RS59002B1 - Pirimido[4,5-b]indol derivati i njihova primena u ekspanziji hematopoetskih matičnih ćelija - Google Patents
Pirimido[4,5-b]indol derivati i njihova primena u ekspanziji hematopoetskih matičnih ćelijaInfo
- Publication number
- RS59002B1 RS59002B1 RS20190858A RSP20190858A RS59002B1 RS 59002 B1 RS59002 B1 RS 59002B1 RS 20190858 A RS20190858 A RS 20190858A RS P20190858 A RSP20190858 A RS P20190858A RS 59002 B1 RS59002 B1 RS 59002B1
- Authority
- RS
- Serbia
- Prior art keywords
- pyrimido
- expansion
- stem cells
- hematopoietic stem
- indole derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261591521P | 2012-01-27 | 2012-01-27 | |
EP13740815.9A EP2807165B1 (en) | 2012-01-27 | 2013-01-25 | Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells |
PCT/CA2013/050052 WO2013110198A1 (en) | 2012-01-27 | 2013-01-25 | Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells |
Publications (1)
Publication Number | Publication Date |
---|---|
RS59002B1 true RS59002B1 (sr) | 2019-08-30 |
Family
ID=48872865
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RS20190858A RS59002B1 (sr) | 2012-01-27 | 2013-01-25 | Pirimido[4,5-b]indol derivati i njihova primena u ekspanziji hematopoetskih matičnih ćelija |
Country Status (24)
Country | Link |
---|---|
US (3) | US9409906B2 (sr) |
EP (1) | EP2807165B1 (sr) |
JP (1) | JP6250556B2 (sr) |
KR (1) | KR102098122B1 (sr) |
CN (1) | CN104144931B (sr) |
AU (1) | AU2013212457B2 (sr) |
BR (1) | BR112014018524B1 (sr) |
CA (1) | CA2862140C (sr) |
CY (1) | CY1121799T1 (sr) |
DK (1) | DK2807165T3 (sr) |
ES (1) | ES2733946T3 (sr) |
HK (1) | HK1203945A1 (sr) |
HR (1) | HRP20191189T1 (sr) |
HU (1) | HUE044070T4 (sr) |
IL (1) | IL233587B (sr) |
LT (1) | LT2807165T (sr) |
NZ (1) | NZ627188A (sr) |
PL (1) | PL2807165T3 (sr) |
PT (1) | PT2807165T (sr) |
RS (1) | RS59002B1 (sr) |
SG (1) | SG11201404241SA (sr) |
SI (1) | SI2807165T1 (sr) |
TR (1) | TR201909582T4 (sr) |
WO (1) | WO2013110198A1 (sr) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9409906B2 (en) | 2012-01-27 | 2016-08-09 | Universite De Montreal | Pyrimido[4,5-B]indole derivatives and use thereof in the expansion of hematopoietic stem cells |
EP2970312B1 (en) * | 2013-03-11 | 2017-11-15 | The Regents of The University of Michigan | Bet bromodomain inhibitors and therapeutic methods using the same |
US9757378B2 (en) | 2013-05-17 | 2017-09-12 | Universite De Montreal | Methods to modulate acute myeloid leukemia stem/progenitor cell expansion and/or differentiation |
CN107074861A (zh) * | 2014-02-28 | 2017-08-18 | 密执安大学评议会 | 作为bet溴结构域抑制剂的9h嘧啶并[4,5‑b]吲哚和相关类似物 |
EP3134409B1 (en) | 2014-04-22 | 2020-02-12 | Université de Montréal | Compounds and use thereof in the expansion of hematopoietic stem cells and/or hematopoietic progenitor cells |
DK3194602T3 (da) * | 2014-09-18 | 2020-02-17 | Univ Montreal | Forbindelser og fremgangsmåder til at forstærke virusgenoverførsel til humane hæmatopoietiske celler |
