RU2014108045A - Фармацевтическая композиция для лечения и/или профилактики злокачественной опухоли - Google Patents
Фармацевтическая композиция для лечения и/или профилактики злокачественной опухоли Download PDFInfo
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- RU2014108045A RU2014108045A RU2014108045/10A RU2014108045A RU2014108045A RU 2014108045 A RU2014108045 A RU 2014108045A RU 2014108045/10 A RU2014108045/10 A RU 2014108045/10A RU 2014108045 A RU2014108045 A RU 2014108045A RU 2014108045 A RU2014108045 A RU 2014108045A
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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Abstract
1. Антитело или его фрагмент, который обладает иммунологической реактивностью в отношении белка CAPRIN-1, причем антитело или его фрагмент содержат вариабельную область тяжелой цепи, содержащую определяющие комплементарность области SEQ ID NO: 5, 6 и 7, и вариабельную область легкой цепи, содержащую определяющие комплементарность области SEQ ID NOs: 9, 10 и 11.2. Антитело или его фрагмент по п.1, где антитело представляет собой антитело человека, гуманизированное антитело, химерное антитело, одноцепочечное антитело или полиспецифическое антитело.3. Антитело или его фрагмент по п.1 или 2, где антитело или его фрагмент конъюгированы с противоопухолевым средством.4. Фармацевтическая композиция для лечения и/или профилактики злокачественной опухоли, содержащая антитело или его фрагмент по любому из пп.1-3 в качестве активного ингредиента.5. Фармацевтическая композиция по п.4, где злокачественная опухоль представляет собой рак молочной железы, рак почки, рак поджелудочной железы, рак толстого кишечника, рак легких, опухоль головного мозга, рак желудка, рак шейки матки, рак яичников, рак предстательной железы, рак мочевого пузыря, рак пищевода, лейкоз, лимфому, фибросаркому, мастоцитому или меланому.6. Фармацевтическая комбинация для лечения и/или профилактики злокачественной опухоли, содержащая фармацевтическую композицию по п.4 или 5 и фармацевтическую композицию, содержащую противоопухолевое средство.7. ДНК, кодирующая антитело или его фрагмент по п.1 или 2.8. Способ лечения и/или профилактики злокачественной опухоли, включающий введение антитела или его фрагмента по любому из пп.1-3, фармацевтической композиции по п.4 или 5 или фармацевт
Claims (8)
1. Антитело или его фрагмент, который обладает иммунологической реактивностью в отношении белка CAPRIN-1, причем антитело или его фрагмент содержат вариабельную область тяжелой цепи, содержащую определяющие комплементарность области SEQ ID NO: 5, 6 и 7, и вариабельную область легкой цепи, содержащую определяющие комплементарность области SEQ ID NOs: 9, 10 и 11.
2. Антитело или его фрагмент по п.1, где антитело представляет собой антитело человека, гуманизированное антитело, химерное антитело, одноцепочечное антитело или полиспецифическое антитело.
3. Антитело или его фрагмент по п.1 или 2, где антитело или его фрагмент конъюгированы с противоопухолевым средством.
4. Фармацевтическая композиция для лечения и/или профилактики злокачественной опухоли, содержащая антитело или его фрагмент по любому из пп.1-3 в качестве активного ингредиента.
5. Фармацевтическая композиция по п.4, где злокачественная опухоль представляет собой рак молочной железы, рак почки, рак поджелудочной железы, рак толстого кишечника, рак легких, опухоль головного мозга, рак желудка, рак шейки матки, рак яичников, рак предстательной железы, рак мочевого пузыря, рак пищевода, лейкоз, лимфому, фибросаркому, мастоцитому или меланому.
6. Фармацевтическая комбинация для лечения и/или профилактики злокачественной опухоли, содержащая фармацевтическую композицию по п.4 или 5 и фармацевтическую композицию, содержащую противоопухолевое средство.
7. ДНК, кодирующая антитело или его фрагмент по п.1 или 2.
8. Способ лечения и/или профилактики злокачественной опухоли, включающий введение антитела или его фрагмента по любому из пп.1-3, фармацевтической композиции по п.4 или 5 или фармацевтической комбинации по п.6 исследуемому индивидууму.
