RU2014153529A - Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки - Google Patents
Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки Download PDFInfo
- Publication number
- RU2014153529A RU2014153529A RU2014153529A RU2014153529A RU2014153529A RU 2014153529 A RU2014153529 A RU 2014153529A RU 2014153529 A RU2014153529 A RU 2014153529A RU 2014153529 A RU2014153529 A RU 2014153529A RU 2014153529 A RU2014153529 A RU 2014153529A
- Authority
- RU
- Russia
- Prior art keywords
- cells
- pancreatic endoderm
- endoderm cells
- activin
- expression
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/04—Plant cells or tissues
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
Abstract
1. Способ индукции экспрессии инсулина в клетках, экспрессирующих гормоны, включающий культивирование клеток панкреатической энтодермы с эфриновым лигандом.2. Способ по п. 2, в котором культивирование клеток панкреатической энтодермы с эфриновым лигандом также усиливает экспрессию ΝΚΧ6.1.3. Способ по п. 2, в котором культивирование клеток панкреатической энтодермы с эфриновым лигандом усиливает экспрессию инсулина и ΝΚΧ6.1 в клетках панкреатической энтодермы по сравнению с экспрессией инсулина и ΝΚΧ6.1 в необработанных клетках панкреатической энтодермы.4. Способ по п. 3, в котором клетки панкреатической энтодермы, по существу, не экспрессируют CDX2 или SOX2.5. Способ по п. 4, в котором клетки панкреатической энтодермы экспрессируют приблизительно менее 10% CDX2 или SOX2.6. Способ по любому из пп. 1-5, в котором эфриновым лигандом является эфрин A3 или эфрин A4.7. Способ по п. 6, в котором клетки панкреатической энтодермы получают путем поэтапной дифференцировки плюрипотентных стволовых клеток.8. Способ по п. 7, в котором плюрипотентные стволовые клетки представляют собой эмбриональные плюрипотентные стволовые клетки человека.9. Клетки, экспрессирующие инсулин и ΝΚΧ6.1, полученные способом по п. 1.10. Популяция клеток, полученная путем культивирования клеток панкреатической энтодермы с эфриновым лигандом, причем популяция клеток экспрессирует повышенные количества инсулина и ΝΚΧ6.1 по сравнению с клетками панкреатической энтодермы, не обработанными эфриновым лигандом.11. Популяция клеток по п. 10, где эфриновым лигандом является эфрин A3 или эфрин A4.12. Способ повышения экспрессии соматостатина в клетках, экспрессирующих гормоны, включающий культивирование клеток панкреатической
Claims (27)
1. Способ индукции экспрессии инсулина в клетках, экспрессирующих гормоны, включающий культивирование клеток панкреатической энтодермы с эфриновым лигандом.
2. Способ по п. 2, в котором культивирование клеток панкреатической энтодермы с эфриновым лигандом также усиливает экспрессию ΝΚΧ6.1.
3. Способ по п. 2, в котором культивирование клеток панкреатической энтодермы с эфриновым лигандом усиливает экспрессию инсулина и ΝΚΧ6.1 в клетках панкреатической энтодермы по сравнению с экспрессией инсулина и ΝΚΧ6.1 в необработанных клетках панкреатической энтодермы.
4. Способ по п. 3, в котором клетки панкреатической энтодермы, по существу, не экспрессируют CDX2 или SOX2.
5. Способ по п. 4, в котором клетки панкреатической энтодермы экспрессируют приблизительно менее 10% CDX2 или SOX2.
6. Способ по любому из пп. 1-5, в котором эфриновым лигандом является эфрин A3 или эфрин A4.
7. Способ по п. 6, в котором клетки панкреатической энтодермы получают путем поэтапной дифференцировки плюрипотентных стволовых клеток.
8. Способ по п. 7, в котором плюрипотентные стволовые клетки представляют собой эмбриональные плюрипотентные стволовые клетки человека.
9. Клетки, экспрессирующие инсулин и ΝΚΧ6.1, полученные способом по п. 1.
10. Популяция клеток, полученная путем культивирования клеток панкреатической энтодермы с эфриновым лигандом, причем популяция клеток экспрессирует повышенные количества инсулина и ΝΚΧ6.1 по сравнению с клетками панкреатической энтодермы, не обработанными эфриновым лигандом.
11. Популяция клеток по п. 10, где эфриновым лигандом является эфрин A3 или эфрин A4.
12. Способ повышения экспрессии соматостатина в клетках, экспрессирующих гормоны, включающий культивирование клеток панкреатической энтодермы в среде, содержащей активин А или активин С.
13. Способ по п. 12, в котором подавлена экспрессия инсулина, глюкагона и грелина.
14. Способ по п. 12, в котором популяция клеток панкреатической энтодермы, обработанных активином А или активином С, экспрессирует больше соматостатина, чем популяция клеток панкреатической энтодермы, не обработанных активином А или активином С.
15. Способ по п. 14, в котором экспрессия инсулина подавлена в популяции клеток панкреатической энтодермы, обработанных активином А или активином С, по сравнению с экспрессией инсулина в популяции клеток панкреатической энтодермы, не обработанных активином А или активином С.
16. Способ по п. 12, в котором экспрессия глюкагона подавлена в популяции клеток панкреатической энтодермы, обработанных активином А или активином С, по сравнению с экспрессией глюкагона в популяции клеток панкреатической энтодермы, не обработанных активином А или активином С.
17. Способ по п. 12, в котором экспрессия грелина подавлена в популяции клеток панкреатической энтодермы, обработанных активином А или активином С, по сравнению с экспрессией грелина в популяции клеток панкреатической энтодермы, не обработанных активином А или активином С.
18. Способ по любому из пп. 12-17, в котором клетки панкреатической энтодермы, по существу, не экспрессируют CDX2 или SOX2.
19. Способ по п. 18, в котором клетки панкреатической энтодермы, обработанные активином А или активином С, получают путем поэтапной дифференцировки плюрипотентных клеток.
20. Способ по п. 19, в котором плюрипотентные клетки, из которых получают клетки панкреатической энтодермы, являются эмбриональными плюрипотентными клетками человека.
21. Способ повышения экспрессии NKX6.1 путем обработки клеток панкреатической энтодермы средой, содержащей семафорин 3А или эпиген.
22. Способ по п. 21, в котором популяция клеток панкреатической энтодермы, обработанная средой, содержащей семафорин 3А или эпиген, экспрессирует повышенное количество NKX6.1 по сравнению с клетками панкреатической энтодермы, не обработанными средой, содержащей семафорин 3А или эпиген.
23. Способ по п. 21, в котором уровень экспрессии инсулина, глюкагона и грелина не изменяется в клетках панкреатической энтодермы, обработанных средой, содержащей семафорин 3А или эпиген, по сравнению с клетками панкреатической энтодермы, не обработанными средой, содержащей семафорин 3А или эпиген.
24. Способ индукции формирования эндокринных кластеров, включающий культивирование панкреатических эндокринных клеток с агонистом рецептора сфингозина-1.
25. Способ по п. 24, в котором для обработки панкреатических эндокринных клеток в качестве агониста рецептора сфингозина-1 используют сфингозин-1-фосфат (S1P).
26. Способ по п. 24, в котором панкреатические эндокринные клетки получают путем поэтапной дифференцировки плюрипотентных стволовых клеток.