JP2018502115A (ja) * | 2014-12-31 | 2018-01-25 | アントフロゲネシス コーポレーション | ナチュラルキラー細胞及びその使用 |
EP3247808B1 (en) | 2015-01-21 | 2021-05-05 | Fred Hutchinson Cancer Research Center | Point-of-care and/or portable platform for gene therapy |
JP6954844B2 (ja) * | 2015-06-05 | 2021-10-27 | エマ−ケベック | 造血幹細胞を培養するため及び/又は造血幹細胞を前駆体へ分化させるための方法及びその使用 |
WO2016210292A1 (en) | 2015-06-25 | 2016-12-29 | Children's Medical Center Corporation | Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance |
CN105316293A (zh) * | 2015-09-23 | 2016-02-10 | 广东颐养抗衰老研究院 | 一种体外获得造血干/祖细胞的方法 |
CA3002066A1 (en) * | 2015-10-15 | 2017-04-20 | Celularity Inc. | Natural killer cells and ilc3 cells and uses thereof |
CA3009727A1 (en) * | 2015-12-28 | 2017-07-06 | Novartis Ag | Compositions and methods for the treatment of hemoglobinopathies |
EP3429603B1 (en) | 2016-03-15 | 2021-12-29 | Children's Medical Center Corporation | Methods and compositions relating to hematopoietic stem cell expansion |
JP2019519486A (ja) * | 2016-05-07 | 2019-07-11 | セルラリティ インコーポレイテッド | ナチュラルキラー細胞を使用して急性骨髄性白血病および多発性骨髄腫を処置する方法 |
SG10202101478YA (en) * | 2016-08-18 | 2021-03-30 | Nat Univ Singapore | Substituted azole derivatives for generation, proliferation and differentiation of hematopoietic stem and progenitor cells |
JP2019532672A (ja) | 2016-09-28 | 2019-11-14 | ノバルティス アーゲー | 多孔質膜系巨大分子送達システム |
TW201839136A (zh) | 2017-02-06 | 2018-11-01 | 瑞士商諾華公司 | 治療血色素異常症之組合物及方法 |
BR112020006256A2 (pt) | 2017-09-29 | 2020-10-20 | Intellia Therapeutics, Inc. | método in vitro de administração de mrna usando nanopartículas de lipídio |
BR112020008330A2 (pt) * | 2017-11-03 | 2020-10-06 | Universite De Montreal | compostos e uso dos mesmos na expansão de células- tronco e/ou células progenitoras |
CN111902411A (zh) * | 2018-01-03 | 2020-11-06 | 美真达治疗公司 | 用于扩增造血干细胞和祖细胞以及治疗遗传性代谢紊乱的组合物和方法 |
JP7467358B2 (ja) * | 2018-02-20 | 2024-04-15 | ウニヴェルシテ・ドゥ・モントリオール | 免疫応答を媒介するin vivoでのNK細胞およびDC細胞の拡大 |
KR102329235B1 (ko) * | 2018-11-21 | 2021-11-22 | 한국화학연구원 | Irak4 저해제로서 신규의 삼중고리 화합물 |
US11697799B2 (en) | 2019-04-15 | 2023-07-11 | Ossium Health, Inc. | System and method for extraction and cryopreservation of bone marrow |
JP2023506842A (ja) | 2019-12-18 | 2023-02-20 | ノバルティス アーゲー | 異常ヘモグロビン症の治療用組成物及び方法 |
KR20220114569A (ko) * | 2019-12-18 | 2022-08-17 | 유니버시떼 드 몬트리얼 | 항암 화합물로서 cullin 3 어댑터 kbtbd4의 모듈레이터 |
TW202137978A (zh) * | 2019-12-26 | 2021-10-16 | 日商大日本住友製藥股份有限公司 | 造血幹細胞之培養方法 |
EP4146797A1 (en) | 2020-05-06 | 2023-03-15 | Orchard Therapeutics (Europe) Limited | Treatment for neurodegenerative diseases |
WO2021256977A1 (en) * | 2020-06-15 | 2021-12-23 | Subramaniam Agatheeswaran | Novel methods and compounds for protein degradation |
US20230256029A1 (en) * | 2020-06-25 | 2023-08-17 | Angiocrine Bioscience, Inc. | Endothelial cells for mitigation of chemotherapy-induced toxicity |
