RU2016144668A - Комбинированная терапия противоопухолевым алкалоидом - Google Patents
Комбинированная терапия противоопухолевым алкалоидом Download PDFInfo
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- RU2016144668A RU2016144668A RU2016144668A RU2016144668A RU2016144668A RU 2016144668 A RU2016144668 A RU 2016144668A RU 2016144668 A RU2016144668 A RU 2016144668A RU 2016144668 A RU2016144668 A RU 2016144668A RU 2016144668 A RU2016144668 A RU 2016144668A
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- Prior art keywords
- cancer
- synergistic combination
- antibiotic
- pharmaceutically acceptable
- acceptable salt
- Prior art date
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- 238000002648 combination therapy Methods 0.000 title 1
- 239000011885 synergistic combination Substances 0.000 claims 12
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- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 claims 4
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- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 claims 2
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- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- XDXDZDZNSLXDNA-TZNDIEGXSA-N Idarubicin Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XDXDZDZNSLXDNA-TZNDIEGXSA-N 0.000 claims 1
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- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 claims 1
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- CFCUWKMKBJTWLW-BKHRDMLASA-N mithramycin Chemical compound O([C@@H]1C[C@@H](O[C@H](C)[C@H]1O)OC=1C=C2C=C3C[C@H]([C@@H](C(=O)C3=C(O)C2=C(O)C=1C)O[C@@H]1O[C@H](C)[C@@H](O)[C@H](O[C@@H]2O[C@H](C)[C@H](O)[C@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@@](C)(O)C3)C2)C1)[C@H](OC)C(=O)[C@@H](O)[C@@H](C)O)[C@H]1C[C@@H](O)[C@H](O)[C@@H](C)O1 CFCUWKMKBJTWLW-BKHRDMLASA-N 0.000 claims 1
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- KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 claims 1
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Claims (12)
1. Фармацевтическая синергическая комбинация для лечения рака, содержащая терапевтически эффективное количество РМ01183 или его фармацевтически приемлемой соли и терапевтически эффективное количество противоракового антибиотика.
2. Синергическая комбинация по п. 1, где рак, подлежащий лечению, выбран из рака легкого, саркомы, злокачественной меланомы, рака мочевого пузыря, рака предстательной железы, рака поджелудочной железы, рака щитовидной железы, рака желудка, рака яичника, гепатомы, рака молочной железы, колоректального рака, рака почки, рака пищевода, нейробластомы, рака головного мозга, рака шейки матки, анального рака, рака яичка, лейкоза, множественной миеломы и лимфомы.
3. Синергическая комбинация по п. 2, где рак, подлежащий лечению, выбран из рака легкого, саркомы, злокачественной меланомы, рака предстательной железы, рака поджелудочной железы, рака желудка, рака яичника, гепатомы, рака молочной железы, колоректального рака, рака почки, рака головного мозга, лейкоза и лимфомы.
4. Синергическая комбинация по п. 3, где РМ01183 или его фармацевтически приемлемая соль и противораковый антибиотик образуют часть одного и того же лекарственного средства.
5. Синергическая комбинация по п. 3, где РМ01183 или его фармацевтически приемлемая соль и противораковый антибиотик представлены в форме отдельных лекарственных средств для введения в одно и то же время или в разное время.
6. Синергическая комбинация по п. 5, где РМ01183 или его фармацевтически приемлемая соль и противораковый антибиотик представлены в форме отдельных лекарственных средств для введения в разное время.
7. Синергическая комбинация по п. 6, где противораковый антибиотик выбран из даунорубицина, доксорубицина, эпирубицина, идарубицина, митоксантрона, пиксантрона, валрубицина, митомицина С, блеомицина, актиномицина D и митрамицина.
8. Синергическая комбинация по п. 7, где противораковый антибиотик выбран из даунорубицина, доксорубицина, митомицина С и актиномицина D.
9. Синергическая комбинация по п. 8, где противораковый антибиотик представляет собой доксорубицин.
10. Способ лечения рака, включающий введение пациенту, который нуждается в указанном лечении, синергической комбинации по любому из пп. 1-9.
11. Применение синергической комбинации по любому из пп. 1-9 для лечения рака.
12. Применение синергической комбинации по любому из пп. 1-9 в производстве лекарственного средства для лечения рака.
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2016
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2017
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2018
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2019
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2020
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2023
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