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Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5644110B2 (ja) | 2008-08-05 | 2014-12-24 | 東レ株式会社 | 癌の検出方法 |
KR101667319B1 (ko) | 2008-08-05 | 2016-10-18 | 도레이 카부시키가이샤 | 암의 치료 및 예방용 의약 조성물 |
EP2532743B1 (en) * | 2010-02-04 | 2015-04-15 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prevention of cancer |
BR112014002619A2 (pt) * | 2011-08-04 | 2018-10-09 | Toray Industries, Inc | composição farmacêutica e método de tratamento e/ou prevenção de câncer pancreático e combinação farmacêutica |
BR112014002616B1 (pt) | 2011-08-04 | 2022-01-18 | Toray Industries, Inc | Método para detectar câncer pancreático |
PL2818483T3 (pl) | 2012-02-21 | 2018-01-31 | Toray Industries | Kompozycja lecznicza do leczenia i/lub zapobiegania nowotworowi |
EP2832365B1 (en) * | 2012-03-30 | 2017-11-01 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prevention of liver cancer |
CN104203281B (zh) | 2012-03-30 | 2019-07-26 | 东丽株式会社 | 胆囊癌的治疗和/或预防用药物组合物 |
CN104471404B (zh) | 2012-07-19 | 2017-03-01 | 东丽株式会社 | 癌的检测方法 |
KR102056654B1 (ko) | 2012-07-19 | 2019-12-17 | 도레이 카부시키가이샤 | 암의 검출 방법 |
TR201819812T4 (tr) | 2013-08-09 | 2019-01-21 | Toray Industries | Kanserin Tedavisi Ve/Veya Önlenmesi Amacına Yönelik Farmasötik Bileşim |
CN115317603A (zh) | 2016-07-07 | 2022-11-11 | 小利兰·斯坦福大学托管委员会 | 抗体佐剂缀合物 |
MX2019004779A (es) | 2016-10-28 | 2019-08-12 | Toray Industries | Composicion farmaceutica para tratamiento y/o prevencion de cancer. |
CA3095719A1 (en) | 2018-03-30 | 2019-10-03 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prevention of cancer |
BR112021000340A2 (pt) * | 2018-07-11 | 2021-04-13 | Hedgehog, Inc. | Epítopo específico para proteína smo, anticorpo ou fragmento do mesmo, molécula de ácido nucléico, vetor, célula hospedeira, composição de vacina, composição farmacêutica, uso do anticorpo, método para quantificar proteína smo, método para prover informação quanto ao diagnóstico de doença e kit para quantificar proteína smo |
KR20220004634A (ko) | 2019-03-15 | 2022-01-11 | 볼트 바이오테라퓨틱스 인코퍼레이티드 | Her2를 표적으로 하는 면역접합체 |
TW202112752A (zh) | 2019-06-13 | 2021-04-01 | 美商博特生物治療公司 | 胺基苯并氮呯化合物、免疫接合物及其用途 |
WO2021067242A1 (en) | 2019-09-30 | 2021-04-08 | Bolt Biotherapeutics, Inc. | Amide-linked, aminobenzazepine immunoconjugates, and uses thereof |
IL292396A (en) | 2019-10-25 | 2022-06-01 | Bolt Biotherapeutics Inc | Thianozapine immunoconjugates and uses thereof |
EP4119157A4 (en) | 2020-03-12 | 2024-03-27 | Toray Industries | MEDICINE FOR THE TREATMENT AND/OR PREVENTION OF CANCER |
EP4119160A4 (en) | 2020-03-12 | 2024-04-03 | Toray Industries | MEDICINE FOR THE TREATMENT AND/OR PREVENTION OF CANCER |
JPWO2021182572A1 (ru) | 2020-03-12 | 2021-09-16 | ||
BR112022018166A2 (pt) | 2020-03-12 | 2022-10-25 | Toray Industries | Medicamento para tratamento e/ou prevenção de câncer, agentes que aumentam a eficácia de droga de uma composição farmacêutica e método para tratar e/ou prevenir câncer |
BR112022018157A2 (pt) | 2020-03-12 | 2022-10-25 | Toray Industries | Medicamento para o tratamento e/ou prevenção do câncer, agentes que aumentam a eficácia de um fármaco e método para o tratamento e/ou prevenção do câncer |
CN115996756A (zh) | 2020-05-08 | 2023-04-21 | 博尔特生物治疗药物有限公司 | 弹性蛋白酶底物肽连接子免疫缀合物及其用途 |
CN111979278B (zh) * | 2020-07-27 | 2022-04-22 | 河北圣雪大成制药有限责任公司 | 一种通过发酵降低大观霉素杂质e的方法 |
IL300316A (en) | 2020-08-13 | 2023-04-01 | Bolt Biotherapeutics Inc | Immune conjugates of pyrazolozapines and their uses |
KR20240024803A (ko) | 2021-06-23 | 2024-02-26 | 도레이 카부시키가이샤 | 암의 치료 및/또는 예방을 위한 의약품 |