WO2022020210A1 (en) | 2020-07-18 | 2022-01-27 | Ossium Health, Inc. | Permeation of whole vertebral bodies with a cryoprotectant using vacuum assisted diffusion |
AU2021360590A1 (en) | 2020-10-14 | 2023-06-15 | Ossium Health, Inc. | Systems and methods for extraction and cryopreservation of bone marrow |
EP4262831A1 (en) | 2020-12-18 | 2023-10-25 | Ossium Health, Inc. | Methods of cell therapies |
WO2022230793A1 (ja) * | 2021-04-26 | 2022-11-03 | 住友ファーマ株式会社 | オキセピン誘導体 |
WO2022232839A1 (en) | 2021-04-30 | 2022-11-03 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for improved production of primary cd34+ cells |
WO2022269518A2 (en) | 2021-06-23 | 2022-12-29 | Novartis Ag | Compositions and methods for the treatment of hemoglobinopathies |
GB202111169D0 (en) | 2021-08-03 | 2021-09-15 | Adaptimmune Ltd | Methods of T cell production |
CN114736862A (zh) * | 2022-05-18 | 2022-07-12 | 诺航生物技术研究院徐州有限公司 | 一种造血干细胞培养基和造血干细胞的体外扩增方法 |
US11945818B1 (en) | 2023-09-06 | 2024-04-02 | King Faisal University | Pyrrolo[3,2-c]quinoline compounds as CK2 inhibitors |
CN117229284B (zh) * | 2023-11-10 | 2024-02-06 | 上海泽德曼医药科技有限公司 | 三环稠杂环类化合物、其制备方法及其在医药上的应用 |
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-
2013
- 2013-01-25 US US14/374,953 patent/US9409906B2/en active Active
- 2013-01-25 CA CA2862140A patent/CA2862140C/en active Active
- 2013-01-25 JP JP2014553589A patent/JP6250556B2/ja active Active
- 2013-01-25 KR KR1020147023818A patent/KR102098122B1/ko active IP Right Grant
- 2013-01-25 WO PCT/CA2013/050052 patent/WO2013110198A1/en active Application Filing
- 2013-01-25 HU HUE13740815A patent/HUE044070T4/hu unknown
- 2013-01-25 BR BR112014018524-7A patent/BR112014018524B1/pt active IP Right Grant
- 2013-01-25 SG SG11201404241SA patent/SG11201404241SA/en unknown
- 2013-01-25 RS RS20190858A patent/RS59002B1/sr unknown
- 2013-01-25 CN CN201380007006.5A patent/CN104144931B/zh active Active
- 2013-01-25 AU AU2013212457A patent/AU2013212457B2/en active Active
- 2013-01-25 PL PL13740815T patent/PL2807165T3/pl unknown
- 2013-01-25 DK DK13740815.9T patent/DK2807165T3/da active
- 2013-01-25 NZ NZ627188A patent/NZ627188A/en unknown
- 2013-01-25 LT LTEP13740815.9T patent/LT2807165T/lt unknown
- 2013-01-25 PT PT13740815T patent/PT2807165T/pt unknown
- 2013-01-25 SI SI201331486T patent/SI2807165T1/sl unknown
- 2013-01-25 ES ES13740815T patent/ES2733946T3/es active Active
- 2013-01-25 TR TR2019/09582T patent/TR201909582T4/tr unknown
- 2013-01-25 EP EP13740815.9A patent/EP2807165B1/en active Active
-
2014
- 2014-07-10 IL IL23358714A patent/IL233587B/en active IP Right Grant
-
2015
- 2015-05-11 HK HK15104426.9A patent/HK1203945A1/xx unknown
-
2016
- 2016-02-18 US US15/047,292 patent/US20160222017A1/en not_active Abandoned
- 2016-12-02 US US15/368,082 patent/US10336747B2/en active Active
-
2019
- 2019-07-02 HR HRP20191189TT patent/HRP20191189T1/hr unknown
- 2019-07-05 CY CY20191100713T patent/CY1121799T1/el unknown
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