RS51232B - Novi postupak sinteze derivata 1,3,4,5-tetrahidro-2h-3benzazepin-2-on-a i primena u sintezi ivabradina i njegovih adicionih soli sa farmaceutski prihvatljivom kiselinom - Google Patents
Novi postupak sinteze derivata 1,3,4,5-tetrahidro-2h-3benzazepin-2-on-a i primena u sintezi ivabradina i njegovih adicionih soli sa farmaceutski prihvatljivom kiselinomInfo
- Publication number
- RS51232B RS51232B RSP-2010/0006A RSP20100006A RS51232B RS 51232 B RS51232 B RS 51232B RS P20100006 A RSP20100006 A RS P20100006A RS 51232 B RS51232 B RS 51232B
- Authority
- RS
- Serbia
- Prior art keywords
- synthesis
- ivabradine
- benzazepin
- tetrahydro
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Postupak za sintezu jedinjenja formule (I):u kojoj R1 i R2, isti ili različiti, svaki predstavlja linearnu ili razgranatu alkoksi(C1-C8)grupu ili obrazuju, zajedno sa ugljenikovim atomom koji ih nosi, 1,3-dioksanski, 1,3-dioksolanski ili 1,3-dioksepanski prsten, naznačen time što se jedinjenje formule (VI):u kojoj su R1 i R2, kao što su prethodno definisani, podvrgava reakciji katalitičke hidrogenacije, u ne-kiselom rastvaraču, zatim se reakciona mešavina filtrira da bi se dobilo jedinjenje formule (I).Prijava sadrži još 8 patentnih zahteva.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0403828A FR2868775B1 (fr) | 2004-04-13 | 2004-04-13 | Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS51232B true RS51232B (sr) | 2010-12-31 |
Family
ID=34941961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RSP-2010/0006A RS51232B (sr) | 2004-04-13 | 2005-02-21 | Novi postupak sinteze derivata 1,3,4,5-tetrahidro-2h-3benzazepin-2-on-a i primena u sintezi ivabradina i njegovih adicionih soli sa farmaceutski prihvatljivom kiselinom |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US7064200B2 (sr) |
| EP (1) | EP1614687B1 (sr) |
| JP (2) | JP4515933B2 (sr) |
| KR (1) | KR100636499B1 (sr) |
| CN (1) | CN100348585C (sr) |
| AR (1) | AR047707A1 (sr) |
| AT (1) | ATE448221T1 (sr) |
| AU (1) | AU2005200884B2 (sr) |
| BR (1) | BRPI0500590B8 (sr) |
| CA (1) | CA2496712C (sr) |
| CY (1) | CY1109740T1 (sr) |
| DE (1) | DE602005017541D1 (sr) |
| DK (1) | DK1614687T3 (sr) |
| EA (1) | EA007743B1 (sr) |
| EG (1) | EG25619A (sr) |
| ES (1) | ES2336461T3 (sr) |
| FR (1) | FR2868775B1 (sr) |
| GE (1) | GEP20074136B (sr) |
| HK (1) | HK1079777A1 (sr) |
| HR (1) | HRP20100024T1 (sr) |
| MA (1) | MA27598A1 (sr) |
| MX (1) | MXPA05003696A (sr) |
| MY (1) | MY140904A (sr) |
| NO (1) | NO329861B1 (sr) |
| NZ (1) | NZ538328A (sr) |
| PL (1) | PL1614687T3 (sr) |
| PT (1) | PT1614687E (sr) |
| RS (1) | RS51232B (sr) |
| SG (1) | SG116574A1 (sr) |
| SI (1) | SI1614687T1 (sr) |
| UA (1) | UA81773C2 (sr) |
| WO (1) | WO2005111027A1 (sr) |
| ZA (1) | ZA200501468B (sr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2868777B1 (fr) * | 2004-04-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| FR2868775B1 (fr) * | 2004-04-13 | 2008-04-11 | Servier Lab | Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| GT200500185A (es) * | 2004-08-09 | 2006-04-10 | Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos | |
| EP2471780B1 (en) | 2007-05-30 | 2014-11-26 | Ind-Swift Laboratories Limited | Crystalline Ivabradine Oxalate Salts and Polymorphs Thereof |
| ES2402765T3 (es) | 2008-12-22 | 2013-05-08 | Krka, D.D., Novo Mesto | Procedimiento de preparación de ivabradina |
| FR2940287B1 (fr) * | 2008-12-24 | 2010-12-24 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable. |
| EA201290772A1 (ru) | 2010-02-12 | 2013-02-28 | КРКА, д.д., НОВО МЕСТО | Новые формы ивабрадина гидрохлорида |