27. Способ по п. 26, в котором плюрипотентные стволовые клетки представляют собой эмбриональные плюрипотентные стволовые клетки человека.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261657160P | 2012-06-08 | 2012-06-08 | |
| US61/657,160 | 2012-06-08 | ||
| PCT/US2013/044472 WO2013184888A1 (en) | 2012-06-08 | 2013-06-06 | Differentiation of human embryonic stem cells into pancreatic endocrine cells |
Related Child Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018108850A Division RU2018108850A (ru) | 2012-06-08 | 2013-06-06 | Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки |
| RU2018108851A Division RU2018108851A (ru) | 2012-06-08 | 2013-06-06 | Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки |
| RU2018108847A Division RU2018108847A (ru) | 2012-06-08 | 2013-06-06 | Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2014153529A true RU2014153529A (ru) | 2016-08-10 |
| RU2650813C2 RU2650813C2 (ru) | 2018-04-17 |
Family
ID=49712621
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018108847A RU2018108847A (ru) | 2012-06-08 | 2013-06-06 | Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки |
| RU2014153529A RU2650813C2 (ru) | 2012-06-08 | 2013-06-06 | Использование лигандов эпинефрина для дифференцирования клеток панкреатической эндодермы |
| RU2018108851A RU2018108851A (ru) | 2012-06-08 | 2013-06-06 | Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки |
| RU2018108850A RU2018108850A (ru) | 2012-06-08 | 2013-06-06 | Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018108847A RU2018108847A (ru) | 2012-06-08 | 2013-06-06 | Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018108851A RU2018108851A (ru) | 2012-06-08 | 2013-06-06 | Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки |
| RU2018108850A RU2018108850A (ru) | 2012-06-08 | 2013-06-06 | Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки |
Country Status (20)
| Country | Link |
|---|---|
| US (5) | US10066210B2 (ru) |
| EP (5) | EP3450543A1 (ru) |
| JP (3) | JP6469003B2 (ru) |
| KR (4) | KR20220156115A (ru) |
| CN (4) | CN108034633B (ru) |
| AR (1) | AR091388A1 (ru) |
| AU (4) | AU2013271581B2 (ru) |
| BR (1) | BR112014030682A2 (ru) |
| CA (2) | CA2875786C (ru) |
| DK (1) | DK3450542T3 (ru) |
| ES (2) | ES2690118T3 (ru) |
| HK (1) | HK1209160A1 (ru) |
| IN (1) | IN2014DN10021A (ru) |
| MX (1) | MX358590B (ru) |
| PH (4) | PH12014502661A1 (ru) |
| PL (1) | PL2859091T3 (ru) |
| RU (4) | RU2018108847A (ru) |
| SG (2) | SG10201610313WA (ru) |
| WO (1) | WO2013184888A1 (ru) |
| ZA (3) | ZA201802252B (ru) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
| CN101952415B (zh) | 2007-07-31 | 2017-06-27 | 生命扫描有限公司 | 人胚胎干细胞的分化 |
| CA3123528A1 (en) | 2007-11-27 | 2009-06-04 | Lifescan, Inc. | Differentiation of human embryonic stem cells to pancreatic cells |
| CA2715878C (en) | 2008-02-21 | 2017-06-13 | Centocor Ortho Biotech Inc. | Methods, surface modified plates and compositions for cell attachment, cultivation and detachment |
| EP2942392B1 (en) | 2008-06-30 | 2018-10-03 | Janssen Biotech, Inc. | Differentiation of pluripotent stem cells |
| AU2009308967C1 (en) | 2008-10-31 | 2017-04-20 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells to the pancreatic endocrine lineage |
| KR101687344B1 (ko) | 2008-11-20 | 2016-12-16 | 얀센 바이오테크 인코포레이티드 | 평면 기재상의 세포 부착 및 배양을 위한 방법 및 조성물 |
| CN107267442A (zh) | 2008-11-20 | 2017-10-20 | 詹森生物科技公司 | 微载体上的多能干细胞培养 |
| KR20170118969A (ko) | 2009-07-20 | 2017-10-25 | 얀센 바이오테크 인코포레이티드 | 인간 배아 줄기 세포의 분화 |
| MX343786B (es) | 2009-12-23 | 2016-11-22 | Janssen Biotech Inc | Diferenciacion de celulas madre embrionarias humanas. |
| CN107189979B (zh) | 2010-03-01 | 2021-05-04 | 詹森生物科技公司 | 纯化衍生自多能干细胞的细胞的方法 |
| SG10201503652WA (en) | 2010-05-12 | 2015-08-28 | Janssen Biotech Inc | Differentiation of human embryonic stem cells |
| AU2011296381B2 (en) * | 2010-08-31 | 2016-03-31 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| RU2668798C2 (ru) | 2011-12-22 | 2018-10-02 | Янссен Байотек, Инк. | Способы in vitro пошаговой дифференцировки полюрипотентных клеток |
| CA2866590A1 (en) | 2012-03-07 | 2013-09-12 | Janssen Biotech, Inc. | Defined media for expansion and maintenance of pluripotent stem cells |
| DK3450542T3 (da) * | 2012-06-08 | 2021-11-01 | Janssen Biotech Inc | Differentiering af humane embryonale stamceller til endokrine pancreatiske celler |
| US10370644B2 (en) | 2012-12-31 | 2019-08-06 | Janssen Biotech, Inc. | Method for making human pluripotent suspension cultures and cells derived therefrom |
| US10138465B2 (en) | 2012-12-31 | 2018-11-27 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into pancreatic endocrine cells using HB9 regulators |
| RU2658488C2 (ru) | 2012-12-31 | 2018-06-21 | Янссен Байотек, Инк. | Способ получения клеток, экспрессирующих маркеры, характерные для панкреатических эндокринных клеток |
| RU2018108090A (ru) | 2012-12-31 | 2019-02-25 | Янссен Байотек, Инк. | Суспендирование и кластеризация плюрипотентных клеток человека с целью их дифференцировки в панкреатические эндокринные клетки |
| US8859286B2 (en) | 2013-03-14 | 2014-10-14 | Viacyte, Inc. | In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells |
| JP6514689B2 (ja) | 2013-06-11 | 2019-05-15 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ＳＣ−β細胞及び組成物並びにその生成方法 |
| RU2694311C2 (ru) | 2014-05-16 | 2019-07-11 | Янссен Байотек, Инк. | Применение малых молекул для увеличения экспрессии mafa в панкреатических эндокринных клетках |
| US10472610B2 (en) * | 2014-05-21 | 2019-11-12 | Kyoto University | Method for generating pancreatic bud cells and therapeutic agent for pancreatic disease containing pancreatic bud cells |
| CN113234661A (zh) | 2014-12-18 | 2021-08-10 | 哈佛学院校长同事会 | 干细胞来源的β细胞的产生方法及其使用方法 |
| US10190096B2 (en) | 2014-12-18 | 2019-01-29 | President And Fellows Of Harvard College | Methods for generating stem cell-derived β cells and uses thereof |
| WO2016100898A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Serum-free in vitro directed differentiation protocol for generating stem cell-derived b cells and uses thereof |
| US20190169574A1 (en) * | 2016-02-04 | 2019-06-06 | Nestec S.A. | In vitro production of pancreatic beta cells |
| MA45479A (fr) | 2016-04-14 | 2019-02-20 | Janssen Biotech Inc | Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen |
| MA45502A (fr) * | 2016-06-21 | 2019-04-24 | Janssen Biotech Inc | Génération de cellules bêta fonctionnelles dérivées de cellules souches pluripotentes humaines ayant une respiration mitochondriale glucose-dépendante et une réponse en sécrétion d'insuline en deux phases |
| US20210147807A1 (en) * | 2017-06-14 | 2021-05-20 | Helmholtz Zentrum Munchen - Deutsches Forschungszentrum Fur Gesundheit Und Umwelt (Gmbh) | Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells |
| US10391156B2 (en) | 2017-07-12 | 2019-08-27 | Viacyte, Inc. | University donor cells and related methods |
| JP7428653B2 (ja) | 2017-11-15 | 2024-02-06 | バーテックス ファーマシューティカルズ インコーポレイテッド | 島細胞製造組成物および使用方法 |
| US20210207099A1 (en) * | 2018-05-16 | 2021-07-08 | Washington University | Methods and compositions for generating cells of endodermal lineage and beta cells and uses thereof |
| CA3108275A1 (en) | 2018-08-10 | 2020-02-13 | Vertex Pharmaceuticals Incorporated | Stem cell derived islet differentiation |