EP4360648A1 (en) | 2021-06-23 | 2024-05-01 | Toray Industries, Inc. | Medicament for treatment and/or prevention of cancer |
WO2023008462A1 (ja) | 2021-07-27 | 2023-02-02 | 東レ株式会社 | 癌の治療及び/又は予防のための医薬品 |
AU2022316644A1 (en) | 2021-07-27 | 2024-02-29 | Toray Industries, Inc. | Medicament for treatment and/or prevention of cancer |
CA3227698A1 (en) | 2021-07-27 | 2023-02-02 | Toray Industries, Inc. | Medicament for treatment and/or prevention of cancer |
JPWO2023033129A1 (ru) | 2021-09-03 | 2023-03-09 | ||
WO2023076599A1 (en) | 2021-10-29 | 2023-05-04 | Bolt Biotherapeutics, Inc. | Tlr agonist immunoconjugates with cysteine-mutant antibodies, and uses thereof |
Family Cites Families (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US5994524A (en) | 1994-07-13 | 1999-11-30 | Chugai Seiyaku Kabushiki Kaisha | Polynucleotides which encode reshaped IL-8-specific antibodies and methods to produce the same |
US5698396A (en) | 1995-06-07 | 1997-12-16 | Ludwig Institute For Cancer Research | Method for identifying auto-immunoreactive substances from a subject |
FR2761994B1 (fr) | 1997-04-11 | 1999-06-18 | Centre Nat Rech Scient | Preparation de recepteurs membranaires a partir de baculovirus extracellulaires |
PL343322A1 (en) | 1998-04-03 | 2001-08-13 | Chugai Pharmaceutical Co Ltd | Humanized antibody against human tissue factor (tf) and process for constructing humanized antibody |
US20030118599A1 (en) | 1999-04-02 | 2003-06-26 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
IL140845A0 (en) | 1998-07-14 | 2002-02-10 | Corixa Corp | Compositions for therapy and diagnosis of prostate cancer |
RU2234942C2 (ru) | 1998-07-14 | 2004-08-27 | Корикса Корпорейшн | Выделенный опухолевый полипептид предстательной железы и кодирующий его полинуклеотид |
US6969518B2 (en) | 1998-12-28 | 2005-11-29 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of breast cancer |
US6335170B1 (en) | 1999-02-22 | 2002-01-01 | Torben F. Orntoft | Gene expression in bladder tumors |
US6444425B1 (en) | 1999-04-02 | 2002-09-03 | Corixa Corporation | Compounds for therapy and diagnosis of lung cancer and methods for their use |
EP1187915A2 (en) | 1999-04-02 | 2002-03-20 | Corixa Corporation | Compounds for therapy and diagnosis of lung cancer and methods for their use |
US6949245B1 (en) | 1999-06-25 | 2005-09-27 | Genentech, Inc. | Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies |
EP1224285A4 (en) | 1999-10-29 | 2004-12-08 | Human Genome Sciences Inc | 27 HUMAN SECRETED PROTEINS |
US20020006404A1 (en) | 1999-11-08 | 2002-01-17 | Idec Pharmaceuticals Corporation | Treatment of cell malignancies using combination of B cell depleting antibody and immune modulating antibody related applications |
AU2001261007A1 (en) | 2000-03-29 | 2001-10-08 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
ES2295228T3 (es) | 2000-11-30 | 2008-04-16 | Medarex, Inc. | Roedores transcromosomicos transgenicos para la preparacion de anticuerpos humanos. |
US7919467B2 (en) | 2000-12-04 | 2011-04-05 | Immunotope, Inc. | Cytotoxic T-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of cancer |
US20040029114A1 (en) | 2001-01-24 | 2004-02-12 | Eos Technology, Inc. | Methods of diagnosis of breast cancer, compositions and methods of screening for modulators of breast cancer |
RU2306952C2 (ru) | 2001-01-31 | 2007-09-27 | Байоджен Айдек Инк. | Лечение в-клеточных злокачественных опухолей с использованием комбинации применений, связанных с антителами, уменьшающими количество b-клеток, и с иммуномодулирующими антителами |
US20040236091A1 (en) | 2001-03-28 | 2004-11-25 | Chicz Roman M. | Translational profiling |
