RU95110698A - Способ лечения инфекций, вызываемых вирусом гепатита в - Google Patents

Способ лечения инфекций, вызываемых вирусом гепатита в

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Publication number
RU95110698A
RU95110698A RU95110698/14A RU95110698A RU95110698A RU 95110698 A RU95110698 A RU 95110698A RU 95110698/14 A RU95110698/14 A RU 95110698/14A RU 95110698 A RU95110698 A RU 95110698A RU 95110698 A RU95110698 A RU 95110698A
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RU
Russia
Prior art keywords
treatment
hepatitis
virus
infections caused
monophosphate
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RU95110698/14A
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English (en)
Other versions
RU2157215C2 (ru
Inventor
П.Шинази Рэймонд
Us]
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Эмори Юниверсити (Us)
Эмори Юниверсити
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Publication of RU95110698A publication Critical patent/RU95110698A/ru
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Publication of RU2157215C2 publication Critical patent/RU2157215C2/ru

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/08—Bridged systems

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Abstract

Изобретение относится к способу лечения людей, инфицированных вирусом гепатита В, заключающемуся во введении эффективного количества энантиомерно чистого бета-1-диоксоланилпуриннуклеозида формулы (I), где R - ОН, С1, NНили Н, а X выбирают из группы, включающей в себя алкил, ацил, монофосфат, дифосфат и трифосфа, или его фармацевтически приемлемой соли.

Claims (1)

  1. Изобретение относится к способу лечения людей, инфицированных вирусом гепатита В, заключающемуся во введении эффективного количества энантиомерно чистого бета-1-диоксоланилпуриннуклеозида формулы (I), где R - ОН, С1, NН2 или Н, а X выбирают из группы, включающей в себя алкил, ацил, монофосфат, дифосфат и трифосфа, или его фармацевтически приемлемой соли.
RU95110698/14A 1992-10-28 1993-10-28 Способ лечения инфекций, вызываемых вирусом гепатита в RU2157215C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/967,460 1992-10-28
US07/967,460 US5444063A (en) 1990-12-05 1992-10-28 Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity

Publications (2)

Publication Number Publication Date
RU95110698A true RU95110698A (ru) 1996-12-20
RU2157215C2 RU2157215C2 (ru) 2000-10-10

Family

ID=25512829

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95110698/14A RU2157215C2 (ru) 1992-10-28 1993-10-28 Способ лечения инфекций, вызываемых вирусом гепатита в

Country Status (15)

Country Link
US (4) US5444063A (ru)
EP (1) EP0666749B1 (ru)
JP (1) JP3117217B2 (ru)
KR (1) KR100304246B1 (ru)
CN (3) CN1044089C (ru)
AT (1) ATE165004T1 (ru)
AU (1) AU693079B2 (ru)
CA (2) CA2147893C (ru)
DE (1) DE69318031T2 (ru)
DK (1) DK0666749T3 (ru)
ES (1) ES2115918T3 (ru)
HK (2) HK1014663A1 (ru)
RU (1) RU2157215C2 (ru)
TW (1) TW420612B (ru)
WO (1) WO1994009793A1 (ru)

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ATE165004T1 (de) 1998-05-15
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CA2147893A1 (en) 1994-05-11
CN1679612A (zh) 2005-10-12
DK0666749T3 (da) 1999-01-04
CN1044089C (zh) 1999-07-14
US5830898A (en) 1998-11-03
CA2268703C (en) 2001-05-01
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US5684010A (en) 1997-11-04
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US5444063A (en) 1995-08-22
RU2157215C2 (ru) 2000-10-10
DE69318031D1 (de) 1998-05-20
CN1195526C (zh) 2005-04-06
JP3117217B2 (ja) 2000-12-11
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CN1092427A (zh) 1994-09-21
TW420612B (en) 2001-02-01
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