| CN111848743B (zh) * | 2018-09-03 | 2021-05-11 | 吉林省汇融生物科技有限公司 | 表皮干细胞向胰腺细胞分化的改进方法 |
| US10724052B2 (en) | 2018-09-07 | 2020-07-28 | Crispr Therapeutics Ag | Universal donor cells |
| US11014897B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Solid forms comprising a thiazolidinone compound, compositions and methods of use thereof |
| US11014940B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Thiazolidinone and oxazolidinone compounds and formulations |
| US11013723B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Solid forms of a thiazolidinone compound, compositions and methods of use thereof |
| US11186556B1 (en) | 2018-10-16 | 2021-11-30 | Celgene Corporation | Salts of a thiazolidinone compound, solid forms, compositions and methods of use thereof |
| AU2020284245B2 (en) | 2019-05-31 | 2023-10-05 | Viacyte, Inc. | A biocompatible membrane composite |
| US20220234006A1 (en) | 2019-05-31 | 2022-07-28 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
| WO2020243665A1 (en) | 2019-05-31 | 2020-12-03 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
| EP3976237A1 (en) | 2019-05-31 | 2022-04-06 | W.L. Gore & Associates Inc. | Cell encapsulation devices with controlled oxygen diffusion distances |
| EP4025224A1 (en) | 2019-09-05 | 2022-07-13 | CRISPR Therapeutics AG | Universal donor cells |
| CA3150235A1 (en) | 2019-09-05 | 2021-03-11 | Alireza Rezania | UNIVERSAL DONOR CELLS |
| TW202130805A (zh) * | 2019-10-21 | 2021-08-16 | 日商武田藥品工業股份有限公司 | 增生抑制劑 |
| JP2024503290A (ja) | 2020-12-31 | 2024-01-25 | クリスパー セラピューティクス アクチェンゲゼルシャフト | ユニバーサルドナー細胞 |
| CN114634904B (zh) * | 2022-05-17 | 2022-09-13 | 天津外泌体科技有限公司 | 高纯度胰腺祖细胞的产生方法 |
Family Cites Families (272)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3209652A (en) | 1961-03-30 | 1965-10-05 | Burgsmueller Karl | Thread whirling method |
| AT326803B (de) | 1968-08-26 | 1975-12-29 | Binder Fa G | Maschenware sowie verfahren zur herstellung derselben |
| US3935067A (en) | 1974-11-22 | 1976-01-27 | Wyo-Ben Products, Inc. | Inorganic support for culture media |
| CA1201400A (en) | 1982-04-16 | 1986-03-04 | Joel L. Williams | Chemically specific surfaces for influencing cell activity during culture |
| US4499802A (en) | 1982-09-29 | 1985-02-19 | Container Graphics Corporation | Rotary cutting die with scrap ejection |
| US4537773A (en) | 1983-12-05 | 1985-08-27 | E. I. Du Pont De Nemours And Company | α-Aminoboronic acid derivatives |
| US4557264A (en) | 1984-04-09 | 1985-12-10 | Ethicon Inc. | Surgical filament from polypropylene blended with polyethylene |
| US5215893A (en) | 1985-10-03 | 1993-06-01 | Genentech, Inc. | Nucleic acid encoding the ba chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid |
| US5089396A (en) | 1985-10-03 | 1992-02-18 | Genentech, Inc. | Nucleic acid encoding β chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid |
| US4737578A (en) | 1986-02-10 | 1988-04-12 | The Salk Institute For Biological Studies | Human inhibin |
| US5863531A (en) | 1986-04-18 | 1999-01-26 | Advanced Tissue Sciences, Inc. | In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework |
| US5804178A (en) | 1986-11-20 | 1998-09-08 | Massachusetts Institute Of Technology | Implantation of cell-matrix structure adjacent mesentery, omentum or peritoneum tissue |
| CA1340581C (en) | 1986-11-20 | 1999-06-08 | Joseph P. Vacanti | Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices |
| US5567612A (en) | 1986-11-20 | 1996-10-22 | Massachusetts Institute Of Technology | Genitourinary cell-matrix structure for implantation into a human and a method of making |
| NZ229354A (en) | 1988-07-01 | 1990-09-26 | Becton Dickinson Co | Treating polymer surfaces with a gas plasma and then applying a layer of endothelial cells to the surface |
| EP0363125A3 (en) | 1988-10-03 | 1990-08-16 | Hana Biologics Inc. | Proliferated pancreatic endocrine cell product and process |
| SU1767433A1 (ru) | 1989-11-27 | 1992-10-07 | Пермский государственный медицинский институт | Способ определени инсулинорезистентности имунного генеза у больных сахарным диабетом I типа |
| US5837539A (en) | 1990-11-16 | 1998-11-17 | Osiris Therapeutics, Inc. | Monoclonal antibodies for human mesenchymal stem cells |
| WO1992019759A1 (en) | 1991-04-25 | 1992-11-12 | Chugai Seiyaku Kabushiki Kaisha | Reconstituted human antibody against human interleukin 6 receptor |
| US5449383A (en) | 1992-03-18 | 1995-09-12 | Chatelier; Ronald C. | Cell growth substrates |
| GB9206861D0 (en) | 1992-03-28 | 1992-05-13 | Univ Manchester | Wound healing and treatment of fibrotic disorders |
| CA2114282A1 (en) | 1993-01-28 | 1994-07-29 | Lothar Schilder | Multi-layered implant |
| JP3525221B2 (ja) | 1993-02-17 | 2004-05-10 | 味の素株式会社 | 免疫抑制剤 |
| WO1994023572A1 (en) | 1993-04-08 | 1994-10-27 | Human Cell Cultures, Inc. | Cell culturing method and medium |
| US5523226A (en) | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
| GB9310557D0 (en) | 1993-05-21 | 1993-07-07 | Smithkline Beecham Plc | Novel process and apparatus |
| TW257671B (ru) | 1993-11-19 | 1995-09-21 | Ciba Geigy | |
| US6703017B1 (en) | 1994-04-28 | 2004-03-09 | Ixion Biotechnology, Inc. | Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures |
| US6001647A (en) | 1994-04-28 | 1999-12-14 | Ixion Biotechnology, Inc. | In vitro growth of functional islets of Langerhans and in vivo uses thereof |
| US5834308A (en) | 1994-04-28 | 1998-11-10 | University Of Florida Research Foundation, Inc. | In vitro growth of functional islets of Langerhans |
| US6083903A (en) | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
| EP0800829B2 (en) | 1994-12-29 | 2012-07-25 | Chugai Seiyaku Kabushiki Kaisha | Use of a pm-1 antibody or of a mh 166 antibody for enhancing the anti-tumor effect of cisplatin or carboplatin |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5718922A (en) | 1995-05-31 | 1998-02-17 | Schepens Eye Research Institute, Inc. | Intravitreal microsphere drug delivery and method of preparation |
| US5908782A (en) | 1995-06-05 | 1999-06-01 | Osiris Therapeutics, Inc. | Chemically defined medium for human mesenchymal stem cells |
| US5681561A (en) | 1995-06-07 | 1997-10-28 | Life Medical Sciences, Inc. | Compositions and methods for improving autologous fat grafting |
| EP0986635A4 (en) | 1997-01-10 | 2001-11-07 | Life Technologies Inc | SERUM SUBSTITUTE FOR EMBRYONIC STEM CELLS |
| PT1028954E (pt) | 1997-04-24 | 2003-11-28 | Ortho Mcneil Pharm Inc | Imidazoles substituidos uteis no tratamento de doencas inflamatorias |
| US6261549B1 (en) | 1997-07-03 | 2001-07-17 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells from peripheral blood |
| US6670127B2 (en) | 1997-09-16 | 2003-12-30 | Egea Biosciences, Inc. | Method for assembly of a polynucleotide encoding a target polypeptide |
| ATE462004T1 (de) | 1997-09-16 | 2010-04-15 | Centocor Inc | Methoden zur kompletten chemischen synthese und zusammensetzung von genen und genomen |
| AU1197699A (en) | 1997-10-23 | 1999-05-10 | Geron Corporation | Methods and materials for the growth of primate-derived primordial stem cells |
| US6372779B1 (en) | 1997-12-29 | 2002-04-16 | Ortho Pharmaceutical Corporation | Anti-inflammatory compounds |
