RU2017108862A - Лечение патологических состояний суставов - Google Patents
Лечение патологических состояний суставов Download PDFInfo
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- RU2017108862A RU2017108862A RU2017108862A RU2017108862A RU2017108862A RU 2017108862 A RU2017108862 A RU 2017108862A RU 2017108862 A RU2017108862 A RU 2017108862A RU 2017108862 A RU2017108862 A RU 2017108862A RU 2017108862 A RU2017108862 A RU 2017108862A
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- 230000001575 pathological effect Effects 0.000 title claims 5
- 238000000034 method Methods 0.000 claims 33
- 239000000203 mixture Substances 0.000 claims 13
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims 8
- DZTHIGRZJZPRDV-GFCCVEGCSA-N N-acetyl-D-tryptophan Chemical compound C1=CC=C2C(C[C@@H](NC(=O)C)C(O)=O)=CNC2=C1 DZTHIGRZJZPRDV-GFCCVEGCSA-N 0.000 claims 5
- DZTHIGRZJZPRDV-UHFFFAOYSA-N Nalpha-Acetyltryptophan Natural products C1=CC=C2C(CC(NC(=O)C)C(O)=O)=CNC2=C1 DZTHIGRZJZPRDV-UHFFFAOYSA-N 0.000 claims 5
- 238000002347 injection Methods 0.000 claims 5
- 239000007924 injection Substances 0.000 claims 5
- 229940116191 n-acetyltryptophan Drugs 0.000 claims 5
- RVLCUCVJZVRNDC-IMJSIDKUSA-N 2-[(2s,5s)-5-methyl-3,6-dioxopiperazin-2-yl]acetic acid Chemical compound C[C@@H]1NC(=O)[C@H](CC(O)=O)NC1=O RVLCUCVJZVRNDC-IMJSIDKUSA-N 0.000 claims 4
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims 4
- 102000008100 Human Serum Albumin Human genes 0.000 claims 4
- 108091006905 Human Serum Albumin Proteins 0.000 claims 4
- 108010038239 aspartyl-alanyl-diketopiperazine Proteins 0.000 claims 4
- WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical compound CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 claims 4
- 229960002446 octanoic acid Drugs 0.000 claims 4
- 201000008482 osteoarthritis Diseases 0.000 claims 4
- 102000009027 Albumins Human genes 0.000 claims 3
- 108010088751 Albumins Proteins 0.000 claims 3
- 230000003902 lesion Effects 0.000 claims 3
- 238000000108 ultra-filtration Methods 0.000 claims 3
- 208000012659 Joint disease Diseases 0.000 claims 2
- 230000006378 damage Effects 0.000 claims 2
- 230000014759 maintenance of location Effects 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000000472 traumatic effect Effects 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 230000000202 analgesic effect Effects 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940124599 anti-inflammatory drug Drugs 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 230000009693 chronic damage Effects 0.000 claims 1
- 230000003111 delayed effect Effects 0.000 claims 1
- 238000000432 density-gradient centrifugation Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000000706 filtrate Substances 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 210000001503 joint Anatomy 0.000 claims 1
- 230000002980 postoperative effect Effects 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 238000000527 sonication Methods 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/38—Albumins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (33)
1. Способ лечения патологического состояния сустава, включающий введение нуждающемуся в этом животному эффективного количества фармацевтической композиции, содержащей DA-DKP, в многодозовом режиме.
2. Способ по п. 1, в котором патологическим состоянием сустава является заболевание сустава.
3. Способ по п. 2, в котором заболеванием сустава является дегенеративное заболевание сустава.
4. Способ по п. 3, в котором дегенеративным заболеванием сустава является остеоартрит.
5. Способ по п. 1, в котором патологическим состоянием сустава является поражение сустава.
6. Способ по п. 5, в котором поражением сустава является по меньшей мере одно из следующих: травматическое поражение и послеоперационное поражение.
7. Способ по п. 5, в котором поражением сустава является хроническое повреждение травматического характера.
8. Способ по п. 1, в котором патологическим состоянием сустава является воспаление.
9. Способ по п. 1, в котором композицию вводят с помощью пути введения, выбранного из группы, включающей локальное введение, местное введение и инъекцию.
10. Способ по п. 9, в котором введение с помощью инъекции проводят с помощью внутрисуставной инъекции.
11. Способ по п. 10, в котором композиция, вводимая с помощью внутрисуставной инъекции, представляет собой композицию, имеющая концентрацию DA-DKP, равную от примерно 50 мкМ до примерно 350 мкМ.
12. Способ по п. 1, в котором композиция дополнительно содержит N-ацетилтриптофан (NAT), каприловую кислоту, каприлат или их комбинации.
13. Способ по п. 10, в котором композиция, представляет собой композицию, имеющая концентрацию NAT, каприловой кислоты, каприлата или их комбинации, равную от примерно 4 мМ до примерно 20 мМ.
14. Способ по п. 1, в котором DA-DKP содержится в композиции, полученной путем удаления альбумина из раствора композиции сывороточного альбумина человека.
