RU2017113604A - Наконечники для назальной доставки лекарственных средств - Google Patents
Наконечники для назальной доставки лекарственных средств Download PDFInfo
- Publication number
- RU2017113604A RU2017113604A RU2017113604A RU2017113604A RU2017113604A RU 2017113604 A RU2017113604 A RU 2017113604A RU 2017113604 A RU2017113604 A RU 2017113604A RU 2017113604 A RU2017113604 A RU 2017113604A RU 2017113604 A RU2017113604 A RU 2017113604A
- Authority
- RU
- Russia
- Prior art keywords
- tip
- drug
- channel
- propellant
- distal end
- Prior art date
Links
- 239000003814 drug Substances 0.000 title claims 16
- 229940079593 drug Drugs 0.000 claims 15
- 239000003380 propellant Substances 0.000 claims 10
- 239000012530 fluid Substances 0.000 claims 2
- 239000007789 gas Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 238000005096 rolling process Methods 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/08—Inhaling devices inserted into the nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
- A61D7/04—Devices for anaesthetising animals by gases or vapours; Inhaling devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/12—Preparation of respiratory gases or vapours by mixing different gases
- A61M16/122—Preparation of respiratory gases or vapours by mixing different gases with dilution
- A61M16/125—Diluting primary gas with ambient air
- A61M16/127—Diluting primary gas with ambient air by Venturi effect, i.e. entrainment mixers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
- B05B1/14—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means with multiple outlet openings; with strainers in or outside the outlet opening
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
- B05B7/02—Spray pistols; Apparatus for discharge
- B05B7/08—Spray pistols; Apparatus for discharge with separate outlet orifices, e.g. to form parallel jets, i.e. the axis of the jets being parallel, to form intersecting jets, i.e. the axis of the jets converging but not necessarily intersecting at a point
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/20—Valves specially adapted to medical respiratory devices
- A61M16/208—Non-controlled one-way valves, e.g. exhalation, check, pop-off non-rebreathing valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0612—Eyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0618—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1042—Alimentary tract
- A61M2210/1067—Anus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/14—Female reproductive, genital organs
- A61M2210/1475—Vagina
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Otolaryngology (AREA)
- Emergency Medicine (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Medicinal Preparation (AREA)
- Nozzles (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (22)
1. Наконечник для выдачи препарата пользователю, содержащий:
корпус наконечника, имеющий центральную ось;
множество каналов, размещенных в пределах корпуса, причем каждый из них имеет проксимальный и дистальный конец;
впуск, расположенный у проксимального конца каждого из каналов; и
выпускное отверстие, расположенное у дистального конца каждого из каналов с образованием множества выпускных отверстий.
2. Наконечник по п. 1, в котором каждое из выпускных отверстий расположены на равном расстоянии от центральной оси корпуса наконечника.
3. Наконечник по п. 1, в котором выпускные отверстия расположены так, что из наконечника выходит узкий шлейф.
4. Наконечник по п. 4, в котором угол наклона шлейфа составляет приблизительно 5 градусов, приблизительно 4 градуса, приблизительно 3 градуса, приблизительно 2 градуса, приблизительно 1 градус.
5. Наконечник по п. 4, в котором угол наклона шлейфа составляет 5 градусов.
6. Наконечник по п. 1, дополнительно содержащий контейнер, содержащий пропеллент в сообщении по текучей среде с впуском, при этом пропеллент выполнен с возможностью выталкивания препарата из впуска через множество каналов и за пределы множества выпускных отверстий.
7. Наконечник для выдачи препарата пользователю, содержащий:
корпус наконечника;
канал для препарата, размещенный в пределах корпуса наконечника, при этом канал для препарата имеет проксимальный конец и дистальный конец, причем проксимальный канал выполнен с возможностью приема препарата, а дистальный конец канала для препарата имеет выпускное отверстие;
канал для пропеллента, имеющий проксимальный конец и дистальный конец, при этом проксимальный конец выполнен с возможностью приема пропеллента, а дистальный конец канала для пропеллента имеет выпускное отверстие; и
контрольный запорный клапан, который предотвращает протекание пропеллента через камеру для препарата при высвобождении препарата.