| ATE316795T1 (de) | 1998-03-18 | 2006-02-15 | Osiris Therapeutics Inc | Mesenchymale stammzellen für die prävention und behandlung von immunantworten bei transplantationen |
| MY132496A (en) | 1998-05-11 | 2007-10-31 | Vertex Pharma | Inhibitors of p38 |
| US6413773B1 (en) | 1998-06-01 | 2002-07-02 | The Regents Of The University Of California | Phosphatidylinositol 3-kinase inhibitors as stimulators of endocrine differentiation |
| US6667176B1 (en) | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
| US7410798B2 (en) | 2001-01-10 | 2008-08-12 | Geron Corporation | Culture system for rapid expansion of human embryonic stem cells |
| US6610540B1 (en) | 1998-11-18 | 2003-08-26 | California Institute Of Technology | Low oxygen culturing of central nervous system progenitor cells |
| US6413556B1 (en) | 1999-01-08 | 2002-07-02 | Sky High, Llc | Aqueous anti-apoptotic compositions |
| CA2359159A1 (en) | 1999-01-21 | 2000-07-27 | Vitro Diagnostics, Inc. | Immortalized cell lines and methods of making the same |
| US6815203B1 (en) | 1999-06-23 | 2004-11-09 | Joslin Diabetes Center, Inc. | Methods of making pancreatic islet cells |
| US6333029B1 (en) | 1999-06-30 | 2001-12-25 | Ethicon, Inc. | Porous tissue scaffoldings for the repair of regeneration of tissue |
| US6306424B1 (en) | 1999-06-30 | 2001-10-23 | Ethicon, Inc. | Foam composite for the repair or regeneration of tissue |
| CA2385628A1 (en) | 1999-09-27 | 2001-04-05 | Ammon B. Peck | Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures |
| US6685936B2 (en) | 1999-10-12 | 2004-02-03 | Osiris Therapeutics, Inc. | Suppressor cells induced by culture with mesenchymal stem cells for treatment of immune responses in transplantation |
| US20030082155A1 (en) | 1999-12-06 | 2003-05-01 | Habener Joel F. | Stem cells of the islets of langerhans and their use in treating diabetes mellitus |
| US6753153B2 (en) | 1999-12-13 | 2004-06-22 | The Scripps Research Institute | Markers for identification and isolation of pancreatic islet α and β progenitors |
| US7439064B2 (en) | 2000-03-09 | 2008-10-21 | Wicell Research Institute, Inc. | Cultivation of human embryonic stem cells in the absence of feeder cells or without conditioned medium |
| US7005252B1 (en) | 2000-03-09 | 2006-02-28 | Wisconsin Alumni Research Foundation | Serum free cultivation of primate embryonic stem cells |
| US6436704B1 (en) | 2000-04-10 | 2002-08-20 | Raven Biotechnologies, Inc. | Human pancreatic epithelial progenitor cells and methods of isolation and use thereof |
| US6458589B1 (en) | 2000-04-27 | 2002-10-01 | Geron Corporation | Hepatocyte lineage cells derived from pluripotent stem cells |
| CN1449439A (zh) | 2000-06-26 | 2003-10-15 | 株式会社雷诺再生医学研究所 | 细胞级分包括能分化为神经细胞的细胞 |
| CZ20031125A3 (cs) | 2000-10-23 | 2003-10-15 | Smithkline Beecham Corporation | Nové sloučeniny |
| EP1345946B1 (en) | 2000-12-08 | 2005-08-10 | Ortho-McNeil Pharmaceutical, Inc. | Macroheterocylic compounds useful as kinase inhibitors |
| YU46603A (sh) | 2000-12-08 | 2006-05-25 | Ortho-Mcneil Pharmaceutical Inc. | Indazolil-supstituisana jedinjenja pirolina, kao inhibitori kinaze |
| US6599323B2 (en) | 2000-12-21 | 2003-07-29 | Ethicon, Inc. | Reinforced tissue implants and methods of manufacture and use |
| JP2005503759A (ja) | 2001-01-24 | 2005-02-10 | アメリカ合衆国 | 幹細胞の膵臓内分泌細胞への分化方法 |
| EP1360189A1 (en) | 2001-01-25 | 2003-11-12 | Millennium Pharmaceuticals, Inc. | Formulation of boronic acid compounds |
| US6656488B2 (en) | 2001-04-11 | 2003-12-02 | Ethicon Endo-Surgery, Inc. | Bioabsorbable bag containing bioabsorbable materials of different bioabsorption rates for tissue engineering |
| JP2004527249A (ja) | 2001-04-19 | 2004-09-09 | デヴェロゲン アクチエンゲゼルシャフト フュア エントヴィックルングスビオローギッシェ フォルシュング | 幹細胞をインスリン産生細胞に分化する方法 |
| EP1391505B1 (en) | 2001-04-24 | 2009-01-28 | Ajinomoto Co., Inc. | Stem cells and method of separating the same |
| CA2447015A1 (en) | 2001-05-15 | 2002-11-21 | Rappaport Family Institute For Research In The Medical Sciences | Insulin producing cells derived from human embryonic stem cells |
| US6626950B2 (en) | 2001-06-28 | 2003-09-30 | Ethicon, Inc. | Composite scaffold with post anchor for the repair and regeneration of tissue |
| KR100418195B1 (ko) | 2001-07-05 | 2004-02-11 | 주식회사 우리기술 | 전력케이블의 다중절연진단장치 및 그 방법 |
| GB0117583D0 (en) | 2001-07-19 | 2001-09-12 | Astrazeneca Ab | Novel compounds |
| US7432104B2 (en) | 2001-08-06 | 2008-10-07 | Bresgen Inc. | Methods for the culture of human embryonic stem cells on human feeder cells |
| US6617152B2 (en) | 2001-09-04 | 2003-09-09 | Corning Inc | Method for creating a cell growth surface on a polymeric substrate |
| EP1298201A1 (en) | 2001-09-27 | 2003-04-02 | Cardion AG | Process for the production of cells exhibiting an islet-beta-cell-like state |
| JP2005506074A (ja) | 2001-10-18 | 2005-03-03 | イクシオン・バイオテクノロジー・インコーポレーテッド | 肝臓の幹細胞および前駆細胞の膵臓機能細胞への転換 |
| DE60233248D1 (de) | 2001-11-15 | 2009-09-17 | Childrens Medical Center | Verfahren zur isolierung, expansion und differenzierung fötaler stammzellen aus chorionzotte, fruchtwasser und plazenta und therapeutische verwendungen davon |
| CN101240262A (zh) | 2001-12-07 | 2008-08-13 | 杰龙公司 | 源自人胚胎干细胞的胰岛细胞 |
| CN1630526B (zh) | 2001-12-07 | 2010-05-05 | 马克罗珀尔生物外科公司 | 用加工的脂肪抽吸细胞来治疗患者的***和方法 |
| WO2003054169A1 (en) | 2001-12-21 | 2003-07-03 | Thromb-X Nv | Compositions for the in vitro derivation and culture of embryonic stem (es) cell lines with germline transmission capability |
| US20050095703A1 (en) | 2001-12-28 | 2005-05-05 | Henrik Semb | Method for the establishment of a pluripotent human blastocyst - derived stem cell line |
| US20030162290A1 (en) | 2002-01-25 | 2003-08-28 | Kazutomo Inoue | Method for inducing differentiation of embryonic stem cells into functioning cells |
| US20030180268A1 (en) | 2002-02-05 | 2003-09-25 | Anthony Atala | Tissue engineered construct for supplementing or replacing a damaged organ |
| GB0207440D0 (en) * | 2002-03-28 | 2002-05-08 | Ppl Therapeutics Scotland Ltd | Tolerogenic antigen-presenting cells |
| JPWO2003087349A1 (ja) | 2002-04-17 | 2005-08-18 | 大塚製薬株式会社 | 間葉系細胞から膵β細胞を形成する方法 |
| US20040161419A1 (en) | 2002-04-19 | 2004-08-19 | Strom Stephen C. | Placental stem cells and uses thereof |
| ATE387444T1 (de) | 2002-05-08 | 2008-03-15 | Janssen Pharmaceutica Nv | Substituierte pyrroline als kinase inhibitoren |
| US20060003446A1 (en) | 2002-05-17 | 2006-01-05 | Gordon Keller | Mesoderm and definitive endoderm cell populations |
| EP1507848A4 (en) * | 2002-05-28 | 2005-11-23 | Becton Dickinson Co | EXPANSION AND TRANSDIFFERENCING OF HUMAN AZINUS CELLS |
| US6987110B2 (en) | 2002-06-05 | 2006-01-17 | Janssen Pharmaceutica N.V. | Substituted pyrrolines as kinase inhibitors |
| GB0212976D0 (en) | 2002-06-06 | 2002-07-17 | Tonejet Corp Pty Ltd | Ejection method and apparatus |
| CN1171991C (zh) | 2002-07-08 | 2004-10-20 | 徐如祥 | 人神经干细胞的培养方法 |
| US6877147B2 (en) | 2002-07-22 | 2005-04-05 | Broadcom Corporation | Technique to assess timing delay by use of layout quality analyzer comparison |
| US7838290B2 (en) | 2002-07-25 | 2010-11-23 | The Scripps Research Institute | Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith |
