RS59002B1 - Pirimido[4,5-b]indol derivati i njihova primena u ekspanziji hematopoetskih matičnih ćelija - Google Patents

Pirimido[4,5-b]indol derivati i njihova primena u ekspanziji hematopoetskih matičnih ćelija

Info

Publication number
RS59002B1
RS59002B1 RS20190858A RSP20190858A RS59002B1 RS 59002 B1 RS59002 B1 RS 59002B1 RS 20190858 A RS20190858 A RS 20190858A RS P20190858 A RSP20190858 A RS P20190858A RS 59002 B1 RS59002 B1 RS 59002B1
Authority
RS
Serbia
Prior art keywords
pyrimido
expansion
stem cells
hematopoietic stem
indole derivatives
Prior art date
Application number
RS20190858A
Other languages
English (en)
Inventor
Guy Sauvageau
Yves Gareau
Réjean Ruel
Stéphane Gingras
Iman Fares
Original Assignee
Univ Montreal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48872865&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RS59002(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Montreal filed Critical Univ Montreal
Publication of RS59002B1 publication Critical patent/RS59002B1/sr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0647Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
RS20190858A 2012-01-27 2013-01-25 Pirimido[4,5-b]indol derivati i njihova primena u ekspanziji hematopoetskih matičnih ćelija RS59002B1 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261591521P 2012-01-27 2012-01-27
EP13740815.9A EP2807165B1 (en) 2012-01-27 2013-01-25 Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells
PCT/CA2013/050052 WO2013110198A1 (en) 2012-01-27 2013-01-25 Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells

Publications (1)

Publication Number Publication Date
RS59002B1 true RS59002B1 (sr) 2019-08-30

Family

ID=48872865

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20190858A RS59002B1 (sr) 2012-01-27 2013-01-25 Pirimido[4,5-b]indol derivati i njihova primena u ekspanziji hematopoetskih matičnih ćelija

Country Status (24)

Country Link
US (3) US9409906B2 (sr)
EP (1) EP2807165B1 (sr)
JP (1) JP6250556B2 (sr)
KR (1) KR102098122B1 (sr)
CN (1) CN104144931B (sr)
AU (1) AU2013212457B2 (sr)
BR (1) BR112014018524B1 (sr)
CA (1) CA2862140C (sr)
CY (1) CY1121799T1 (sr)
DK (1) DK2807165T3 (sr)
ES (1) ES2733946T3 (sr)
HK (1) HK1203945A1 (sr)
HR (1) HRP20191189T1 (sr)
HU (1) HUE044070T4 (sr)
IL (1) IL233587B (sr)
LT (1) LT2807165T (sr)
NZ (1) NZ627188A (sr)
PL (1) PL2807165T3 (sr)
PT (1) PT2807165T (sr)
RS (1) RS59002B1 (sr)
SG (1) SG11201404241SA (sr)
SI (1) SI2807165T1 (sr)
TR (1) TR201909582T4 (sr)
WO (1) WO2013110198A1 (sr)

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EP3134409B1 (en) 2014-04-22 2020-02-12 Université de Montréal Compounds and use thereof in the expansion of hematopoietic stem cells and/or hematopoietic progenitor cells
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KR102329235B1 (ko) * 2018-11-21 2021-11-22 한국화학연구원 Irak4 저해제로서 신규의 삼중고리 화합물
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KR20220114569A (ko) * 2019-12-18 2022-08-17 유니버시떼 드 몬트리얼 항암 화합물로서 cullin 3 어댑터 kbtbd4의 모듈레이터
TW202137978A (zh) * 2019-12-26 2021-10-16 日商大日本住友製藥股份有限公司 造血幹細胞之培養方法
EP4146797A1 (en) 2020-05-06 2023-03-15 Orchard Therapeutics (Europe) Limited Treatment for neurodegenerative diseases
WO2021256977A1 (en) * 2020-06-15 2021-12-23 Subramaniam Agatheeswaran Novel methods and compounds for protein degradation
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WO2022230793A1 (ja) * 2021-04-26 2022-11-03 住友ファーマ株式会社 オキセピン誘導体
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Also Published As

Publication number Publication date
CA2862140A1 (en) 2013-08-01
JP6250556B2 (ja) 2017-12-20
HRP20191189T1 (hr) 2019-10-04
BR112014018524A2 (pt) 2021-06-08
BR112014018524B1 (pt) 2023-03-28
CA2862140C (en) 2020-04-21
CN104144931A (zh) 2014-11-12
LT2807165T (lt) 2019-07-25
BR112014018524A8 (pt) 2017-07-11
AU2013212457B2 (en) 2017-02-16
HUE044070T4 (hu) 2019-12-30
TR201909582T4 (tr) 2019-07-22
PL2807165T3 (pl) 2019-09-30
PT2807165T (pt) 2019-07-12
KR102098122B1 (ko) 2020-04-07
ES2733946T3 (es) 2019-12-03
SG11201404241SA (en) 2014-08-28
EP2807165A4 (en) 2015-08-26
KR20140121454A (ko) 2014-10-15
SI2807165T1 (sl) 2019-08-30
CY1121799T1 (el) 2020-07-31
IL233587A0 (en) 2014-08-31
US20170334904A1 (en) 2017-11-23
CN104144931B (zh) 2018-04-10
EP2807165B1 (en) 2019-05-15
US20160222017A1 (en) 2016-08-04
JP2015504902A (ja) 2015-02-16
US10336747B2 (en) 2019-07-02
WO2013110198A1 (en) 2013-08-01
HUE044070T2 (hu) 2019-09-30
US20150011543A1 (en) 2015-01-08
US9409906B2 (en) 2016-08-09
HK1203945A1 (en) 2015-11-06
DK2807165T3 (da) 2019-07-15
NZ627188A (en) 2015-12-24
IL233587B (en) 2019-11-28
AU2013212457A1 (en) 2014-09-18
EP2807165A1 (en) 2014-12-03

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