PT2970260T - Derivados de imidazo[4,5-c]piridina e pirrolo[2,3-c]piridina como inibidores de ssao - Google Patents

Derivados de imidazo[4,5-c]piridina e pirrolo[2,3-c]piridina como inibidores de ssao

Info

Publication number
PT2970260T
PT2970260T PT14711578T PT14711578T PT2970260T PT 2970260 T PT2970260 T PT 2970260T PT 14711578 T PT14711578 T PT 14711578T PT 14711578 T PT14711578 T PT 14711578T PT 2970260 T PT2970260 T PT 2970260T
Authority
PT
Portugal
Prior art keywords
pyridine
pyrrolo
imidazo
ssao inhibitors
derivatives
Prior art date
Application number
PT14711578T
Other languages
English (en)
Inventor
Espensen Max
Patient Lee
Evans David
Simpson Iain
Savory Edward
Original Assignee
Proximagen Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proximagen Llc filed Critical Proximagen Llc
Publication of PT2970260T publication Critical patent/PT2970260T/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
    • C07C53/16—Halogenated acetic acids
    • C07C53/18—Halogenated acetic acids containing fluorine
PT14711578T 2013-03-13 2014-03-13 Derivados de imidazo[4,5-c]piridina e pirrolo[2,3-c]piridina como inibidores de ssao PT2970260T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1304526.5A GB201304526D0 (en) 2013-03-13 2013-03-13 New compounds

Publications (1)

Publication Number Publication Date
PT2970260T true PT2970260T (pt) 2019-06-04

Family

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PT14711578T PT2970260T (pt) 2013-03-13 2014-03-13 Derivados de imidazo[4,5-c]piridina e pirrolo[2,3-c]piridina como inibidores de ssao

Country Status (22)

Country Link
US (9) US9428498B2 (pt)
EP (1) EP2970260B1 (pt)
JP (2) JP6334577B2 (pt)
KR (1) KR102187811B1 (pt)
CN (1) CN105189494B (pt)
AU (1) AU2014229763B2 (pt)
BR (1) BR112015022011B1 (pt)
CA (1) CA2902121C (pt)
DK (1) DK2970260T3 (pt)
EA (1) EA034066B1 (pt)
ES (1) ES2727977T3 (pt)
GB (1) GB201304526D0 (pt)
HK (1) HK1214249A1 (pt)
HU (1) HUE043456T2 (pt)
MX (1) MX368149B (pt)
NZ (1) NZ711229A (pt)
PL (1) PL2970260T3 (pt)
PT (1) PT2970260T (pt)
SG (2) SG11201507182TA (pt)
TR (1) TR201907590T4 (pt)
WO (1) WO2014140592A1 (pt)
ZA (1) ZA201506182B (pt)

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GB201416444D0 (en) * 2014-09-17 2014-10-29 Proximagen Ltd New compounds
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WO2021195406A1 (en) * 2020-03-26 2021-09-30 Proximagen, Llc New therapeutic uses of compounds

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US20170247378A1 (en) 2017-08-31
HK1214249A1 (zh) 2016-07-22
JP6334577B2 (ja) 2018-05-30
NZ711229A (en) 2020-07-31
US10968223B2 (en) 2021-04-06
US9951068B2 (en) 2018-04-24
JP2016510801A (ja) 2016-04-11
CA2902121C (en) 2022-09-20
EP2970260B1 (en) 2019-04-24
CN105189494B (zh) 2017-04-26
PL2970260T3 (pl) 2019-10-31
BR112015022011A2 (pt) 2017-07-18
US11512082B2 (en) 2022-11-29
WO2014140592A1 (en) 2014-09-18
US20160326172A1 (en) 2016-11-10
US10590125B2 (en) 2020-03-17
MX2015012010A (es) 2016-04-07
GB201304526D0 (en) 2013-04-24
US20200002335A1 (en) 2020-01-02
HUE043456T2 (hu) 2019-08-28
CA2902121A1 (en) 2014-09-18
KR20150139832A (ko) 2015-12-14
DK2970260T3 (da) 2019-05-27
US20180194763A1 (en) 2018-07-12
AU2014229763A8 (en) 2015-09-24
MX368149B (es) 2019-09-20
US20200262835A1 (en) 2020-08-20
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