| US20040110287A1 (en) | 2002-07-29 | 2004-06-10 | Es Cell International Pte Ltd. | Multi-step method for the differentiation of insulin positive, glucose responsive cells |
| US20040063204A1 (en) | 2002-08-14 | 2004-04-01 | Lijun Yang | Bone marrow cell differentiation |
| AU2003268534A1 (en) | 2002-09-06 | 2004-03-29 | Amcyte Inc. | Cd56 positive human adult pancreatic endocrine progenitor cells |
| US9969977B2 (en) | 2002-09-20 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
| US20040062753A1 (en) | 2002-09-27 | 2004-04-01 | Alireza Rezania | Composite scaffolds seeded with mammalian cells |
| US20060252150A1 (en) | 2002-11-08 | 2006-11-09 | Linzhao Cheng | Human embryonic stem cell cultures, and compositions and methods for growing same |
| US7144999B2 (en) | 2002-11-23 | 2006-12-05 | Isis Pharmaceuticals, Inc. | Modulation of hypoxia-inducible factor 1 alpha expression |
| US20060040385A1 (en) | 2002-12-05 | 2006-02-23 | Technion Research & Development Foundation Ltd. | Cultured human pancreatic islets, and uses thereof |
| SI1572984T1 (sl) | 2002-12-16 | 2016-07-29 | Technion Research & Development Foundation Ltd. | Kulturni sistem brez hranilnih celic, brez kseno-komponent, za humane embrionalne matične celice |
| US20050118148A1 (en) | 2002-12-20 | 2005-06-02 | Roland Stein | Compositions and methods related to mammalian Maf-A |
| CA2514539C (en) | 2003-01-29 | 2012-03-06 | Takeda Pharmaceutical Company Limited | Process for producing coated preparation |
| RU2359671C2 (ru) | 2003-01-29 | 2009-06-27 | Такеда Фармасьютикал Компани Лимитед | Способ получения препарата с покрытием |
| US20070155661A1 (en) | 2003-02-14 | 2007-07-05 | The Board Of Trustees Of The Leland Standord Junior University | Methods and compositions for modulating the development of stem cells |
| WO2005045001A2 (en) | 2003-02-14 | 2005-05-19 | The Board Of Trustees Of The Leland Stanford Junior University | Insulin-producing cells derived from stem cells |
| US20070020242A1 (en) | 2003-03-27 | 2007-01-25 | Ixion Biotechnology, Inc. | Method for transdifferentiation of non-pancreatic stem cells to the pancreatic pathway |
| WO2004090110A2 (en) | 2003-03-31 | 2004-10-21 | Bresagen Inc. | Compositions and methods for the control, differentiation and/or manipulation of pluripotent cells through a gamma-secretase signaling pathway |
| US20090203141A1 (en) | 2003-05-15 | 2009-08-13 | Shi-Lung Lin | Generation of tumor-free embryonic stem-like pluripotent cells using inducible recombinant RNA agents |
| KR20060021908A (ko) * | 2003-06-23 | 2006-03-08 | 프라운호퍼-게젤샤프트 추르 푀르데룽 데어 안제반텐 포르슝 에 파우 | 췌장 호르몬을 생산하는 세포로 줄기세포를 분화시키는방법 |
| WO2005038012A2 (en) | 2003-06-27 | 2005-04-28 | Ethicon Incorporated | Cartilage and bone repair and regeneration using postpartum-derived cells |
| IL161903A0 (en) | 2003-07-17 | 2005-11-20 | Gamida Cell Ltd | Ex vivo progenitor and stem cell expansion for usein the treatment of disease of endodermally- deri ved organs |
| ITRM20030395A1 (it) | 2003-08-12 | 2005-02-13 | Istituto Naz Per Le Malattie Infettive Lazz | Terreno di coltura per il mantenimento, la proliferazione e il differenziamento di cellule di mammifero. |
| US7569385B2 (en) | 2003-08-14 | 2009-08-04 | The Regents Of The University Of California | Multipotent amniotic fetal stem cells |
| US7157275B2 (en) | 2003-08-15 | 2007-01-02 | Becton, Dickinson And Company | Peptides for enhanced cell attachment and growth |
| EP1670900A4 (en) | 2003-08-27 | 2008-06-11 | Stemcells California Inc | ENHANCED PANCREATIC STEM CELL AND PRECURSOR CELL POPULATIONS AND METHOD OF IDENTIFYING, INSULATING AND ENRICHING SUCH POPULATIONS |
| CA2550010A1 (en) | 2003-12-17 | 2005-06-30 | Allergan, Inc. | Methods for treating retinoid responsive disorders using selective inhibitors of cyp26a and cyp26b |
| US20060030042A1 (en) | 2003-12-19 | 2006-02-09 | Ali Brivanlou | Maintenance of embryonic stem cells by the GSK-3 inhibitor 6-bromoindirubin-3'-oxime |
| US7541185B2 (en) | 2003-12-23 | 2009-06-02 | Cythera, Inc. | Methods for identifying factors for differentiating definitive endoderm |
| US20050266554A1 (en) | 2004-04-27 | 2005-12-01 | D Amour Kevin A | PDX1 expressing endoderm |
| MX2009009225A (es) | 2003-12-23 | 2009-09-28 | Cythera Inc | Endodermo definitivo. |
| US7625753B2 (en) | 2003-12-23 | 2009-12-01 | Cythera, Inc. | Expansion of definitive endoderm cells |
| CN109628371B (zh) | 2003-12-23 | 2021-02-19 | 维亚希特公司 | 定形内胚层 |
| US20050233446A1 (en) | 2003-12-31 | 2005-10-20 | Parsons Xuejun H | Defined media for stem cell culture |
| TWI334443B (en) | 2003-12-31 | 2010-12-11 | Ind Tech Res Inst | Method of single cell culture of undifferentiated human embryonic stem cells |
| US20080241107A1 (en) | 2004-01-23 | 2008-10-02 | Copland Iii John A | Methods and Compositions For Preparing Pancreatic Insulin Secreting Cells |
| US7794704B2 (en) | 2004-01-23 | 2010-09-14 | Advanced Cell Technology, Inc. | Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration |
| GB2441530B (en) | 2004-02-12 | 2009-09-23 | Univ Newcastle | Stem Cells |
| JP4901471B2 (ja) | 2004-02-19 | 2012-03-21 | 国立大学法人京都大学 | 体細胞核初期化物質のスクリーニング方法 |
| US20060281174A1 (en) * | 2004-03-09 | 2006-12-14 | Gang Xu | Methods for generating insulin-producing cells |
| WO2005086845A2 (en) | 2004-03-10 | 2005-09-22 | Regents Of The University Of California | Compositions and methods for growth of embryonic stem cells |
| RU2375448C2 (ru) | 2004-03-23 | 2009-12-10 | Асубио Фарма Ко., Лтд. | Способ выращивания плюрипотентных стволовых клеток |
| WO2005097980A2 (en) | 2004-03-26 | 2005-10-20 | Geron Corporation | New protocols for making hepatocytes from embryonic stem cells |
| CA2555571C (en) | 2004-04-01 | 2012-10-16 | Wisconsin Alumni Research Foundation | Differentiation of stem cells to endoderm and pancreatic lineage |
| EP1740612B1 (en) | 2004-04-27 | 2019-08-07 | Viacyte, Inc. | Pdx1 expressing endoderm |
| CA2966883A1 (en) | 2004-07-09 | 2006-02-16 | Cythera, Inc. | Methods for identifying factors for differentiating definitive endoderm |
| US8187878B2 (en) | 2004-08-13 | 2012-05-29 | University Of Georgia Research Foundation, Inc. | Methods for increasing definitive endoderm differentiation of pluripotent human embryonic stem cells with PI-3 kinase inhibitors |
| US20080268533A1 (en) | 2004-08-25 | 2008-10-30 | University Of Georgia Research Foundation, Inc. | Methods and Compositions Utilizing Myc and Gsk3Beta to Manipulate the Pluripotency of Embryonic Stem Cells |
| DE102004043256B4 (de) | 2004-09-07 | 2013-09-19 | Rheinische Friedrich-Wilhelms-Universität Bonn | Skalierbarer Prozess zur Kultivierung undifferenzierter Stammzellen in Suspension |
| NZ553235A (en) | 2004-09-08 | 2009-11-27 | Wisconsin Alumni Res Found | Culturing human pluripotent stem cells |
| EP1791948B1 (en) | 2004-09-08 | 2012-03-14 | Wisconsin Alumni Research Foundation | Medium and culture of embryonic stem cells |
| GB2437689B (en) | 2005-01-28 | 2009-10-28 | Novathera Ltd | Culture and screening methods |
| JP2008528038A (ja) | 2005-01-31 | 2008-07-31 | エス セル インターナショナル ピーティーイー リミテッド | 胚性幹細胞の指示された分化及びその利用 |
| WO2006088867A2 (en) | 2005-02-15 | 2006-08-24 | Medistem Laboratories, Incorporated | Method for expansion of stem cells |
| ES2627419T3 (es) | 2005-03-04 | 2017-07-28 | Lifescan, Inc. | Células estromales adultas derivadas del páncreas |