8. Наконечник по п. 7, в котором препарат представляет собой жидкость, порошок, газ или их сочетание.
9. Наконечник по п. 7, в котором канал для пропеллента центрирован в пределах канала для препарата.
10. Наконечник по п. 7, в котором контрольный запорный клапан содержит шар, диаметр которого меньше диаметра канала для препарата.
11. Наконечник по п. 10, в котором шар выполнен из пластика.
12. Наконечник по п. 10, в котором шар выполнен с возможностью качения к дистальному концу канала для препарата в местоположение за отверстием наконечника, предотвращая, таким образом, прохождение пропеллента через канал для препарата.
13. Наконечник по п. 7, дополнительно содержащий по меньшей мере второй канал для препарата, при этом наконечник выполнен с возможностью выдачи более одного препарата за раз.
14. Наконечник по п. 7, дополнительно содержащий контейнер, содержащий пропеллент в сообщении по текучей среде с каналом для пропеллента.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161484048P | 2011-05-09 | 2011-05-09 | |
| US61/484,048 | 2011-05-09 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013154420A Division RU2618084C2 (ru) | 2011-05-09 | 2012-05-09 | Наконечники для назальной доставки лекарственных средств |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2017113604A true RU2017113604A (ru) | 2019-01-28 |
| RU2017113604A3 RU2017113604A3 (ru) | 2020-07-28 |
| RU2741249C2 RU2741249C2 (ru) | 2021-01-22 |
Family
ID=47139631
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013154420A RU2618084C2 (ru) | 2011-05-09 | 2012-05-09 | Наконечники для назальной доставки лекарственных средств |
| RU2017113604A RU2741249C2 (ru) | 2011-05-09 | 2012-05-09 | Наконечники для назальной доставки лекарственных средств |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013154420A RU2618084C2 (ru) | 2011-05-09 | 2012-05-09 | Наконечники для назальной доставки лекарственных средств |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US9919117B2 (ru) |
| EP (2) | EP2707146B1 (ru) |
| JP (2) | JP6645735B2 (ru) |
| CN (2) | CN107376071B (ru) |
| AU (2) | AU2012253569B2 (ru) |
| BR (1) | BR112013028572B8 (ru) |
| CA (1) | CA2835208C (ru) |
| RU (2) | RU2618084C2 (ru) |
| WO (1) | WO2012154859A1 (ru) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2713762C (en) | 2008-02-07 | 2016-10-18 | University Of Washington | Circumferential aerosol device |
| WO2011124094A1 (zh) | 2010-04-07 | 2011-10-13 | Zhuang Kunjie | 一种双极化微带天线 |
| WO2012119153A2 (en) | 2011-03-03 | 2012-09-07 | Impel Neuropharma Inc. | Nasal drug delivery device |
| RU2618084C2 (ru) | 2011-05-09 | 2017-05-02 | Импел Ньюрофарма Инк. | Наконечники для назальной доставки лекарственных средств |
| CA2908158A1 (en) * | 2013-04-04 | 2014-10-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, Centers For Disease Control And Prevention | Nasal aerosol delivery system |
| EP2991713B1 (en) | 2013-04-28 | 2019-06-19 | Impel Neuropharma Inc. | Medical unit dose container |
| JP6570189B2 (ja) * | 2013-10-15 | 2019-09-04 | ミスティック ファーマシューティカルズ， インコーポレイテッド | 制御可能な速度の乱流形成ノズル |
