 (en) | 2019-03-21 | 2021-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A Dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| BR112021023110A2 (pt) * | 2019-05-23 | 2022-04-12 | Novartis Ag | Métodos de tratamento de síndrome de sjögren com o uso de um inibidor de tirosina quinase de bruton |
| US20220401436A1 (en) | 2019-11-08 | 2022-12-22 | INSERM (Institute National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| WO2022140246A1 (en) | 2020-12-21 | 2022-06-30 | Hangzhou Jijing Pharmaceutical Technology Limited | Methods and compounds for targeted autophagy |
| WO2023110936A1 (en) | 2021-12-14 | 2023-06-22 | Netherlands Translational Research Center Holding B.V | Reversible macrocyclic kinase inhibitors |
| WO2023110970A1 (en) | 2021-12-14 | 2023-06-22 | Netherlands Translational Research Center Holding B.V | Macrocyclic btk inhibitors |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9608435D0 (en) | 1996-04-24 | 1996-06-26 | Celltech Therapeutics Ltd | Chemical compounds |
| CA2369076A1 (en) * | 2000-02-05 | 2001-08-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compositions useful as inhibitors of erk |
| DE60211348T2 (de) | 2001-08-13 | 2007-02-08 | Janssen Pharmaceutica N.V. | 2,4,5-trisubstituted thiazolyl derivative und deren antiinflammatorische wirkung |
| WO2003072541A2 (en) * | 2001-09-27 | 2003-09-04 | Smithkline Beecham Corporation | Chemical compounds |
| FR2881426B1 (fr) | 2005-02-03 | 2007-03-30 | Aventis Pharma Sa | Pyrolles et imidazoles substitues, compositions les contenant, procede de frabrication et utilisation |
| WO2007117692A2 (en) | 2006-04-11 | 2007-10-18 | Vertex Pharmaceuticals Incorporated | Thiazoles, imidazoles, and pyrazoles useful as inhibitors of protein kinases |
| EP2081435B1 (en) | 2006-09-22 | 2016-05-04 | Pharmacyclics LLC | Inhibitors of bruton's tyrosine kinase |
| EP2560007A1 (en) | 2007-03-28 | 2013-02-20 | Pharmacyclics, Inc. | Identification of bruton's tyrosine kinase inhibitors |
| ES2445099T3 (es) | 2008-07-29 | 2014-02-28 | Université de Liège | Una prueba de marcador genético para braquispina y fertilidad en ganado vacuno |
| GB0820819D0 (en) | 2008-11-13 | 2008-12-24 | Sareum Ltd | Pharmaceutical compounds |
| CA2750935A1 (en) | 2009-01-30 | 2010-08-12 | Millennium Pharmaceuticals, Inc. | Heteroaryls and their use as pi3k inhibitors |
| JP2013514287A (ja) | 2009-12-17 | 2013-04-25 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | スフィンゴシンキナーゼの阻害薬 |
| MX2012013622A (es) | 2010-05-31 | 2013-02-01 | Ono Pharmaceutical Co | Derivado de purinona. |
| EP2603216A4 (en) | 2010-08-11 | 2013-12-18 | Millennium Pharm Inc | HETEROARYLE AND USES THEREOF |
| US8377946B1 (en) | 2011-12-30 | 2013-02-19 | Pharmacyclics, Inc. | Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors |
| EP2809673B1 (en) * | 2012-01-31 | 2016-11-02 | Nanjing Allgen Pharma Co. Ltd. | Spirocyclic molecules as bruton's tyrosine kinase inhibitors |
| BR112015002590A2 (pt) * | 2012-08-10 | 2019-08-06 | Boehringer Ingelheim Int | compostos heteroaromáticos como inibidores de tirosina cinase de bruton (btk) |
| JP6178861B2 (ja) | 2012-11-02 | 2017-08-09 | ファイザー・インク | ブルトン型チロシンキナーゼ阻害剤 |
| CN103848810A (zh) * | 2012-11-30 | 2014-06-11 | 北京赛林泰医药技术有限公司 | 鲁顿酪氨酸激酶抑制剂 |