| US20060212476A1 (en) | 2005-03-18 | 2006-09-21 | Bogle Phillip L | Method and apparatus for tracking candidate referrers |
| GB0505970D0 (en) | 2005-03-23 | 2005-04-27 | Univ Edinburgh | Culture medium containing kinase inhibitor, and uses thereof |
| CN100425694C (zh) | 2005-04-15 | 2008-10-15 | 北京大学 | 诱导胚胎干细胞向胰腺细胞分化的方法 |
| WO2006113470A2 (en) | 2005-04-15 | 2006-10-26 | Geron Corporation | Cancer treatment by combined inhibition of proteasome and telomerase activities |
| EP1875234B1 (en) | 2005-04-26 | 2011-06-22 | Aarhus Universitet | Biosurface structure array |
| JP5092124B2 (ja) | 2005-05-24 | 2012-12-05 | 国立大学法人 熊本大学 | Ｅｓ細胞の分化誘導方法 |
| AU2006202209B2 (en) | 2005-05-27 | 2011-04-14 | Lifescan, Inc. | Amniotic fluid derived cells |
| AU2006257859B2 (en) | 2005-06-10 | 2009-12-10 | Irm Llc | Compounds that maintain pluripotency of embryonic stem cells |
| US20090053181A1 (en) * | 2005-06-13 | 2009-02-26 | Novo Nordisk A/S | Modulation of Cells |
| WO2006138433A2 (en) | 2005-06-14 | 2006-12-28 | The Regents Of The University Of California | Induction of cell differentiation by class i bhlh polypeptides |
| US20080199959A1 (en) | 2005-06-21 | 2008-08-21 | Ge Healthcare Bio-Sciences Ab | Method For Cell Culture |
| WO2007002086A2 (en) | 2005-06-22 | 2007-01-04 | Geron Corporation | Suspension culture of human embryonic stem cells |
| CA2611438C (en) | 2005-06-30 | 2014-01-07 | Janssen Pharmaceutica N.V. | Cyclic anilino-pyridinotriazines |
| GB2443370A (en) | 2005-07-29 | 2008-04-30 | Australian Stem Cell Ct Ltd | Compositions and methods for growth of pluripotent cells |
| WO2007016485A2 (en) | 2005-07-29 | 2007-02-08 | Athersys, Inc. | Use of a gsk-3 inhibitor to maintain potency of cultured cells |
| WO2007025234A2 (en) | 2005-08-26 | 2007-03-01 | The Trustees Of Columbia University In The City Of New York | Generation of pancreatic endocrine cells from primary duct cell cultures and methods of use for treatment of diabetes |
| EP1962719A4 (en) | 2005-08-29 | 2011-05-04 | Technion Res And Dev Of Foundation Ltd | MEDIA FOR BREEDING STEM CELLS |
| CN101341245A (zh) | 2005-09-02 | 2009-01-07 | 新加坡科技研究局 | 获取祖细胞系的方法 |
| AU2006292021B2 (en) | 2005-09-12 | 2012-05-31 | Es Cell International Pte Ltd. | Cardiomyocyte production |
| WO2007035843A2 (en) * | 2005-09-21 | 2007-03-29 | Dask Technologies, Llc | Methods and compositions for organ and tissue functionality |
| US8409859B2 (en) | 2005-10-14 | 2013-04-02 | Regents Of The University Of Minnesota | Differentiation of non-embryonic stem cells to cells having a pancreatic phenotype |
| US7732202B2 (en) | 2005-10-21 | 2010-06-08 | International Stem Cell Corporation | Oxygen tension for the parthenogenic activation of human oocytes for the production of human embryonic stem cells |
| ES2743202T3 (es) | 2005-10-27 | 2020-02-18 | Viacyte Inc | Endodermo de intestino proximal dorsal y ventral que expresa PDX1 |
| UA96139C2 (ru) * | 2005-11-08 | 2011-10-10 | Дженентек, Інк. | Антитело к нейропилину-1 (nrp1) |
| EA018039B1 (ru) | 2005-12-13 | 2013-05-30 | Киото Юниверсити | Ядерный фактор перепрограммирования |
| WO2007082963A1 (es) | 2006-01-18 | 2007-07-26 | Fundación Instituto Valenciano De Infertilidad | Líneas de células madre embrionarias humanas y métodos para usar las mismas |
| SG10201405107YA (en) | 2006-02-23 | 2014-10-30 | Viacyte Inc | Compositions and methods useful for culturing differentiable cells |
| US7695965B2 (en) | 2006-03-02 | 2010-04-13 | Cythera, Inc. | Methods of producing pancreatic hormones |
| SG10201405380QA (en) * | 2006-03-02 | 2014-10-30 | Cythera Inc | Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production |
| US8741643B2 (en) | 2006-04-28 | 2014-06-03 | Lifescan, Inc. | Differentiation of pluripotent stem cells to definitive endoderm lineage |
| EP2021462B1 (en) | 2006-04-28 | 2019-01-09 | Lifescan, Inc. | Differentiation of human embryonic stem cells |
| GB2452186B (en) | 2006-05-02 | 2011-01-26 | Wisconsin Alumni Res Found | Method of differentiating stem cells into cells of the endoderm and pancreatic lineage |
| US8685730B2 (en) | 2006-05-02 | 2014-04-01 | Wisconsin Alumni Research Foundation | Methods and devices for differentiating pluripotent stem cells into cells of the pancreatic lineage |
| US9598673B2 (en) | 2006-05-19 | 2017-03-21 | Creative Medical Health | Treatment of disc degenerative disease |
| WO2007139929A2 (en) | 2006-05-25 | 2007-12-06 | The Burnham Institute For Medical Research | Methods for culture and production of single cell populations of human embryonic stem cells |
| CN101541953A (zh) | 2006-06-02 | 2009-09-23 | 佐治亚大学研究基金会 | 通过从人胚胎干细胞获得的定形内胚层细胞的分化得到胰和肝内胚层细胞及组织 |
| US20090298169A1 (en) | 2006-06-02 | 2009-12-03 | The University Of Georgia Research Foundation | Pancreatic and Liver Endoderm Cells and Tissue by Differentiation of Definitive Endoderm Cells Obtained from Human Embryonic Stems |
| WO2007149182A2 (en) | 2006-06-19 | 2007-12-27 | Geron Corporation | Differentiation and enrichment of islet-like cells from human pluripotent stem cells |
| CN100494359C (zh) | 2006-06-23 | 2009-06-03 | 中日友好医院 | 神经干细胞三维立体培养体外扩增的方法 |
| US20080003676A1 (en) | 2006-06-26 | 2008-01-03 | Millipore Corporation | Growth of embryonic stem cells |
| AU2007297575A1 (en) | 2006-06-26 | 2008-03-27 | Lifescan, Inc. | Pluripotent stem cell culture |
| GB2454386B (en) | 2006-07-06 | 2011-07-06 | Es Cell Int Pte Ltd | Method for embryonic stem cell culture on a positively charged support surface |
| AU2007277364B2 (en) | 2006-07-26 | 2010-08-12 | Viacyte, Inc. | Methods of producing pancreatic hormones |
| ES2874223T3 (es) | 2006-08-02 | 2021-11-04 | Technion Res & Dev Foundation | Métodos de expansión de células madre embrionarias en un cultivo en suspensión |
| KR101331510B1 (ko) | 2006-08-30 | 2013-11-20 | 재단법인서울대학교산학협력재단 | 저농도의 포도당을 함유하는 인간 배아줄기세포용 배지조성물 및 이를 이용한 인간 배아 줄기세포로부터 인슐린생산 세포 또는 세포괴로 분화시키는 방법, 그리고그로부터 유도된 인슐린 생산 세포 또는 세포괴 |
| JP2008099662A (ja) | 2006-09-22 | 2008-05-01 | Institute Of Physical & Chemical Research | 幹細胞の培養方法 |
| WO2008039521A2 (en) | 2006-09-26 | 2008-04-03 | Nmt Medical, Inc. | Method for modifying a medical implant surface for promoting tissue growth |
| US20100323442A1 (en) | 2006-10-17 | 2010-12-23 | Emmanuel Edward Baetge | Modulation of the phosphatidylinositol-3-kinase pathway in the differentiation of human embryonic stem cells |
| JP5343267B2 (ja) | 2006-10-17 | 2013-11-13 | スティーフェル・ラボラトリーズ・インコーポレーテッド | タラロゾール代謝物 |
| CA2666789C (en) | 2006-10-18 | 2016-11-22 | Yong Zhao | Embryonic-like stem cells derived from adult human peripheral blood and methods of use |
| WO2008056779A1 (fr) | 2006-11-09 | 2008-05-15 | Japan As Represented By The President Of International Medical Center Of Japan | Procédé destiné à la culture et au passage d'une cellule souche embryonnaire de primate, et procédé destiné à induire la différenciation de la cellule souche embryonnaire |
| WO2008086005A1 (en) | 2007-01-09 | 2008-07-17 | University Of South Florida | Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof |
| EP1947193A1 (en) * | 2007-01-17 | 2008-07-23 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Screening method for anti-diabetic compounds |
