RS63818B1 - Konstruisani polipeptidi za vezivanje za receptor transferina - Google Patents

Konstruisani polipeptidi za vezivanje za receptor transferina

Info

Publication number
RS63818B1
RS63818B1 RS20221129A RSP20221129A RS63818B1 RS 63818 B1 RS63818 B1 RS 63818B1 RS 20221129 A RS20221129 A RS 20221129A RS P20221129 A RSP20221129 A RS P20221129A RS 63818 B1 RS63818 B1 RS 63818B1
Authority
RS
Serbia
Prior art keywords
receptor binding
transferrin receptor
binding polypeptides
engineered transferrin
engineered
Prior art date
Application number
RS20221129A
Other languages
English (en)
Inventor
Xiaocheng Chen
Mark S Dennis
Mihalis Kariolis
Adam P Silverman
Ankita Srivastava
Ryan J Watts
Robert C Wells
Joy Yu Zuchero
Original Assignee
Denali Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Denali Therapeutics Inc filed Critical Denali Therapeutics Inc
Publication of RS63818B1 publication Critical patent/RS63818B1/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70582—CD71
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2881—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1058—Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B20/00—Methods specially adapted for identifying library members
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
RS20221129A 2017-02-17 2018-02-15 Konstruisani polipeptidi za vezivanje za receptor transferina RS63818B1 (sr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762460692P 2017-02-17 2017-02-17
US201762543658P 2017-08-10 2017-08-10
US201762583314P 2017-11-08 2017-11-08
EP18708025.4A EP3583120B1 (en) 2017-02-17 2018-02-15 Engineered transferrin receptor binding polypeptides
PCT/US2018/018371 WO2018152326A1 (en) 2017-02-17 2018-02-15 Engineered transferrin receptor binding polypeptides

Publications (1)

Publication Number Publication Date
RS63818B1 true RS63818B1 (sr) 2023-01-31

Family

ID=61521837

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20221129A RS63818B1 (sr) 2017-02-17 2018-02-15 Konstruisani polipeptidi za vezivanje za receptor transferina

Country Status (32)

Country Link
US (4) US11795232B2 (sr)
EP (2) EP3583120B1 (sr)
JP (2) JP2020508049A (sr)
KR (1) KR20190129868A (sr)
CN (1) CN110506055A (sr)
AU (2) AU2018221731C1 (sr)
BR (1) BR112019016989A2 (sr)
CA (1) CA3053375A1 (sr)
CL (1) CL2019002307A1 (sr)
CO (1) CO2019008873A2 (sr)
CR (1) CR20190372A (sr)
DK (1) DK3583120T3 (sr)
EC (1) ECSP19058592A (sr)
ES (1) ES2932759T3 (sr)
FI (1) FI3583120T3 (sr)
HR (1) HRP20221505T1 (sr)
HU (1) HUE060983T2 (sr)
IL (2) IL307373A (sr)
LT (1) LT3583120T (sr)
MD (1) MD3583120T2 (sr)
MX (2) MX2019009818A (sr)
NZ (1) NZ756763A (sr)
PE (1) PE20191551A1 (sr)
PH (1) PH12019550147A1 (sr)
PL (1) PL3583120T3 (sr)
PT (1) PT3583120T (sr)
RS (1) RS63818B1 (sr)
SG (1) SG11201907427YA (sr)
SI (1) SI3583120T1 (sr)
TW (1) TWI797106B (sr)
UA (1) UA127985C2 (sr)
WO (1) WO2018152326A1 (sr)

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MA50746A (fr) 2017-10-02 2020-08-12 Denali Therapeutics Inc Protéines de fusion comprenant des enzymes d'enzymothérapie substitutive
WO2020037150A2 (en) * 2018-08-16 2020-02-20 Denali Therapeutics Inc. Engineered bispecific proteins
SG11202101436SA (en) * 2018-08-22 2021-03-30 Denali Therapeutics Inc Anti-her2 polypeptides and methods of use thereof
KR20220130678A (ko) 2019-12-23 2022-09-27 데날리 테라퓨틱스 인크. 프로그라눌린 변이체들
TW202138384A (zh) 2019-12-23 2021-10-16 美商戴納立製藥公司 顆粒蛋白前體變異體
TW202128771A (zh) 2020-01-13 2021-08-01 美商戴納立製藥公司 抗trem2 抗體及其使用方法
BR112022013756A2 (pt) * 2020-01-13 2022-10-11 Denali Therapeutics Inc Anticorpos anti-trem2 e métodos de uso dos mesmos
CN111110834A (zh) * 2020-02-24 2020-05-08 中国科学院昆明动物研究所 转铁蛋白或过表达转铁蛋白在制备治疗和/或预防溃疡性结肠炎的药物中的应用
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WO2023279099A1 (en) 2021-07-01 2023-01-05 Denali Therapeutics Inc. Oligonucleotide conjugates targeted to the transferrin receptor
WO2023114499A1 (en) 2021-12-17 2023-06-22 Denali Therapeutics Inc. Polypeptide engineering, libraries, and engineered cd98 heavy chain and transferrin receptor binding polypeptides
WO2023192282A1 (en) 2022-03-28 2023-10-05 Denali Therapeutics Inc. Methods for treating brain glucose hypometabolism
WO2023192288A1 (en) 2022-03-28 2023-10-05 Denali Therapeutics Inc. Monovalent anti-trem2 binding molecules and methods of use thereof
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