WO2002083070A2 (en) | 2001-04-10 | 2002-10-24 | Corixa Corporation | Compounds for immunotherapy and diagnosis of colon cancer and methods for their use |
CN1789416B (zh) | 2001-05-11 | 2011-11-16 | 协和发酵麒麟株式会社 | 含人抗体λ轻链基因的人类人工染色体 |
EP1516049A4 (en) | 2001-05-11 | 2006-01-11 | Corixa Corp | COMPOSITIONS AND METHODS FOR THE TREATMENT AND DIAGNOSIS OF LUNG CANCER |
US20030190640A1 (en) | 2001-05-31 | 2003-10-09 | Mary Faris | Genes expressed in prostate cancer |
US20040142325A1 (en) | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
EP2388265A1 (en) | 2002-02-22 | 2011-11-23 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
US20050003390A1 (en) | 2002-05-17 | 2005-01-06 | Axenovich Sergey A. | Targets for controlling cellular growth and for diagnostic methods |
US20040126379A1 (en) | 2002-08-21 | 2004-07-01 | Boehringer Ingelheim International Gmbh | Compositions and methods for treating cancer using cytotoxic CD44 antibody immunoconjugates and chemotherapeutic agents |
CA2504144A1 (en) | 2002-11-26 | 2004-06-10 | Genentech, Inc. | Compositions and methods for the diagnosis of immune related diseases using pro7 |
WO2004076682A2 (en) | 2003-02-26 | 2004-09-10 | Surromed, Inc. | Targets for controlling cellular growth and for diagnostic methods |
WO2004097051A2 (en) | 2003-04-29 | 2004-11-11 | Wyeth | Methods for diagnosing aml and mds differential gene expression |
KR20060031809A (ko) | 2003-06-09 | 2006-04-13 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | 암 치료 및 진단용 조성물 및 방법 |
US20070048738A1 (en) | 2003-07-14 | 2007-03-01 | Mayo Foundation For Medical Education And Research | Methods and compositions for diagnosis, staging and prognosis of prostate cancer |
US20050032113A1 (en) | 2003-07-17 | 2005-02-10 | Mitsubishi Pharma Corporation | Membrane protein library for proteome analysis and method for preparing same |
WO2005116076A2 (en) | 2004-01-26 | 2005-12-08 | Debiovision Inc. | Neoplasm-specific polypeptides and their uses |
EP2332990A1 (en) | 2004-03-19 | 2011-06-15 | Imclone LLC | Human anti-epidermal growth factor receptor antibody |
EP2404935A1 (en) | 2004-03-30 | 2012-01-11 | Glaxo Group Limited | Immunoglobulin binding HOSM |
WO2005100998A2 (en) | 2004-04-16 | 2005-10-27 | Europroteome Ag | Membrane markers for use in cancer diagnosis and therapy |
WO2006002378A2 (en) | 2004-06-23 | 2006-01-05 | Avalon Pharmaceuticals | Determining cancer-linked genes and therapeutic targets using molecular cytogenetic methods |
KR20170134771A (ko) | 2005-01-21 | 2017-12-06 | 제넨테크, 인크. | Her 항체의 고정 용량 투여법 |
JP4134179B2 (ja) | 2005-02-04 | 2008-08-13 | 株式会社ソニー・コンピュータエンタテインメント | ソフトウエアによる動的予測方法および装置 |
CA2598217A1 (en) | 2005-02-18 | 2006-08-24 | Marsha A. Moses | Cyr61 as a biomarker for diagnosis and prognosis of cancers of epithelial origin |
MX2007011024A (es) | 2005-03-11 | 2009-11-23 | Vermillion Inc | Biomarcadores para cancer de ovario y cancer de endometrio: hepcidin. |
JP2006316040A (ja) | 2005-05-13 | 2006-11-24 | Genentech Inc | Herceptin(登録商標)補助療法 |
US8014957B2 (en) | 2005-12-15 | 2011-09-06 | Fred Hutchinson Cancer Research Center | Genes associated with progression and response in chronic myeloid leukemia and uses thereof |
CA2642342A1 (en) | 2006-02-14 | 2007-08-23 | Dana-Farber Cancer Institute, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of cancer |
WO2008073162A2 (en) | 2006-08-17 | 2008-06-19 | Cell Signaling Technology, Inc. | Lysine acetylation sites |
US20080107668A1 (en) | 2006-08-30 | 2008-05-08 | Immunotope, Inc. | Cytotoxic t-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of cancer |