| CA2676044C (en) | 2007-01-30 | 2019-10-22 | University Of Georgia Research Foundation, Inc. | Early mesoderm cells, a stable population of mesendoderm cells that has utility for generation of endoderm and mesoderm lineages and multipotent migratory cells (mmc) |
| GB0703188D0 (en) | 2007-02-19 | 2007-03-28 | Roger Land Building | Large scale production of stem cells |
| WO2008148105A1 (en) | 2007-05-25 | 2008-12-04 | Medistem Laboratories, Inc. | Endometrial stem cells and methods of making and using same |
| DK2173863T3 (en) | 2007-06-29 | 2019-01-21 | Fujifilm Cellular Dynamics Inc | Automated method and apparatus for embryonic stem cell culture |
| MX2010000746A (es) * | 2007-07-18 | 2010-07-05 | Lifescan Inc | Diferenciacion de celulas madre embrionarias humanas. |
| JP6087043B2 (ja) | 2007-07-31 | 2017-03-01 | ライフスキャン・インコーポレイテッドＬｉｆｅｓｃａｎ，Ｉｎｃ． | ヒトフィーダー細胞を用いた多能性幹細胞の分化 |
| CN101952415B (zh) | 2007-07-31 | 2017-06-27 | 生命扫描有限公司 | 人胚胎干细胞的分化 |
| WO2009027644A2 (en) | 2007-08-24 | 2009-03-05 | Stichting Het Nederlands Kanker Instituut | Composition |
| WO2009061442A1 (en) | 2007-11-06 | 2009-05-14 | Children's Medical Center Corporation | Method to produce induced pluripotent stem (ips) cells form non-embryonic human cells |
| CA3123528A1 (en) * | 2007-11-27 | 2009-06-04 | Lifescan, Inc. | Differentiation of human embryonic stem cells to pancreatic cells |
| SG154367A1 (en) | 2008-01-31 | 2009-08-28 | Es Cell Int Pte Ltd | Method of differentiating stem cells |
| WO2009096049A1 (ja) | 2008-02-01 | 2009-08-06 | Kyoto University | 人工多能性幹細胞由来分化細胞 |
| EP2250252A2 (en) | 2008-02-11 | 2010-11-17 | Cambridge Enterprise Limited | Improved reprogramming of mammalian cells, and the cells obtained |
| CA2715878C (en) | 2008-02-21 | 2017-06-13 | Centocor Ortho Biotech Inc. | Methods, surface modified plates and compositions for cell attachment, cultivation and detachment |
| WO2009110215A1 (ja) | 2008-03-03 | 2009-09-11 | 独立行政法人 科学技術振興機構 | 繊毛細胞の分化誘導方法 |
| WO2009116951A2 (en) | 2008-03-17 | 2009-09-24 | Agency For Science, Technology And Research | Microcarriers for stem cell culture |
| RU2359030C1 (ru) | 2008-03-19 | 2009-06-20 | Общество С Ограниченной Ответственностью "Лаборатория Клеточных Технологий" | Способ получения эндотелиальных клеток из эмбриональных стволовых клеток человека (варианты) |
| DK2283117T3 (da) | 2008-04-21 | 2014-01-20 | Viacyte Inc | Fremgangsmåde til oprensning af pancreatiske endodermceller afledt fra humane embryoniske stamceller |
| US8338170B2 (en) | 2008-04-21 | 2012-12-25 | Viacyte, Inc. | Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells |
| WO2009132083A2 (en) | 2008-04-22 | 2009-10-29 | President And Fellows Of Harvard College | Compositions and methods for promoting the generation of pdx1+ pancreatic cells |
| US7939322B2 (en) | 2008-04-24 | 2011-05-10 | Centocor Ortho Biotech Inc. | Cells expressing pluripotency markers and expressing markers characteristic of the definitive endoderm |
| US8623648B2 (en) | 2008-04-24 | 2014-01-07 | Janssen Biotech, Inc. | Treatment of pluripotent cells |
| US20090298178A1 (en) | 2008-06-03 | 2009-12-03 | D Amour Kevin Allen | Growth factors for production of definitive endoderm |
| EP2297319B1 (en) | 2008-06-03 | 2015-10-07 | Viacyte, Inc. | Growth factors for production of definitive endoderm |
| MX2011000123A (es) * | 2008-06-30 | 2011-02-25 | Centocor Ortho Biotech Inc | Diferenciacion de las celulas madre pluripotentes. |
| DE102008032236A1 (de) | 2008-06-30 | 2010-04-01 | Eberhard-Karls-Universität Tübingen | Isolierung und/oder Identifizierung von Stammzellen mit adipozytärem, chondrozytärem und pankreatischem Differenzierungspotential |
| EP2942392B1 (en) | 2008-06-30 | 2018-10-03 | Janssen Biotech, Inc. | Differentiation of pluripotent stem cells |
| US20100028307A1 (en) | 2008-07-31 | 2010-02-04 | O'neil John J | Pluripotent stem cell differentiation |
| WO2010022395A2 (en) | 2008-08-22 | 2010-02-25 | President And Fellows Of Harvard College | Methods of reprogramming cells |
| ES2727950T3 (es) | 2008-10-31 | 2019-10-21 | Janssen Biotech Inc | Diferenciación de células madre embrionarias humanas en linaje endocrino pancreático |
| AU2009308967C1 (en) | 2008-10-31 | 2017-04-20 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells to the pancreatic endocrine lineage |
| US8008075B2 (en) | 2008-11-04 | 2011-08-30 | Viacyte, Inc. | Stem cell aggregate suspension compositions and methods of differentiation thereof |
| CA2742583C (en) | 2008-11-04 | 2022-09-27 | Viacyte, Inc. | Stem cell aggregate suspension compositions and methods for differentiation thereof |
| CN102282254B (zh) | 2008-11-14 | 2015-12-16 | 维赛特公司 | 源于人多能干细胞的胰腺细胞的包封 |
| CN107267442A (zh) | 2008-11-20 | 2017-10-20 | 詹森生物科技公司 | 微载体上的多能干细胞培养 |
| US20110229441A1 (en) | 2008-12-05 | 2011-09-22 | Association Francaise Contre Les Myopathies | Method and Medium for Neural Differentiation of Pluripotent Cells |
| US9109245B2 (en) * | 2009-04-22 | 2015-08-18 | Viacyte, Inc. | Cell compositions derived from dedifferentiated reprogrammed cells |
| KR20170118969A (ko) | 2009-07-20 | 2017-10-25 | 얀센 바이오테크 인코포레이티드 | 인간 배아 줄기 세포의 분화 |
| CN103952372B (zh) | 2009-07-20 | 2016-10-05 | 詹森生物科技公司 | 人胚胎干细胞的分化 |
| CN102482640B (zh) * | 2009-07-20 | 2015-03-11 | 詹森生物科技公司 | 人胚胎干细胞的分化 |
| CA2778817A1 (en) | 2009-10-29 | 2011-05-19 | Janssen Biotech, Inc. | Pluripotent stem cells |
| FI20096288A0 (fi) | 2009-12-04 | 2009-12-04 | Kristiina Rajala | Formulations and methods for culturing stem cells |
| MX343786B (es) | 2009-12-23 | 2016-11-22 | Janssen Biotech Inc | Diferenciacion de celulas madre embrionarias humanas. |
| KR101923537B1 (ko) | 2009-12-23 | 2018-11-29 | 얀센 바이오테크 인코포레이티드 | 인간 배아 줄기 세포의 분화 |
| WO2011081222A1 (ja) * | 2009-12-29 | 2011-07-07 | 武田薬品工業株式会社 | 膵ホルモン産生細胞の製造法 |
| WO2011096223A1 (ja) | 2010-02-03 | 2011-08-11 | 独立行政法人国立がん研究センター | 誘導肝幹細胞及びその製造方法、並びに、該細胞の応用 |
| EP2542666A4 (en) | 2010-03-02 | 2014-05-07 | Univ Singapore | CULTURE ADDITIVES FOR PROMOTING A STEM CELL PROGRAMMING AND DIFFERENTIATION REACTION |
| CN102959076B (zh) | 2010-03-31 | 2015-09-16 | 斯克里普斯研究所 | 重编程细胞 |
| WO2011139628A1 (en) | 2010-04-25 | 2011-11-10 | Mount Sinai School Of Medicine | Generation of anterior foregut endoderm from pluripotent cells |
| SG10201503652WA (en) | 2010-05-12 | 2015-08-28 | Janssen Biotech Inc | Differentiation of human embryonic stem cells |
| WO2011160066A1 (en) * | 2010-06-17 | 2011-12-22 | Regents Of The University Of Minnesota | Production of insulin producing cells |
| BR112013002811A8 (pt) | 2010-08-05 | 2020-01-28 | Wisconsin Alumni Res Found | meios básicos simplificados para cultura celular pluripotente de humano |
| JP5881606B2 (ja) * | 2010-08-06 | 2016-03-09 | 大日本住友製薬株式会社 | 脊髄損傷治療用製剤 |
| US9181528B2 (en) | 2010-08-31 | 2015-11-10 | Janssen Biotech, Inc. | Differentiation of pluripotent stem cells |
| PL2853589T3 (pl) | 2010-08-31 | 2018-05-30 | Janssen Biotech, Inc | Różnicowanie ludzkich zarodkowych komórek macierzystych |
| MY177150A (en) | 2011-02-28 | 2020-09-08 | Stempeutics Res Malaysia Sdn Bhd | Isolation and expansion of adult stem cells, their therapeutic composition and uses thereof |
| WO2013055834A2 (en) | 2011-10-11 | 2013-04-18 | The New York Stem Cell Foundation | Er stress relievers in beta cell protection |
