RO116729B1 - Derivaţi de dihidropiranopiridine, procedeu şi intermediar pentru prepararea acestora - Google Patents
Derivaţi de dihidropiranopiridine, procedeu şi intermediar pentru prepararea acestoraInfo
- Publication number
- RO116729B1 RO116729B1 RO96-00283A RO9600283A RO116729B1 RO 116729 B1 RO116729 B1 RO 116729B1 RO 9600283 A RO9600283 A RO 9600283A RO 116729 B1 RO116729 B1 RO 116729B1
- Authority
- RO
- Romania
- Prior art keywords
- derivatives
- preparing
- formula
- hydrogen
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
Abstract
Invenţia se referă la derivaţi de dihidropiranopiridine cu formula (I):în care = a=a=a=aeste un radical bivalent cu formula: =N-CH=CH-CH= (a) =CH-N=CH-CH= (b) =CH-CH=N-CH= (c) =CH-CH=CH-N= (d) în care unul sau doi atomi de hidrogen, din radicalii bivalenţi, pot fi substituiţi cu halogen, hidroxi, Calchil sau Calchiloxi; Reste hidrogen sau Calchil; Reste hidrogen sau C; Reste hidrogen sau Calchil; Alkeste Calcandiil; Alkeste Calcandiil, la procedeele de preparare a acestor compuşi şi la un intermediar utilizat la obţinerea derivaţilor cu formula (i). Derivaţii de dihidropiranopiridine cu formula (I) sunt utilizaţi la tratarea bolilor caracterizate printr-o vasodilataţie excesivă, în special migrena, în tratamentul insuficienţei venoase şi a hipotensiunii.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP93202440 | 1993-08-19 | ||
| PCT/EP1994/002700 WO1995005381A1 (en) | 1993-08-19 | 1994-08-12 | Vasoconstrictive substituted dihydropyranopyridines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RO116729B1 true RO116729B1 (ro) | 2001-05-30 |
Family
ID=8214053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO96-00283A RO116729B1 (ro) | 1993-08-19 | 1994-08-12 | Derivaţi de dihidropiranopiridine, procedeu şi intermediar pentru prepararea acestora |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5691344A (ro) |
| EP (1) | EP0714395B1 (ro) |
| JP (1) | JP3650398B2 (ro) |
| KR (1) | KR100330697B1 (ro) |
| CN (1) | CN1051085C (ro) |
| AT (1) | ATE178330T1 (ro) |
| AU (1) | AU684819B2 (ro) |
| BR (1) | BR9407298A (ro) |
| CA (1) | CA2168022C (ro) |
| CZ (1) | CZ286645B6 (ro) |
| DE (1) | DE69417560T2 (ro) |
| DK (1) | DK0714395T3 (ro) |
| ES (1) | ES2132424T3 (ro) |
| FI (1) | FI113773B (ro) |
| GR (1) | GR3029924T3 (ro) |
| HU (1) | HU228673B1 (ro) |
| IL (1) | IL110688A (ro) |
| MY (1) | MY111419A (ro) |
| NO (1) | NO315001B1 (ro) |
| NZ (1) | NZ271383A (ro) |
| PL (1) | PL177516B1 (ro) |
| RO (1) | RO116729B1 (ro) |
| RU (1) | RU2135501C1 (ro) |
| SI (1) | SI0714395T1 (ro) |
| SK (1) | SK282108B6 (ro) |
| WO (1) | WO1995005381A1 (ro) |
| ZA (1) | ZA946268B (ro) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6818659B2 (en) | 2001-11-06 | 2004-11-16 | Bristol-Myers Squibb Pharma, Inc. | (2S)-2-amino-4-(2-amino-(3,4,5,6-tetrahydropyrimidin-4-yl) butanoyl and its use in cyclic and acyclic peptides |
| JP7171444B2 (ja) * | 2016-07-01 | 2022-11-15 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | ウイルス感染治療用のジヒドロピラノピリミジン |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU576868B2 (en) * | 1984-06-11 | 1988-09-08 | E.I. Du Pont De Nemours And Company | Thiophene and pyridine sulfonamides |
| CH674984A5 (ro) * | 1987-05-16 | 1990-08-15 | Sandoz Ag | |
| DE3901814A1 (de) * | 1988-07-28 | 1990-02-01 | Bayer Ag | Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga |
| US5140031A (en) * | 1989-05-31 | 1992-08-18 | E. R. Squibb & Sons, Inc. | Pyranyl cyanoguanidine derivatives |
| US5250450A (en) * | 1991-04-08 | 1993-10-05 | Micron Technology, Inc. | Insulated-gate vertical field-effect transistor with high current drive and minimum overlap capacitance |
| DE4120322A1 (de) * | 1991-06-20 | 1992-12-24 | Bayer Ag | Aminomethyl-substituierte 2,3-dihydropyrano(2,3-b)pyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
| SI9300097B (en) * | 1992-02-27 | 2001-12-31 | Janssen Pharmaceutica Nv | (benzodioxan, benzofuran or benzopyran) alkylamino) alkyl substituted guanidines |
-
1994
- 1994-08-12 HU HU9600374A patent/HU228673B1/hu unknown
- 1994-08-12 AT AT94924873T patent/ATE178330T1/de active
