RU2012150453A - Иммуностимулирующие олигонуклеотиды - Google Patents
Иммуностимулирующие олигонуклеотиды Download PDFInfo
- Publication number
- RU2012150453A RU2012150453A RU2012150453/10A RU2012150453A RU2012150453A RU 2012150453 A RU2012150453 A RU 2012150453A RU 2012150453/10 A RU2012150453/10 A RU 2012150453/10A RU 2012150453 A RU2012150453 A RU 2012150453A RU 2012150453 A RU2012150453 A RU 2012150453A
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- Prior art keywords
- antigen
- immunogenic composition
- composition according
- bacterium
- causes
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Abstract
1. Иммуногенная композиция, содержащая антиген и иммуностимулирующий олигонуклеотид, состоящий из нуклеотидной последовательности 5' TCGTCGTTTTTCGGTGCTTTT 3' (SEQ ID NO:1), дополнительно содержащая фармацевтически приемлемый носитель.2. Иммуногенная композиция по п.1, где иммуностимулирующий олигонуклеотид находится в количестве, эффективном для индукции антиген-специфического иммунного ответа.3. Иммуногенная композиция по п.2, где индуцированный антиген-специфический иммунный ответ представляет собой Th1-иммунный ответ.4. Иммуногенная композиция по п.1, где антиген представляет собой микробный антиген, аутоантиген или вещество, вызывающее привыкание, выбранное из кокаина и никотина.5. Иммуногенная композиция по п.4, где микробный антиген представляет собой бактериальный антиген, вирусный антиген или паразитарный антиген.6. Иммуногенная композиция по п.5, где:а) бактериальный антиген ассоциирован с Staphylococcus aureus, бактерией, вызывающей кариес зубов, или бактерией, вызывающей периодонтальное заболевание;б) вирусный антиген ассоциирован с респираторно-синцитиальным вирусом (RSV), вирусом простого герпеса 1, вирусом простого герпеса 2, вирусом иммунодефицита человека-1 (HIV-1) или HIV-2, илив) паразитарный антиген ассоциирован с паразитом, вызывающим малярию.7. Иммуногенная композиция по п.6, где:а) бактерия, которая вызывает кариес зубов, представляет собой Streptococcus mutans, Streptococcus sobrinus, Streptococcus sanguis, Lactobacillus acidophilis или Actinomyces viscosus; илиб) бактерия, которая вызывает периодонтальное заболевание, представляет собой Porphyromonas gingivalis или Actinobacillus actinomycetemcomitans.8. Иммуногенная композиция по п.4, где аутоантиген представляет собой опухолевый антиген, антиген, ас
Claims (22)
1. Иммуногенная композиция, содержащая антиген и иммуностимулирующий олигонуклеотид, состоящий из нуклеотидной последовательности 5' TCGTCGTTTTTCGGTGCTTTT 3' (SEQ ID NO:1), дополнительно содержащая фармацевтически приемлемый носитель.
2. Иммуногенная композиция по п.1, где иммуностимулирующий олигонуклеотид находится в количестве, эффективном для индукции антиген-специфического иммунного ответа.
3. Иммуногенная композиция по п.2, где индуцированный антиген-специфический иммунный ответ представляет собой Th1-иммунный ответ.
4. Иммуногенная композиция по п.1, где антиген представляет собой микробный антиген, аутоантиген или вещество, вызывающее привыкание, выбранное из кокаина и никотина.
5. Иммуногенная композиция по п.4, где микробный антиген представляет собой бактериальный антиген, вирусный антиген или паразитарный антиген.
6. Иммуногенная композиция по п.5, где:
а) бактериальный антиген ассоциирован с Staphylococcus aureus, бактерией, вызывающей кариес зубов, или бактерией, вызывающей периодонтальное заболевание;
б) вирусный антиген ассоциирован с респираторно-синцитиальным вирусом (RSV), вирусом простого герпеса 1, вирусом простого герпеса 2, вирусом иммунодефицита человека-1 (HIV-1) или HIV-2, или
в) паразитарный антиген ассоциирован с паразитом, вызывающим малярию.