15. Способ по п. 14, в котором стадия удаления альбумина включает обработку композиции сывороточного альбумина человека по методике разделения, выбранной из группы, включающей ультрафильтрование, центрифугирование в градиенте плотности сахарозы, хроматографию, осаждение соли и обработку ультразвуком.
16. Способ по п. 15, в котором стадия удаления включает пропускание композиции сывороточного альбумина человека через ультрафильтрующую мембрану, обладающую номинальной задерживаемой молекулярной массой, которая обеспечивает удерживание альбумина и при использовании которой полученный фильтрат содержит DA-DKP.
17. Способ по п. 16, в котором ультрафильтрующая мембрана обладает номинальной задерживаемой молекулярной массой, равной менее 50 кДа, менее 40 кДа, менее 30 кДа, менее 20 кДа, менее 10 кДа, менее 5 кДа или менее 3 кДа.
18. Способ по п. 14, в котором композиция дополнительно содержит NAT, каприловую кислоту, каприлат или их комбинации.
19. Способ по п. 18, в котором композиция, представляет собой композицию, имеющую концентрацию NAT, каприловой кислоты, каприлата или их комбинации, равной от примерно 4 мМ до примерно 20 мМ.
20. Способ по п. 1, в котором фармацевтическая композиция дополнительно содержит второе лекарственное средство, выбранное из группы, включающей анальгетическое, противовоспалительное лекарственное средство и их комбинации.
21. Способ по п. 1, в котором количество доз в многодозовом режиме равно от 2 до 10.
22. Способ по п. 1, в котором количество доз в многодозовом режиме равно от 2 до 8.
23. Способ по п. 1, в котором количество доз в многодозовом режиме равно от 2 до 6.
24. Способ по п. 1, в котором количество доз в многодозовом режиме равно от 2 до 4.
25. Способ по п. 1, в котором количество доз в многодозовом режиме равно 3.
26. Способ по п. 1, в котором промежуток времени между дозами в многодозовом режиме составляет от 2 дней до 6 недель.
27. Способ по п. 1, в котором промежуток времени между дозами в многодозовом режиме составляет от 2 дней до 6 недель.
28. Способ по п. 1, в котором промежуток времени между дозами в многодозовом режиме составляет от 2 дней до 5 недель.
29. Способ по п. 1, в котором промежуток времени между дозами в многодозовом режиме составляет от 2 дней до 4 недель.
30. Способ по п. 1, в котором промежуток времени между дозами в многодозовом режиме составляет от 2 дней до 3 недель.
31. Способ по п. 1, в котором промежуток времени между дозами в многодозовом режиме составляет от 1 недели до 3 недель.
32. Способ по п. 1, в котором промежуток времени между дозами в многодозовом режиме составляет примерно 2 недели.
33. Способ лечения остеоартрита, включающий введение с помощью внутрисуставной инъекции в пораженный сустав первой дозы, второй дозы и третьей дозы, в котором каждая первая доза, вторая доза и третья доза содержит 4 мл фракции сывороточного альбумина человека, имеющей ММ, равную <5000, , и в котором вторую дозу вводят через две недели после первой дозы и третью дозу вводят через две недели после второй дозы.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462038682P | 2014-08-18 | 2014-08-18 | |
| US62/038,682 | 2014-08-18 | ||
| PCT/US2015/045706 WO2016028790A1 (en) | 2014-08-18 | 2015-08-18 | Treatment of joint conditions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2020136589A Division RU2020136589A (ru) | 2014-08-18 | 2015-08-18 | Лечение дегенеративных заболеваний суставов |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2017108862A true RU2017108862A (ru) | 2018-09-20 |
| RU2017108862A3 RU2017108862A3 (ru) | 2019-01-23 |
| RU2736513C2 RU2736513C2 (ru) | 2020-11-17 |
Family
ID=55301320
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017108862A RU2736513C2 (ru) | 2014-08-18 | 2015-08-18 | Лечение патологических состояний суставов |
| RU2020136589A RU2020136589A (ru) | 2014-08-18 | 2015-08-18 | Лечение дегенеративных заболеваний суставов |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2020136589A RU2020136589A (ru) | 2014-08-18 | 2015-08-18 | Лечение дегенеративных заболеваний суставов |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US9956217B2 (ru) |
| EP (2) | EP3183240A4 (ru) |
| JP (3) | JP6723222B2 (ru) |
| KR (1) | KR20170045274A (ru) |
| CN (1) | CN106604915A (ru) |
| AU (1) | AU2015305611B2 (ru) |
| CA (1) | CA2958080A1 (ru) |
| IL (2) | IL250513B (ru) |
| RU (2) | RU2736513C2 (ru) |
