RU2013126140A - Антинеопластические комбинации, содержащие hki-272 и винорелбин - Google Patents
Антинеопластические комбинации, содержащие hki-272 и винорелбин Download PDFInfo
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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Abstract
1. Способ лечения новообразования у субъекта, где указанныйспособ включает введение винорелбина или его аналоге и введение HKI-272 или его аналога.2. Способ лечения по п.1, где стадии введения осуществляются одновременно, последовательно, совместно, в определенном порядке или согласно определенной временной зависимости.3. Способ лечения по п.1, где указанные винорелбин или его аналог вводят в виде разовой дозы.4. Способ лечения по п.1, где указанные HKI-272 или его аналог вводят в виде разовой дозы.5. Способ лечения по п.1, где указанные винорелбин или его аналог означает винорелбин.6. Способ лечения по п.1, где указанные HKI-272 или его аналог означает HKI-272.7. Способ лечения по п.1, где один или оба указанных компонента, т.е. винорелбин или его аналог и HKI-272 или его аналог, вводят указанному субъекту внутривенно.8. Способ лечения по п.1, где один или оба указанных компонента, т.е. винорелбин или его аналог и HKI-272 или его аналог, вводят указанному субъекту перорально.9. Способ лечения по п.1, где указанное новообразование связано с избыточной экспрессией или амплификацией HER-2.10. Способ лечения по п.1, где указанное новообразование является метастатическим.11. Способ лечения по п.1, где указанное новообразованиевыбрано из группы, состоящей из рака легких, рака груди, миеломы, рака простаты, раковых образований головы и шеи, переходно-клеточной карциномы, мелкоклеточной нейроэндокринной карциномы шейки матки и крупноклеточной нейроэндокринной карциномы шейки матки.12. Способ лечения по п.11, где указанное новообразование является раком груди.13. Способ лечения по п.12, где указанный рак груди является HER-2-положительным раком груди с метастазами.14. С�
Claims (28)
1. Способ лечения новообразования у субъекта, где указанный
способ включает введение винорелбина или его аналоге и введение HKI-272 или его аналога.
2. Способ лечения по п.1, где стадии введения осуществляются одновременно, последовательно, совместно, в определенном порядке или согласно определенной временной зависимости.
3. Способ лечения по п.1, где указанные винорелбин или его аналог вводят в виде разовой дозы.
4. Способ лечения по п.1, где указанные HKI-272 или его аналог вводят в виде разовой дозы.
5. Способ лечения по п.1, где указанные винорелбин или его аналог означает винорелбин.
6. Способ лечения по п.1, где указанные HKI-272 или его аналог означает HKI-272.
7. Способ лечения по п.1, где один или оба указанных компонента, т.е. винорелбин или его аналог и HKI-272 или его аналог, вводят указанному субъекту внутривенно.
8. Способ лечения по п.1, где один или оба указанных компонента, т.е. винорелбин или его аналог и HKI-272 или его аналог, вводят указанному субъекту перорально.
9. Способ лечения по п.1, где указанное новообразование связано с избыточной экспрессией или амплификацией HER-2.
10. Способ лечения по п.1, где указанное новообразование является метастатическим.
11. Способ лечения по п.1, где указанное новообразование
выбрано из группы, состоящей из рака легких, рака груди, миеломы, рака простаты, раковых образований головы и шеи, переходно-клеточной карциномы, мелкоклеточной нейроэндокринной карциномы шейки матки и крупноклеточной нейроэндокринной карциномы шейки матки.
12. Способ лечения по п.11, где указанное новообразование является раком груди.
13. Способ лечения по п.12, где указанный рак груди является HER-2-положительным раком груди с метастазами.
14. Способ лечения по п.1, где указанное новообразование является солидной опухолью на поздней стадии.
15. Способ лечения по п.1, где указанные винорелбин или его аналог вводят в количестве не менее чем примерно 20 мг/л.
16. Способ лечения по п.15, где указанные винорелбин или его аналог вводят в количестве от примерно 20 до примерно 25 мг/л.
17. Способ лечения по п.16, где указанные винорелбин или его аналог вводят в количестве примерно 25 мг/л.
18. Способ лечения по п.1, где указанные HKI-272 или его аналог вводят в количестве не менее примерно 120 мг.
19. Способ лечения по п.18, где указанные HKI-272 или его аналог вводят в количестве не менее примерно 160 мг.
20. Способ лечения по п.19, где указанные HKI-272 или его аналог вводят в количестве не менее примерно 240 мг.
21. Способ лечения по п.4, где указанная разовая доза представляет собой таблетку.
22. Способ лечения по п.1, где указанные HKI-272 или его
аналог вводят ежедневно.
23. Способ лечения по п.1, где указанные HKI-272 или его аналог вводят по меньшей мере один раз в день.
24. Способ лечения по п.1, где указанные HKI-272 или его аналог вводят в день 1 осуществления указанного способа лечения.
