RU2004116308A - Морфогенные белки кости (вмр), рецепторы вмр и связывающие вмр белки и их применение для диагностики и лечения глаукомы - Google Patents
Морфогенные белки кости (вмр), рецепторы вмр и связывающие вмр белки и их применение для диагностики и лечения глаукомы Download PDFInfo
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
- G01N2333/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
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Claims (7)
1. Способ диагностирования глаукомы в пробе, полученной из клетки или жидкости организма, детектированием измененной экспрессии гена, члена семейства морфогенных белков кости, включающий следующие стадии:
g) получение пробы ткани или жидкости от пациента с подозрением на глаукому;
h) выделение ДНК из указанной пробы;
i) получение множества праймеров для ПЦР, при этом каждый из указанных праймеров включает последовательность, состоящую из 18-1547 смежных нуклеотидов из последовательностей SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:7, SEQ ID NO:37, SEQ ID NO:39, SEQ ID NO:41, SEQ ID NO:43, SEQ ID NO:45, SEQ ID NO:47 или SEQ ID NO:53;
j) амплификация областей выделенной ДНК с использованием указанных праймеров с получением продукта ПЦР;
k) выделение продукта ПЦР; и
l) идентификация различий между последовательностью амплифицированной выделенной ДНК и последовательностью праймера,
при этом различие между амплифицированной последовательностью и праймером является диагностическим признаком глаукомы.
2. Способ по п.1, отличающийся тем, что указанная проба ткани или жидкости представляет собой клетки крови или буккальные клетки.
3. Способ по п.1, отличающийся тем, что праймеры включают последовательности, состоящие из 20-100 смежных нуклеотидов из последовательностей SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:7, SEQ ID NO:37, SEQ ID NO:39, SEQ ID NO:41, SEQ ID NO:43, SEQ ID NO:45, SEQ ID NO:47 или SEQ ID NO:53.
4. Способ по п.1, отличающийся тем, что праймеры включают последовательности, состоящие из 20-50 смежных нуклеотидов из последовательности SEQ ID NO:3.
5. Способ по п.1, отличающийся тем, что продукт ПЦР выделяют с помощью SSCP, DGGE, ASO или RFLP.
6. Способ лечения глаукомы, включающий введение пациенту, нуждающемуся в этом, композиции, включающей последовательность, состоящую, по меньшей мере, из одного соединения, выбранного из группы, состоящей из агониста ВМР-2, агониста ВМР-4, агониста ВМР-5, агониста ВМР-7, агониста Smad 1/5, антагониста хордина, антагониста гремлина и антагониста фоллистатина.
7. Способ идентификации терапевтического средства для лечения глаукомы, включающий
d) получение первой композиции, содержащей популяцию рекомбинантных клеток, экспрессирующих ВМР-2А, ВМР-4, ВМР-5 или ВМР-7;
e) получение соединения-кандидата;
f) инкубацию указанной композиции и указанного соединения-кандидата;
g) тестирование указанной композиции на ее способность воздействовать на индуцированные ВМР пути передачи сигнала с участием Smad или регулируемую ВМР экспрессию гена; и
h) идентификацию соединения-кандидата, которое ингибирует или стимулирует индуцированные ВМР пути передачи сигнала с участием Smad или регулируемую ВМР экспрессию гена.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33485201P | 2001-10-31 | 2001-10-31 | |
| US60/334,852 | 2001-10-31 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008122296/15A Division RU2008122296A (ru) | 2001-10-31 | 2008-06-03 | Морфогенные белки кости (вмр), рецепторы вмр и связывающие вмр белки и их применение для диагностики и лечения глаукомы |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2004116308A true RU2004116308A (ru) | 2005-03-27 |
| RU2336902C2 RU2336902C2 (ru) | 2008-10-27 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004116308/15A RU2336902C2 (ru) | 2001-10-31 | 2002-10-31 | Морфогенные белки кости (вмр), рецепторы вмр и связывающие вмр белки и их применение для диагностики и лечения глаукомы |
| RU2008122296/15A RU2008122296A (ru) | 2001-10-31 | 2008-06-03 | Морфогенные белки кости (вмр), рецепторы вмр и связывающие вмр белки и их применение для диагностики и лечения глаукомы |
| RU2012120343/15A RU2012120343A (ru) | 2001-10-31 | 2012-05-16 | Морфогенные белки кости (bmp), рецепторы вмр и связывающие вмр белки и их применение для диагностики и лечения глаукомы |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008122296/15A RU2008122296A (ru) | 2001-10-31 | 2008-06-03 | Морфогенные белки кости (вмр), рецепторы вмр и связывающие вмр белки и их применение для диагностики и лечения глаукомы |
| RU2012120343/15A RU2012120343A (ru) | 2001-10-31 | 2012-05-16 | Морфогенные белки кости (bmp), рецепторы вмр и связывающие вмр белки и их применение для диагностики и лечения глаукомы |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US7405192B2 (ru) |
| EP (2) | EP1440159B1 (ru) |
| JP (2) | JP4255382B2 (ru) |
| KR (4) | KR101072867B1 (ru) |
| CN (2) | CN1966725A (ru) |
| AT (1) | ATE349554T1 (ru) |
| BR (1) | BR0213738A (ru) |
| CA (1) | CA2463143A1 (ru) |
| DE (1) | DE60217152T2 (ru) |
| ES (1) | ES2278079T3 (ru) |
| HK (1) | HK1069851A1 (ru) |
| MX (1) | MXPA04003697A (ru) |
| PL (2) | PL373863A1 (ru) |
| RU (3) | RU2336902C2 (ru) |
| WO (1) | WO2003055443A2 (ru) |
| ZA (1) | ZA200402662B (ru) |
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| CA2475769C (en) * | 2003-08-28 | 2018-12-11 | Veridex, Llc | Colorectal cancer prognostics |
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| CN102973947A (zh) | 2004-06-01 | 2013-03-20 | 健泰科生物技术公司 | 抗体-药物偶联物和方法 |
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