RS51751B - Derivati arilmetilamina koji se koriste kao inhibitori triptaze - Google Patents

Derivati arilmetilamina koji se koriste kao inhibitori triptaze

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Publication number
RS51751B
RS51751B YU87202A YUP87202A RS51751B RS 51751 B RS51751 B RS 51751B YU 87202 A YU87202 A YU 87202A YU P87202 A YUP87202 A YU P87202A RS 51751 B RS51751 B RS 51751B
Authority
RS
Serbia
Prior art keywords
tryptase
tryptase inhibitors
arylmethylamine
derivatives
arylmethylamine derivatives
Prior art date
Application number
YU87202A
Other languages
English (en)
Inventor
Paul R. Eastwood
Peter C. Astles
Olivier Houille
Julian Levell
Heinz Pauls
Mark Czekaj
Guyan Liang
Yong Gong
James Pribish
Kent Neuenschwander
Original Assignee
Aventis Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Inc. filed Critical Aventis Pharmaceuticals Inc.
Priority to MEP-546/08A priority Critical patent/MEP54608A/xx
Priority claimed from PCT/US2001/013811 external-priority patent/WO2001090101A1/en
Publication of YU87202A publication Critical patent/YU87202A/sh
Publication of RS51751B publication Critical patent/RS51751B/sr

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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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Abstract

Jedinjenje formula (I):gde:Ar je aril grupa ili heteroaril grupa, i grupa je beta u odnosu na grupuna aril grupi, pri čemu:- - - - - - je jednostruka ili dvostruka veza;R1 i R2 su svaki nezavisno odabrani od vodonika ili C1-4 alkila; R3 je aril ili heteroarilR4 je vodonik, acil, alkoksi, alkiloksikarbonil, karboksi, cijano, halogen, hidroksi, -C(=O)-NY1Y2 ili alkil po izboru supstituisan sa alkoksi, alkilkarbamino, alkilsulfonilamino, hidroksi, -S(O)m-alkil ili -NY1Y2;Y1 i Y2 su nezavisno vodonik, alkenil, alkil, aril, arilalkil, cikloalkil, heteroaril, heteroarilalkil iliheterocikloalkil; ili -NY1Y2 grupa može da formira ciklični amin; m je nula ili broj 1 do 2; n je 2;N-oksid datog jedinjenja, farmaceutski prihvatljiva so datog jedinjenja, solvat datog jedinjenja i hidrat datog jedinjenja.Prijava sadrži još 57 patentnih zahteva.
YU87202A 2000-05-22 2001-04-27 Derivati arilmetilamina koji se koriste kao inhibitori triptaze RS51751B (sr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MEP-546/08A MEP54608A (en) 2000-05-22 2001-04-27 Arylmethylamine derivatives for use as tryptase inhibitors

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0012362.0A GB0012362D0 (en) 2000-05-22 2000-05-22 Chemical compounds
US09/843,126 US6977263B2 (en) 2000-05-22 2001-04-26 Chemical compounds
PCT/US2001/013811 WO2001090101A1 (en) 2000-05-22 2001-04-27 Arylmethylamine derivatives for use as tryptase inhibitors

Publications (2)

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YU87202A YU87202A (sh) 2006-05-25
RS51751B true RS51751B (sr) 2011-12-31

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YU87202A RS51751B (sr) 2000-05-22 2001-04-27 Derivati arilmetilamina koji se koriste kao inhibitori triptaze

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US (1) US6977263B2 (sr)
JP (1) JP4796732B2 (sr)
CN (1) CN1740169B (sr)
AT (1) ATE452884T1 (sr)
CR (1) CR6824A (sr)
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PT1296972E (pt) 2010-03-03
CR6824A (es) 2008-11-25
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MEP54608A (en) 2011-05-10
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