| FR2956401B1 (fr) * | 2010-02-17 | 2012-02-03 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| FR2971507B1 (fr) * | 2011-02-14 | 2013-01-18 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| FR2984320B1 (fr) * | 2011-12-20 | 2013-11-29 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| FR2993561B1 (fr) * | 2012-07-17 | 2014-10-31 | Servier Lab | Procede de synthese enzymatique de la (7s)-1-(3,4-dimethoxy bicyclo[4.2.0]octa-1,3,5-triene 7-yl) n-methyl methanamine, et application a la synthese de l'ivabradine et de ses sels |
| FR3003859B1 (fr) * | 2013-03-26 | 2015-03-13 | Servier Lab | "procede de synthese de derives de la 7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2-one et application a la synthese de l'ivabradine" |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3119874A1 (de) * | 1981-05-19 | 1982-12-09 | Dr. Karl Thomae Gmbh, 7950 Biberach | "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel" |
| DE3418270A1 (de) * | 1984-05-17 | 1985-11-21 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| EP0204349A3 (de) * | 1985-06-01 | 1990-01-03 | Dr. Karl Thomae GmbH | Neue heteroaromatische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| DE3519735A1 (de) * | 1985-06-01 | 1986-12-04 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue heteroaromatische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| FR2681862B1 (fr) * | 1991-09-27 | 1993-11-12 | Adir Cie | Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent. |
| FR2868777B1 (fr) * | 2004-04-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
| FR2868775B1 (fr) * | 2004-04-13 | 2008-04-11 | Servier Lab | Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
-
2004
- 2004-04-13 FR FR0403828A patent/FR2868775B1/fr not_active Expired - Fee Related
-
2005
- 2005-02-07 CA CA2496712A patent/CA2496712C/fr active Active
- 2005-02-15 SG SG200500770A patent/SG116574A1/en unknown
- 2005-02-17 US US11/060,043 patent/US7064200B2/en active Active
- 2005-02-18 BR BRPI0500590A patent/BRPI0500590B8/pt active IP Right Grant
- 2005-02-18 CN CNB2005100542167A patent/CN100348585C/zh active Active
- 2005-02-18 ZA ZA2005/01468A patent/ZA200501468B/en unknown
- 2005-02-18 GE GEAP8647A patent/GEP20074136B/en unknown
- 2005-02-18 NZ NZ538328A patent/NZ538328A/en unknown
- 2005-02-18 JP JP2005041810A patent/JP4515933B2/ja active Active
- 2005-02-18 UA UAA200501524A patent/UA81773C2/uk unknown
- 2005-02-18 AR ARP050100586A patent/AR047707A1/es active IP Right Grant
- 2005-02-18 MA MA28112A patent/MA27598A1/fr unknown
- 2005-02-18 NO NO20050888A patent/NO329861B1/no unknown
- 2005-02-18 AU AU2005200884A patent/AU2005200884B2/en active Active
- 2005-02-18 MY MYPI20050621A patent/MY140904A/en unknown
- 2005-02-19 EG EG2005020086A patent/EG25619A/xx active
- 2005-02-19 KR KR1020050013860A patent/KR100636499B1/ko active IP Right Grant
- 2005-02-21 EA EA200500240A patent/EA007743B1/ru unknown
- 2005-02-21 DK DK05290383.8T patent/DK1614687T3/da active
- 2005-02-21 SI SI200530864T patent/SI1614687T1/sl unknown
- 2005-02-21 DE DE602005017541T patent/DE602005017541D1/de active Active
- 2005-02-21 WO PCT/FR2005/000396 patent/WO2005111027A1/fr active Application Filing
- 2005-02-21 PT PT05290383T patent/PT1614687E/pt unknown
- 2005-02-21 PL PL05290383T patent/PL1614687T3/pl unknown
- 2005-02-21 AT AT05290383T patent/ATE448221T1/de active
- 2005-02-21 RS RSP-2010/0006A patent/RS51232B/sr unknown
- 2005-02-21 ES ES05290383T patent/ES2336461T3/es active Active
- 2005-02-21 EP EP05290383A patent/EP1614687B1/fr active Active
- 2005-04-07 MX MXPA05003696A patent/MXPA05003696A/es active IP Right Grant
- 2005-12-22 HK HK05111843A patent/HK1079777A1/xx unknown
-
2009
- 2009-09-25 JP JP2009220529A patent/JP5277130B2/ja active Active
-
2010
- 2010-01-13 HR HR20100024T patent/HRP20100024T1/hr unknown
- 2010-01-19 CY CY20101100053T patent/CY1109740T1/el unknown
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