| WO (1) | WO2016028790A1 (ru) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7931301A (en) | 2000-08-04 | 2002-02-18 | Dmi Biosciences Inc | Method of using diketopiperazines and composition containing them |
| CA3050734A1 (en) | 2003-05-15 | 2004-12-02 | Ampio Pharmaceuticals, Inc. | Treatment of t-cell mediated diseases |
| US8217047B2 (en) | 2008-05-27 | 2012-07-10 | Dmi Acquisition Corp. | Therapeutic methods and compounds |
| KR20140075772A (ko) | 2011-10-10 | 2014-06-19 | 앰피오 파마슈티컬스 인코퍼레이티드 | 면역 내성을 증가시킨 이식 의료 장비, 및 그의 제조 및 이식 방법 |
| US8980834B2 (en) * | 2011-10-10 | 2015-03-17 | Ampio Pharmaceuticals, Inc. | Treatment of degenerative joint disease |
| SG11201400283RA (en) | 2011-10-28 | 2014-03-28 | Ampio Pharmaceuticals Inc | Treatment of rhinitis |
| MX2015010937A (es) | 2013-03-15 | 2015-10-29 | Ampio Pharmaceuticals Inc | Composiciones para la movilizacion, autodireccion, expansion y diferenciacion de celulas madre y metodos para usar las mismas. |
| JP6723222B2 (ja) * | 2014-08-18 | 2020-07-15 | アンピオ ファーマシューティカルズ，インコーポレイテッド | 関節病態の治療 |
| WO2016209969A1 (en) | 2015-06-22 | 2016-12-29 | Ampio Pharmaceuticals, Inc. | Use of low molecular weight fractions of human serum albumin in treating diseases |
| CN110551175B (zh) * | 2018-06-04 | 2021-07-02 | 首都医科大学 | 氨基酸和氨甲环酸修饰的二酮哌嗪,其制备,活性及应用 |
| WO2021195265A1 (en) | 2020-03-24 | 2021-09-30 | Ampio Pharmaceuticals, Inc. | Methods for treating diseases associated with respiratory viruses |
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|---|---|---|---|---|
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| BE765030A (fr) | 1970-04-02 | 1971-08-16 | Snam Progetti | Composes contenant un noyau de dicetopiperazine et leur procedede fabrication |
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| IT1212892B (it) | 1983-10-11 | 1989-11-30 | Della Valle Francesco | Acido ialuronico ottenuto per mezzodi filtrazione molecolare sprovvisto di attivita' infiammatoria e sua utilizzazione terapeutica |
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-
2015
- 2015-08-18 JP JP2017509768A patent/JP6723222B2/ja not_active Expired - Fee Related
- 2015-08-18 US US14/829,289 patent/US9956217B2/en active Active
- 2015-08-18 EP EP15833436.7A patent/EP3183240A4/en not_active Withdrawn
- 2015-08-18 RU RU2017108862A patent/RU2736513C2/ru active
- 2015-08-18 AU AU2015305611A patent/AU2015305611B2/en not_active Ceased
- 2015-08-18 EP EP22166994.8A patent/EP4066836A1/en not_active Withdrawn
- 2015-08-18 WO PCT/US2015/045706 patent/WO2016028790A1/en active Application Filing
- 2015-08-18 RU RU2020136589A patent/RU2020136589A/ru unknown
- 2015-08-18 CN CN201580044705.6A patent/CN106604915A/zh active Pending
- 2015-08-18 KR KR1020177007625A patent/KR20170045274A/ko not_active Application Discontinuation
- 2015-08-18 CA CA2958080A patent/CA2958080A1/en not_active Abandoned
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2017
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2018
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2019
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2020
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2021
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- 2021-07-20 IL IL285003A patent/IL285003A/en unknown
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2022
- 2022-04-13 JP JP2022066206A patent/JP2022095876A/ja active Pending
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| Publication number | Publication date |
|---|---|
| US20200000800A1 (en) | 2020-01-02 |
| CN106604915A (zh) | 2017-04-26 |
| RU2017108862A3 (ru) | 2019-01-23 |
| JP6723222B2 (ja) | 2020-07-15 |
| US20190022087A1 (en) | 2019-01-24 |
| AU2015305611B2 (en) | 2020-04-23 |
| US11090301B2 (en) | 2021-08-17 |
| JP2020164538A (ja) | 2020-10-08 |
| EP3183240A1 (en) | 2017-06-28 |
| JP2022095876A (ja) | 2022-06-28 |
| JP2017524024A (ja) | 2017-08-24 |
| KR20170045274A (ko) | 2017-04-26 |
| IL250513B (en) | 2021-08-31 |
| IL285003A (en) | 2021-08-31 |
| RU2736513C2 (ru) | 2020-11-17 |
| US10342793B2 (en) | 2019-07-09 |
| IL250513A0 (en) | 2017-03-30 |
| AU2015305611A1 (en) | 2017-04-06 |
| CA2958080A1 (en) | 2016-02-25 |
| RU2020136589A (ru) | 2020-12-24 |
| EP4066836A1 (en) | 2022-10-05 |
| US20160045493A1 (en) | 2016-02-18 |
| US20210330668A1 (en) | 2021-10-28 |
| WO2016028790A1 (en) | 2016-02-25 |
| US9956217B2 (en) | 2018-05-01 |
| EP3183240A4 (en) | 2018-06-27 |
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