US7615349B2 (en) | 2006-09-07 | 2009-11-10 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Melanoma gene signature |
WO2008059252A2 (en) | 2006-11-15 | 2008-05-22 | Oxford Biomedica (Uk) Limited | Methods and composition fro t cell receptors which recognize 5t4 antigen |
JP5663834B2 (ja) | 2008-03-14 | 2015-02-04 | 東ソー株式会社 | 遺伝子組換え抗体の製造方法 |
JP5644110B2 (ja) | 2008-08-05 | 2014-12-24 | 東レ株式会社 | 癌の検出方法 |
KR101667319B1 (ko) * | 2008-08-05 | 2016-10-18 | 도레이 카부시키가이샤 | 암의 치료 및 예방용 의약 조성물 |
BRPI0912462B1 (pt) | 2008-08-05 | 2022-03-22 | Toray Industries, Inc | Uso de um agente indutor de imunidade, uso de um polipeptídeo e uso de um vetor recombinante |
JP5734978B2 (ja) | 2009-08-19 | 2015-06-17 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | Ffpe材料におけるインテグリン複合体検出のための抗体 |
CN102648280B (zh) | 2009-09-22 | 2014-10-08 | 普罗拜奥根股份公司 | 生产含有特定聚糖结构之分子的方法 |
RU2418587C1 (ru) * | 2010-01-21 | 2011-05-20 | Государственное образовательное учреждение высшего профессионального образования "Нижегородская государственная медицинская академия Федерального Агентства по здравоохранению и социальному развитию" (ГОУ ВПО "НижГМА Росздрава") | Способ лечения злокачественных опухолей головного мозга |
PL2532367T3 (pl) | 2010-02-04 | 2019-02-28 | Toray Industries, Inc. | Środek farmaceutyczny do leczenia i/lub zapobiegania nowotworu |
DK2532364T3 (en) | 2010-02-04 | 2016-08-15 | Toray Industries | PHARMACEUTICAL COMPOSITION CONTAINING ANTI CAPRIN-1 ANTIBODIES FOR TREATMENT AND / OR PREVENTION OF CANCER |
LT2531206T (lt) | 2010-02-04 | 2017-09-25 | Morphotek, Inc. | Chlorotoksino polipeptidai ir konjugatai ir jų naudojimas |
JP5742714B2 (ja) | 2010-02-04 | 2015-07-01 | 東レ株式会社 | 癌の治療及び/又は予防用医薬組成物 |
WO2011096519A1 (ja) | 2010-02-04 | 2011-08-11 | 東レ株式会社 | 癌の治療及び/又は予防用医薬組成物 |
RU2597971C2 (ru) | 2010-02-04 | 2016-09-20 | Торэй Индастриз, Инк. | Фармацевтическая композиция для лечения и/или профилактики рака |
EP2532743B1 (en) | 2010-02-04 | 2015-04-15 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prevention of cancer |
JP5312368B2 (ja) | 2010-02-16 | 2013-10-09 | 富士フイルム株式会社 | 金属複合基板およびその製造方法 |
WO2013018894A1 (ja) | 2011-08-04 | 2013-02-07 | 東レ株式会社 | 癌の治療及び/又は予防用医薬組成物 |
BR112014002616B1 (pt) | 2011-08-04 | 2022-01-18 | Toray Industries, Inc | Método para detectar câncer pancreático |
BR112014002619A2 (pt) | 2011-08-04 | 2018-10-09 | Toray Industries, Inc | composição farmacêutica e método de tratamento e/ou prevenção de câncer pancreático e combinação farmacêutica |
EP2832365B1 (en) | 2012-03-30 | 2017-11-01 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prevention of liver cancer |
CN104203281B (zh) | 2012-03-30 | 2019-07-26 | 东丽株式会社 | 胆囊癌的治疗和/或预防用药物组合物 |
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CN103764825B (zh) | 2015-09-02 |
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CN103764825A (zh) | 2014-04-30 |
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US20140178373A1 (en) | 2014-06-26 |
JPWO2013018889A1 (ja) | 2015-03-05 |
BR112014002618A2 (pt) | 2018-01-23 |
DK2740795T3 (en) | 2017-01-16 |
PT2740795T (pt) | 2017-01-09 |
HUE030137T2 (en) | 2017-04-28 |
MX2014001370A (es) | 2014-03-21 |
AU2012290952A1 (en) | 2014-03-20 |
BR112014002618B1 (pt) | 2022-09-20 |
EP2740795A1 (en) | 2014-06-11 |
MX348577B (es) | 2017-06-20 |
EP2740795A4 (en) | 2015-04-15 |
CA2844034C (en) | 2019-07-16 |
KR101980554B1 (ko) | 2019-05-21 |
WO2013018889A1 (ja) | 2013-02-07 |
ES2609859T3 (es) | 2017-04-24 |
PL2740795T3 (pl) | 2017-04-28 |
RU2611197C2 (ru) | 2017-02-21 |
US9181348B2 (en) | 2015-11-10 |
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