| WO2015149922A2 (en) * | 2014-03-31 | 2015-10-08 | Boehringer Ingelheim Vetmedica Gmbh | Inhaler |
| EP3125821B1 (en) * | 2014-03-31 | 2023-06-07 | Boehringer Ingelheim Vetmedica GmbH | Insert for an inhaler |
| FR3025110B1 (fr) * | 2014-09-02 | 2016-12-23 | Univ Francois-Rabelais De Tours | Dispositif de pulverisation nasale de produit fluide |
| EP3283151B1 (en) * | 2015-04-15 | 2022-07-20 | Philip Morris Products S.A. | Dry powder inhaler and method of use |
| NZ741171A (en) * | 2015-09-10 | 2022-01-28 | Impel Neuropharma Inc | In-line nasal delivery device |
| CN105366214A (zh) * | 2015-12-16 | 2016-03-02 | 广州立白企业集团有限公司 | 一种多出液孔气雾剂喷雾盖 |
| GB201700727D0 (en) * | 2017-01-16 | 2017-03-01 | Teva Pharma | Inhalers and airflow adaptors therefor |
| KR101943258B1 (ko) * | 2017-09-08 | 2019-01-30 | 시오 컴퍼니 리미티드 | 노즐, 노즐 고정 구조 및 노즐 조립체 |
| AU2018334334B2 (en) | 2017-09-15 | 2024-06-13 | Shin Nippon Biomedical Laboratories, Ltd. | Medicine storage cartridge with nozzle, sprayer therefor, and powdered medicine dispensing device for nasal cavity |
| US10368502B2 (en) | 2017-09-25 | 2019-08-06 | Multiple Energy Technologies Llc | Bioceramic and carbon-based hydroponic systems, methods and devices |
| EP3713626A4 (en) | 2017-11-21 | 2021-08-18 | Impel Neuropharma Inc. | INTRA-NASAL DEVICE WITH INPUT INTERFACE |
| JP7191099B2 (ja) | 2017-11-21 | 2022-12-16 | インペル ファーマシューティカルズ インコーポレイテッド | 浸漬管を備えた鼻腔内装置 |
| US11232874B2 (en) * | 2017-12-18 | 2022-01-25 | Ge-Hitachi Nuclear Energy Americas Llc | Multiple-path flow restrictor nozzle |
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| EP3735244B1 (en) * | 2018-01-05 | 2022-11-23 | Impel Pharmaceuticals Inc. | Intranasal delivery of dihydroergotamine by precision olfactory device |
| EP3735223A4 (en) | 2018-01-05 | 2021-10-13 | Impel Neuropharma Inc. | INTRANASAL ADMINISTRATION OF OLANZAPINE BY A PRECISION OLFACTORY DEVICE |
| MX2020010706A (es) | 2018-04-12 | 2021-01-20 | Rocket Science Health Corp | Proceso, sistema y dispositivo de entrega intranasal de medicamentos. |
| US20190336986A1 (en) * | 2018-05-02 | 2019-11-07 | Bryan Tapocik | Sprayer with a six-hole spray pattern |
| KR20210034047A (ko) | 2018-07-19 | 2021-03-29 | 임펠 뉴로파마 인코포레이티드 | 파킨슨 병 치료를 위한 레보도파 및 도파 데카르복실라아제 저해제의 기도 전달 |
| EA202191856A1 (ru) | 2019-01-03 | 2021-09-02 | Импел Ньюрофарма, Инк. | Устройство для назальной доставки лекарственных средств |
| BR112021023049A8 (pt) | 2019-05-17 | 2022-10-18 | Impel Neuropharma Inc | Dispositivo de dispensação nasal de uso único |
| US11052205B2 (en) | 2019-06-11 | 2021-07-06 | Neosinus Health Inc | Devices and methods for delivering fluid to a nasal cavity |
| EP4028085A4 (en) * | 2019-09-13 | 2023-10-04 | Janssen Pharmaceuticals, Inc. | INTRANASAL ADMINISTRATION OF ESKETAMINE |
| GB202011729D0 (en) | 2020-07-29 | 2020-09-09 | Kindeva Drug Delivery Lp | Device for delivery of a compound to a region of the nasal cavity |
| EP4101486A1 (de) * | 2021-06-11 | 2022-12-14 | Aptar Radolfzell GmbH | Flüssigkeitsspender für nasale anwendungen |
| CN115365022A (zh) * | 2022-08-30 | 2022-11-22 | 中国人民解放军陆军装甲兵学院 | 粒子射流喷嘴 |
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