- 1994-08-12 KR KR1019960700633A patent/KR100330697B1/ko not_active IP Right Cessation
- 1994-08-12 AU AU74995/94A patent/AU684819B2/en not_active Expired
- 1994-08-12 US US08/586,851 patent/US5691344A/en not_active Expired - Lifetime
- 1994-08-12 PL PL94313080A patent/PL177516B1/pl unknown
- 1994-08-12 CA CA002168022A patent/CA2168022C/en not_active Expired - Lifetime
- 1994-08-12 NZ NZ271383A patent/NZ271383A/en not_active IP Right Cessation
- 1994-08-12 RU RU96105947A patent/RU2135501C1/ru active
- 1994-08-12 CN CN94193178A patent/CN1051085C/zh not_active Expired - Lifetime
- 1994-08-12 JP JP50675095A patent/JP3650398B2/ja not_active Expired - Lifetime
- 1994-08-12 SI SI9430252T patent/SI0714395T1/xx unknown
- 1994-08-12 CZ CZ1996373A patent/CZ286645B6/cs not_active IP Right Cessation
- 1994-08-12 DK DK94924873T patent/DK0714395T3/da active
- 1994-08-12 ES ES94924873T patent/ES2132424T3/es not_active Expired - Lifetime
- 1994-08-12 EP EP94924873A patent/EP0714395B1/en not_active Expired - Lifetime
- 1994-08-12 DE DE69417560T patent/DE69417560T2/de not_active Expired - Lifetime
- 1994-08-12 RO RO96-00283A patent/RO116729B1/ro unknown
- 1994-08-12 WO PCT/EP1994/002700 patent/WO1995005381A1/en active IP Right Grant
- 1994-08-12 SK SK194-96A patent/SK282108B6/sk not_active IP Right Cessation
- 1994-08-12 BR BR9407298A patent/BR9407298A/pt not_active Application Discontinuation
- 1994-08-17 IL IL11068894A patent/IL110688A/en not_active IP Right Cessation
- 1994-08-17 MY MYPI94002159A patent/MY111419A/en unknown
- 1994-08-18 ZA ZA946268A patent/ZA946268B/xx unknown
-
1996
- 1996-02-16 FI FI960721A patent/FI113773B/fi not_active IP Right Cessation
- 1996-02-19 NO NO19960647A patent/NO315001B1/no not_active IP Right Cessation
-
1999
- 1999-04-07 GR GR990401017T patent/GR3029924T3/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR860004850A (ko) | 1α-히드록시 비타민 D₃유도체의 제조방법 | |
| AU8682191A (en) | Azasteroid compounds for the treatment of prostatic hypertrophy, their preparation and use | |
| ES479134A1 (es) | Un procedimiento para la preparacion de un derivado de car- boestirilo. | |
| YU28784A (en) | Process for making n-phenyl-benzamide derivatives | |
| CA2217771A1 (en) | O-carbamoyl-phenylalaninol having substituent at benzene ring, its pharmaceutically useful salts and method for preparing the same | |
| FI956279A0 (fi) | Menetelmiä ja välituotteita 5-/2-(4-(bentsoisotiatsol-3-yyli)piperatsin-1-yyli)etyyli/-6-kloori-1,3-dihydroindol-2-onin valmistamiseksi | |
| PT73601A (en) | Process for the preparation of piperidilydene derivatives having pharmaceutical properties | |
| CA2048010A1 (en) | Proline derivatives | |
| YU125489A (en) | Process for preparing derivatives of condensed pyrazol-3-oxo-propannitryl | |
| RO116729B1 (ro) | Derivaţi de dihidropiranopiridine, procedeu şi intermediar pentru prepararea acestora | |
| ZA831674B (en) | Phenylpiperazine derivatives and process for producing the same | |
| BG103271A (en) | Derivatives of n-(benzothiazol-2-yl) piperidine-1-ethaneamines, method for their preparation and application as therapeutical means | |
| AU8831391A (en) | Chroman derivatives | |
| UA66888C2 (uk) | 3-тетрагідропіридин-4-іл індоли, спосіб їх отримання та спосіб лікування психічних розладів | |
| TW225989B (ro) | ||
| HUT71512A (en) | N-(3-chlorophenyl)-piperazine derivatives for producing alkyl-trazodon derivatives and process for producing them | |
| MY111216A (en) | 2-hydroxy-3-[1-(1h-imidazol-4-yl)alkyl]-benzenecarboximidamides | |
| PT83061A (en) | Process for the preparation of steroidic aromatase inhibitors | |
| UA41890C2 (uk) | Спосіб одержання похідних 2-перфторалкіл-3-оксазолін-5-ону (варіанти), перфторалканоїламінонітрильні проміжні сполуки | |
| MX9702089A (es) | Carboxamidas biciclicas como antagonistas de 5-ht1a. | |
| NO974747L (no) | Fremgangsmåte for fremstilling av streptograminer | |
| ES463228A1 (es) | Procedimiento para preparar quinolinonas | |
| DE3563625D1 (en) | Benzotricyclic nitrogen-containing diones and a process for the production thereof | |
| GR3020844T3 (en) | PROCESS FOR PRODUCING -g(b)-CARBOLINE DERIVATES | |
| HUT36820A (en) | Process for preparing dibenz/b,f/oxepins |