7. Иммуногенная композиция по п.6, где:
а) бактерия, которая вызывает кариес зубов, представляет собой Streptococcus mutans, Streptococcus sobrinus, Streptococcus sanguis, Lactobacillus acidophilis или Actinomyces viscosus; или
б) бактерия, которая вызывает периодонтальное заболевание, представляет собой Porphyromonas gingivalis или Actinobacillus actinomycetemcomitans.
8. Иммуногенная композиция по п.4, где аутоантиген представляет собой опухолевый антиген, антиген, ассоциированный с болезнью Альцгеймера, антиген против человеческого антитела, антиген, который экспрессируется из человеческих эндогенных ретровирусных элементов, или никотиновый гаптен, конъюгированный с носителем.
9. Иммуногенная композиция по п.8, где:
а) опухолевый антиген представляет собой HER2 (рецептор человеческого эпидермального фактора роста 2), MAGE (антиген, ассоциированный с меланомой), NY-ESO (раково-тестикулярный антиген), PSA (простатспецифический антиген), СЕА (карциноэмбриональный антиген) или вариант EGFR (рецептор эпителиального фактора роста);
б) антиген, ассоциированный с болезнью Альцгеймера, представляет собой tau или β-амилоид;
в) антиген представляет собой IgE; или
г) носитель, с которым конъюгирован никотиновый гаптен, представляет собой дифтерийный токсин (DT).
10. Иммуногенная композиция по п.1, где антиген представляет собой пептид, рекомбинантный белок, очищенный белок, цельный убитый патоген, живой ослабленный вирус или вирусный вектор, живую ослабленную бактерию или бактериальный вектор, полисахарид, гаптен или кодируется плазмидной ДНК.
11. Иммуногенная композиция по п.1, где антиген конъюгирован с носителем.
12. Иммуногенная композиция по п.11, где носитель представляет собой дифтерийный токсин (DT) или вирусоподобную частицу, где вирусоподобная частица представляет собой РНК-фаг Q-β, поверхностный антиген гепатита В (HBsAg) или коровый антиген гепатита В (HBcAg).
13. Иммуногенная композиция по п.1, дополнительно содержащая один или более адъювантов.
14. Иммуногенная композиция по п.13, где адъювант представляет собой агонист Toll-подобного рецептора (TLR), который не является TLR9.
15. Иммуногенная композиция по п.14, где агонист представляет собой агонист TLR3, TLR4, TLR5, TLR7 или TLR8.
16. Иммуногенная композиция по п.15, где:
а) агонист TLR3 представляет собой стабилизированную poly I:C (полиинозиновая-полицитидиловая кислота);
б) агонист TLR4 представляет собой производное липополисахарида (LPS), выбранное из MPL (монофосфориллипид А) или GLA (гамма-линоленовая кислота);
в) агонист TLR5 представляет собой флагеллин; или
г) агонист TLR7 или TLR8 представляет собой небольшую молекулу имидазохинолинового семейства.
17. Иммуногенная композиция по п.13, где адъювант представляет собой соль алюминия, иммуностимулирующий комплекс (ISCOM), эмульсию масло-в-воде или вода-в-масле, липосому или систему доставки, выбранную из наночастицы или микрочастицы
18. Иммуногенная композиция по п.17, где соль алюминия представляет собой гидрат окиси алюминия.
19. Иммуногенная композиция по п.1, где
а) иммуностимулирующий олигонуклеотид содержит одну или более фосфоротиоатных связей; или
б) иммуностимулирующий олигонуклеотид содержит пиримидин-пуриновый динуклеотид.
20. Иммуногенная композиция по п.1, где иммуногенная композиция приготовлена для введения.
21. Иммуногенная композиция по п.1, где:
а) иммуногенная композиция приготовлена для введения парентеральным путем, где парентеральный путь представляет собой внутримышечный, подкожный, интрадермальный, внутривенный или интраперитонеальный путь; или
б) иммуногенная композиция приготовлена для введения местным путем, где местный путь представляет собой кожный, трансдермальный пути или путь через поверхность слизистой оболочки.
22. Иммуногенная композиция по п.21, где путь через поверхность слизистой оболочки представляет собой пероральный, интраназальный, интравагинальный, интраректальный, интрабуккальный или внутриглазной пути.
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