| EP2970163B1 (en) * | 2013-03-14 | 2018-02-28 | Boehringer Ingelheim International GmbH | 5-thiazolecarboxamide dervatives and their use as btk inhibitors |
| US9828364B2 (en) | 2014-01-29 | 2017-11-28 | Boehringer Ingelheim International Gmbh | Pyrazole compounds as BTK inhibitors |
| EA034561B1 (ru) * | 2015-12-16 | 2020-02-20 | Бёрингер Ингельхайм Интернациональ Гмбх | Бипиразолильные производные, пригодные для лечения аутоиммунных заболеваний |
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2016
- 2016-12-15 EA EA201891399A patent/EA034561B1/ru not_active IP Right Cessation
- 2016-12-15 LT LTEPPCT/US2016/066799T patent/LT3390390T/lt unknown
- 2016-12-15 PT PT168673788T patent/PT3390390T/pt unknown
- 2016-12-15 EP EP16867378.8A patent/EP3390390B1/en active Active
- 2016-12-15 KR KR1020187020450A patent/KR20180095655A/ko not_active Application Discontinuation
- 2016-12-15 RS RS20211356A patent/RS62525B1/sr unknown
- 2016-12-15 CN CN201680072250.3A patent/CN108368086B/zh active Active
- 2016-12-15 ES ES16867378T patent/ES2897910T3/es active Active
- 2016-12-15 AU AU2016370743A patent/AU2016370743B2/en active Active
- 2016-12-15 HU HUE16867378A patent/HUE056877T2/hu unknown
- 2016-12-15 HR HRP20211845TT patent/HRP20211845T1/hr unknown
- 2016-12-15 DK DK16867378.8T patent/DK3390390T3/da active
- 2016-12-15 SI SI201631382T patent/SI3390390T1/sl unknown
- 2016-12-15 US US15/379,745 patent/US9975882B2/en active Active
- 2016-12-15 PL PL16867378T patent/PL3390390T3/pl unknown
- 2016-12-15 TW TW105141510A patent/TWI726017B/zh active
- 2016-12-15 SG SG11201804890TA patent/SG11201804890TA/en unknown
- 2016-12-15 MX MX2018007333A patent/MX2018007333A/es active IP Right Grant
- 2016-12-15 PE PE2018001111A patent/PE20181074A1/es unknown
- 2016-12-15 WO PCT/US2016/066799 patent/WO2017106429A2/en active Application Filing
- 2016-12-15 BR BR112018011969-5A patent/BR112018011969B1/pt active IP Right Grant
- 2016-12-15 CA CA3005268A patent/CA3005268A1/en active Granted
- 2016-12-15 JP JP2018531127A patent/JP6976947B2/ja active Active
- 2016-12-15 MY MYPI2018000892A patent/MY197440A/en unknown
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2017
- 2017-10-12 US US15/782,214 patent/US20180030037A1/en not_active Abandoned
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2018
- 2018-04-09 US US15/947,978 patent/US20180222893A1/en not_active Abandoned
- 2018-05-10 IL IL259281A patent/IL259281B/en active IP Right Grant
- 2018-06-12 CO CONC2018/0005954A patent/CO2018005954A2/es unknown
- 2018-06-13 CL CL2018001569A patent/CL2018001569A1/es unknown
- 2018-06-13 PH PH12018501248A patent/PH12018501248A1/en unknown
- 2018-06-23 SA SA518391864A patent/SA518391864B1/ar unknown
- 2018-09-21 US US16/137,790 patent/US20190092759A1/en not_active Abandoned
- 2018-12-11 HK HK18115878.5A patent/HK1256795A1/zh unknown
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2019
- 2019-08-29 US US16/555,205 patent/US20200055843A1/en not_active Abandoned
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2020
- 2020-07-23 US US16/936,821 patent/US20210009567A1/en not_active Abandoned
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2021
- 2021-11-24 CY CY20211101015T patent/CY1124749T1/el unknown
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