25. Способ лечения по п.10, где указанные HKI-272 или его аналог вводят в день 2 осуществления указанного способа лечения.
26. Способ лечения по п.1, где указанные HKI-272 или его аналог вводят в течение по меньшей мере 2 последовательных недель.
27. Способ лечения по п.1, дополнительно включающий радиационное лечение.
28. Комбинация HKI-272 и винорелбина для лечения новообразования.
Applications Claiming Priority (2)
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US7333008P | 2008-06-17 | 2008-06-17 | |
US61/073,330 | 2008-06-17 |
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RU2010151787/15A Division RU2492860C2 (ru) | 2008-06-17 | 2009-06-17 | Антиопластические комбинации, содержащие нкi-272 и винорелбин |
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RU2018137037A Division RU2018137037A (ru) | 2008-06-17 | 2018-10-22 | Антинеопластические комбинации, содержащие hki-272 и винорелбин |
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RU2013126140A true RU2013126140A (ru) | 2014-12-20 |
RU2670974C2 RU2670974C2 (ru) | 2018-10-26 |
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RU2010151787/15A RU2492860C2 (ru) | 2008-06-17 | 2009-06-17 | Антиопластические комбинации, содержащие нкi-272 и винорелбин |
RU2013126140A RU2670974C2 (ru) | 2008-06-17 | 2013-06-06 | Антинеопластические комбинации, содержащие hki-272 и винорелбин |
RU2018137037A RU2018137037A (ru) | 2008-06-17 | 2018-10-22 | Антинеопластические комбинации, содержащие hki-272 и винорелбин |
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US (4) | US20090312360A1 (ru) |
EP (6) | EP2915532B1 (ru) |
JP (6) | JP2011524423A (ru) |
KR (4) | KR20180128078A (ru) |
CN (2) | CN102099034A (ru) |
AU (1) | AU2009271419B2 (ru) |
BR (1) | BRPI0914790A2 (ru) |
CA (1) | CA2725598C (ru) |
CY (1) | CY1114552T1 (ru) |
DK (2) | DK2310011T3 (ru) |
ES (6) | ES2531322T3 (ru) |
HK (1) | HK1214178A1 (ru) |
HR (1) | HRP20130842T1 (ru) |
IL (2) | IL209412A (ru) |
MX (2) | MX365008B (ru) |
NZ (3) | NZ600982A (ru) |
PL (2) | PL2310011T3 (ru) |
PT (1) | PT2310011E (ru) |
RU (3) | RU2492860C2 (ru) |
SG (1) | SG191676A1 (ru) |
SI (1) | SI2310011T1 (ru) |
WO (1) | WO2010008744A2 (ru) |
ZA (1) | ZA201008166B (ru) |
Families Citing this family (11)
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WO2006084058A2 (en) | 2005-02-03 | 2006-08-10 | The General Hospital Corporation | Method for treating gefitinib resistant cancer |
WO2007056118A1 (en) | 2005-11-04 | 2007-05-18 | Wyeth | Antineoplastic combinations with mtor inhibitor, herceptin, and/or hki-272 |
US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
AU2016202225B2 (en) * | 2008-06-17 | 2017-09-28 | Wyeth Llc | Antineoplastic combinations containing HKI-272 and vinorelbine |
EP2915532B1 (en) | 2008-06-17 | 2016-10-19 | Wyeth LLC | Antineoplastic combinations containing hki-272 and vinorelbine |
ES2614912T3 (es) | 2008-08-04 | 2017-06-02 | Wyeth Llc | Combinaciones antineoplásicas de 4-anilino-3-cianoquinolinas y capecitabina |
EP3000467B1 (en) | 2009-04-06 | 2023-03-01 | Wyeth LLC | Treatment regimen utilizing neratinib for breast cancer |
CN102724962B (zh) | 2009-11-09 | 2017-05-17 | 惠氏有限责任公司 | 包衣药物球状体及其用于消除或减少病症比如呕吐和腹泻的用途 |
KR102427777B1 (ko) * | 2012-06-26 | 2022-08-01 | 델 마 파마슈티컬스 | 디안하이드로갈락티톨, 디아세틸디안하이드로갈락티톨, 디브로모둘시톨, 또는 그의 유사체 또는 유도체를 이용하여 유전학적 다형성이 있는 환자에 있어서 티로신-키나아제-억제제 내성 악성종양, ahi1 조절곤란 또는 돌연변이를 치료하는 방법 |
SG11201703810QA (en) * | 2014-11-10 | 2017-06-29 | Del Mar Pharmaceuticals | Dianhydrogalactitol together with radiation to treat non-small-cell carcinoma of the lung and glioblastoma multiforme |
WO2021185234A1 (zh) * | 2020-03-16 | 2021-09-23 | 正大天晴药业集团股份有限公司 | 作为c-Met激酶抑制剂的化合物的联用药物组合物及其用途 |
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