| US9670463B2 (en) | 2011-10-14 | 2017-06-06 | Children's Medical Center Corporation | Inhibition and enhancement of reprogramming by chromatin modifying enzymes |
| RU2668798C2 (ru) | 2011-12-22 | 2018-10-02 | Янссен Байотек, Инк. | Способы in vitro пошаговой дифференцировки полюрипотентных клеток |
| US10519422B2 (en) | 2012-02-29 | 2019-12-31 | Riken | Method of producing human retinal pigment epithelial cells |
| DK3450542T3 (da) * | 2012-06-08 | 2021-11-01 | Janssen Biotech Inc | Differentiering af humane embryonale stamceller til endokrine pancreatiske celler |
| CN104903440B (zh) | 2012-09-03 | 2018-04-06 | 诺和诺德股份有限公司 | 使用小分子从多能干细胞产生胰内胚层 |
| US10138465B2 (en) | 2012-12-31 | 2018-11-27 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into pancreatic endocrine cells using HB9 regulators |
| US8859286B2 (en) | 2013-03-14 | 2014-10-14 | Viacyte, Inc. | In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells |
| JP6602745B2 (ja) | 2013-03-15 | 2019-11-06 | ザ ジャクソン ラボラトリー | 非胚性幹細胞の単離とその使用 |
| CN105233291A (zh) * | 2014-07-09 | 2016-01-13 | 博笛生物科技有限公司 | 用于治疗癌症的联合治疗组合物和联合治疗方法 |
| WO2017048193A1 (en) * | 2015-09-15 | 2017-03-23 | Agency For Science, Technology And Research (A*Star) | Derivation of liver organoids from human pluripotent stem cells |
| JP7389980B2 (ja) * | 2018-12-06 | 2023-12-01 | 国立大学法人 琉球大学 | ヒト膵臓組織特異的幹／前駆細胞の人工作製方法 |
-
2013
- 2013-06-06 DK DK18190030.9T patent/DK3450542T3/da active
- 2013-06-06 RU RU2018108847A patent/RU2018108847A/ru not_active Application Discontinuation
- 2013-06-06 EP EP18191243.7A patent/EP3450543A1/en not_active Withdrawn
- 2013-06-06 CN CN201810038231.XA patent/CN108034633B/zh active Active
- 2013-06-06 KR KR1020227039793A patent/KR20220156115A/ko active IP Right Grant
- 2013-06-06 EP EP18190030.9A patent/EP3450542B1/en active Active
- 2013-06-06 AU AU2013271581A patent/AU2013271581B2/en active Active
- 2013-06-06 BR BR112014030682A patent/BR112014030682A2/pt not_active Application Discontinuation
- 2013-06-06 EP EP13799837.3A patent/EP2859091B1/en active Active
- 2013-06-06 RU RU2014153529A patent/RU2650813C2/ru active
- 2013-06-06 KR KR1020207014164A patent/KR102285014B1/ko active IP Right Grant
- 2013-06-06 US US13/911,829 patent/US10066210B2/en active Active
- 2013-06-06 WO PCT/US2013/044472 patent/WO2013184888A1/en active Application Filing
- 2013-06-06 CA CA2875786A patent/CA2875786C/en active Active
- 2013-06-06 RU RU2018108851A patent/RU2018108851A/ru not_active Application Discontinuation
- 2013-06-06 JP JP2015516197A patent/JP6469003B2/ja active Active
- 2013-06-06 SG SG10201610313WA patent/SG10201610313WA/en unknown
- 2013-06-06 MX MX2014014986A patent/MX358590B/es active IP Right Grant
- 2013-06-06 EP EP21193941.8A patent/EP3957714A1/en active Pending
- 2013-06-06 CA CA3173122A patent/CA3173122A1/en active Pending
- 2013-06-06 KR KR1020217023975A patent/KR102468315B1/ko active IP Right Grant
- 2013-06-06 EP EP18191263.5A patent/EP3450544A1/en not_active Withdrawn
- 2013-06-06 RU RU2018108850A patent/RU2018108850A/ru not_active Application Discontinuation
- 2013-06-06 CN CN201810037871.9A patent/CN108103006A/zh active Pending
- 2013-06-06 ES ES13799837.3T patent/ES2690118T3/es active Active
- 2013-06-06 CN CN201380030234.4A patent/CN104334719B/zh active Active
- 2013-06-06 ES ES18190030T patent/ES2897649T3/es active Active
- 2013-06-06 KR KR1020157000172A patent/KR102114209B1/ko active IP Right Grant
- 2013-06-06 CN CN201810037759.5A patent/CN108103005A/zh active Pending
- 2013-06-06 PL PL13799837T patent/PL2859091T3/pl unknown
- 2013-06-06 SG SG11201408124PA patent/SG11201408124PA/en unknown
- 2013-06-07 AR ARP130102023 patent/AR091388A1/es unknown
-
2014
- 2014-11-26 IN IN10021DEN2014 patent/IN2014DN10021A/en unknown
- 2014-11-28 PH PH12014502661A patent/PH12014502661A1/en unknown
-
2015
- 2015-10-12 HK HK15109905.8A patent/HK1209160A1/xx not_active IP Right Cessation
-
2016
- 2016-11-01 US US15/340,418 patent/US10208288B2/en active Active
-
2018
- 2018-04-06 ZA ZA2018/02252A patent/ZA201802252B/en unknown
- 2018-04-06 ZA ZA2018/02253A patent/ZA201802253B/en unknown
- 2018-04-06 ZA ZA2018/02251A patent/ZA201802251B/en unknown
- 2018-06-18 PH PH12018501295A patent/PH12018501295A1/en unknown
- 2018-06-18 PH PH12018501294A patent/PH12018501294A1/en unknown
- 2018-06-18 PH PH12018501293A patent/PH12018501293A1/en unknown
- 2018-07-24 AU AU2018208647A patent/AU2018208647A1/en not_active Abandoned
- 2018-07-24 AU AU2018208650A patent/AU2018208650A1/en not_active Abandoned
- 2018-07-24 AU AU2018208646A patent/AU2018208646A1/en not_active Abandoned
- 2018-08-31 US US16/119,995 patent/US20190010466A1/en not_active Abandoned
- 2018-08-31 US US16/119,862 patent/US10519424B2/en active Active
- 2018-08-31 US US16/119,887 patent/US20190010465A1/en not_active Abandoned
- 2018-10-31 JP JP2018205548A patent/JP2019050811A/ja active Pending
- 2018-10-31 JP JP2018205547A patent/JP6694037B2/ja active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2014153529A (ru) | Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки | |
| PH12016502274A1 (en) | Use of small molecules to enhance mafa expression in pancreatic endocrine cells | |
| GB201105226D0 (en) | Methods | |
| PH12015501465A1 (en) | Culturing of human embryonic stem cells at the air-liquid interface for differentiation into pancreatic endocrine cells | |
| PH12015501477A1 (en) | Suspension and clustering of human pluripotent cells for differentiation into pancreatic endocrine cells | |
| GB2485112A (en) | Differentiation of human embryonic stem cells | |
| WO2010115050A3 (en) | Embryonic stem cell specific micrornas promote induced pluripotency | |
| BR112017007770A2 (pt) | cultura in vitro, população de hipscs, método para modificar um locus-alvo genômico, e, hipsc. | |
| MX369388B (es) | Moduladores heterociclicos de sintesis lipidica. | |
| SG10201806217UA (en) | Culture medium composition | |
| PH12014502686A1 (en) | Differentiation of human embryonic stem cells into pancreatic endoderm | |
| MX2016005658A (es) | Suspensión y agrupamiento de células madre humanas pluripotentes para la diferenciación a células endocrinas pancreáticas. | |
| EA201591252A1 (ru) | СПОСОБЫ ВВЕДЕНИЯ dsRNA В СЕМЕНА РАСТЕНИЙ ДЛЯ МОДУЛЯЦИИ ЭКСПРЕССИИ ГЕНОВ | |
| MX2016013832A (es) | Composiciones y metodos para tratar hemoglobinopatias. | |
| BR112013002859A2 (pt) | sistema e aparelho para tratamento de células | |
| PH12017501153A1 (en) | Suspension culturing of pluripotent stem cells | |
| UA115652C2 (uk) | Сполука, що містить модифікований олігонуклеотид, комплементарна mir-21 | |
| WO2009137844A3 (en) | Pancreatic endocrine progenitor cells derived from pluripotent stem cells | |
| NZ611862A (en) | Animal cell culturing method | |
| EP2582791A4 (en) | NEOGENESIS OF HAIRFOLLICLES | |
| MY189592A (en) | Method for producing cerebellar progenitor tissue | |
| MX2016004616A (es) | Parches de células musculares y usos de los mismos. | |
| WO2012141471A3 (ko) | 역분화-증진제를 이용한 역분화 만능 줄기세포의 제조방법 | |
| AU2012256014A8 (en) | Use of Zscan4 and Zscan4-dependent genes for direct reprogramming of somatic cells | |
| MX2018003354A (es) | Seleccion de celulas pluripotentes para producir ratones hembra xy fertiles. |